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The map label for this gene is strD [H]

Identifier: 94984300

GI number: 94984300

Start: 178980

End: 180077

Strand: Reverse

Name: strD [H]

Synonym: Dgeo_0192

Alternate gene names: 94984300

Gene position: 180077-178980 (Counterclockwise)

Preceding gene: 94984301

Following gene: 94984299

Centisome position: 7.3

GC content: 69.13

Gene sequence:

>1098_bases
GTGACCTCTGCCCCGCCTCTCCCTTCTCTCACAGACGTGCCGCTATACTCGGTTCACCCTATGAAAGGTGTGATCCTCGC
TGCCGGGCGTGGCAGCCGTCTTTTTCCCGTCAGCGCGGGCAGGCCCAAGCATGCGGTGCCGATCGCCGGAGTGCCGATCA
TCGCGTGGGCAGTGCGGGCCGTACGGGAAGCGGGGGTGGAGGAGGTGGCAGTGGTTACCAGCTCCAACAACGAGGCAGCG
CTGCGCGAAGCCACCCGGGACGAAGGGCCACTGACCTTTTTGCGGCAGGAGGAACCGCGCGGCACCGGTGACGCCGTGCT
GGCGGCCCGCGCCTTTCTGGAGGGCAGCCCGGCCCTGCTGTATCTGGGTGACAACCTGTTCGCGGATCCCCTGACGCCCC
TGACCGAGGCCCTGCAGGACGCGGACGCGGCTCTGGGCGTCAAACAGGTCCCCGATCCCAGCGCCTATGGCGTGGCAGCC
GTTCGGGACAACCTCCTCACCAACTTGGATGAGAAACCTGCCGCTCCAGCCAGCGATCTAGCGGCCTGCGGCGTCTTCGC
CTTTCACCCACATGTGCTGGAGGAGGTCGCGCGGCTCGAACCGAGCGTACGCGGTGAGATCGAGTTTCCGCAGGCGCTGC
TGCGGGTGATCGCGGCGGGCGGGCGGGTGCGGGCGGTGACATTCCCAGGGTTCTGGAGCGACGCGGGGACACCCGCCGAC
CTGCTCAGTGCCAGCGCCCATTTCCTGAGCAAGCTGGCGCCGCGGGTGGACGGCGAGGTGCGCCGCAGCAGCCTGAGCGG
ACCGGTCGTGATCGAGGCGGGCGCCACGGTGGAGGACTCTCTCCTGGTTGGCCCGGTGCTGATTGGAGCGGGAGCCAGCG
TCCGCGGCAGCACCGTGGGGCCAAATGTCAGTGTTGGCCCGCAAGCCCGGCTCGAGGGCGCGACCCTATCCGATACCCTG
ATCGACGAGGCCGCGACTGTCCGCTCTCCCACCCGTCCCCTCGTGCGGACGGTGGTTGGGCGCCGGGCCACCATCACCGC
GCCGAGCGCCAGCGGTCTGCAGATCGTGGTGGGCGACTACAGCGTGGTGCGCGTGTGA

Upstream 100 bases:

>100_bases
GGTGCTCGACGCGGGCCACTACCCCTGGCTCGACGATGAGGACGCCTTTGCGGAGGCGCTGGAGGAGGCCTTGACGCGTT
AGGGTAGGAGAAGCGCTAGG

Downstream 100 bases:

>100_bases
AGGCCATCACCCAAAGCTTACGCTCCTCCACACCACCCGCTTGTACCCCTGCCTTACGCTGGGGCATGACCCGACAGCAG
GACGAGAACCGCACCGACCA

Product: nucleotidyl transferase

Products: NA

Alternate protein names: Sugar-nucleotidylation enzyme; dTDP-glucose pyrophosphorylase; dTDP-glucose synthase [H]

Number of amino acids: Translated: 365; Mature: 364

Protein sequence:

>365_residues
MTSAPPLPSLTDVPLYSVHPMKGVILAAGRGSRLFPVSAGRPKHAVPIAGVPIIAWAVRAVREAGVEEVAVVTSSNNEAA
LREATRDEGPLTFLRQEEPRGTGDAVLAARAFLEGSPALLYLGDNLFADPLTPLTEALQDADAALGVKQVPDPSAYGVAA
VRDNLLTNLDEKPAAPASDLAACGVFAFHPHVLEEVARLEPSVRGEIEFPQALLRVIAAGGRVRAVTFPGFWSDAGTPAD
LLSASAHFLSKLAPRVDGEVRRSSLSGPVVIEAGATVEDSLLVGPVLIGAGASVRGSTVGPNVSVGPQARLEGATLSDTL
IDEAATVRSPTRPLVRTVVGRRATITAPSASGLQIVVGDYSVVRV

Sequences:

>Translated_365_residues
MTSAPPLPSLTDVPLYSVHPMKGVILAAGRGSRLFPVSAGRPKHAVPIAGVPIIAWAVRAVREAGVEEVAVVTSSNNEAA
LREATRDEGPLTFLRQEEPRGTGDAVLAARAFLEGSPALLYLGDNLFADPLTPLTEALQDADAALGVKQVPDPSAYGVAA
VRDNLLTNLDEKPAAPASDLAACGVFAFHPHVLEEVARLEPSVRGEIEFPQALLRVIAAGGRVRAVTFPGFWSDAGTPAD
LLSASAHFLSKLAPRVDGEVRRSSLSGPVVIEAGATVEDSLLVGPVLIGAGASVRGSTVGPNVSVGPQARLEGATLSDTL
IDEAATVRSPTRPLVRTVVGRRATITAPSASGLQIVVGDYSVVRV
>Mature_364_residues
TSAPPLPSLTDVPLYSVHPMKGVILAAGRGSRLFPVSAGRPKHAVPIAGVPIIAWAVRAVREAGVEEVAVVTSSNNEAAL
REATRDEGPLTFLRQEEPRGTGDAVLAARAFLEGSPALLYLGDNLFADPLTPLTEALQDADAALGVKQVPDPSAYGVAAV
RDNLLTNLDEKPAAPASDLAACGVFAFHPHVLEEVARLEPSVRGEIEFPQALLRVIAAGGRVRAVTFPGFWSDAGTPADL
LSASAHFLSKLAPRVDGEVRRSSLSGPVVIEAGATVEDSLLVGPVLIGAGASVRGSTVGPNVSVGPQARLEGATLSDTLI
DEAATVRSPTRPLVRTVVGRRATITAPSASGLQIVVGDYSVVRV

Specific function: Involved in the biosynthesis of the streptose moiety of streptomycin. Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis [H]

COG id: COG1209

COG function: function code M; dTDP-glucose pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-1-phosphate thymidylyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI11761621, Length=337, Percent_Identity=27.5964391691395, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI11761619, Length=337, Percent_Identity=27.5964391691395, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI31881779, Length=359, Percent_Identity=27.2980501392758, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI45447090, Length=359, Percent_Identity=27.2980501392758, Blast_Score=81, Evalue=2e-15,
Organism=Escherichia coli, GI1790224, Length=234, Percent_Identity=32.0512820512821, Blast_Score=117, Evalue=8e-28,
Organism=Escherichia coli, GI1788351, Length=244, Percent_Identity=30.327868852459, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI1788355, Length=274, Percent_Identity=24.0875912408759, Blast_Score=63, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI133931050, Length=361, Percent_Identity=27.9778393351801, Blast_Score=122, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6320148, Length=340, Percent_Identity=26.1764705882353, Blast_Score=100, Evalue=3e-22,
Organism=Drosophila melanogaster, GI21355443, Length=335, Percent_Identity=28.3582089552239, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24644084, Length=335, Percent_Identity=28.3582089552239, Blast_Score=113, Evalue=2e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005908
- InterPro:   IPR005835 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.24 [H]

Molecular weight: Translated: 37728; Mature: 37597

Theoretical pI: Translated: 5.23; Mature: 5.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
0.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
0.3 %Met     (Mature Protein)
0.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSAPPLPSLTDVPLYSVHPMKGVILAAGRGSRLFPVSAGRPKHAVPIAGVPIIAWAVRA
CCCCCCCCCCCCCCCEEECCCCEEEEECCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHH
VREAGVEEVAVVTSSNNEAALREATRDEGPLTFLRQEEPRGTGDAVLAARAFLEGSPALL
HHHCCCCEEEEEECCCCCHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHHHCCCCEEE
YLGDNLFADPLTPLTEALQDADAALGVKQVPDPSAYGVAAVRDNLLTNLDEKPAAPASDL
EECCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCHHHH
AACGVFAFHPHVLEEVARLEPSVRGEIEFPQALLRVIAAGGRVRAVTFPGFWSDAGTPAD
HHHHHHHCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCCCHH
LLSASAHFLSKLAPRVDGEVRRSSLSGPVVIEAGATVEDSLLVGPVLIGAGASVRGSTVG
HHHHHHHHHHHHHHHCCCHHHHHCCCCCEEEECCCCCCCCEEECCEEEECCCCCCCCCCC
PNVSVGPQARLEGATLSDTLIDEAATVRSPTRPLVRTVVGRRATITAPSASGLQIVVGDY
CCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHCCCEEEECCCCCCCEEEECCE
SVVRV
EEEEC
>Mature Secondary Structure 
TSAPPLPSLTDVPLYSVHPMKGVILAAGRGSRLFPVSAGRPKHAVPIAGVPIIAWAVRA
CCCCCCCCCCCCCCEEECCCCEEEEECCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHH
VREAGVEEVAVVTSSNNEAALREATRDEGPLTFLRQEEPRGTGDAVLAARAFLEGSPALL
HHHCCCCEEEEEECCCCCHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHHHCCCCEEE
YLGDNLFADPLTPLTEALQDADAALGVKQVPDPSAYGVAAVRDNLLTNLDEKPAAPASDL
EECCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCHHHH
AACGVFAFHPHVLEEVARLEPSVRGEIEFPQALLRVIAAGGRVRAVTFPGFWSDAGTPAD
HHHHHHHCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCCCHH
LLSASAHFLSKLAPRVDGEVRRSSLSGPVVIEAGATVEDSLLVGPVLIGAGASVRGSTVG
HHHHHHHHHHHHHHHCCCHHHHHCCCCCEEEECCCCCCCCEEECCEEEECCCCCCCCCCC
PNVSVGPQARLEGATLSDTLIDEAATVRSPTRPLVRTVVGRRATITAPSASGLQIVVGDY
CCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHCCCEEEECCCCCCCEEEECCE
SVVRV
EEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3118332 [H]