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The map label for this gene is dck [H]

Identifier: 94984209

GI number: 94984209

Start: 95398

End: 96021

Strand: Reverse

Name: dck [H]

Synonym: Dgeo_0101

Alternate gene names: 94984209

Gene position: 96021-95398 (Counterclockwise)

Preceding gene: 94984210

Following gene: 94984207

Centisome position: 3.89

GC content: 61.86

Gene sequence:

>624_bases
ATGTACCTCGCCCTCTCCGGCAACATCGGCAGCGGCAAGAGCACCCTCACACGGATGCTGGCCGAACGATACGGTTTGCG
GCCCGTGTATGAGCCATACGCGGAAAATCCCTACCTAGAAGATTTTTACCGCGACATGCGGCGCTATTCCTTTCACAGTC
AGGTGTACTTCCTCTCGCGACGACTGGAACAGCATCTGAACCTGGTCACGGGCGCGCGGTACGTGATCCAGGACCGCACC
GTGTTCGAAGACGCCAACATCTTCGCGCGGAACCTCTTTGAATCGGGGCAGATGGAGGCGCGCGACTGGGCCACCTACCT
GGGCCTGTACCAGGGGATCCTCCCCGCGCTGCGGGTGCCTGATCTCCTGATTCACATCGACGCCAGTGTGCCCACCCTGA
AAAAACGCATCGCGCAGCGCGGGCGGGCCTATGAAAAGGCAATTCCCGACACCTACCTGGCAGGACTCAACCGGCTCTAC
GCACAGTGGATCGAGAACTTTGACGCCTGTCCCGTGATGCGGGTCCCAGGCGACGAACTCGACTTCGTGCAGGACCCGGC
CGCCTTCCGCTGGGTATGTGACCGGGTGCAGGCCTACGGCTTCGGGCTGCCGCTGCTGCGCTAA

Upstream 100 bases:

>100_bases
GCGGCCCTACCCACCCGAACAGAGGAAGGTACGGCCTGATGAGGCATGCGGCACAGGGCGTGAGGAGCGAGAAAACCAGC
TTCTCCCCAGGGAGGCCCTG

Downstream 100 bases:

>100_bases
GACACAGCAGGGCCAGCTCCAGGCTCAGGCCCCTGCGCCTTCCCCCACATGCTCCAGGACGTTTCGCAGCAGGTCCGTCA
CATGCGCGTCGGCCAGGCGG

Product: deoxynucleoside kinase

Products: NA

Alternate protein names: dAK/dCK [H]

Number of amino acids: Translated: 207; Mature: 207

Protein sequence:

>207_residues
MYLALSGNIGSGKSTLTRMLAERYGLRPVYEPYAENPYLEDFYRDMRRYSFHSQVYFLSRRLEQHLNLVTGARYVIQDRT
VFEDANIFARNLFESGQMEARDWATYLGLYQGILPALRVPDLLIHIDASVPTLKKRIAQRGRAYEKAIPDTYLAGLNRLY
AQWIENFDACPVMRVPGDELDFVQDPAAFRWVCDRVQAYGFGLPLLR

Sequences:

>Translated_207_residues
MYLALSGNIGSGKSTLTRMLAERYGLRPVYEPYAENPYLEDFYRDMRRYSFHSQVYFLSRRLEQHLNLVTGARYVIQDRT
VFEDANIFARNLFESGQMEARDWATYLGLYQGILPALRVPDLLIHIDASVPTLKKRIAQRGRAYEKAIPDTYLAGLNRLY
AQWIENFDACPVMRVPGDELDFVQDPAAFRWVCDRVQAYGFGLPLLR
>Mature_207_residues
MYLALSGNIGSGKSTLTRMLAERYGLRPVYEPYAENPYLEDFYRDMRRYSFHSQVYFLSRRLEQHLNLVTGARYVIQDRT
VFEDANIFARNLFESGQMEARDWATYLGLYQGILPALRVPDLLIHIDASVPTLKKRIAQRGRAYEKAIPDTYLAGLNRLY
AQWIENFDACPVMRVPGDELDFVQDPAAFRWVCDRVQAYGFGLPLLR

Specific function: Plays an essential role in generating the deoxyribonucleotide precursors dATP AND dCTP for DNA metabolism. The phosphate acceptor specificity is strict toward deoxyadenosine (dAdo) and deoxycytidine (dCyd). The specificity toward the sugar moiety of the n

COG id: COG1428

COG function: function code F; Deoxynucleoside kinases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DCK/DGK family [H]

Homologues:

Organism=Homo sapiens, GI290656975, Length=189, Percent_Identity=26.984126984127, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI290656936, Length=189, Percent_Identity=26.984126984127, Blast_Score=68, Evalue=7e-12,
Organism=Homo sapiens, GI18426967, Length=217, Percent_Identity=29.4930875576037, Blast_Score=66, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002624 [H]

Pfam domain/function: PF01712 dNK [H]

EC number: =2.7.1.74; =2.7.1.76 [H]

Molecular weight: Translated: 24033; Mature: 24033

Theoretical pI: Translated: 8.16; Mature: 8.16

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYLALSGNIGSGKSTLTRMLAERYGLRPVYEPYAENPYLEDFYRDMRRYSFHSQVYFLSR
CEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
RLEQHLNLVTGARYVIQDRTVFEDANIFARNLFESGQMEARDWATYLGLYQGILPALRVP
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCC
DLLIHIDASVPTLKKRIAQRGRAYEKAIPDTYLAGLNRLYAQWIENFDACPVMRVPGDEL
CEEEEECCCCHHHHHHHHHHCHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCEEECCCCCC
DFVQDPAAFRWVCDRVQAYGFGLPLLR
CHHCCCHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MYLALSGNIGSGKSTLTRMLAERYGLRPVYEPYAENPYLEDFYRDMRRYSFHSQVYFLSR
CEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
RLEQHLNLVTGARYVIQDRTVFEDANIFARNLFESGQMEARDWATYLGLYQGILPALRVP
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCC
DLLIHIDASVPTLKKRIAQRGRAYEKAIPDTYLAGLNRLYAQWIENFDACPVMRVPGDEL
CEEEEECCCCHHHHHHHHHHCHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCEEECCCCCC
DFVQDPAAFRWVCDRVQAYGFGLPLLR
CHHCCCHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7584024; 9384377 [H]