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The map label for this gene is cof [H]

Identifier: 94972086

GI number: 94972086

Start: 432423

End: 433208

Strand: Direct

Name: cof [H]

Synonym: Dgeo_2618

Alternate gene names: 94972086

Gene position: 432423-433208 (Clockwise)

Preceding gene: 94972093

Following gene: 94972079

Centisome position: 75.32

GC content: 67.43

Gene sequence:

>786_bases
ATGCGCCTGCTTGCCTTCGATCTGGACGGAACGCTGCTGGACCGGGACCACATGGTGCCTCCCCGGACCCTAGCGATCAT
CGCGCGGCTGCGCGAACACGGCTGCCGAGTCGCCGTGATCACCGGACGGGCCGACGTGCCGACGGAGGTGCTGGTGGGTC
TGCGCCCAGACGCGGTGGCGGTGAATACCGGCGGGCGGGTGTTGGTGGGTGAAGAAGTGTTGGCCGACGAGCACTTCACG
CCCGAGCAAACGCGGGCGCTGCTGGAGCGGCTGCCCAAGGATCGCCCGGTCTTCGGCTTTGGTCCGGGAACGTTCTACGC
ACCCGATCCCCACGCTGCACACTTGACCGCCTGGCACGCCAAGCGGCGAGGGTTGCCACTGGCACACGCCGCGGCAGGCC
CGCTGCAAAAACTGGACATTGAGCTGGCCTGGAACGATCCCGCCGCGCCCGAACTGATCACCCCCCTGCGGCAGGTCCCC
GGGGTGAATGTCACCAGCAGTGTCAGCGGCGACCTTCAGTACCTCACGGTCACGCCGGAAGCGGCCAACAAGGGCGCTGC
AGTGCAGCGGATTGCAGGGGCGCTGGGCATTCCCCTAGACCACACCCTTGCCTTTGGTGACAGTGAAAACGACCTTGCCA
TGTTCAAGGTCGCCGGGGTCGCGGTGCAGGTAGGCGAGGCGGAGTGTTTGCAAGACGCCGCTCACCACCGGGTCAGCTGC
TCGGCGCTTGGCCTCCCCGCCTGGCTGGCCGAGTATGCGGAAGAACTCGCGCGCGAGCTGGCCTGA

Upstream 100 bases:

>100_bases
GAACAGGATGCTCCCACAGTAGAAGTGGAAATTATTTCTGTCAAGGCAGCGTGGTCTTGAAACTCTTTTCTTAGCAGGCT
CTTGGTGGCACACTGTCGCC

Downstream 100 bases:

>100_bases
GCGTCAAAGACAAGCAAAGACAGACCGGGACTTCCCAATCTGCCTCCCAACTGCGCCTCAGCGCCTATTTCCAGCCCAGC
CGTGCCGAAACCTGACCCGC

Product: HAD family hydrolase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 261; Mature: 261

Protein sequence:

>261_residues
MRLLAFDLDGTLLDRDHMVPPRTLAIIARLREHGCRVAVITGRADVPTEVLVGLRPDAVAVNTGGRVLVGEEVLADEHFT
PEQTRALLERLPKDRPVFGFGPGTFYAPDPHAAHLTAWHAKRRGLPLAHAAAGPLQKLDIELAWNDPAAPELITPLRQVP
GVNVTSSVSGDLQYLTVTPEAANKGAAVQRIAGALGIPLDHTLAFGDSENDLAMFKVAGVAVQVGEAECLQDAAHHRVSC
SALGLPAWLAEYAEELARELA

Sequences:

>Translated_261_residues
MRLLAFDLDGTLLDRDHMVPPRTLAIIARLREHGCRVAVITGRADVPTEVLVGLRPDAVAVNTGGRVLVGEEVLADEHFT
PEQTRALLERLPKDRPVFGFGPGTFYAPDPHAAHLTAWHAKRRGLPLAHAAAGPLQKLDIELAWNDPAAPELITPLRQVP
GVNVTSSVSGDLQYLTVTPEAANKGAAVQRIAGALGIPLDHTLAFGDSENDLAMFKVAGVAVQVGEAECLQDAAHHRVSC
SALGLPAWLAEYAEELARELA
>Mature_261_residues
MRLLAFDLDGTLLDRDHMVPPRTLAIIARLREHGCRVAVITGRADVPTEVLVGLRPDAVAVNTGGRVLVGEEVLADEHFT
PEQTRALLERLPKDRPVFGFGPGTFYAPDPHAAHLTAWHAKRRGLPLAHAAAGPLQKLDIELAWNDPAAPELITPLRQVP
GVNVTSSVSGDLQYLTVTPEAANKGAAVQRIAGALGIPLDHTLAFGDSENDLAMFKVAGVAVQVGEAECLQDAAHHRVSC
SALGLPAWLAEYAEELARELA

Specific function: Catalyzes the hydrolysis of 4-amino-2-methyl-5- hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2- methyl-5-hydroxymethylpyrimidine phosphate (HMP-P) [H]

COG id: COG0561

COG function: function code R; Predicted hydrolases of the HAD superfamily

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HAD-like hydrolase superfamily. Cof family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023214
- InterPro:   IPR013200
- InterPro:   IPR006379
- InterPro:   IPR000150 [H]

Pfam domain/function: PF08282 Hydrolase_3 [H]

EC number: NA

Molecular weight: Translated: 27871; Mature: 27871

Theoretical pI: Translated: 5.53; Mature: 5.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLLAFDLDGTLLDRDHMVPPRTLAIIARLREHGCRVAVITGRADVPTEVLVGLRPDAVA
CEEEEEECCCEEECCCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHEECCCCEEE
VNTGGRVLVGEEVLADEHFTPEQTRALLERLPKDRPVFGFGPGTFYAPDPHAAHLTAWHA
EECCCEEEECHHHHCCCCCCHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCHHHHHHHH
KRRGLPLAHAAAGPLQKLDIELAWNDPAAPELITPLRQVPGVNVTSSVSGDLQYLTVTPE
HHCCCCCHHHCCCCCEEEEEEEEECCCCCCHHHHHHHHCCCCCEECCCCCCEEEEEECCC
AANKGAAVQRIAGALGIPLDHTLAFGDSENDLAMFKVAGVAVQVGEAECLQDAAHHRVSC
CCCCCHHHHHHHHHHCCCCCCEEEECCCCCCEEEEEEECEEEECCHHHHHHHHHHCEEEH
SALGLPAWLAEYAEELARELA
HHCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRLLAFDLDGTLLDRDHMVPPRTLAIIARLREHGCRVAVITGRADVPTEVLVGLRPDAVA
CEEEEEECCCEEECCCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHEECCCCEEE
VNTGGRVLVGEEVLADEHFTPEQTRALLERLPKDRPVFGFGPGTFYAPDPHAAHLTAWHA
EECCCEEEECHHHHCCCCCCHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCHHHHHHHH
KRRGLPLAHAAAGPLQKLDIELAWNDPAAPELITPLRQVPGVNVTSSVSGDLQYLTVTPE
HHCCCCCHHHCCCCCEEEEEEEEECCCCCCHHHHHHHHCCCCCEECCCCCCEEEEEECCC
AANKGAAVQRIAGALGIPLDHTLAFGDSENDLAMFKVAGVAVQVGEAECLQDAAHHRVSC
CCCCCHHHHHHHHHHCCCCCCEEEECCCCCCEEEEEEECEEEECCHHHHHHHHHHCEEEH
SALGLPAWLAEYAEELARELA
HHCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA