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The map label for this gene is mhpF [C]

Identifier: 94314127

GI number: 94314127

Start: 1902532

End: 1903476

Strand: Direct

Name: mhpF [C]

Synonym: Rmet_5208

Alternate gene names: 94314127

Gene position: 1902532-1903476 (Clockwise)

Preceding gene: 94314126

Following gene: 94314128

Centisome position: 73.74

GC content: 66.24

Gene sequence:

>945_bases
ATGAAACCCTGCAAGGTAGCCATCATCGGTTCCGGCAACATCGGCACCGACCTGATGATCAAGATCCTGCGCCACGGCAA
GCATGTCGAGATGGGCGCCATGGTGGGGATCGATCCCACCTCGGAAGGCCTGGCGCGCGCGACACGCCTCGGCGTGCCGG
TCACCGCCGCCGGCATCGACGGCCTGCTGGCCATGCCGGAGTTCGGTGAGATCCGCATCGCCTTCGATGCCACCAGCGCC
GGCGCGCACGCCCGCCACAACGCCACGCTGCAGGCGCACAACGTGCGCGTGATCGATCTGACACCAGCTGCCATCGGCCC
CTACGTGGTGCCCAGCGTCAATGCCGGCGAACATCTTGATGCGCCGAACCTCAACATGGTCACCTGCGGCGGCCAGGCCA
CCATTCCCATCGTGGCAGCCGTGGCCAGCGTGACGCCGGTCCACTATGCGGAGATCGTGGCCTCGATCGCGAGCAAGTCC
GCCGGCCCCGGCACGCGCGACAACATCGACGAGTTCACGGAAACGACCTCCCGCGCCATCGAATCAGTGGGCGGCGCCAG
GCGCGGCAAGGCCATCATCGTTCTCAACCCGGCCGAGCCGCCGCTGATCATGCGCGACACCGTGTGCTGCCTGATCGACG
AAGCCGACACCGCGGCGATCGAAGCCGCGGTGCACGCGATGGTGGAACGCATGCAGGGCTATGTGCCCGGATACCGGCTC
AAACAGCGTGTGCAGTTCGACCGCATCGACACACCGGTGAATGTGCCCGGCCTCGGACCGACGACCGGCCTGAAGGTCAC
GGTCTTCCTGGAAGTGGAAGGCGCCGCGCACTACCTGCCCGCCTATGCAGGCAATCTGGACATCATGACGAGCGCCGCGC
TCGCATGCGCCGAACGCGTCGCACAGGCATTGGGCAATCATCATGCCCTGTCGGCAGCAAGCTAA

Upstream 100 bases:

>100_bases
ATGGTCGCCGTGCAGCCGGGCAATGTCTTTACCGCCAGCATCGAGGGCCTGGGTAGCGTGACCGCGTCGTTCCAGGCCGT
CAGACAAGGAGACGCCTGAG

Downstream 100 bases:

>100_bases
GGAGCCGGTCATGACCGACAAGAAACTTTATATCTCCGATGTGACCCTGCGTGATGGTAGCCACGCGATCCGTCACCAGT
ACTCGGTTCCGCAGGTGCGT

Product: acetaldehyde dehydrogenase

Products: NA

Alternate protein names: Acetaldehyde dehydrogenase [acetylating] 2

Number of amino acids: Translated: 314; Mature: 314

Protein sequence:

>314_residues
MKPCKVAIIGSGNIGTDLMIKILRHGKHVEMGAMVGIDPTSEGLARATRLGVPVTAAGIDGLLAMPEFGEIRIAFDATSA
GAHARHNATLQAHNVRVIDLTPAAIGPYVVPSVNAGEHLDAPNLNMVTCGGQATIPIVAAVASVTPVHYAEIVASIASKS
AGPGTRDNIDEFTETTSRAIESVGGARRGKAIIVLNPAEPPLIMRDTVCCLIDEADTAAIEAAVHAMVERMQGYVPGYRL
KQRVQFDRIDTPVNVPGLGPTTGLKVTVFLEVEGAAHYLPAYAGNLDIMTSAALACAERVAQALGNHHALSAAS

Sequences:

>Translated_314_residues
MKPCKVAIIGSGNIGTDLMIKILRHGKHVEMGAMVGIDPTSEGLARATRLGVPVTAAGIDGLLAMPEFGEIRIAFDATSA
GAHARHNATLQAHNVRVIDLTPAAIGPYVVPSVNAGEHLDAPNLNMVTCGGQATIPIVAAVASVTPVHYAEIVASIASKS
AGPGTRDNIDEFTETTSRAIESVGGARRGKAIIVLNPAEPPLIMRDTVCCLIDEADTAAIEAAVHAMVERMQGYVPGYRL
KQRVQFDRIDTPVNVPGLGPTTGLKVTVFLEVEGAAHYLPAYAGNLDIMTSAALACAERVAQALGNHHALSAAS
>Mature_314_residues
MKPCKVAIIGSGNIGTDLMIKILRHGKHVEMGAMVGIDPTSEGLARATRLGVPVTAAGIDGLLAMPEFGEIRIAFDATSA
GAHARHNATLQAHNVRVIDLTPAAIGPYVVPSVNAGEHLDAPNLNMVTCGGQATIPIVAAVASVTPVHYAEIVASIASKS
AGPGTRDNIDEFTETTSRAIESVGGARRGKAIIVLNPAEPPLIMRDTVCCLIDEADTAAIEAAVHAMVERMQGYVPGYRL
KQRVQFDRIDTPVNVPGLGPTTGLKVTVFLEVEGAAHYLPAYAGNLDIMTSAALACAERVAQALGNHHALSAAS

Specific function: Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD(+) and coenzyme A. Is the final enzyme in the meta- cleavage pathway for the degradation of aromatic compounds

COG id: COG4569

COG function: function code Q; Acetaldehyde dehydrogenase (acetylating)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acetaldehyde dehydrogenase family

Homologues:

Organism=Escherichia coli, GI1786547, Length=308, Percent_Identity=70.7792207792208, Blast_Score=432, Evalue=1e-122,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ACDH2_RALME (Q1LCQ9)

Other databases:

- EMBL:   CP000353
- RefSeq:   YP_587336.1
- ProteinModelPortal:   Q1LCQ9
- SMR:   Q1LCQ9
- STRING:   Q1LCQ9
- GeneID:   4042069
- GenomeReviews:   CP000353_GR
- KEGG:   rme:Rmet_5208
- eggNOG:   COG4569
- HOGENOM:   HBG300125
- OMA:   HAMVERM
- ProtClustDB:   PRK08300
- BioCyc:   RMET266264:RMET_5208-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01657
- InterPro:   IPR003361
- InterPro:   IPR015426
- InterPro:   IPR016040
- InterPro:   IPR000534
- Gene3D:   G3DSA:3.40.50.720
- PANTHER:   PTHR21123
- PIRSF:   PIRSF015689
- SMART:   SM00859
- TIGRFAMs:   TIGR03215

Pfam domain/function: PF09290 AcetDehyd-dimer; PF01118 Semialdhyde_dh

EC number: =1.2.1.10

Molecular weight: Translated: 32613; Mature: 32613

Theoretical pI: Translated: 6.43; Mature: 6.43

Prosite motif: NA

Important sites: BINDING 285-285

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPCKVAIIGSGNIGTDLMIKILRHGKHVEMGAMVGIDPTSEGLARATRLGVPVTAAGID
CCCEEEEEEECCCCCHHHHHHHHHCCCCEEECEEEECCCCHHHHHHHHHCCCCEEECCCC
GLLAMPEFGEIRIAFDATSAGAHARHNATLQAHNVRVIDLTPAAIGPYVVPSVNAGEHLD
CEEECCCCCCEEEEEECCCCCCCCCCCCEEEECCEEEEEECCCCCCCEECCCCCCCCCCC
APNLNMVTCGGQATIPIVAAVASVTPVHYAEIVASIASKSAGPGTRDNIDEFTETTSRAI
CCCCEEEEECCCCHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHH
ESVGGARRGKAIIVLNPAEPPLIMRDTVCCLIDEADTAAIEAAVHAMVERMQGYVPGYRL
HHHCCCCCCCEEEEECCCCCCEEECCCEEEEEECCCHHHHHHHHHHHHHHHHCCCCCHHH
KQRVQFDRIDTPVNVPGLGPTTGLKVTVFLEVEGAAHYLPAYAGNLDIMTSAALACAERV
HHHHHHHHCCCCCCCCCCCCCCCEEEEEEEEECCCCCCCCHHCCCCHHHHHHHHHHHHHH
AQALGNHHALSAAS
HHHHCCCCCCCCCC
>Mature Secondary Structure
MKPCKVAIIGSGNIGTDLMIKILRHGKHVEMGAMVGIDPTSEGLARATRLGVPVTAAGID
CCCEEEEEEECCCCCHHHHHHHHHCCCCEEECEEEECCCCHHHHHHHHHCCCCEEECCCC
GLLAMPEFGEIRIAFDATSAGAHARHNATLQAHNVRVIDLTPAAIGPYVVPSVNAGEHLD
CEEECCCCCCEEEEEECCCCCCCCCCCCEEEECCEEEEEECCCCCCCEECCCCCCCCCCC
APNLNMVTCGGQATIPIVAAVASVTPVHYAEIVASIASKSAGPGTRDNIDEFTETTSRAI
CCCCEEEEECCCCHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHH
ESVGGARRGKAIIVLNPAEPPLIMRDTVCCLIDEADTAAIEAAVHAMVERMQGYVPGYRL
HHHCCCCCCCEEEEECCCCCCEEECCCEEEEEECCCHHHHHHHHHHHHHHHHCCCCCHHH
KQRVQFDRIDTPVNVPGLGPTTGLKVTVFLEVEGAAHYLPAYAGNLDIMTSAALACAERV
HHHHHHHHCCCCCCCCCCCCCCCEEEEEEEEECCCCCCCCHHCCCCHHHHHHHHHHHHHH
AQALGNHHALSAAS
HHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA