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The map label for this gene is ilvR [H]

Identifier: 94313827

GI number: 94313827

Start: 1568253

End: 1569158

Strand: Reverse

Name: ilvR [H]

Synonym: Rmet_4905

Alternate gene names: 94313827

Gene position: 1569158-1568253 (Counterclockwise)

Preceding gene: 94313832

Following gene: 94313824

Centisome position: 60.82

GC content: 64.35

Gene sequence:

>906_bases
TTGACTGAGCATCGAAAATTTCGATGCTTGAATCCCGCCTTGCTCCGCTATTTCAAGACCTTTCTCGTGGCCGCCGAAAC
CGGTTCGTTCTCGTCGGCCGGCGCGCGGCTCGGGCTGACGCAGTCGGCGGTCAGCACCCAGATTCGCCGGTTGGAAGAAG
ATCTCGGCTGCACGTTGTTCGATCGATCGGGCAAATCGGTGACCCTGAGCGAGGAGGGCCGGCAGATGCTGGCGGACGCC
TCGCGCATCGTTGCGCTCTACGAGTCGATGAAGGGCGCGCGACTGCAGCGCGATACGGCGCCGCTGGATCTGGGGGCGGT
ATCGACCGTGCAGGCCAGTCTGTTGCCGCGTGCCATGCAACGTTTTCGCGTCGCGTTTCCTGACACCCACGTCAATATCG
TGCCGGGCATGTCGACGCAGTTGCTGACGCAGGTCGATGCCCGCGAGCTGGATATTGCGGTGCTGGTCAAGCCGCGGCTC
GGCATTCCACCCGAACTGAAGTGGGTGCCGCTGGTGAAGGAGCGCTTCGTGGCGGTGGCGCCGAAGGGGGCGCCGGCCGA
CCTGAAGACGCTGCTGTCGACAGTCCCGTTTATCCGATACAACCGCCACTCGACCGGCGGGCAACTCGTGGACCGCTATC
TCAAACGGCACCGCCTTTGGGTACGCGAGGGCATGGAGTTGGACGAGCCTGCAGTCATCCTGCAGATGGTTGGCGAGGGG
CTCGGTTGCGCGATCATTCCTTGCGAGCTTGTGCCGCTGGCGCAGACCCCGAATGTCGAGCAGGTGCCGATGCCGGGTAT
GCCGATGTATCGGGAGATCGGCGTGCTGGTCCGGCAATCGGCGTTGAAGCGTGCCAGCGCGGCGGCGCTCATCGACGCGT
TCGTGGCGGCCTGCCACGAACGCTAG

Upstream 100 bases:

>100_bases
ACAGGGGAATGGCGTTCATGGTGGGGCGTTATCTCCATGGATGCGTGAAGGCGTCGTTGATTGTAATCAGCAGAACTCGT
AATATGAAACGAATCATTTT

Downstream 100 bases:

>100_bases
TGTTGCCTTCCGGCGCGCTCAGGAGCGTTCAGGCGCCAGCCGCTTGCGGCGTGACGCCATCTGCCCGAGGGGCCGGGCGC
CGTACCATCAATGCGAGCAG

Product: putative LysR family transcriptional regulator

Products: NA

Alternate protein names: Isoleucine biosynthesis transcriptional activator [H]

Number of amino acids: Translated: 301; Mature: 300

Protein sequence:

>301_residues
MTEHRKFRCLNPALLRYFKTFLVAAETGSFSSAGARLGLTQSAVSTQIRRLEEDLGCTLFDRSGKSVTLSEEGRQMLADA
SRIVALYESMKGARLQRDTAPLDLGAVSTVQASLLPRAMQRFRVAFPDTHVNIVPGMSTQLLTQVDARELDIAVLVKPRL
GIPPELKWVPLVKERFVAVAPKGAPADLKTLLSTVPFIRYNRHSTGGQLVDRYLKRHRLWVREGMELDEPAVILQMVGEG
LGCAIIPCELVPLAQTPNVEQVPMPGMPMYREIGVLVRQSALKRASAAALIDAFVAACHER

Sequences:

>Translated_301_residues
MTEHRKFRCLNPALLRYFKTFLVAAETGSFSSAGARLGLTQSAVSTQIRRLEEDLGCTLFDRSGKSVTLSEEGRQMLADA
SRIVALYESMKGARLQRDTAPLDLGAVSTVQASLLPRAMQRFRVAFPDTHVNIVPGMSTQLLTQVDARELDIAVLVKPRL
GIPPELKWVPLVKERFVAVAPKGAPADLKTLLSTVPFIRYNRHSTGGQLVDRYLKRHRLWVREGMELDEPAVILQMVGEG
LGCAIIPCELVPLAQTPNVEQVPMPGMPMYREIGVLVRQSALKRASAAALIDAFVAACHER
>Mature_300_residues
TEHRKFRCLNPALLRYFKTFLVAAETGSFSSAGARLGLTQSAVSTQIRRLEEDLGCTLFDRSGKSVTLSEEGRQMLADAS
RIVALYESMKGARLQRDTAPLDLGAVSTVQASLLPRAMQRFRVAFPDTHVNIVPGMSTQLLTQVDARELDIAVLVKPRLG
IPPELKWVPLVKERFVAVAPKGAPADLKTLLSTVPFIRYNRHSTGGQLVDRYLKRHRLWVREGMELDEPAVILQMVGEGL
GCAIIPCELVPLAQTPNVEQVPMPGMPMYREIGVLVRQSALKRASAAALIDAFVAACHER

Specific function: Positively regulates the expression of the ilvD gene while negatively autoregulating its own expression [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI145693105, Length=276, Percent_Identity=25, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1788887, Length=244, Percent_Identity=26.2295081967213, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI1787879, Length=248, Percent_Identity=27.8225806451613, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1788748, Length=247, Percent_Identity=24.6963562753036, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI157672245, Length=303, Percent_Identity=26.0726072607261, Blast_Score=82, Evalue=6e-17,
Organism=Escherichia coli, GI1788481, Length=237, Percent_Identity=28.2700421940928, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1789204, Length=244, Percent_Identity=26.6393442622951, Blast_Score=75, Evalue=7e-15,
Organism=Escherichia coli, GI1790208, Length=251, Percent_Identity=27.8884462151394, Blast_Score=74, Evalue=9e-15,
Organism=Escherichia coli, GI87082132, Length=238, Percent_Identity=25.2100840336134, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1787601, Length=171, Percent_Identity=26.9005847953216, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI2367136, Length=250, Percent_Identity=28, Blast_Score=68, Evalue=7e-13,
Organism=Escherichia coli, GI1790399, Length=145, Percent_Identity=28.2758620689655, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1788296, Length=235, Percent_Identity=27.2340425531915, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI1787530, Length=275, Percent_Identity=24, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 33169; Mature: 33038

Theoretical pI: Translated: 9.72; Mature: 9.72

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEHRKFRCLNPALLRYFKTFLVAAETGSFSSAGARLGLTQSAVSTQIRRLEEDLGCTLF
CCCCCCEEECCHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCEEEE
DRSGKSVTLSEEGRQMLADASRIVALYESMKGARLQRDTAPLDLGAVSTVQASLLPRAMQ
ECCCCEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
RFRVAFPDTHVNIVPGMSTQLLTQVDARELDIAVLVKPRLGIPPELKWVPLVKERFVAVA
HHHHCCCCCCEEEECCCHHHHHHHHCHHHCCEEEEEECCCCCCCCCCEEHHHHHCEEEEC
PKGAPADLKTLLSTVPFIRYNRHSTGGQLVDRYLKRHRLWVREGMELDEPAVILQMVGEG
CCCCCHHHHHHHHHCCHHEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCC
LGCAIIPCELVPLAQTPNVEQVPMPGMPMYREIGVLVRQSALKRASAAALIDAFVAACHE
CCEEEECCEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
R
C
>Mature Secondary Structure 
TEHRKFRCLNPALLRYFKTFLVAAETGSFSSAGARLGLTQSAVSTQIRRLEEDLGCTLF
CCCCCEEECCHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCEEEE
DRSGKSVTLSEEGRQMLADASRIVALYESMKGARLQRDTAPLDLGAVSTVQASLLPRAMQ
ECCCCEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
RFRVAFPDTHVNIVPGMSTQLLTQVDARELDIAVLVKPRLGIPPELKWVPLVKERFVAVA
HHHHCCCCCCEEEECCCHHHHHHHHCHHHCCEEEEEECCCCCCCCCCEEHHHHHCEEEEC
PKGAPADLKTLLSTVPFIRYNRHSTGGQLVDRYLKRHRLWVREGMELDEPAVILQMVGEG
CCCCCHHHHHHHHHCCHHEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCC
LGCAIIPCELVPLAQTPNVEQVPMPGMPMYREIGVLVRQSALKRASAAALIDAFVAACHE
CCEEEECCEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
R
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8113165; 11259647 [H]