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The map label for this gene is frmC [C]

Identifier: 94313707

GI number: 94313707

Start: 1429453

End: 1430301

Strand: Direct

Name: frmC [C]

Synonym: Rmet_4785

Alternate gene names: 94313707

Gene position: 1429453-1430301 (Clockwise)

Preceding gene: 94313706

Following gene: 94313709

Centisome position: 55.4

GC content: 66.31

Gene sequence:

>849_bases
ATGGAACTGCTGTCAGAACACGGCTGCCACGGCGGCGTCCAGCGCTTCTACCAGCACCAGTCGGTGGCCATCGGGCTGCC
GATGCGGTTCTCGGTCTATCTCCCGCCGCAGGCGCTGCAACCCGGCGCGAAGCCGCTGCCAGCGCTGTTCTATCTGGCCG
GCCTGACCTGCACCGAGGAAACCTTCGCGATCAAGGCTAACGCGCAGCGCTTTGCCGCCGAGCACGGCCTGATCCTGGTG
GGCCCGGATACGAGTCCGCGCGGCGCGCATGTGCCGGGCGAGGCCGATGCGTGGGACTTCGGCGTGGGCGCCGGCTTCTA
CGTGGATGCGGTCGAAACGCCATGGCGCATGCACTGGCGCATGGAGAGCTACGTTGCGGATGAGTTGTTCCAGTTGGTGA
CCCGCGAGCTTCCCGCCGATGCGGCACGGGTAGGGATCTTTGGGCATTCCATGGGTGGACATGGCGCGCTGGTACTGGCC
CAGCGCTTCCCGCAGCGGTTCCGATCGGTATCGGCGTTCGCGCCAATCGCGGCGCCGTCGGACTGCCCGTGGGGCGTGAA
GGCGTTCACCGGCTACCTTGGCGAAGATCGCAGCCGCTGGGCCCAGCACGATGCCAGTGCCCTGATGCGCGCGCAGACGT
CGGCACCCTTCCCGGCCGGCATCCTGATCGATCAGGGGCTCGCCGACAAATTCCTGGCCGAGCAACTGCATCCGGAAGTG
TTCGAGGCCGCCTGTGAAAAGGCCGGGCAGCCCCTGACACTACGTCGGCACGACGGGTACGACCACGGGTACTACTTCAT
CTCGACGTTCATTGCCGACCACGTGCGGCATCACGCAGAGCAGCTTTAA

Upstream 100 bases:

>100_bases
TCACGCATACGCTGCCGCTCGACCGCATCAACGAGGGCTTCGACCTGATGAAGCGCGGCGAATCGATCCGCTCGGTGGTC
CTGTACTGAGGACGCGATCC

Downstream 100 bases:

>100_bases
GGACTGATGCCGGCGCATCCCGGCGCCGGCATCCATTCACGCCTGAATCCCTCTAGCCGCCGCAGAGCGTCCTCTCGCAT
GGGATGCCATCACCGTCGCC

Product: S-formylglutathione hydrolase

Products: NA

Alternate protein names: FGH [H]

Number of amino acids: Translated: 282; Mature: 282

Protein sequence:

>282_residues
MELLSEHGCHGGVQRFYQHQSVAIGLPMRFSVYLPPQALQPGAKPLPALFYLAGLTCTEETFAIKANAQRFAAEHGLILV
GPDTSPRGAHVPGEADAWDFGVGAGFYVDAVETPWRMHWRMESYVADELFQLVTRELPADAARVGIFGHSMGGHGALVLA
QRFPQRFRSVSAFAPIAAPSDCPWGVKAFTGYLGEDRSRWAQHDASALMRAQTSAPFPAGILIDQGLADKFLAEQLHPEV
FEAACEKAGQPLTLRRHDGYDHGYYFISTFIADHVRHHAEQL

Sequences:

>Translated_282_residues
MELLSEHGCHGGVQRFYQHQSVAIGLPMRFSVYLPPQALQPGAKPLPALFYLAGLTCTEETFAIKANAQRFAAEHGLILV
GPDTSPRGAHVPGEADAWDFGVGAGFYVDAVETPWRMHWRMESYVADELFQLVTRELPADAARVGIFGHSMGGHGALVLA
QRFPQRFRSVSAFAPIAAPSDCPWGVKAFTGYLGEDRSRWAQHDASALMRAQTSAPFPAGILIDQGLADKFLAEQLHPEV
FEAACEKAGQPLTLRRHDGYDHGYYFISTFIADHVRHHAEQL
>Mature_282_residues
MELLSEHGCHGGVQRFYQHQSVAIGLPMRFSVYLPPQALQPGAKPLPALFYLAGLTCTEETFAIKANAQRFAAEHGLILV
GPDTSPRGAHVPGEADAWDFGVGAGFYVDAVETPWRMHWRMESYVADELFQLVTRELPADAARVGIFGHSMGGHGALVLA
QRFPQRFRSVSAFAPIAAPSDCPWGVKAFTGYLGEDRSRWAQHDASALMRAQTSAPFPAGILIDQGLADKFLAEQLHPEV
FEAACEKAGQPLTLRRHDGYDHGYYFISTFIADHVRHHAEQL

Specific function: Serine hydrolase involved in the detoxification of formaldehyde. Hydrolyzes S-formylglutathione to glutathione and formate [H]

COG id: COG0627

COG function: function code R; Predicted esterase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the esterase D family [H]

Homologues:

Organism=Homo sapiens, GI33413400, Length=283, Percent_Identity=51.2367491166078, Blast_Score=316, Evalue=1e-86,
Organism=Escherichia coli, GI1786551, Length=282, Percent_Identity=46.8085106382979, Blast_Score=272, Evalue=2e-74,
Organism=Escherichia coli, GI1788477, Length=282, Percent_Identity=49.290780141844, Blast_Score=269, Evalue=2e-73,
Organism=Caenorhabditis elegans, GI17510185, Length=282, Percent_Identity=48.936170212766, Blast_Score=261, Evalue=4e-70,
Organism=Saccharomyces cerevisiae, GI6322393, Length=297, Percent_Identity=37.7104377104377, Blast_Score=195, Evalue=7e-51,
Organism=Drosophila melanogaster, GI45551932, Length=284, Percent_Identity=51.056338028169, Blast_Score=284, Evalue=5e-77,
Organism=Drosophila melanogaster, GI24648347, Length=284, Percent_Identity=51.056338028169, Blast_Score=283, Evalue=8e-77,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000801
- InterPro:   IPR014186 [H]

Pfam domain/function: PF00756 Esterase [H]

EC number: =3.1.2.12 [H]

Molecular weight: Translated: 31010; Mature: 31010

Theoretical pI: Translated: 6.45; Mature: 6.45

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELLSEHGCHGGVQRFYQHQSVAIGLPMRFSVYLPPQALQPGAKPLPALFYLAGLTCTEE
CCCCHHCCCCHHHHHHHHHCCEEEECCEEEEEECCHHHCCCCCCCHHHHHHHHCCCCCCC
TFAIKANAQRFAAEHGLILVGPDTSPRGAHVPGEADAWDFGVGAGFYVDAVETPWRMHWR
EEEEECCHHHHHHHCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCHHHHHH
MESYVADELFQLVTRELPADAARVGIFGHSMGGHGALVLAQRFPQRFRSVSAFAPIAAPS
HHHHHHHHHHHHHHHHCCCCHHHEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCC
DCPWGVKAFTGYLGEDRSRWAQHDASALMRAQTSAPFPAGILIDQGLADKFLAEQLHPEV
CCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCHHHHHHHHHHCHHH
FEAACEKAGQPLTLRRHDGYDHGYYFISTFIADHVRHHAEQL
HHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MELLSEHGCHGGVQRFYQHQSVAIGLPMRFSVYLPPQALQPGAKPLPALFYLAGLTCTEE
CCCCHHCCCCHHHHHHHHHCCEEEECCEEEEEECCHHHCCCCCCCHHHHHHHHCCCCCCC
TFAIKANAQRFAAEHGLILVGPDTSPRGAHVPGEADAWDFGVGAGFYVDAVETPWRMHWR
EEEEECCHHHHHHHCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCHHHHHH
MESYVADELFQLVTRELPADAARVGIFGHSMGGHGALVLAQRFPQRFRSVSAFAPIAAPS
HHHHHHHHHHHHHHHHCCCCHHHEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCC
DCPWGVKAFTGYLGEDRSRWAQHDASALMRAQTSAPFPAGILIDQGLADKFLAEQLHPEV
CCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCHHHHHHHHHHCHHH
FEAACEKAGQPLTLRRHDGYDHGYYFISTFIADHVRHHAEQL
HHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800; 10675023 [H]