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The map label for this gene is lrp [H]

Identifier: 94313483

GI number: 94313483

Start: 1170793

End: 1171263

Strand: Reverse

Name: lrp [H]

Synonym: Rmet_4561

Alternate gene names: 94313483

Gene position: 1171263-1170793 (Counterclockwise)

Preceding gene: 94313485

Following gene: 94313481

Centisome position: 45.4

GC content: 62.42

Gene sequence:

>471_bases
GTGAACAACCCGCTCAAACTCGATGAGATCGATCGTCGCATCCTGCGCGAGTTGCGCCGCGACGGCCGTATCTCCAATGC
GAAGCTGGCCGAGCGTGTCGGCCTGTCCGCCACGCCTTGCTGGAACCGGGTCAAGGCCCTGGAGGACGCTGGCGTAATCA
GTGGCTATGCCGCGCTGCTGAACCAGAAGGCGCTGGGCTTGCCTGATACGGTGCTGATCGAAGTCACGCTCGATCGCCAC
GACGACGAGATGTTCAATCGCTTCGGCGAGGCGCTGGCGCAGTTGCCTGAAGTGCTGGAGGCTCATCTGCTGACGGGCGA
GTACGACTACCTGATCAAGGTGGCGGTGGCAGGTACGGAAGGCTATGAGGAATTCCTGCGCCACAAGCTCTACAAGCTTC
CCGGCCTGCGACACAGCCACTCGACTTTCGTGCTGCGCACGCTGAAGCGCGAGCCGTCGGTCGAACCCTGA

Upstream 100 bases:

>100_bases
AATTGGCTTCTGATTTTTCTGTGTGGACCGCCAATTTTCAGAATGAATATCTTCGTTGGTGTAGATTTGAGGTTATTTCA
TCTTCACTGGACGATTTTCC

Downstream 100 bases:

>100_bases
TCCTGGCTGGAACCTAGCGGGCAGCCAGCCTGCCGAGCCGGGGCGCGAGCGCGGTGGTCACCACGCCCATCCCGATCAGT
GCGAGGCCGATCGACAGATC

Product: AsnC family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 156; Mature: 156

Protein sequence:

>156_residues
MNNPLKLDEIDRRILRELRRDGRISNAKLAERVGLSATPCWNRVKALEDAGVISGYAALLNQKALGLPDTVLIEVTLDRH
DDEMFNRFGEALAQLPEVLEAHLLTGEYDYLIKVAVAGTEGYEEFLRHKLYKLPGLRHSHSTFVLRTLKREPSVEP

Sequences:

>Translated_156_residues
MNNPLKLDEIDRRILRELRRDGRISNAKLAERVGLSATPCWNRVKALEDAGVISGYAALLNQKALGLPDTVLIEVTLDRH
DDEMFNRFGEALAQLPEVLEAHLLTGEYDYLIKVAVAGTEGYEEFLRHKLYKLPGLRHSHSTFVLRTLKREPSVEP
>Mature_156_residues
MNNPLKLDEIDRRILRELRRDGRISNAKLAERVGLSATPCWNRVKALEDAGVISGYAALLNQKALGLPDTVLIEVTLDRH
DDEMFNRFGEALAQLPEVLEAHLLTGEYDYLIKVAVAGTEGYEEFLRHKLYKLPGLRHSHSTFVLRTLKREPSVEP

Specific function: Mediates a global response to leucine. Exogenous leucine affects the expression of a number of different operons; lrp mediates this effect for at least some of these operons. For example it is regulator of the branched-chain amino acid transport genes [H]

COG id: COG1522

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH asnC-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787116, Length=144, Percent_Identity=44.4444444444444, Blast_Score=130, Evalue=6e-32,
Organism=Escherichia coli, GI87081742, Length=148, Percent_Identity=39.1891891891892, Blast_Score=117, Evalue=3e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011008
- InterPro:   IPR000485
- InterPro:   IPR019885
- InterPro:   IPR019888
- InterPro:   IPR019887
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01037 AsnC_trans_reg [H]

EC number: NA

Molecular weight: Translated: 17690; Mature: 17690

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: PS50956 HTH_ASNC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNPLKLDEIDRRILRELRRDGRISNAKLAERVGLSATPCWNRVKALEDAGVISGYAALL
CCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCHHHHHHHHHHCCHHHHHHHHH
NQKALGLPDTVLIEVTLDRHDDEMFNRFGEALAQLPEVLEAHLLTGEYDYLIKVAVAGTE
HCCCCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCC
GYEEFLRHKLYKLPGLRHSHSTFVLRTLKREPSVEP
CHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MNNPLKLDEIDRRILRELRRDGRISNAKLAERVGLSATPCWNRVKALEDAGVISGYAALL
CCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCHHHHHHHHHHCCHHHHHHHHH
NQKALGLPDTVLIEVTLDRHDDEMFNRFGEALAQLPEVLEAHLLTGEYDYLIKVAVAGTE
HCCCCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCC
GYEEFLRHKLYKLPGLRHSHSTFVLRTLKREPSVEP
CHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]