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The map label for this gene is pdhA [H]

Identifier: 94313061

GI number: 94313061

Start: 708407

End: 709510

Strand: Reverse

Name: pdhA [H]

Synonym: Rmet_4134

Alternate gene names: 94313061

Gene position: 709510-708407 (Counterclockwise)

Preceding gene: 94313062

Following gene: 94313060

Centisome position: 27.5

GC content: 67.03

Gene sequence:

>1104_bases
ATGGGCACTGTTGCGCGTTTTGAAATCGGCTTTACCCGCTACCTCTCCCCCGACGGCTCGCCAGAGCCCGACCTTCCCGA
CTTTGCCCGCGATCCGGCCACCCTGCTGCCGCTCTATCGCGCCATGGTGCTGACCCGGCAGTTCGATCTCAAGGCCATCG
CGATGCAACGTACCGGCCAGATCGGCACGTTCGCGTCCGCGCTGGGCCAGGAAGCGATCGGCGTCGGCGTGGCCACGGCG
ATGCGCCGCGACGACGTGCTGGTGCCGTCGTACCGCGATCATGCCGCGCAGTTTGTGCGGGGCGTCACGATGACGGAGAG
CCTGCTGTACTGGGGTGGCGACGAACGCGGCAGCGCGTTTGCCGCAGTGCCATATGACTTCGGCAACTGCGTGCCGATCG
GCACCCAGGTTGGCCATGCGGCCGGCGTGGCCTACACGTTCAAGCTGCGCCAGGCACCGAACGTGGCGGTGTGCATCCTC
GGCGACGGCGGCACCTCGAAGGGTGACTTCTACGAGGGGATGAACATGGCCGGCGCGTGGCACGTCCCGCTGGTCATCGT
TATCAACAACAACCAGTGGGCCATCTCGATGCCGCGCGCCAAGCAGACGGCGGCGGCGACGCTGGCCCAGAAGGCGATCG
CAGCGGGCATTCCGGGCGAACAGATCGACGGCAACGACGTGATTGCCGTGCGGCAGCGCGTTGGCGCGGCCATCGAACAT
GCGCGCCACGGCGGCGGGCCGACGTTGATCGAGGCGGTGAGCTACCGCCTGGGCGACCATACGACAGCCGATGATGCGTC
GCGCTACCGGGACGAGGCATCGGTCAAGGAAGCCTGGCGCTGCGAGCCCATTATCCGGCTGCGAGACTACCTGGCCCGCC
TCGGCGCCTGGGACGCCGCGCAGGAAGAGGCGCTGATCAAGGAATGCCAGCAGGCCGTCGGCGCGGCCGTGCAGGCCTAT
CTTGCGCTGCCGCATCCCGATGCATCGGCGATGTTCGATTGCCTGTATGAAACGCTGCCCGACGCCATGGCCGAACAACT
CGACACCGCGCGGCAATACGACGCCTCTGGCAAGACCGATACCTCGGGAGCCCATCATGGCTGA

Upstream 100 bases:

>100_bases
CGATTCCGTGCCCTACACTCAAAGGCAGCAGCGTTCACAAGATGCTGCGCCGCACAGGACACCGCGAACCACAAGGGAGC
AACCTCAAGGGGACAACCAC

Downstream 100 bases:

>100_bases
ACTGCATATGGTGGAAGCCGTCAACCTGGCCCTGGCCCATGCCCTCGCCAACGATCCCGACGTGGTGCTGCTGGGCGAGG
ACATCGGCGTGAACGGCGGC

Product: putative puryvate dehydrogenase E1 component subunit alpha

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 367; Mature: 366

Protein sequence:

>367_residues
MGTVARFEIGFTRYLSPDGSPEPDLPDFARDPATLLPLYRAMVLTRQFDLKAIAMQRTGQIGTFASALGQEAIGVGVATA
MRRDDVLVPSYRDHAAQFVRGVTMTESLLYWGGDERGSAFAAVPYDFGNCVPIGTQVGHAAGVAYTFKLRQAPNVAVCIL
GDGGTSKGDFYEGMNMAGAWHVPLVIVINNNQWAISMPRAKQTAAATLAQKAIAAGIPGEQIDGNDVIAVRQRVGAAIEH
ARHGGGPTLIEAVSYRLGDHTTADDASRYRDEASVKEAWRCEPIIRLRDYLARLGAWDAAQEEALIKECQQAVGAAVQAY
LALPHPDASAMFDCLYETLPDAMAEQLDTARQYDASGKTDTSGAHHG

Sequences:

>Translated_367_residues
MGTVARFEIGFTRYLSPDGSPEPDLPDFARDPATLLPLYRAMVLTRQFDLKAIAMQRTGQIGTFASALGQEAIGVGVATA
MRRDDVLVPSYRDHAAQFVRGVTMTESLLYWGGDERGSAFAAVPYDFGNCVPIGTQVGHAAGVAYTFKLRQAPNVAVCIL
GDGGTSKGDFYEGMNMAGAWHVPLVIVINNNQWAISMPRAKQTAAATLAQKAIAAGIPGEQIDGNDVIAVRQRVGAAIEH
ARHGGGPTLIEAVSYRLGDHTTADDASRYRDEASVKEAWRCEPIIRLRDYLARLGAWDAAQEEALIKECQQAVGAAVQAY
LALPHPDASAMFDCLYETLPDAMAEQLDTARQYDASGKTDTSGAHHG
>Mature_366_residues
GTVARFEIGFTRYLSPDGSPEPDLPDFARDPATLLPLYRAMVLTRQFDLKAIAMQRTGQIGTFASALGQEAIGVGVATAM
RRDDVLVPSYRDHAAQFVRGVTMTESLLYWGGDERGSAFAAVPYDFGNCVPIGTQVGHAAGVAYTFKLRQAPNVAVCILG
DGGTSKGDFYEGMNMAGAWHVPLVIVINNNQWAISMPRAKQTAAATLAQKAIAAGIPGEQIDGNDVIAVRQRVGAAIEHA
RHGGGPTLIEAVSYRLGDHTTADDASRYRDEASVKEAWRCEPIIRLRDYLARLGAWDAAQEEALIKECQQAVGAAVQAYL
ALPHPDASAMFDCLYETLPDAMAEQLDTARQYDASGKTDTSGAHHG

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG1071

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI11386135, Length=353, Percent_Identity=31.1614730878187, Blast_Score=154, Evalue=9e-38,
Organism=Homo sapiens, GI258645172, Length=353, Percent_Identity=31.1614730878187, Blast_Score=151, Evalue=1e-36,
Organism=Homo sapiens, GI291084742, Length=314, Percent_Identity=27.7070063694268, Blast_Score=123, Evalue=3e-28,
Organism=Homo sapiens, GI4505685, Length=314, Percent_Identity=27.7070063694268, Blast_Score=123, Evalue=3e-28,
Organism=Homo sapiens, GI291084744, Length=322, Percent_Identity=27.639751552795, Blast_Score=122, Evalue=5e-28,
Organism=Homo sapiens, GI4885543, Length=313, Percent_Identity=27.4760383386581, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI291084757, Length=309, Percent_Identity=25.2427184466019, Blast_Score=97, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI86563355, Length=347, Percent_Identity=31.4121037463977, Blast_Score=155, Evalue=3e-38,
Organism=Caenorhabditis elegans, GI86563357, Length=347, Percent_Identity=31.4121037463977, Blast_Score=155, Evalue=3e-38,
Organism=Caenorhabditis elegans, GI17536047, Length=293, Percent_Identity=28.6689419795222, Blast_Score=125, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI32564172, Length=293, Percent_Identity=28.6689419795222, Blast_Score=125, Evalue=3e-29,
Organism=Saccharomyces cerevisiae, GI6321026, Length=325, Percent_Identity=28.6153846153846, Blast_Score=145, Evalue=1e-35,
Organism=Drosophila melanogaster, GI21355903, Length=356, Percent_Identity=29.2134831460674, Blast_Score=149, Evalue=3e-36,
Organism=Drosophila melanogaster, GI24639748, Length=322, Percent_Identity=28.2608695652174, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24639740, Length=341, Percent_Identity=26.099706744868, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24639744, Length=341, Percent_Identity=26.099706744868, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI28571106, Length=341, Percent_Identity=26.099706744868, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24639746, Length=307, Percent_Identity=26.7100977198697, Blast_Score=105, Evalue=6e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001017
- InterPro:   IPR017596 [H]

Pfam domain/function: PF00676 E1_dh [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 39386; Mature: 39255

Theoretical pI: Translated: 5.21; Mature: 5.21

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGTVARFEIGFTRYLSPDGSPEPDLPDFARDPATLLPLYRAMVLTRQFDLKAIAMQRTGQ
CCCCEEEEECEEEEECCCCCCCCCCCHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHCCC
IGTFASALGQEAIGVGVATAMRRDDVLVPSYRDHAAQFVRGVTMTESLLYWGGDERGSAF
HHHHHHHHCHHHHHHHHHHHHCCCCEECCCHHHHHHHHHHHHHHHHHHHEECCCCCCCEE
AAVPYDFGNCVPIGTQVGHAAGVAYTFKLRQAPNVAVCILGDGGTSKGDFYEGMNMAGAW
EECCCCCCCEEECCCCCCCHHCEEEEEEECCCCCEEEEEEECCCCCCCCHHHCCCCCCEE
HVPLVIVINNNQWAISMPRAKQTAAATLAQKAIAAGIPGEQIDGNDVIAVRQRVGAAIEH
CCCEEEEEECCEEEEECCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHH
ARHGGGPTLIEAVSYRLGDHTTADDASRYRDEASVKEAWRCEPIIRLRDYLARLGAWDAA
HHCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCHH
QEEALIKECQQAVGAAVQAYLALPHPDASAMFDCLYETLPDAMAEQLDTARQYDASGKTD
HHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
TSGAHHG
CCCCCCC
>Mature Secondary Structure 
GTVARFEIGFTRYLSPDGSPEPDLPDFARDPATLLPLYRAMVLTRQFDLKAIAMQRTGQ
CCCEEEEECEEEEECCCCCCCCCCCHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHCCC
IGTFASALGQEAIGVGVATAMRRDDVLVPSYRDHAAQFVRGVTMTESLLYWGGDERGSAF
HHHHHHHHCHHHHHHHHHHHHCCCCEECCCHHHHHHHHHHHHHHHHHHHEECCCCCCCEE
AAVPYDFGNCVPIGTQVGHAAGVAYTFKLRQAPNVAVCILGDGGTSKGDFYEGMNMAGAW
EECCCCCCCEEECCCCCCCHHCEEEEEEECCCCCEEEEEEECCCCCCCCHHHCCCCCCEE
HVPLVIVINNNQWAISMPRAKQTAAATLAQKAIAAGIPGEQIDGNDVIAVRQRVGAAIEH
CCCEEEEEECCEEEEECCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHH
ARHGGGPTLIEAVSYRLGDHTTADDASRYRDEASVKEAWRCEPIIRLRDYLARLGAWDAA
HHCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCHH
QEEALIKECQQAVGAAVQAYLALPHPDASAMFDCLYETLPDAMAEQLDTARQYDASGKTD
HHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
TSGAHHG
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA