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The map label for this gene is gluP [H]

Identifier: 94312789

GI number: 94312789

Start: 403659

End: 405323

Strand: Reverse

Name: gluP [H]

Synonym: Rmet_3861

Alternate gene names: 94312789

Gene position: 405323-403659 (Counterclockwise)

Preceding gene: 94312790

Following gene: 94312788

Centisome position: 15.71

GC content: 66.01

Gene sequence:

>1665_bases
ATGGAGCAATCGCAACGCTGGCGGCAAAGGGCCACCCCTGCCCGCCCGATAGGCGCCTTCTACGTGCGCCAGTTTGGCGC
CGCGCTGTTCATGCGGCTGATCTTGTGGGCGATCTTTGGTGGCCTGGCTGCGCTGCTGCTGGTCAGCATGCGCGGCAACG
CCGGCTCCGTTTTGATGAGCCTAGTGCTGCTAGGCATCCTGATCCTCTTTGAATGGGGATGGGGACGCCATGCGCCGCTC
GGCAAACCATTGCTGACCATCGATGCCAGCGGCATCGGTTCCACGGCATTCCCGCGCAAACGCCGCCATCTGCGCTGGCG
AGACATCGCTGGTGCGGCGATACGCGACGTGCGGGGCGCCGGCGAGACCCTTGTCATCGAAACGGTCGAAACGAAGCCCG
GCGGCCGTCGGAAAGCGCGTCGCGCCTATCAGGTACGACTGGCCATGCTGCGCAAGTCCGATCAGCAACTCGTTCAGGCA
CTGGTGGCGCACCACATGCGCGTGGCTGGCATCACGCCGTCCGCCGACGTTGTTGCCGAGCGGGCCTTCGTGGCGCAAAT
GCAGGCGCTGCCCCGCACCTGGGGCCTGTACAGCATGATCGCCGTGAACGTGCTCATCTGGCTCATCATGCTTTCGCGCG
GCGCCGCGCTGGATGGCGCCGCGCCAAAGATGCTCATTGACTGGGGCGGCAATCTTGGCGCGCTGACGCAGGACGGTCAG
TGGTGGCGGCTGCTGACGGCCACCTTCCTTCACGGCAGCCTCAAGCATCTGGCCGCCAATATGGTGGTGCTCTACTTGCT
CGGCACGCATGTGGAACGATTCTTTGGCACGCGCAGCTTCCTGCTGATCTACGTTGGCGCCGGCCTGCTCGGCAGCGCAT
TGAGCCTCTATTTCGCGGCGCAGGCCTCGGTGTCCGTCGGCGCCTCGGGAGCGGTGTTCGGCATCGGCGGCGCGCTGCTT
GTCGCGGCACTGCTGCATCGCCGCGAACTGCCGCAGAGCATTCGCAATCGACTCGTCAGCGATGCCGTGATCATGATCGG
CTACTCGCTCGCACAGGGCTTCCTGTCGACGCGTGTGGATAACGCCGCGCATGTGGGTGGCTTGATTGGCGGCGCGCTGC
TGGCGTTGTGCCTGCCGGTCCGGCTGTCGCCGGAGACTTACCGCAAGAAGCTGCGCCGTGGCACGTTGATGGCCACCGTG
ACGGCCATCGTCGCGGTGGTCGGTGTGGCCGCGTTTGCGCCGCCCGCACCGCTGACCCTGCGCGCCCAGCTGGCCGGTTC
CCGACAGTTCGAAGTGGCCGCCGATCGCTTCATGACCGCGCTTCGGGCGACGCAAGCCGATATCGAGGCCATGAAGGCCG
GCAAAATGCCCGAGCGCGAGGTCGACGCGCGTACCCGAACCATCCACGCGCCCGCCTTCGAGCAAGCGCTGTCCGGTCTG
GTGCGCGTCACGCTGCCGCCCGGCGATTCGCGCGCGCCCTTGCTGCAGGACATGACCCTGCTGGCAGATGCCATGCACGA
GTACCTGCGCATGGATTCCGTCTGGGACGCCAGCGCCAACAGACACGTCCCCGCCGATGCCGCGCGTGGCGACGCATTGA
ATGCCAATATCGAGCGACTGACGCAACGGATCAACACGCGCCTGGCTGAGAAGCGCAAGAAATAG

Upstream 100 bases:

>100_bases
ACAGGCAGTGCCTCTATCGTCGCGTCACGCGCGCCGTGGCTCCGTCACCGGGAATGCCACTCGAGATGACGCGAACCTTG
AATCCGTTTCGGGAAGAACG

Downstream 100 bases:

>100_bases
GCATTCACTAGGCAGTCATTGGGCAGTCATCGCACGACGCCGGGCGGGCCGGACTCGTACTGTAAAGTACGGCCTATCTC
CGATCCGCCTGGGCCCACGC

Product: putative intramembrane serine protease

Products: NA

Alternate protein names: Intramembrane serine protease [H]

Number of amino acids: Translated: 554; Mature: 554

Protein sequence:

>554_residues
MEQSQRWRQRATPARPIGAFYVRQFGAALFMRLILWAIFGGLAALLLVSMRGNAGSVLMSLVLLGILILFEWGWGRHAPL
GKPLLTIDASGIGSTAFPRKRRHLRWRDIAGAAIRDVRGAGETLVIETVETKPGGRRKARRAYQVRLAMLRKSDQQLVQA
LVAHHMRVAGITPSADVVAERAFVAQMQALPRTWGLYSMIAVNVLIWLIMLSRGAALDGAAPKMLIDWGGNLGALTQDGQ
WWRLLTATFLHGSLKHLAANMVVLYLLGTHVERFFGTRSFLLIYVGAGLLGSALSLYFAAQASVSVGASGAVFGIGGALL
VAALLHRRELPQSIRNRLVSDAVIMIGYSLAQGFLSTRVDNAAHVGGLIGGALLALCLPVRLSPETYRKKLRRGTLMATV
TAIVAVVGVAAFAPPAPLTLRAQLAGSRQFEVAADRFMTALRATQADIEAMKAGKMPEREVDARTRTIHAPAFEQALSGL
VRVTLPPGDSRAPLLQDMTLLADAMHEYLRMDSVWDASANRHVPADAARGDALNANIERLTQRINTRLAEKRKK

Sequences:

>Translated_554_residues
MEQSQRWRQRATPARPIGAFYVRQFGAALFMRLILWAIFGGLAALLLVSMRGNAGSVLMSLVLLGILILFEWGWGRHAPL
GKPLLTIDASGIGSTAFPRKRRHLRWRDIAGAAIRDVRGAGETLVIETVETKPGGRRKARRAYQVRLAMLRKSDQQLVQA
LVAHHMRVAGITPSADVVAERAFVAQMQALPRTWGLYSMIAVNVLIWLIMLSRGAALDGAAPKMLIDWGGNLGALTQDGQ
WWRLLTATFLHGSLKHLAANMVVLYLLGTHVERFFGTRSFLLIYVGAGLLGSALSLYFAAQASVSVGASGAVFGIGGALL
VAALLHRRELPQSIRNRLVSDAVIMIGYSLAQGFLSTRVDNAAHVGGLIGGALLALCLPVRLSPETYRKKLRRGTLMATV
TAIVAVVGVAAFAPPAPLTLRAQLAGSRQFEVAADRFMTALRATQADIEAMKAGKMPEREVDARTRTIHAPAFEQALSGL
VRVTLPPGDSRAPLLQDMTLLADAMHEYLRMDSVWDASANRHVPADAARGDALNANIERLTQRINTRLAEKRKK
>Mature_554_residues
MEQSQRWRQRATPARPIGAFYVRQFGAALFMRLILWAIFGGLAALLLVSMRGNAGSVLMSLVLLGILILFEWGWGRHAPL
GKPLLTIDASGIGSTAFPRKRRHLRWRDIAGAAIRDVRGAGETLVIETVETKPGGRRKARRAYQVRLAMLRKSDQQLVQA
LVAHHMRVAGITPSADVVAERAFVAQMQALPRTWGLYSMIAVNVLIWLIMLSRGAALDGAAPKMLIDWGGNLGALTQDGQ
WWRLLTATFLHGSLKHLAANMVVLYLLGTHVERFFGTRSFLLIYVGAGLLGSALSLYFAAQASVSVGASGAVFGIGGALL
VAALLHRRELPQSIRNRLVSDAVIMIGYSLAQGFLSTRVDNAAHVGGLIGGALLALCLPVRLSPETYRKKLRRGTLMATV
TAIVAVVGVAAFAPPAPLTLRAQLAGSRQFEVAADRFMTALRATQADIEAMKAGKMPEREVDARTRTIHAPAFEQALSGL
VRVTLPPGDSRAPLLQDMTLLADAMHEYLRMDSVWDASANRHVPADAARGDALNANIERLTQRINTRLAEKRKK

Specific function: Rhomboid-type serine protease that catalyzes intramembrane proteolysis. Important for normal cell division and sporulation. May act as a glucose exporter [H]

COG id: COG0705

COG function: function code R; Uncharacterized membrane protein (homolog of Drosophila rhomboid)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 2 TPR repeats [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002610
- InterPro:   IPR022764
- InterPro:   IPR001440
- InterPro:   IPR013026
- InterPro:   IPR011990
- InterPro:   IPR019734 [H]

Pfam domain/function: PF01694 Rhomboid; PF00515 TPR_1 [H]

EC number: =3.4.21.105 [H]

Molecular weight: Translated: 60151; Mature: 60151

Theoretical pI: Translated: 11.67; Mature: 11.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEQSQRWRQRATPARPIGAFYVRQFGAALFMRLILWAIFGGLAALLLVSMRGNAGSVLMS
CCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
LVLLGILILFEWGWGRHAPLGKPLLTIDASGIGSTAFPRKRRHLRWRDIAGAAIRDVRGA
HHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCCCCCHHHHCCCHHHHHHHHHHHHCCC
GETLVIETVETKPGGRRKARRAYQVRLAMLRKSDQQLVQALVAHHMRVAGITPSADVVAE
CCEEEEEEECCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCHHHHHH
RAFVAQMQALPRTWGLYSMIAVNVLIWLIMLSRGAALDGAAPKMLIDWGGNLGALTQDGQ
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCCCCCC
WWRLLTATFLHGSLKHLAANMVVLYLLGTHVERFFGTRSFLLIYVGAGLLGSALSLYFAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
QASVSVGASGAVFGIGGALLVAALLHRRELPQSIRNRLVSDAVIMIGYSLAQGFLSTRVD
HCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
NAAHVGGLIGGALLALCLPVRLSPETYRKKLRRGTLMATVTAIVAVVGVAAFAPPAPLTL
CHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEE
RAQLAGSRQFEVAADRFMTALRATQADIEAMKAGKMPEREVDARTRTIHAPAFEQALSGL
EHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCHHHEEECHHHHHHHCCC
VRVTLPPGDSRAPLLQDMTLLADAMHEYLRMDSVWDASANRHVPADAARGDALNANIERL
EEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHH
TQRINTRLAEKRKK
HHHHHHHHHHHCCC
>Mature Secondary Structure
MEQSQRWRQRATPARPIGAFYVRQFGAALFMRLILWAIFGGLAALLLVSMRGNAGSVLMS
CCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
LVLLGILILFEWGWGRHAPLGKPLLTIDASGIGSTAFPRKRRHLRWRDIAGAAIRDVRGA
HHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCCCCCHHHHCCCHHHHHHHHHHHHCCC
GETLVIETVETKPGGRRKARRAYQVRLAMLRKSDQQLVQALVAHHMRVAGITPSADVVAE
CCEEEEEEECCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCHHHHHH
RAFVAQMQALPRTWGLYSMIAVNVLIWLIMLSRGAALDGAAPKMLIDWGGNLGALTQDGQ
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCCCCCC
WWRLLTATFLHGSLKHLAANMVVLYLLGTHVERFFGTRSFLLIYVGAGLLGSALSLYFAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
QASVSVGASGAVFGIGGALLVAALLHRRELPQSIRNRLVSDAVIMIGYSLAQGFLSTRVD
HCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
NAAHVGGLIGGALLALCLPVRLSPETYRKKLRRGTLMATVTAIVAVVGVAAFAPPAPLTL
CHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEE
RAQLAGSRQFEVAADRFMTALRATQADIEAMKAGKMPEREVDARTRTIHAPAFEQALSGL
EHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCHHHEEECHHHHHHHCCC
VRVTLPPGDSRAPLLQDMTLLADAMHEYLRMDSVWDASANRHVPADAARGDALNANIERL
EEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHH
TQRINTRLAEKRKK
HHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377 [H]