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The map label for this gene is acrR [H]

Identifier: 94312518

GI number: 94312518

Start: 3894393

End: 3895121

Strand: Reverse

Name: acrR [H]

Synonym: Rmet_3587

Alternate gene names: 94312518

Gene position: 3895121-3894393 (Counterclockwise)

Preceding gene: 94312522

Following gene: 94312516

Centisome position: 99.16

GC content: 65.84

Gene sequence:

>729_bases
ATGGTCAGACGTACCAAGGAAGAAGCGCTAGAGACGCGCAACCGCATTCTGGATGCGGCAGAGGCCGTGTTCCACGCCCG
TGGCGTGGCACGTCCTTCGCTGGCGGACATTGCCGAGGCGGCAGGCGTCACGCGCGGCGCGATCTATTGGCATTTCAAGA
ACAAGAGCGACGTGTTCGCCGCGATGTGCGATCGCGTCAACTTGCCTGTCGAGGCGCTCTGCTCGCCCGAGCGCATTGCC
TCGCAGGAAGACCCGCTCGGCAGCATCCGCGACATCTGCGCATTCGTGTTCCGCCAGACCGTCAACAATCCCCAATGGCG
CCGCGTGTTCGAAATCATCTTCCACAAGTGCGAGATGGTCGAGGACAACGGCGCCATCTTCGTGCGCCAGCGCCAGTCGC
ACCAGGAAGGCACGGTGAAGATGCGCGAGCATCTGCGGCTAGCGATGGAGCGCGGCCAGTTGCCCGCCGACCTCGACCTG
CCACTGGCCGTCAATGCCTTTCACGCCGCGATCGGTGGCGTGCTGGCGCACTGGCTGTTCTCCCCCGAGGATTTCGAACT
GGCCCGCGAGGCCGAACGCCTGGCGGACGCATTCATCGACACATTGCGCCTCTCGCCGGCTCTGCGCGTGGGCTACGTGC
CACGCCCCATGGCGCCGCTCGATGCGGAAATGGCGGCCCTGTGCGAACGGCAGCCCCAGCAGCCCCAGCAGGCCCTGGCG
CCGACCTGA

Upstream 100 bases:

>100_bases
GCCTAGTGCCGTTGCGCAATTTGGAGAGAGAAGCGCCTTGCCATCCACCGGCAGCGCCTATGGAGACCTGGCGACCACCG
CCGTCCGGGTAAAGAGGGAA

Downstream 100 bases:

>100_bases
TTCCGACCTGATTCCGACCTGATTCCCGAACGGATTGCTGAGCGGGCTATGAGTTGGCTATGCGCCGTCAACCGCGCATG
GCTTCGCGCCAACGCGCGAT

Product: DNA-binding transcriptional repressor

Products: NA

Alternate protein names: Antibiotic efflux pump ArpABC operon regulator [H]

Number of amino acids: Translated: 242; Mature: 242

Protein sequence:

>242_residues
MVRRTKEEALETRNRILDAAEAVFHARGVARPSLADIAEAAGVTRGAIYWHFKNKSDVFAAMCDRVNLPVEALCSPERIA
SQEDPLGSIRDICAFVFRQTVNNPQWRRVFEIIFHKCEMVEDNGAIFVRQRQSHQEGTVKMREHLRLAMERGQLPADLDL
PLAVNAFHAAIGGVLAHWLFSPEDFELAREAERLADAFIDTLRLSPALRVGYVPRPMAPLDAEMAALCERQPQQPQQALA
PT

Sequences:

>Translated_242_residues
MVRRTKEEALETRNRILDAAEAVFHARGVARPSLADIAEAAGVTRGAIYWHFKNKSDVFAAMCDRVNLPVEALCSPERIA
SQEDPLGSIRDICAFVFRQTVNNPQWRRVFEIIFHKCEMVEDNGAIFVRQRQSHQEGTVKMREHLRLAMERGQLPADLDL
PLAVNAFHAAIGGVLAHWLFSPEDFELAREAERLADAFIDTLRLSPALRVGYVPRPMAPLDAEMAALCERQPQQPQQALA
PT
>Mature_242_residues
MVRRTKEEALETRNRILDAAEAVFHARGVARPSLADIAEAAGVTRGAIYWHFKNKSDVFAAMCDRVNLPVEALCSPERIA
SQEDPLGSIRDICAFVFRQTVNNPQWRRVFEIIFHKCEMVEDNGAIFVRQRQSHQEGTVKMREHLRLAMERGQLPADLDL
PLAVNAFHAAIGGVLAHWLFSPEDFELAREAERLADAFIDTLRLSPALRVGYVPRPMAPLDAEMAALCERQPQQPQQALA
PT

Specific function: Probable regulatory protein for the antibiotic efflux pump arpABC operon. May function as a repressor [H]

COG id: COG1309

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH tetR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786669, Length=209, Percent_Identity=39.2344497607655, Blast_Score=148, Evalue=3e-37,
Organism=Escherichia coli, GI1789664, Length=197, Percent_Identity=31.4720812182741, Blast_Score=108, Evalue=4e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009057
- InterPro:   IPR015893
- InterPro:   IPR011075
- InterPro:   IPR013572
- InterPro:   IPR001647 [H]

Pfam domain/function: PF08361 TetR_C_2; PF00440 TetR_N [H]

EC number: NA

Molecular weight: Translated: 27206; Mature: 27206

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: PS01081 HTH_TETR_1 ; PS50977 HTH_TETR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVRRTKEEALETRNRILDAAEAVFHARGVARPSLADIAEAAGVTRGAIYWHFKNKSDVFA
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCEEEEEECCCCHHHH
AMCDRVNLPVEALCSPERIASQEDPLGSIRDICAFVFRQTVNNPQWRRVFEIIFHKCEMV
HHHHHCCCCHHHHCCCHHHCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHC
EDNGAIFVRQRQSHQEGTVKMREHLRLAMERGQLPADLDLPLAVNAFHAAIGGVLAHWLF
CCCCEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHC
SPEDFELAREAERLADAFIDTLRLSPALRVGYVPRPMAPLDAEMAALCERQPQQPQQALA
CCCHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCCCCCHHHHHHHHCCCCCHHHHCC
PT
CC
>Mature Secondary Structure
MVRRTKEEALETRNRILDAAEAVFHARGVARPSLADIAEAAGVTRGAIYWHFKNKSDVFA
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCEEEEEECCCCHHHH
AMCDRVNLPVEALCSPERIASQEDPLGSIRDICAFVFRQTVNNPQWRRVFEIIFHKCEMV
HHHHHCCCCHHHHCCCHHHCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHC
EDNGAIFVRQRQSHQEGTVKMREHLRLAMERGQLPADLDLPLAVNAFHAAIGGVLAHWLF
CCCCEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHC
SPEDFELAREAERLADAFIDTLRLSPALRVGYVPRPMAPLDAEMAALCERQPQQPQQALA
CCCHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCCCCCHHHHHHHHCCCCCHHHHCC
PT
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11160799 [H]