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The map label for this gene is hisD [H]

Identifier: 94312179

GI number: 94312179

Start: 3519981

End: 3521315

Strand: Reverse

Name: hisD [H]

Synonym: Rmet_3248

Alternate gene names: 94312179

Gene position: 3521315-3519981 (Counterclockwise)

Preceding gene: 94312180

Following gene: 94312178

Centisome position: 89.64

GC content: 66.52

Gene sequence:

>1335_bases
ATGAACGATACCGAAATGGAAAACCTGTCGATCCGCCGGCTTGATTCGCGCGAGCCCGGTTTCGCCGGCGCGCTGCGTCA
GGTGCTGGCGTTCGAAGCATCCGAAGACGAGGCGATCGACCGCGCTGCTGCCGATATCCTGGCCGATGTGCGCCGCCGTG
GCGACGAGGCCGTGCTCGAGTACACGCGCCGCTTCGATCGCATGGAGGCCTCGTCGATGTCGGCACTGGCATTGTCGCAA
TCCGAACTGGAAGCCGCGCTGGAGGACCTCGAGCCGAAGCGCCGCGCCGCGCTGGAAGCCGCCGCTGCCCGCGTGCGTGC
GTACCACGAGAAGCAGAAAATCGAATGCGGCAGCCATAGCTGGGAATACACCGAGGCCGATGGCACGATGCTGGGCCAGA
AGGTGACCCCGCTCGACCGCGTGGGCCTCTACGTGCCGGGTGGCAAGGCCGCCTACCCGTCGTCGGTGCTGATGAATGCA
ATTCCGGCGCGCGTGGCTGGCGTCAAGGAAGTCATCATGGTCGTCCCGACGCCGGGCGGCGTGCGTAACGAACTGGTGCT
GGCCGCCGCGCAGATCGCCGGCGTCGATCGCGTGTACACGATTGGTGGCGCGCAGGCCGTGGGCGCGCTCGCGTACGGCA
CCGCCACGCTGCCGCAGGTCGACAAGATCGTCGGCCCGGGCAATGCCTACGTGGCCGCTGCCAAGCGCCGCGTGTTCGGC
ACGGTCGGTATCGACATGATCGCCGGCCCGTCGGAAATCCTCGTGATCTGCGATGGCACCACCGACCCCGACTGGGTGGC
GATGGACCTGTTCTCGCAGGCCGAGCACGACGAACTCGCGCAATCGATCCTGCTGTGCCCGGATGCCGAGTACCTGAACC
GCGTGCTGGAAAGTATCCAGCGCCAGTTGCCGACGATGCCCCGCCGCGAGGTCATCGCCGCGTCGCTGTCGGGCCGTGGC
GCACTGGTCAAGGTGCGCGACATGGAGGAAGCCTGCGAGATTGCCAACGCGATCGCGCCGGAGCACCTCGAGATCTCCGC
CGAGAATCCGCGCCAGTGGAGCGAGAAGATTCGCCATGCCGGCGCCATCTTCCTGGGCCGTTACACGAGCGAGTCGCTCG
GCGACTACTGTGCCGGCCCGAACCACGTGCTCCCCACTTCGCGCACCGCCCGTTTTTCGTCGCCGCTGGGTGTCTATGAC
TTCCAGAAGCGTTCGAGCCTGATCGAGGTGAGCGAGAACGGTGCGCAGATGCTGGGCCAGATCGCTGCCGAGCTTGCCTA
TGGCGAAGGCCTGCAGGCCCACGCGCGCAGTGCCGAGTACCGCTTCAAACGTTAA

Upstream 100 bases:

>100_bases
AAGCGCGAACGGCTGGCGCCGATTCTCGATGCATTTGAACGGGCCTCGGCCGCGCTCGCCTGAGGCGGGCGGTGACCGGA
GACCCGCGAGGAAAGAAGTC

Downstream 100 bases:

>100_bases
GCTGGATTCATCAAAGCAGGACCAACGAGGACCATCATGTCAGCCGTAGACCCATCCCTGATCGAACGCATCATCCGTGA
CGACGTGCGCGCCATGGGCG

Product: bifunctional histidinal dehydrogenase/ histidinol dehydrogenase

Products: NA

Alternate protein names: HDH 1 [H]

Number of amino acids: Translated: 444; Mature: 444

Protein sequence:

>444_residues
MNDTEMENLSIRRLDSREPGFAGALRQVLAFEASEDEAIDRAAADILADVRRRGDEAVLEYTRRFDRMEASSMSALALSQ
SELEAALEDLEPKRRAALEAAAARVRAYHEKQKIECGSHSWEYTEADGTMLGQKVTPLDRVGLYVPGGKAAYPSSVLMNA
IPARVAGVKEVIMVVPTPGGVRNELVLAAAQIAGVDRVYTIGGAQAVGALAYGTATLPQVDKIVGPGNAYVAAAKRRVFG
TVGIDMIAGPSEILVICDGTTDPDWVAMDLFSQAEHDELAQSILLCPDAEYLNRVLESIQRQLPTMPRREVIAASLSGRG
ALVKVRDMEEACEIANAIAPEHLEISAENPRQWSEKIRHAGAIFLGRYTSESLGDYCAGPNHVLPTSRTARFSSPLGVYD
FQKRSSLIEVSENGAQMLGQIAAELAYGEGLQAHARSAEYRFKR

Sequences:

>Translated_444_residues
MNDTEMENLSIRRLDSREPGFAGALRQVLAFEASEDEAIDRAAADILADVRRRGDEAVLEYTRRFDRMEASSMSALALSQ
SELEAALEDLEPKRRAALEAAAARVRAYHEKQKIECGSHSWEYTEADGTMLGQKVTPLDRVGLYVPGGKAAYPSSVLMNA
IPARVAGVKEVIMVVPTPGGVRNELVLAAAQIAGVDRVYTIGGAQAVGALAYGTATLPQVDKIVGPGNAYVAAAKRRVFG
TVGIDMIAGPSEILVICDGTTDPDWVAMDLFSQAEHDELAQSILLCPDAEYLNRVLESIQRQLPTMPRREVIAASLSGRG
ALVKVRDMEEACEIANAIAPEHLEISAENPRQWSEKIRHAGAIFLGRYTSESLGDYCAGPNHVLPTSRTARFSSPLGVYD
FQKRSSLIEVSENGAQMLGQIAAELAYGEGLQAHARSAEYRFKR
>Mature_444_residues
MNDTEMENLSIRRLDSREPGFAGALRQVLAFEASEDEAIDRAAADILADVRRRGDEAVLEYTRRFDRMEASSMSALALSQ
SELEAALEDLEPKRRAALEAAAARVRAYHEKQKIECGSHSWEYTEADGTMLGQKVTPLDRVGLYVPGGKAAYPSSVLMNA
IPARVAGVKEVIMVVPTPGGVRNELVLAAAQIAGVDRVYTIGGAQAVGALAYGTATLPQVDKIVGPGNAYVAAAKRRVFG
TVGIDMIAGPSEILVICDGTTDPDWVAMDLFSQAEHDELAQSILLCPDAEYLNRVLESIQRQLPTMPRREVIAASLSGRG
ALVKVRDMEEACEIANAIAPEHLEISAENPRQWSEKIRHAGAIFLGRYTSESLGDYCAGPNHVLPTSRTARFSSPLGVYD
FQKRSSLIEVSENGAQMLGQIAAELAYGEGLQAHARSAEYRFKR

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine [H]

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1788331, Length=422, Percent_Identity=42.4170616113744, Blast_Score=309, Evalue=2e-85,
Organism=Saccharomyces cerevisiae, GI6319819, Length=408, Percent_Identity=36.2745098039216, Blast_Score=247, Evalue=3e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131 [H]

Pfam domain/function: PF00815 Histidinol_dh [H]

EC number: =1.1.1.23 [H]

Molecular weight: Translated: 48104; Mature: 48104

Theoretical pI: Translated: 4.92; Mature: 4.92

Prosite motif: PS00611 HISOL_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNDTEMENLSIRRLDSREPGFAGALRQVLAFEASEDEAIDRAAADILADVRRRGDEAVLE
CCCCCCCCCCEEECCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCHHHHH
YTRRFDRMEASSMSALALSQSELEAALEDLEPKRRAALEAAAARVRAYHEKQKIECGSHS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
WEYTEADGTMLGQKVTPLDRVGLYVPGGKAAYPSSVLMNAIPARVAGVKEVIMVVPTPGG
CCEECCCCCCCCCCCCCHHHCCEECCCCCCCCCHHHHHHHHHHHHHCCEEEEEEECCCCC
VRNELVLAAAQIAGVDRVYTIGGAQAVGALAYGTATLPQVDKIVGPGNAYVAAAKRRVFG
CHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHCCCCCCHHHHHCCCCCHHHHHHHHHHHH
TVGIDMIAGPSEILVICDGTTDPDWVAMDLFSQAEHDELAQSILLCPDAEYLNRVLESIQ
HCCHHEECCCCEEEEEECCCCCCCHHHHHHHHCCCHHHHHHHHCCCCCHHHHHHHHHHHH
RQLPTMPRREVIAASLSGRGALVKVRDMEEACEIANAIAPEHLEISAENPRQWSEKIRHA
HHCCCCCHHHHHHHHCCCCCCEEEECCHHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHC
GAIFLGRYTSESLGDYCAGPNHVLPTSRTARFSSPLGVYDFQKRSSLIEVSENGAQMLGQ
CCEEEECCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCEEECCHHHHHHHH
IAAELAYGEGLQAHARSAEYRFKR
HHHHHHHCCCHHHHHCCCCCCCCC
>Mature Secondary Structure
MNDTEMENLSIRRLDSREPGFAGALRQVLAFEASEDEAIDRAAADILADVRRRGDEAVLE
CCCCCCCCCCEEECCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCHHHHH
YTRRFDRMEASSMSALALSQSELEAALEDLEPKRRAALEAAAARVRAYHEKQKIECGSHS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
WEYTEADGTMLGQKVTPLDRVGLYVPGGKAAYPSSVLMNAIPARVAGVKEVIMVVPTPGG
CCEECCCCCCCCCCCCCHHHCCEECCCCCCCCCHHHHHHHHHHHHHCCEEEEEEECCCCC
VRNELVLAAAQIAGVDRVYTIGGAQAVGALAYGTATLPQVDKIVGPGNAYVAAAKRRVFG
CHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHCCCCCCHHHHHCCCCCHHHHHHHHHHHH
TVGIDMIAGPSEILVICDGTTDPDWVAMDLFSQAEHDELAQSILLCPDAEYLNRVLESIQ
HCCHHEECCCCEEEEEECCCCCCCHHHHHHHHCCCHHHHHHHHCCCCCHHHHHHHHHHHH
RQLPTMPRREVIAASLSGRGALVKVRDMEEACEIANAIAPEHLEISAENPRQWSEKIRHA
HHCCCCCHHHHHHHHCCCCCCEEEECCHHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHC
GAIFLGRYTSESLGDYCAGPNHVLPTSRTARFSSPLGVYDFQKRSSLIEVSENGAQMLGQ
CCEEEECCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCEEECCHHHHHHHH
IAAELAYGEGLQAHARSAEYRFKR
HHHHHHHCCCHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA