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The map label for this gene is hisC [H]

Identifier: 94312178

GI number: 94312178

Start: 3518844

End: 3519944

Strand: Reverse

Name: hisC [H]

Synonym: Rmet_3247

Alternate gene names: 94312178

Gene position: 3519944-3518844 (Counterclockwise)

Preceding gene: 94312179

Following gene: 94312177

Centisome position: 89.61

GC content: 64.49

Gene sequence:

>1101_bases
ATGTCAGCCGTAGACCCATCCCTGATCGAACGCATCATCCGTGACGACGTGCGCGCCATGGGCGCCTACCACGTGGCCGA
TTCGCACGGACTGGTGAAGCTCGACGCGATGGAGAATCCGTACCGGCTGCCGCCCGAGCTGCGCGCGCAACTGGCCGCGC
GGCTCGGCGAGGTCGCGCTGAATCGCTATCCGGTGCCGAGCAGCGAGGCGCTGCGCGCCAAGCTCAAGACGGTGATGAAC
GTGCCGGCCGGCATGGATGTGCTGCTGGGCAATGGCTCCGACGAAATCATCAGCATGTTGTCGCTGGCCGCGGCCAGGCC
GGGTGCCAAGGTGATGGCGCCGGTGCCGGGCTTCGTCATGTACGCAATGTCGGCGCAGTTCGCCGGGCTCGAGTTCGTTG
GTGTGCCGCTGCGCCCGGACTTCACGCTGGACCGCGCGGCAATGCTGGCGGCGATGGCCGAGCACAAGCCCGCCATCATC
TATCTGGCCTACCCGAACAACCCAACGGGCAACCTGTTCGACGCCGACGATATGGCGGCGATCGTGCGTGCCGCCCAAGG
CGAGGTGTGCCAGAGCCTGGTGGTGGTCGACGAGGCGTACCAGCCGTTCGCGCAGGAAAGCTGGATGCCGCGCCTGACGG
AATTCGGCAACCTGCTGGTCATGCGTACCGTGTCGAAGCTTGGTCTGGCCGGTATCCGTCTGGGCTATGTAGCCGGCGCG
CCCGAATGGTTGTCGCAGCTCGACAAGGTGCGCCCGCCGTACAACGTCAACGTGCTGACCGAAGCCACCGCGCTGTTCGC
CCTCGAACACGTGGCCGTACTGGATGACCAGGCCGCCAAGTTGCGTGCGGAACGGTCGAAACTGGTCGAGGCCATGGCCG
GAATGCCGGGCGTGACGGTGTTCCCGAGCGCGGCCAACTTCGTGCTGGTGCGCGTGCCGAATGCTGCACAGATCTTCGAT
CGCCTGCTGGCCCGGAAGGTATTGATCAAGAACGTGAGTAAAATGCACACGTTGCTGGCCAACTGTCTGCGCGTGACGGT
CAGCACTCCGGAAGAAAACGCGCAGTTTCTTGAGGCATTCAAGGCCTCGTTGCAGGATTAA

Upstream 100 bases:

>100_bases
GCTTGCCTATGGCGAAGGCCTGCAGGCCCACGCGCGCAGTGCCGAGTACCGCTTCAAACGTTAAGCTGGATTCATCAAAG
CAGGACCAACGAGGACCATC

Downstream 100 bases:

>100_bases
CCCCACCATGCGTGTCGCAGAGGTCACCCGCAATACTTCGGAAACGCAGATCCGCGTTTCGCTGAATCTCGATGGCACTG
GCCGCCAGAAACTGGCGTCC

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase 2 [H]

Number of amino acids: Translated: 366; Mature: 365

Protein sequence:

>366_residues
MSAVDPSLIERIIRDDVRAMGAYHVADSHGLVKLDAMENPYRLPPELRAQLAARLGEVALNRYPVPSSEALRAKLKTVMN
VPAGMDVLLGNGSDEIISMLSLAAARPGAKVMAPVPGFVMYAMSAQFAGLEFVGVPLRPDFTLDRAAMLAAMAEHKPAII
YLAYPNNPTGNLFDADDMAAIVRAAQGEVCQSLVVVDEAYQPFAQESWMPRLTEFGNLLVMRTVSKLGLAGIRLGYVAGA
PEWLSQLDKVRPPYNVNVLTEATALFALEHVAVLDDQAAKLRAERSKLVEAMAGMPGVTVFPSAANFVLVRVPNAAQIFD
RLLARKVLIKNVSKMHTLLANCLRVTVSTPEENAQFLEAFKASLQD

Sequences:

>Translated_366_residues
MSAVDPSLIERIIRDDVRAMGAYHVADSHGLVKLDAMENPYRLPPELRAQLAARLGEVALNRYPVPSSEALRAKLKTVMN
VPAGMDVLLGNGSDEIISMLSLAAARPGAKVMAPVPGFVMYAMSAQFAGLEFVGVPLRPDFTLDRAAMLAAMAEHKPAII
YLAYPNNPTGNLFDADDMAAIVRAAQGEVCQSLVVVDEAYQPFAQESWMPRLTEFGNLLVMRTVSKLGLAGIRLGYVAGA
PEWLSQLDKVRPPYNVNVLTEATALFALEHVAVLDDQAAKLRAERSKLVEAMAGMPGVTVFPSAANFVLVRVPNAAQIFD
RLLARKVLIKNVSKMHTLLANCLRVTVSTPEENAQFLEAFKASLQD
>Mature_365_residues
SAVDPSLIERIIRDDVRAMGAYHVADSHGLVKLDAMENPYRLPPELRAQLAARLGEVALNRYPVPSSEALRAKLKTVMNV
PAGMDVLLGNGSDEIISMLSLAAARPGAKVMAPVPGFVMYAMSAQFAGLEFVGVPLRPDFTLDRAAMLAAMAEHKPAIIY
LAYPNNPTGNLFDADDMAAIVRAAQGEVCQSLVVVDEAYQPFAQESWMPRLTEFGNLLVMRTVSKLGLAGIRLGYVAGAP
EWLSQLDKVRPPYNVNVLTEATALFALEHVAVLDDQAAKLRAERSKLVEAMAGMPGVTVFPSAANFVLVRVPNAAQIFDR
LLARKVLIKNVSKMHTLLANCLRVTVSTPEENAQFLEAFKASLQD

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=363, Percent_Identity=30.5785123966942, Blast_Score=142, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6322075, Length=390, Percent_Identity=28.2051282051282, Blast_Score=127, Evalue=3e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.9 [H]

Molecular weight: Translated: 39668; Mature: 39537

Theoretical pI: Translated: 6.38; Mature: 6.38

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAVDPSLIERIIRDDVRAMGAYHVADSHGLVKLDAMENPYRLPPELRAQLAARLGEVAL
CCCCCHHHHHHHHHHHHHHHHHEEEECCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHH
NRYPVPSSEALRAKLKTVMNVPAGMDVLLGNGSDEIISMLSLAAARPGAKVMAPVPGFVM
HCCCCCCHHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHHHHCCCCCCEECCCCHHHH
YAMSAQFAGLEFVGVPLRPDFTLDRAAMLAAMAEHKPAIIYLAYPNNPTGNLFDADDMAA
HHHHHHHCCCEEEECCCCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCHHHHHH
IVRAAQGEVCQSLVVVDEAYQPFAQESWMPRLTEFGNLLVMRTVSKLGLAGIRLGYVAGA
HHHHHHHHHHHHHHHHHHHHCCHHHHCCCHHHHHHCCCHHHHHHHHHCHHHHHHHHHCCC
PEWLSQLDKVRPPYNVNVLTEATALFALEHVAVLDDQAAKLRAERSKLVEAMAGMPGVTV
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEE
FPSAANFVLVRVPNAAQIFDRLLARKVLIKNVSKMHTLLANCLRVTVSTPEENAQFLEAF
CCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCHHHHHHHHH
KASLQD
HHHHCC
>Mature Secondary Structure 
SAVDPSLIERIIRDDVRAMGAYHVADSHGLVKLDAMENPYRLPPELRAQLAARLGEVAL
CCCCHHHHHHHHHHHHHHHHHEEEECCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHH
NRYPVPSSEALRAKLKTVMNVPAGMDVLLGNGSDEIISMLSLAAARPGAKVMAPVPGFVM
HCCCCCCHHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHHHHCCCCCCEECCCCHHHH
YAMSAQFAGLEFVGVPLRPDFTLDRAAMLAAMAEHKPAIIYLAYPNNPTGNLFDADDMAA
HHHHHHHCCCEEEECCCCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCHHHHHH
IVRAAQGEVCQSLVVVDEAYQPFAQESWMPRLTEFGNLLVMRTVSKLGLAGIRLGYVAGA
HHHHHHHHHHHHHHHHHHHHCCHHHHCCCHHHHHHCCCHHHHHHHHHCHHHHHHHHHCCC
PEWLSQLDKVRPPYNVNVLTEATALFALEHVAVLDDQAAKLRAERSKLVEAMAGMPGVTV
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEE
FPSAANFVLVRVPNAAQIFDRLLARKVLIKNVSKMHTLLANCLRVTVSTPEENAQFLEAF
CCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCHHHHHHHHH
KASLQD
HHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA