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The map label for this gene is hisG [H]

Identifier: 94312180

GI number: 94312180

Start: 3521353

End: 3522027

Strand: Reverse

Name: hisG [H]

Synonym: Rmet_3249

Alternate gene names: 94312180

Gene position: 3522027-3521353 (Counterclockwise)

Preceding gene: 94312181

Following gene: 94312179

Centisome position: 89.66

GC content: 64.59

Gene sequence:

>675_bases
ATGAGCCCCGCTTTCAATGCTTCGCCCGACCAGCTTACGCTGGCACTGTCAAAGGGCCGCATCTTCAAGGAAACGCTGCC
ACTGCTGGCTGCCGCCGGCATTCAGGTGACAGAGGATCCCGAGACTTCGCGCAAACTGATCCTGCCCACGTCCGATCCGG
CTGTGCGCGTGATCATCGTGCGTGCTTCGGACGTGCCGACCTACGTGCAGTACGGCGCGGCCGATTTCGGCGTGGCCGGC
AAGGACGTGTTGATGGAGCACGGCATGGCCGGCCTCTACGCGCCGATCGACCTGAACATCGCGCGCTGCCGCATGTCTGT
GGCGGTGCCGGCCGGCTTCGACTACGTCAATGCGGTGCGCCAGGGCGCGCGCCTGGCCGTGGCCACCAAGTACGTGCAGA
CCGCGCGCGAGCACTTCGCGAAGAAGGGTGTGCACGTTGATCTGATCAAGCTCTACGGTTCGATGGAACTGGGGCCGCTG
GTGGGGCTGTCCGACGCGATCGTCGATCTGGTCAGCACCGGCAGCACCTTGCGCGCCAATAACCTCGTCGAGGTGGAGGA
GATCGTCCAGATCTCGTCGCGTCTGGTGGTCAACCAGGCAGCGCTCAAACTCAAGCGCGAACGGCTGGCGCCGATTCTCG
ATGCATTTGAACGGGCCTCGGCCGCGCTCGCCTGA

Upstream 100 bases:

>100_bases
CGGTCGGCGCGAAGATCCTCCGCATCAGCTGAGGCACGACGCCCGCCACGAACGATGCCGAAACGGCAAGCCGCCCCCGA
ACACTGCTGAAGAATCTACG

Downstream 100 bases:

>100_bases
GGCGGGCGGTGACCGGAGACCCGCGAGGAAAGAAGTCATGAACGATACCGAAATGGAAAACCTGTCGATCCGCCGGCTTG
ATTCGCGCGAGCCCGGTTTC

Product: ATP phosphoribosyltransferase catalytic subunit

Products: NA

Alternate protein names: ATP-PRT; ATP-PRTase [H]

Number of amino acids: Translated: 224; Mature: 223

Protein sequence:

>224_residues
MSPAFNASPDQLTLALSKGRIFKETLPLLAAAGIQVTEDPETSRKLILPTSDPAVRVIIVRASDVPTYVQYGAADFGVAG
KDVLMEHGMAGLYAPIDLNIARCRMSVAVPAGFDYVNAVRQGARLAVATKYVQTAREHFAKKGVHVDLIKLYGSMELGPL
VGLSDAIVDLVSTGSTLRANNLVEVEEIVQISSRLVVNQAALKLKRERLAPILDAFERASAALA

Sequences:

>Translated_224_residues
MSPAFNASPDQLTLALSKGRIFKETLPLLAAAGIQVTEDPETSRKLILPTSDPAVRVIIVRASDVPTYVQYGAADFGVAG
KDVLMEHGMAGLYAPIDLNIARCRMSVAVPAGFDYVNAVRQGARLAVATKYVQTAREHFAKKGVHVDLIKLYGSMELGPL
VGLSDAIVDLVSTGSTLRANNLVEVEEIVQISSRLVVNQAALKLKRERLAPILDAFERASAALA
>Mature_223_residues
SPAFNASPDQLTLALSKGRIFKETLPLLAAAGIQVTEDPETSRKLILPTSDPAVRVIIVRASDVPTYVQYGAADFGVAGK
DVLMEHGMAGLYAPIDLNIARCRMSVAVPAGFDYVNAVRQGARLAVATKYVQTAREHFAKKGVHVDLIKLYGSMELGPLV
GLSDAIVDLVSTGSTLRANNLVEVEEIVQISSRLVVNQAALKLKRERLAPILDAFERASAALA

Specific function: Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic

COG id: COG0040

COG function: function code E; ATP phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP phosphoribosyltransferase family. Short subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788330, Length=209, Percent_Identity=31.5789473684211, Blast_Score=91, Evalue=6e-20,
Organism=Saccharomyces cerevisiae, GI6320896, Length=198, Percent_Identity=31.8181818181818, Blast_Score=83, Evalue=4e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001348
- InterPro:   IPR013820
- InterPro:   IPR018198 [H]

Pfam domain/function: PF01634 HisG [H]

EC number: =2.4.2.17 [H]

Molecular weight: Translated: 23953; Mature: 23822

Theoretical pI: Translated: 8.43; Mature: 8.43

Prosite motif: PS01316 ATP_P_PHORIBOSYLTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSPAFNASPDQLTLALSKGRIFKETLPLLAAAGIQVTEDPETSRKLILPTSDPAVRVIIV
CCCCCCCCCCCEEEEECCCCHHHHHHHHHHHCCCEEECCCCCCCEEEEECCCCCEEEEEE
RASDVPTYVQYGAADFGVAGKDVLMEHGMAGLYAPIDLNIARCRMSVAVPAGFDYVNAVR
ECCCCCHHHHHCCCCCCCCCHHHHHHCCCCCEECCCCCCHHHEEEEEECCCCHHHHHHHH
QGARLAVATKYVQTAREHFAKKGVHVDLIKLYGSMELGPLVGLSDAIVDLVSTGSTLRAN
HCCHHHHHHHHHHHHHHHHHHCCCEEEEHHHHCCCCCCCCCCHHHHHHHHHHCCCEECCC
NLVEVEEIVQISSRLVVNQAALKLKRERLAPILDAFERASAALA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SPAFNASPDQLTLALSKGRIFKETLPLLAAAGIQVTEDPETSRKLILPTSDPAVRVIIV
CCCCCCCCCCEEEEECCCCHHHHHHHHHHHCCCEEECCCCCCCEEEEECCCCCEEEEEE
RASDVPTYVQYGAADFGVAGKDVLMEHGMAGLYAPIDLNIARCRMSVAVPAGFDYVNAVR
ECCCCCHHHHHCCCCCCCCCHHHHHHCCCCCEECCCCCCHHHEEEEEECCCCHHHHHHHH
QGARLAVATKYVQTAREHFAKKGVHVDLIKLYGSMELGPLVGLSDAIVDLVSTGSTLRAN
HCCHHHHHHHHHHHHHHHHHHCCCEEEEHHHHCCCCCCCCCCHHHHHHHHHHCCCEECCC
NLVEVEEIVQISSRLVVNQAALKLKRERLAPILDAFERASAALA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA