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The map label for this gene is hmzS [H]

Identifier: 94311947

GI number: 94311947

Start: 3273371

End: 3274783

Strand: Reverse

Name: hmzS [H]

Synonym: Rmet_3015

Alternate gene names: 94311947

Gene position: 3274783-3273371 (Counterclockwise)

Preceding gene: 94311948

Following gene: 94311944

Centisome position: 83.37

GC content: 60.79

Gene sequence:

>1413_bases
ATGGTACGTCCCGATTCCGAAGCCCTTTCTGATGCGAGTCAAGGCGGATCCTGGTCCTTGCAGCGGCGGCTGGCTGCCAG
CTTGGTGATCTGCATTGGAGGAACCTTCGCGATCCTGTTTCCCGTCCTCGACTACCGGATTGACCACGAAATCTATCGAC
GGATGGATACCACCCTGATGCAACGATCAGCGGCGGTGGGGCGCGTGCTGCAGGAGTTGGATGCGAGAAAGCTCGAAAGC
CTCATGCCGGAATATGAGCATGGCGGGCATACCGAGTTCTTCACGATCTTCGATTCACAGACCCACCGGACCTTGCTACG
GTCTCCCAGCAGTGCAGGCGCCGAGCTATCGCTTGGCCCGGTGGAGCAAGGCACCCCGCGCTATTACGACGTGACACTTC
CGGATGGCCACGCGGGCCGCGCGCTGGCGACGCGCGTGTCGGTAACTGGAGAGAGGTCTCAGCTATTAGTCGTCGCAACA
GAACGCCGGGATTGGGATCAAACCGAGCGGCGCATCCACTTTGCGCTCTTGGGCGGTATTGTGCTGGCAACGCTGCTAGC
GACGGGCCTGGCGCTGCTCATGGTTCGGCATATCGTGGTCATGCTGGAGCGGGTCGGCGAGCAACTGGCCGATCTGCGTT
CGGATCGGCCGATTGCGCGGATCGGAGCGGACTTTCCCCGTGAACTGCGTCCGTTTGCCGAAGCCTTCAATCAGGGCTTG
CATCACCTGTATGCGGCCATTGTCCGCGAGCGCCGCTTCTCCCGCGATGTGGCCCACGAGTTGCGCACGCCCCTGGCGGA
AATCCGCATCAGCGCAGAAAACGCTTTGATCGATGCCGACCCGACCCGAATCCAGCGCGCCCTGAATGCAATGATCCAGG
CCAGTTCGCGCATGCAGCGCAGTGTGGACACTCTGCTGTTGTTGGCGCGGCTTGAATCCGGCCAACACACACTTGCGCTG
GATCCTCTGGATCTGACAGCTTTGCTACAAGAGTTGCTGGCGGGACTCAACGTCCAGCAAATGGCACCCAAGTCACCCAT
CCGCGTGACTTTGCCTGAATCGGCATGGGTGCAAAGTGATCAGGGCGTGATCGAACGCATCGTCTCCAACCTCTTGCGCA
ATGCCATTGAATACGCGCCCGAATGCGACGACATTCAATGTAGATTGGAGCGCGAGGCTTCCGGCTGGATGTTGACCATC
GTCAACACAGCTCCCAATTTGCAGGCATCCGATCTGGAGCAATTCGGCCTTCGCTTCTGGCGCAAGGATTCCGAAGGTGG
CACGGCGCACCACGCTGGGCTGGGACTTGCACTGGCCCTGGCGCTCGCGCATGCCATAGACCTACCGCTGGCGTTCTCAC
TGGACAATGGTCGGCTGTCCGCGCGGCTTGGCCCTTGGCCACCGCTGCTCTGA

Upstream 100 bases:

>100_bases
AGAGGTGATCGTCAGCACCTTGCGAACCAAGCTTGCCCAGTGCGGCCTGGATGAACTGATCGTGACACGCCGTGGCTTCG
GCTACATCCTGCCCTGAACG

Downstream 100 bases:

>100_bases
CATTGACACAGATCTACACCGCGGTGCCGAACATGGCTCCCACGCCCGCTGTCACCGCCATGGCAAATGTGCCCCAGAAC
GCGACGCGCAGCGCACTTTT

Product: putative Signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 470; Mature: 470

Protein sequence:

>470_residues
MVRPDSEALSDASQGGSWSLQRRLAASLVICIGGTFAILFPVLDYRIDHEIYRRMDTTLMQRSAAVGRVLQELDARKLES
LMPEYEHGGHTEFFTIFDSQTHRTLLRSPSSAGAELSLGPVEQGTPRYYDVTLPDGHAGRALATRVSVTGERSQLLVVAT
ERRDWDQTERRIHFALLGGIVLATLLATGLALLMVRHIVVMLERVGEQLADLRSDRPIARIGADFPRELRPFAEAFNQGL
HHLYAAIVRERRFSRDVAHELRTPLAEIRISAENALIDADPTRIQRALNAMIQASSRMQRSVDTLLLLARLESGQHTLAL
DPLDLTALLQELLAGLNVQQMAPKSPIRVTLPESAWVQSDQGVIERIVSNLLRNAIEYAPECDDIQCRLEREASGWMLTI
VNTAPNLQASDLEQFGLRFWRKDSEGGTAHHAGLGLALALALAHAIDLPLAFSLDNGRLSARLGPWPPLL

Sequences:

>Translated_470_residues
MVRPDSEALSDASQGGSWSLQRRLAASLVICIGGTFAILFPVLDYRIDHEIYRRMDTTLMQRSAAVGRVLQELDARKLES
LMPEYEHGGHTEFFTIFDSQTHRTLLRSPSSAGAELSLGPVEQGTPRYYDVTLPDGHAGRALATRVSVTGERSQLLVVAT
ERRDWDQTERRIHFALLGGIVLATLLATGLALLMVRHIVVMLERVGEQLADLRSDRPIARIGADFPRELRPFAEAFNQGL
HHLYAAIVRERRFSRDVAHELRTPLAEIRISAENALIDADPTRIQRALNAMIQASSRMQRSVDTLLLLARLESGQHTLAL
DPLDLTALLQELLAGLNVQQMAPKSPIRVTLPESAWVQSDQGVIERIVSNLLRNAIEYAPECDDIQCRLEREASGWMLTI
VNTAPNLQASDLEQFGLRFWRKDSEGGTAHHAGLGLALALALAHAIDLPLAFSLDNGRLSARLGPWPPLL
>Mature_470_residues
MVRPDSEALSDASQGGSWSLQRRLAASLVICIGGTFAILFPVLDYRIDHEIYRRMDTTLMQRSAAVGRVLQELDARKLES
LMPEYEHGGHTEFFTIFDSQTHRTLLRSPSSAGAELSLGPVEQGTPRYYDVTLPDGHAGRALATRVSVTGERSQLLVVAT
ERRDWDQTERRIHFALLGGIVLATLLATGLALLMVRHIVVMLERVGEQLADLRSDRPIARIGADFPRELRPFAEAFNQGL
HHLYAAIVRERRFSRDVAHELRTPLAEIRISAENALIDADPTRIQRALNAMIQASSRMQRSVDTLLLLARLESGQHTLAL
DPLDLTALLQELLAGLNVQQMAPKSPIRVTLPESAWVQSDQGVIERIVSNLLRNAIEYAPECDDIQCRLEREASGWMLTI
VNTAPNLQASDLEQFGLRFWRKDSEGGTAHHAGLGLALALALAHAIDLPLAFSLDNGRLSARLGPWPPLL

Specific function: Member of the two-component regulatory system mtrA/mtrB. Seems to function as a membrane-associated protein kinase that phosphorylates mtrA in response to environmental signals [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1789403, Length=304, Percent_Identity=28.9473684210526, Blast_Score=95, Evalue=8e-21,
Organism=Escherichia coli, GI1788279, Length=277, Percent_Identity=28.158844765343, Blast_Score=92, Evalue=9e-20,
Organism=Escherichia coli, GI1790861, Length=284, Percent_Identity=28.8732394366197, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI1788393, Length=241, Percent_Identity=27.8008298755187, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI1790551, Length=238, Percent_Identity=31.0924369747899, Blast_Score=73, Evalue=5e-14,
Organism=Escherichia coli, GI1787894, Length=233, Percent_Identity=29.6137339055794, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1786783, Length=269, Percent_Identity=23.7918215613383, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1786600, Length=212, Percent_Identity=25.4716981132075, Blast_Score=65, Evalue=7e-12,
Organism=Escherichia coli, GI1790346, Length=226, Percent_Identity=25.6637168141593, Blast_Score=63, Evalue=3e-11,
Organism=Escherichia coli, GI1786912, Length=191, Percent_Identity=29.3193717277487, Blast_Score=62, Evalue=1e-10,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 52098; Mature: 52098

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVRPDSEALSDASQGGSWSLQRRLAASLVICIGGTFAILFPVLDYRIDHEIYRRMDTTLM
CCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QRSAAVGRVLQELDARKLESLMPEYEHGGHTEFFTIFDSQTHRTLLRSPSSAGAELSLGP
HHHHHHHHHHHHHHHHHHHHHCCHHCCCCCCEEEEEECCCHHHHHHCCCCCCCCEEECCC
VEQGTPRYYDVTLPDGHAGRALATRVSVTGERSQLLVVATERRDWDQTERRIHFALLGGI
CCCCCCCEEEEECCCCCCCCHHHHEEEECCCCCEEEEEEECCCCCHHHHHHHHHHHHHHH
VLATLLATGLALLMVRHIVVMLERVGEQLADLRSDRPIARIGADFPRELRPFAEAFNQGL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCHHHHHHHHHHHHHH
HHLYAAIVRERRFSRDVAHELRTPLAEIRISAENALIDADPTRIQRALNAMIQASSRMQR
HHHHHHHHHHHHHHHHHHHHHHCCHHHEEECCCCCEECCCHHHHHHHHHHHHHHHHHHHH
SVDTLLLLARLESGQHTLALDPLDLTALLQELLAGLNVQQMAPKSPIRVTLPESAWVQSD
HHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHCCCHHHCCCCCCEEEECCCHHHCCCC
QGVIERIVSNLLRNAIEYAPECDDIQCRLEREASGWMLTIVNTAPNLQASDLEQFGLRFW
HHHHHHHHHHHHHHHHHHCCCCCCHHHHEECCCCCEEEEEECCCCCCCHHHHHHHHHHHH
RKDSEGGTAHHAGLGLALALALAHAIDLPLAFSLDNGRLSARLGPWPPLL
CCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCEEEECCCCCCCCC
>Mature Secondary Structure
MVRPDSEALSDASQGGSWSLQRRLAASLVICIGGTFAILFPVLDYRIDHEIYRRMDTTLM
CCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QRSAAVGRVLQELDARKLESLMPEYEHGGHTEFFTIFDSQTHRTLLRSPSSAGAELSLGP
HHHHHHHHHHHHHHHHHHHHHCCHHCCCCCCEEEEEECCCHHHHHHCCCCCCCCEEECCC
VEQGTPRYYDVTLPDGHAGRALATRVSVTGERSQLLVVATERRDWDQTERRIHFALLGGI
CCCCCCCEEEEECCCCCCCCHHHHEEEECCCCCEEEEEEECCCCCHHHHHHHHHHHHHHH
VLATLLATGLALLMVRHIVVMLERVGEQLADLRSDRPIARIGADFPRELRPFAEAFNQGL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCHHHHHHHHHHHHHH
HHLYAAIVRERRFSRDVAHELRTPLAEIRISAENALIDADPTRIQRALNAMIQASSRMQR
HHHHHHHHHHHHHHHHHHHHHHCCHHHEEECCCCCEECCCHHHHHHHHHHHHHHHHHHHH
SVDTLLLLARLESGQHTLALDPLDLTALLQELLAGLNVQQMAPKSPIRVTLPESAWVQSD
HHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHCCCHHHCCCCCCEEEECCCHHHCCCC
QGVIERIVSNLLRNAIEYAPECDDIQCRLEREASGWMLTIVNTAPNLQASDLEQFGLRFW
HHHHHHHHHHHHHHHHHHCCCCCCHHHHEECCCCCEEEEEECCCCCCCHHHHHHHHHHHH
RKDSEGGTAHHAGLGLALALALAHAIDLPLAFSLDNGRLSARLGPWPPLL
CCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA