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The map label for this gene is hmzR [H]

Identifier: 94311948

GI number: 94311948

Start: 3274787

End: 3275452

Strand: Reverse

Name: hmzR [H]

Synonym: Rmet_3016

Alternate gene names: 94311948

Gene position: 3275452-3274787 (Counterclockwise)

Preceding gene: 94311949

Following gene: 94311947

Centisome position: 83.39

GC content: 62.61

Gene sequence:

>666_bases
ATGCGCGTATTGATCGTGGAAGACTCGCAAACGCTGGCCGAAGCCCTGAGCCAGAGCCTTCAGTCGGAAGGCTATGCCTG
CGATACAGCAGCCGATGGCGTGTCCGCGCTGAAGTTTCTTGCCAGCTACCGGTACGACGCCATCATTCTGGACTTGATGC
TGCCCCGGCTGGACGGCTTTGGCGTGTTGCGCGCATTGGGCCGGGAGGCCCATGCCGCACCGGTGTTGGTGCTCTCCGCG
CGCGAACTGCTCGACGACCGGGTGCGGGCCTTGGATGCGGGTGCCGATGACTACCTGACAAAACCCTTCGAGCTAGCCGA
ACTGCTGGCTCGCCTGCGGGCGCTAGTACGGCGTCCGCCGCAACGGGACGTTCCAGTTCTGCGCCACGGCGATCTGGAGG
TCGATCCGCGCTCGCGCATCGCGAGGTTCAAGTGCATTGATCTTGGGCTCACGCCGAAGGAGTATGGACTGCTCGACTTG
CTGCTGCGTCGGCGCGGCGCCACGCTGTCGCGCTCGCAGATTTTTGAACATTTGTACGACAGCCGCAGCGATGCATCGGA
CAAAGTGGTAGAGGTGATCGTCAGCACCTTGCGAACCAAGCTTGCCCAGTGCGGCCTGGATGAACTGATCGTGACACGCC
GTGGCTTCGGCTACATCCTGCCCTGA

Upstream 100 bases:

>100_bases
CCTTCGGCCGCGCGTTGCGCGCCGACCTGCTGGCCCAGGGGCTCGAGCCGGAGGCGTTCCACCAAGAGCTTTTCGAGATG
CGCTGAACGGAAGAAAGCAC

Downstream 100 bases:

>100_bases
ACGATGGTACGTCCCGATTCCGAAGCCCTTTCTGATGCGAGTCAAGGCGGATCCTGGTCCTTGCAGCGGCGGCTGGCTGC
CAGCTTGGTGATCTGCATTG

Product: Two component heavy metal response transcriptional DNA binding regulator, winged helix family

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 221; Mature: 221

Protein sequence:

>221_residues
MRVLIVEDSQTLAEALSQSLQSEGYACDTAADGVSALKFLASYRYDAIILDLMLPRLDGFGVLRALGREAHAAPVLVLSA
RELLDDRVRALDAGADDYLTKPFELAELLARLRALVRRPPQRDVPVLRHGDLEVDPRSRIARFKCIDLGLTPKEYGLLDL
LLRRRGATLSRSQIFEHLYDSRSDASDKVVEVIVSTLRTKLAQCGLDELIVTRRGFGYILP

Sequences:

>Translated_221_residues
MRVLIVEDSQTLAEALSQSLQSEGYACDTAADGVSALKFLASYRYDAIILDLMLPRLDGFGVLRALGREAHAAPVLVLSA
RELLDDRVRALDAGADDYLTKPFELAELLARLRALVRRPPQRDVPVLRHGDLEVDPRSRIARFKCIDLGLTPKEYGLLDL
LLRRRGATLSRSQIFEHLYDSRSDASDKVVEVIVSTLRTKLAQCGLDELIVTRRGFGYILP
>Mature_221_residues
MRVLIVEDSQTLAEALSQSLQSEGYACDTAADGVSALKFLASYRYDAIILDLMLPRLDGFGVLRALGREAHAAPVLVLSA
RELLDDRVRALDAGADDYLTKPFELAELLARLRALVRRPPQRDVPVLRHGDLEVDPRSRIARFKCIDLGLTPKEYGLLDL
LLRRRGATLSRSQIFEHLYDSRSDASDKVVEVIVSTLRTKLAQCGLDELIVTRRGFGYILP

Specific function: Member of the two-component regulatory system irlR/irlS. May be involved in invasion of eukaryotic cells and heavy-metal resistance [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1789402, Length=220, Percent_Identity=42.2727272727273, Blast_Score=157, Evalue=4e-40,
Organism=Escherichia coli, GI1790552, Length=220, Percent_Identity=39.0909090909091, Blast_Score=148, Evalue=2e-37,
Organism=Escherichia coli, GI1786784, Length=221, Percent_Identity=38.4615384615385, Blast_Score=145, Evalue=3e-36,
Organism=Escherichia coli, GI87082012, Length=218, Percent_Identity=39.4495412844037, Blast_Score=144, Evalue=5e-36,
Organism=Escherichia coli, GI1787375, Length=220, Percent_Identity=35, Blast_Score=125, Evalue=2e-30,
Organism=Escherichia coli, GI1790860, Length=222, Percent_Identity=38.2882882882883, Blast_Score=123, Evalue=8e-30,
Organism=Escherichia coli, GI1786599, Length=220, Percent_Identity=35.4545454545455, Blast_Score=123, Evalue=1e-29,
Organism=Escherichia coli, GI1786911, Length=220, Percent_Identity=36.8181818181818, Blast_Score=115, Evalue=2e-27,
Organism=Escherichia coli, GI1788394, Length=223, Percent_Identity=33.6322869955157, Blast_Score=105, Evalue=2e-24,
Organism=Escherichia coli, GI2367329, Length=228, Percent_Identity=33.7719298245614, Blast_Score=101, Evalue=4e-23,
Organism=Escherichia coli, GI1789809, Length=227, Percent_Identity=27.7533039647577, Blast_Score=92, Evalue=3e-20,
Organism=Escherichia coli, GI1787229, Length=226, Percent_Identity=30.0884955752212, Blast_Score=88, Evalue=4e-19,
Organism=Escherichia coli, GI1790863, Length=232, Percent_Identity=27.5862068965517, Blast_Score=81, Evalue=7e-17,
Organism=Escherichia coli, GI1787487, Length=115, Percent_Identity=38.2608695652174, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1788550, Length=107, Percent_Identity=32.7102803738318, Blast_Score=70, Evalue=8e-14,
Organism=Escherichia coli, GI1790299, Length=108, Percent_Identity=33.3333333333333, Blast_Score=69, Evalue=2e-13,
Organism=Escherichia coli, GI145693157, Length=105, Percent_Identity=33.3333333333333, Blast_Score=68, Evalue=5e-13,
Organism=Escherichia coli, GI1788713, Length=136, Percent_Identity=32.3529411764706, Blast_Score=65, Evalue=3e-12,
Organism=Escherichia coli, GI145693140, Length=235, Percent_Identity=24.6808510638298, Blast_Score=60, Evalue=1e-10,
Organism=Saccharomyces cerevisiae, GI6322000, Length=106, Percent_Identity=31.1320754716981, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR006291
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 24617; Mature: 24617

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVLIVEDSQTLAEALSQSLQSEGYACDTAADGVSALKFLASYRYDAIILDLMLPRLDGF
CEEEEECCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
GVLRALGREAHAAPVLVLSARELLDDRVRALDAGADDYLTKPFELAELLARLRALVRRPP
HHHHHHCCHHHCCHHHHHHHHHHHHHHHHHHHCCCHHHHCCHHHHHHHHHHHHHHHCCCC
QRDVPVLRHGDLEVDPRSRIARFKCIDLGLTPKEYGLLDLLLRRRGATLSRSQIFEHLYD
CCCCCCEECCCCCCCHHHHHHHHHEEECCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHC
SRSDASDKVVEVIVSTLRTKLAQCGLDELIVTRRGFGYILP
CCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MRVLIVEDSQTLAEALSQSLQSEGYACDTAADGVSALKFLASYRYDAIILDLMLPRLDGF
CEEEEECCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
GVLRALGREAHAAPVLVLSARELLDDRVRALDAGADDYLTKPFELAELLARLRALVRRPP
HHHHHHCCHHHCCHHHHHHHHHHHHHHHHHHHCCCHHHHCCHHHHHHHHHHHHHHHCCCC
QRDVPVLRHGDLEVDPRSRIARFKCIDLGLTPKEYGLLDLLLRRRGATLSRSQIFEHLYD
CCCCCCEECCCCCCCHHHHHHHHHEEECCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHC
SRSDASDKVVEVIVSTLRTKLAQCGLDELIVTRRGFGYILP
CCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9393784 [H]