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The map label for this gene is holA [H]

Identifier: 94311903

GI number: 94311903

Start: 3229087

End: 3230157

Strand: Reverse

Name: holA [H]

Synonym: Rmet_2971

Alternate gene names: 94311903

Gene position: 3230157-3229087 (Counterclockwise)

Preceding gene: 94311904

Following gene: 94311902

Centisome position: 82.23

GC content: 68.63

Gene sequence:

>1071_bases
ATGCAGCTCAAGCTCGACGGACTCGAGGCACATCTGAGGCAGGCGCAGGCCAAGGGCCTGGCGCCGCTTTACGTCGTTCA
CGGCGACGAGCACCTGCTGGTGCTGGAGGCGGTAGATCGCCTGCGCCGCGCTGCGCGAGAGGCCGGTTTCTCCGAACGCG
ACGTGCTGGTGGCCGAACGTGGCTTCCAGTGGGGGCAGGTCATCGAGGCCCAGCAGTCGATGTCGCTGTTCGGCGACCGC
AAGATCGTCGAGTTGCGTATTCCATCGGGCAAGCCGGGCAAGGACGGCGGCGAGGCGTTGCGCGCCGTGGCCGCCCAGCC
GTCGCCGGATGTGGTGATGCTGGTCACACTGCCGCGCCTGGATTTCGCCACGACGAAATCGGCCTGGTTCCAGGCATTGG
AGTCGGCGGGGGTGTCGATCAAGGTCGATGCCGTGGACCGCACGCGGCTGCCCGCCTGGGTGGGCGAACGACTCGGCCTG
CAGCAGCAGCGGGTGGAGCCGGGCGAGCCAGGGCGGCGCGCGCTGCAGTTCATCGCCGAAAAGGTCGAGGGCAACCTGCT
GGCCGCGCATCAGGAAATCCAGAAGCTCGGCCTGCTTTATCCGCCCGGCGCGCTGACCTTCGACCAGGTTCAGGACGCGG
TGCTGAACGTGGCCCGCTACGACGTGTTCAAACTGTCCGAAGCCATGCTCGGCGGCGACGTGCCGCGCCTGGTGCGTATG
CTCGAAGGGCTGCGTGGCGAGGGCGAGGCTACGGTGCTGGTGCTGTGGGCGCTGACCGAGGAAATTCGCGTATTATCCAA
GGTCCGGCAAGGCTTGGCGGGCGGCAAGCCGGCGGGCGTGCTGATGCGCGAACTGCGCGTCTGGGGCCCGCGCGAGCGGC
TCGTACCACAGGCCGCGCAACGGCTGTCGATGCCGCAACTGGAAGCCGCGCTTGCCATGGCCGCGCGGCTGGACCGGCAG
GTCAAGGGCCTGTCCGACCTGCCAGGCGCTGGCGGAGCGGCCGGTGCGTTACCAGCCGAGCCATGGGACGGCCTGATGCA
GCTTGCGCTGATGATCGCCAGACCCGCATGA

Upstream 100 bases:

>100_bases
TGTTGTGAATCAGCTCATGCGCCGGCTGGCCTCGGTCAAGACGATCTGACGCGCCGGGTATCGGCGCGACTCAGGCCGAC
ACAGGAAACATAGGGCGACA

Downstream 100 bases:

>100_bases
GGCCTCCGGGCCCCCGGGGTCCGGACAGGTGACCGGACCACCGAACCAGAACAATCGCCGGCAGCCGCGCCGGCGCATCG
ACATCGCGGCACTCATAGCA

Product: DNA polymerase III subunit delta

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 356; Mature: 356

Protein sequence:

>356_residues
MQLKLDGLEAHLRQAQAKGLAPLYVVHGDEHLLVLEAVDRLRRAAREAGFSERDVLVAERGFQWGQVIEAQQSMSLFGDR
KIVELRIPSGKPGKDGGEALRAVAAQPSPDVVMLVTLPRLDFATTKSAWFQALESAGVSIKVDAVDRTRLPAWVGERLGL
QQQRVEPGEPGRRALQFIAEKVEGNLLAAHQEIQKLGLLYPPGALTFDQVQDAVLNVARYDVFKLSEAMLGGDVPRLVRM
LEGLRGEGEATVLVLWALTEEIRVLSKVRQGLAGGKPAGVLMRELRVWGPRERLVPQAAQRLSMPQLEAALAMAARLDRQ
VKGLSDLPGAGGAAGALPAEPWDGLMQLALMIARPA

Sequences:

>Translated_356_residues
MQLKLDGLEAHLRQAQAKGLAPLYVVHGDEHLLVLEAVDRLRRAAREAGFSERDVLVAERGFQWGQVIEAQQSMSLFGDR
KIVELRIPSGKPGKDGGEALRAVAAQPSPDVVMLVTLPRLDFATTKSAWFQALESAGVSIKVDAVDRTRLPAWVGERLGL
QQQRVEPGEPGRRALQFIAEKVEGNLLAAHQEIQKLGLLYPPGALTFDQVQDAVLNVARYDVFKLSEAMLGGDVPRLVRM
LEGLRGEGEATVLVLWALTEEIRVLSKVRQGLAGGKPAGVLMRELRVWGPRERLVPQAAQRLSMPQLEAALAMAARLDRQ
VKGLSDLPGAGGAAGALPAEPWDGLMQLALMIARPA
>Mature_356_residues
MQLKLDGLEAHLRQAQAKGLAPLYVVHGDEHLLVLEAVDRLRRAAREAGFSERDVLVAERGFQWGQVIEAQQSMSLFGDR
KIVELRIPSGKPGKDGGEALRAVAAQPSPDVVMLVTLPRLDFATTKSAWFQALESAGVSIKVDAVDRTRLPAWVGERLGL
QQQRVEPGEPGRRALQFIAEKVEGNLLAAHQEIQKLGLLYPPGALTFDQVQDAVLNVARYDVFKLSEAMLGGDVPRLVRM
LEGLRGEGEATVLVLWALTEEIRVLSKVRQGLAGGKPAGVLMRELRVWGPRERLVPQAAQRLSMPQLEAALAMAARLDRQ
VKGLSDLPGAGGAAGALPAEPWDGLMQLALMIARPA

Specific function: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The delta subunit seems to interact with the gamma subunit to transfer the b

COG id: COG1466

COG function: function code L; DNA polymerase III, delta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1786859, Length=287, Percent_Identity=29.616724738676, Blast_Score=129, Evalue=3e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008921
- InterPro:   IPR010372
- InterPro:   IPR005790 [H]

Pfam domain/function: PF06144 DNA_pol3_delta [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 38654; Mature: 38654

Theoretical pI: Translated: 8.90; Mature: 8.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQLKLDGLEAHLRQAQAKGLAPLYVVHGDEHLLVLEAVDRLRRAAREAGFSERDVLVAER
CCEECCHHHHHHHHHHHCCCCEEEEEECCCCEEHHHHHHHHHHHHHHCCCCCCCCHHHHC
GFQWGQVIEAQQSMSLFGDRKIVELRIPSGKPGKDGGEALRAVAAQPSPDVVMLVTLPRL
CCCHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCHHHHHHHHHCCCCCCEEEEEEECCC
DFATTKSAWFQALESAGVSIKVDAVDRTRLPAWVGERLGLQQQRVEPGEPGRRALQFIAE
CCHHHHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHCCHHHCCCCCCHHHHHHHHHHH
KVEGNLLAAHQEIQKLGLLYPPGALTFDQVQDAVLNVARYDVFKLSEAMLGGDVPRLVRM
HHCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
LEGLRGEGEATVLVLWALTEEIRVLSKVRQGLAGGKPAGVLMRELRVWGPRERLVPQAAQ
HHCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHH
RLSMPQLEAALAMAARLDRQVKGLSDLPGAGGAAGALPAEPWDGLMQLALMIARPA
HCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure
MQLKLDGLEAHLRQAQAKGLAPLYVVHGDEHLLVLEAVDRLRRAAREAGFSERDVLVAER
CCEECCHHHHHHHHHHHCCCCEEEEEECCCCEEHHHHHHHHHHHHHHCCCCCCCCHHHHC
GFQWGQVIEAQQSMSLFGDRKIVELRIPSGKPGKDGGEALRAVAAQPSPDVVMLVTLPRL
CCCHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCHHHHHHHHHCCCCCCEEEEEEECCC
DFATTKSAWFQALESAGVSIKVDAVDRTRLPAWVGERLGLQQQRVEPGEPGRRALQFIAE
CCHHHHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHCCHHHCCCCCCHHHHHHHHHHH
KVEGNLLAAHQEIQKLGLLYPPGALTFDQVQDAVLNVARYDVFKLSEAMLGGDVPRLVRM
HHCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
LEGLRGEGEATVLVLWALTEEIRVLSKVRQGLAGGKPAGVLMRELRVWGPRERLVPQAAQ
HHCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHH
RLSMPQLEAALAMAARLDRQVKGLSDLPGAGGAAGALPAEPWDGLMQLALMIARPA
HCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8505303; 1400251; 8905232; 9278503; 3316191; 8505304; 1575709 [H]