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The map label for this gene is proA [H]

Identifier: 94311902

GI number: 94311902

Start: 3227680

End: 3228960

Strand: Reverse

Name: proA [H]

Synonym: Rmet_2970

Alternate gene names: 94311902

Gene position: 3228960-3227680 (Counterclockwise)

Preceding gene: 94311903

Following gene: 94311901

Centisome position: 82.2

GC content: 65.5

Gene sequence:

>1281_bases
ATGACCGAGTTCGATCTCCACGCTTACATGACCCGCGTTGGCCAGCAGGCCCGCGCGGCATCGCGCGCCATGGCGCGCGC
TTCCACGGCCGACAAGAACCGTGCGCTGCTGACGATTGCCGCGGCCATCCGCCGCGATGCGGACAAGCTCAAGGCCGTCA
ACGCCCGCGACGTCGAACGCGCCCGCACCAACGGCCAGGACGCCGCCTTCATTGATCGCCTGACACTGTCGGACAAGGCG
ATCGCCACGATGGCAGCCGGCCTCGAGCAGATAGCCGCGCTGGCGGACCCGATCGGCGAAATCTCGAACATGAAGTTCCG
TCCCACCGGCATTCAGGTGGGCCAGATGCGCGTGCCGCTCGGCGTGATCGGCATCATCTATGAATCGCGTCCGAACGTGA
CCATCGATGCGGCGGCGCTGTGCCTGAAGTCGGGCAACTCTACGATTTTGCGTGGCGGCTCCGAGGCGATCGAATCGAAT
ACCGCCCTGGCCGCGCTCGTGGCCGAGGGACTGGCCGCGGCGGGGCTGCCCTCCGAAGCCGTGCAGGTGATCGAAACCAC
GGATCGCGCCGCGGTTGGTCGCCTGATCACGATGACCGAGTATGTCGACGTGATCGTGCCGCGCGGCGGCAAGAGCCTGA
TCGCCCGCTTGATGGAAGAGGCGCGCGTGCCGATGATCAAGCACCTGGACGGCATCTGCCACGTCTATATCGATGACGAC
GCCGACCTGGAAAAGGCCGTGCGCGTGTGCGACAACGCCAAGACGCAGCGCTACGCACCGTGCAACACGATGGAAACGCT
GCTCGTGTCGCGCGAGATAGCTGCGAAGGCGCTGCCGCCGCTGTGCCGTATCTACCAGGAAAAAGGTGTCGAGTTGCGCG
TCTGCCCGGCAACGCGCGCCACGCTGGAAGCCGCCGGCTTCTCGGGCCTGGTCGACGCCACCGAGGAGGACTGGCGTCTC
GAGTACCTGGCGCCGGTGCTGGCGATCCGCACGGTGGACGGACTGGACGCCGCCATCGCGCACATCAACACCTACGGGTC
GGCGCATACCGATTCGATCATCACCGAGAACTACACCACCGGGATGCGTTTTCTGCGTGAAGTCGATTCGGCCAGCGTGA
TGATCAATGCCTCGACGCGCTTTGCCGACGGCTTCGAGTACGGCCTCGGCGCGGAGATCGGCATCTCCAACGACAAGCTC
CACGCTCGCGGCCCGGTGGGCCTGGAGGGGCTGACCTCGCTCAAGTACGTCGTGTTCGGTCACGGCGAGATTCGTACGTA
A

Upstream 100 bases:

>100_bases
AGGTGACCGGACCACCGAACCAGAACAATCGCCGGCAGCCGCGCCGGCGCATCGACATCGCGGCACTCATAGCAGACCGG
GCACAGGCCCGGACACCATC

Downstream 100 bases:

>100_bases
CCGGAGGCGGATCAGCACATGCTCTGGGTCAAGGCGTTCCATATCCTGTTCGTGACTTCGTGGTTCGCGGGGTTGTTCTA
CCTGCCGCGCATTTTCGTCA

Product: gamma-glutamyl phosphate reductase

Products: NA

Alternate protein names: GPR; Glutamate-5-semialdehyde dehydrogenase; Glutamyl-gamma-semialdehyde dehydrogenase; GSA dehydrogenase [H]

Number of amino acids: Translated: 426; Mature: 425

Protein sequence:

>426_residues
MTEFDLHAYMTRVGQQARAASRAMARASTADKNRALLTIAAAIRRDADKLKAVNARDVERARTNGQDAAFIDRLTLSDKA
IATMAAGLEQIAALADPIGEISNMKFRPTGIQVGQMRVPLGVIGIIYESRPNVTIDAAALCLKSGNSTILRGGSEAIESN
TALAALVAEGLAAAGLPSEAVQVIETTDRAAVGRLITMTEYVDVIVPRGGKSLIARLMEEARVPMIKHLDGICHVYIDDD
ADLEKAVRVCDNAKTQRYAPCNTMETLLVSREIAAKALPPLCRIYQEKGVELRVCPATRATLEAAGFSGLVDATEEDWRL
EYLAPVLAIRTVDGLDAAIAHINTYGSAHTDSIITENYTTGMRFLREVDSASVMINASTRFADGFEYGLGAEIGISNDKL
HARGPVGLEGLTSLKYVVFGHGEIRT

Sequences:

>Translated_426_residues
MTEFDLHAYMTRVGQQARAASRAMARASTADKNRALLTIAAAIRRDADKLKAVNARDVERARTNGQDAAFIDRLTLSDKA
IATMAAGLEQIAALADPIGEISNMKFRPTGIQVGQMRVPLGVIGIIYESRPNVTIDAAALCLKSGNSTILRGGSEAIESN
TALAALVAEGLAAAGLPSEAVQVIETTDRAAVGRLITMTEYVDVIVPRGGKSLIARLMEEARVPMIKHLDGICHVYIDDD
ADLEKAVRVCDNAKTQRYAPCNTMETLLVSREIAAKALPPLCRIYQEKGVELRVCPATRATLEAAGFSGLVDATEEDWRL
EYLAPVLAIRTVDGLDAAIAHINTYGSAHTDSIITENYTTGMRFLREVDSASVMINASTRFADGFEYGLGAEIGISNDKL
HARGPVGLEGLTSLKYVVFGHGEIRT
>Mature_425_residues
TEFDLHAYMTRVGQQARAASRAMARASTADKNRALLTIAAAIRRDADKLKAVNARDVERARTNGQDAAFIDRLTLSDKAI
ATMAAGLEQIAALADPIGEISNMKFRPTGIQVGQMRVPLGVIGIIYESRPNVTIDAAALCLKSGNSTILRGGSEAIESNT
ALAALVAEGLAAAGLPSEAVQVIETTDRAAVGRLITMTEYVDVIVPRGGKSLIARLMEEARVPMIKHLDGICHVYIDDDA
DLEKAVRVCDNAKTQRYAPCNTMETLLVSREIAAKALPPLCRIYQEKGVELRVCPATRATLEAAGFSGLVDATEEDWRLE
YLAPVLAIRTVDGLDAAIAHINTYGSAHTDSIITENYTTGMRFLREVDSASVMINASTRFADGFEYGLGAEIGISNDKLH
ARGPVGLEGLTSLKYVVFGHGEIRT

Specific function: Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate [H]

COG id: COG0014

COG function: function code E; Gamma-glutamyl phosphate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyl phosphate reductase family [H]

Homologues:

Organism=Homo sapiens, GI62912457, Length=415, Percent_Identity=36.3855421686747, Blast_Score=257, Evalue=2e-68,
Organism=Homo sapiens, GI21361368, Length=415, Percent_Identity=36.3855421686747, Blast_Score=256, Evalue=2e-68,
Organism=Escherichia coli, GI1786438, Length=416, Percent_Identity=42.5480769230769, Blast_Score=346, Evalue=2e-96,
Organism=Caenorhabditis elegans, GI17569967, Length=416, Percent_Identity=36.5384615384615, Blast_Score=271, Evalue=3e-73,
Organism=Caenorhabditis elegans, GI17569969, Length=416, Percent_Identity=36.5384615384615, Blast_Score=271, Evalue=3e-73,
Organism=Saccharomyces cerevisiae, GI6324899, Length=434, Percent_Identity=38.4792626728111, Blast_Score=288, Evalue=9e-79,
Organism=Drosophila melanogaster, GI21357643, Length=412, Percent_Identity=37.8640776699029, Blast_Score=275, Evalue=4e-74,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR016163
- InterPro:   IPR016162
- InterPro:   IPR015590
- InterPro:   IPR000965
- InterPro:   IPR020593
- InterPro:   IPR012134 [H]

Pfam domain/function: PF00171 Aldedh [H]

EC number: =1.2.1.41 [H]

Molecular weight: Translated: 45731; Mature: 45600

Theoretical pI: Translated: 5.73; Mature: 5.73

Prosite motif: PS01223 PROA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEFDLHAYMTRVGQQARAASRAMARASTADKNRALLTIAAAIRRDADKLKAVNARDVER
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCHHHHHCCCHHHHHH
ARTNGQDAAFIDRLTLSDKAIATMAAGLEQIAALADPIGEISNMKFRPTGIQVGQMRVPL
HHCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEECCCCEEECEEECCE
GVIGIIYESRPNVTIDAAALCLKSGNSTILRGGSEAIESNTALAALVAEGLAAAGLPSEA
EEEEEEEECCCCEEEHHHHHHHHCCCCEEEECCHHHHHCCHHHHHHHHHHHHHCCCCHHH
VQVIETTDRAAVGRLITMTEYVDVIVPRGGKSLIARLMEEARVPMIKHLDGICHVYIDDD
HHHHHHCCHHHHHHHHHHHHHHHEEECCCCHHHHHHHHHHHCCCHHHHCCCEEEEEECCC
ADLEKAVRVCDNAKTQRYAPCNTMETLLVSREIAAKALPPLCRIYQEKGVELRVCPATRA
CCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHCCCEEEECCCCHH
TLEAAGFSGLVDATEEDWRLEYLAPVLAIRTVDGLDAAIAHINTYGSAHTDSIITENYTT
HHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCHHCCCHHH
GMRFLREVDSASVMINASTRFADGFEYGLGAEIGISNDKLHARGPVGLEGLTSLKYVVFG
HHHHHHHCCCCEEEEECCCCCCCCCCCCCCCEECCCCCCEECCCCCCCCHHHHEEEEEEE
HGEIRT
CCCCCC
>Mature Secondary Structure 
TEFDLHAYMTRVGQQARAASRAMARASTADKNRALLTIAAAIRRDADKLKAVNARDVER
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCHHHHHCCCHHHHHH
ARTNGQDAAFIDRLTLSDKAIATMAAGLEQIAALADPIGEISNMKFRPTGIQVGQMRVPL
HHCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEECCCCEEECEEECCE
GVIGIIYESRPNVTIDAAALCLKSGNSTILRGGSEAIESNTALAALVAEGLAAAGLPSEA
EEEEEEEECCCCEEEHHHHHHHHCCCCEEEECCHHHHHCCHHHHHHHHHHHHHCCCCHHH
VQVIETTDRAAVGRLITMTEYVDVIVPRGGKSLIARLMEEARVPMIKHLDGICHVYIDDD
HHHHHHCCHHHHHHHHHHHHHHHEEECCCCHHHHHHHHHHHCCCHHHHCCCEEEEEECCC
ADLEKAVRVCDNAKTQRYAPCNTMETLLVSREIAAKALPPLCRIYQEKGVELRVCPATRA
CCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHCCCEEEECCCCHH
TLEAAGFSGLVDATEEDWRLEYLAPVLAIRTVDGLDAAIAHINTYGSAHTDSIITENYTT
HHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCHHCCCHHH
GMRFLREVDSASVMINASTRFADGFEYGLGAEIGISNDKLHARGPVGLEGLTSLKYVVFG
HHHHHHHCCCCEEEEECCCCCCCCCCCCCCCEECCCCCCEECCCCCCCCHHHHEEEEEEE
HGEIRT
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA