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The map label for this gene is cobC [H]

Identifier: 94311713

GI number: 94311713

Start: 3028347

End: 3029378

Strand: Direct

Name: cobC [H]

Synonym: Rmet_2781

Alternate gene names: 94311713

Gene position: 3028347-3029378 (Clockwise)

Preceding gene: 94311712

Following gene: 94311714

Centisome position: 77.09

GC content: 70.45

Gene sequence:

>1032_bases
ATGACCCACGCACCGATCCGCCACGGCGGCAACCTGCTCGCCGCCGTGCGCCGCTATGGCCGCCCGGCGGAAACGTGGCT
CGACCTGTCGACCGGCATCAATCCCGACGGCTATCCGGTGCCCCTCCTACCCGCTGACGCCTGGCAGCGCCTGCCACAGG
ACGATGATGGCCTGGCGGGCATCGCCGCGCAGGCCTATGGCGCCGCGCACGCGCTGCCCGTGGCCGGCTCGCAGGCCGCC
ATCCGCACCCTGCCGCGACTGCTGCGCCCGGGGCGCGTCGGCATCGCCGCGCTCGGCTACAGCGAATACGCGCCGGCCTT
CGCACAGGCAGGACACACCGTCACTCCGCTGGACGAGGCCGACTTCCAGCGTGCGGATCTGGCCGATGCGCTCGATCACC
TCGTCGTCGTCAATCCGAACAACCCGACGGCCCGGCTGTTGCCCATCGACACCCTGCGGCACTGGCATGAGCGACTGGCA
TCGCGCGGCGGCACGCTGATCGTCGACGAGGCTTTTATCGATTGCACCGGTGCGGCATCGCTGGCCGGAAGCAGCGCGGC
ACCGGGACTGATCGTGCTGCGTTCGCTTGGCAAGTTCTATGGTCTCGCGGGTGTGCGCTGCGGCTTCGTGCTGGCACAGC
CGGCCCTGCTCGACGCCCTGGCCGATCAGCTTGGCCACTGGACCGTGTCGGGCCCGGCACGCGCCGTGGCACGCATCGCG
CTGACCGACACCGCGTGGCAGGCCGCCACACGCACATCGCTGAGCGCGGCAGGACAACGACTGGCGATACTGCTGCGCGA
CCATGGCCTGTCGCCCGTGTCGCAGCCATTGTTCAGCTGGGTGCCCGACGCGCGGGCCGGCAGCCTGCATGAAGCCCTGG
CTCGGCAAGGCGTCTGGACACGCCTGTTCGACGCAGCCGGCGGATGCCCGAGCAGCCTGCGCTTTGGCTTGCCACCTAAC
GACGACGCGGCATGGCAACGGCTGGATGCCGCGCTTGGCCACGCACGCCACGCACTCCCTTCCCTGACCTGA

Upstream 100 bases:

>100_bases
GTCTTCGGCTGGTGCAGCGCGCGGTGTGGCTGTGGCTCGGTCTGGCGATGCTGAGCGTGCCGCTGGTCGACCTGCTCGCC
GGACTGCTGGAGCGCACGCC

Downstream 100 bases:

>100_bases
ATTCCGATGAAAGCCTTCTACGTAGCGAGTGCAGCAAGTGCCCTGCTGATTGCCGCCATGCCGGCGCATGCCGCGGTCTC
CGTGGTCGACGATGCGGGCG

Product: putative threonine-phosphate decarboxylase

Products: NA

Alternate protein names: L-threonine-O-3-phosphate decarboxylase [H]

Number of amino acids: Translated: 343; Mature: 342

Protein sequence:

>343_residues
MTHAPIRHGGNLLAAVRRYGRPAETWLDLSTGINPDGYPVPLLPADAWQRLPQDDDGLAGIAAQAYGAAHALPVAGSQAA
IRTLPRLLRPGRVGIAALGYSEYAPAFAQAGHTVTPLDEADFQRADLADALDHLVVVNPNNPTARLLPIDTLRHWHERLA
SRGGTLIVDEAFIDCTGAASLAGSSAAPGLIVLRSLGKFYGLAGVRCGFVLAQPALLDALADQLGHWTVSGPARAVARIA
LTDTAWQAATRTSLSAAGQRLAILLRDHGLSPVSQPLFSWVPDARAGSLHEALARQGVWTRLFDAAGGCPSSLRFGLPPN
DDAAWQRLDAALGHARHALPSLT

Sequences:

>Translated_343_residues
MTHAPIRHGGNLLAAVRRYGRPAETWLDLSTGINPDGYPVPLLPADAWQRLPQDDDGLAGIAAQAYGAAHALPVAGSQAA
IRTLPRLLRPGRVGIAALGYSEYAPAFAQAGHTVTPLDEADFQRADLADALDHLVVVNPNNPTARLLPIDTLRHWHERLA
SRGGTLIVDEAFIDCTGAASLAGSSAAPGLIVLRSLGKFYGLAGVRCGFVLAQPALLDALADQLGHWTVSGPARAVARIA
LTDTAWQAATRTSLSAAGQRLAILLRDHGLSPVSQPLFSWVPDARAGSLHEALARQGVWTRLFDAAGGCPSSLRFGLPPN
DDAAWQRLDAALGHARHALPSLT
>Mature_342_residues
THAPIRHGGNLLAAVRRYGRPAETWLDLSTGINPDGYPVPLLPADAWQRLPQDDDGLAGIAAQAYGAAHALPVAGSQAAI
RTLPRLLRPGRVGIAALGYSEYAPAFAQAGHTVTPLDEADFQRADLADALDHLVVVNPNNPTARLLPIDTLRHWHERLAS
RGGTLIVDEAFIDCTGAASLAGSSAAPGLIVLRSLGKFYGLAGVRCGFVLAQPALLDALADQLGHWTVSGPARAVARIAL
TDTAWQAATRTSLSAAGQRLAILLRDHGLSPVSQPLFSWVPDARAGSLHEALARQGVWTRLFDAAGGCPSSLRFGLPPND
DAAWQRLDAALGHARHALPSLT

Specific function: Decarboxylates L-threonine-O-3-phosphate to yield (R)-1- amino-2-propanol O-2-phosphate, the precursor for the linkage between the nucleotide loop and the corrin ring in cobalamin [H]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=309, Percent_Identity=28.8025889967638, Blast_Score=77, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR005860
- InterPro:   IPR004838
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =4.1.1.81 [H]

Molecular weight: Translated: 36105; Mature: 35974

Theoretical pI: Translated: 7.42; Mature: 7.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
0.3 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTHAPIRHGGNLLAAVRRYGRPAETWLDLSTGINPDGYPVPLLPADAWQRLPQDDDGLAG
CCCCCCCCCCHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCCCHHHHHHCCCCCCCCHH
IAAQAYGAAHALPVAGSQAAIRTLPRLLRPGRVGIAALGYSEYAPAFAQAGHTVTPLDEA
HHHHHHCCHHCCCCCCCHHHHHHHHHHHCCCCCEEEEECCHHHCHHHHHCCCCCCCCCHH
DFQRADLADALDHLVVVNPNNPTARLLPIDTLRHWHERLASRGGTLIVDEAFIDCTGAAS
HHHHHHHHHHHCCEEEECCCCCCEEEEEHHHHHHHHHHHHHCCCEEEEECHHHCCCCHHH
LAGSSAAPGLIVLRSLGKFYGLAGVRCGFVLAQPALLDALADQLGHWTVSGPARAVARIA
HCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCHHHHHHHHH
LTDTAWQAATRTSLSAAGQRLAILLRDHGLSPVSQPLFSWVPDARAGSLHEALARQGVWT
HHHHHHHHHHHHHHHHCCHHEEEEEECCCCCHHHHHHHHHCCCCCCCHHHHHHHHCCHHH
RLFDAAGGCPSSLRFGLPPNDDAAWQRLDAALGHARHALPSLT
HHHHHCCCCHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
THAPIRHGGNLLAAVRRYGRPAETWLDLSTGINPDGYPVPLLPADAWQRLPQDDDGLAG
CCCCCCCCCHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCCCHHHHHHCCCCCCCCHH
IAAQAYGAAHALPVAGSQAAIRTLPRLLRPGRVGIAALGYSEYAPAFAQAGHTVTPLDEA
HHHHHHCCHHCCCCCCCHHHHHHHHHHHCCCCCEEEEECCHHHCHHHHHCCCCCCCCCHH
DFQRADLADALDHLVVVNPNNPTARLLPIDTLRHWHERLASRGGTLIVDEAFIDCTGAAS
HHHHHHHHHHHCCEEEECCCCCCEEEEEHHHHHHHHHHHHHCCCEEEEECHHHCCCCHHH
LAGSSAAPGLIVLRSLGKFYGLAGVRCGFVLAQPALLDALADQLGHWTVSGPARAVARIA
HCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCHHHHHHHHH
LTDTAWQAATRTSLSAAGQRLAILLRDHGLSPVSQPLFSWVPDARAGSLHEALARQGVWT
HHHHHHHHHHHHHHHHCCHHEEEEEECCCCCHHHHHHHHHCCCCCCCHHHHHHHHCCHHH
RLFDAAGGCPSSLRFGLPPNDDAAWQRLDAALGHARHALPSLT
HHHHHCCCCHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]