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The map label for this gene is hemC [H]

Identifier: 94311681

GI number: 94311681

Start: 2985848

End: 2986852

Strand: Reverse

Name: hemC [H]

Synonym: Rmet_2749

Alternate gene names: 94311681

Gene position: 2986852-2985848 (Counterclockwise)

Preceding gene: 94311686

Following gene: 94311680

Centisome position: 76.04

GC content: 67.36

Gene sequence:

>1005_bases
ATGCAAGCACCCGCCAATCCGTCTTCTTCGTCCGCTGCAGTGTCAAGCAGCATGCCGCACAAGCTGGTCATCGCCTCGCG
CGAAAGCCGGCTGGCGATGTGGCAGGCTGAACATGTTCGTGCTGCGTTGCAACAATACTATCCCTCCTGCGATGTGTCCA
TTCTCGGCATGACGACAAGGGGTGATCAAATTCTCGATAGGACCTTGTCCAAGGTAGGCGGCAAGGGCCTGTTCGTGAAG
GAGCTGGAGGTCGCCATGTCCGAGGGACGCGCCGACCTGGCCGTTCACTCGCTCAAGGATGTGCCGATGGAGCTGCCCGA
AGGCTTCACGCTGACGGCGGTGATGGAGCGCGAGGACCCGCGCGATGCGCTGGTTTCGGCGCAATTCGCCTCGCTCGAAG
AGATGCCGGCCGGAACCGTGGTGGGCACTTCGAGCCTGCGCCGCGAAGCCGCGCTGCGCAGTCGCTTTCCGCATCTGGTG
ATCAAGCCACTCCGGGGAAATCTGGATACGCGCCTGGGCAAGCTGGACCGTGGCGAGTACGGCGCCATCATCCTGGCTGC
GGCCGGGCTCAAGCGACTGGGCCTGGGCGATCGCATCCGCGCGCTGATTGCGCCGGAAAGCTCGCTGCCGGCGGCCGGAC
AAGGCGCCCTGGGCATCGAGATCCGTGCGGATCGTCCCGAACTGGCCGAATGGCTGGCGCCGCTGAACCATCTGCCCACG
CTGCTCGCCGTATCGGCCGAACGGGCCGTCTCACGCCGCCTGGGCGGCTCGTGCCAGGTGCCGCTGGCCGCGCACGCGCG
CTGGCGTGACGCCAGTCTTCAACTCGACGCCTTCGTGGCGCTGCCCGACGGTTCGCGTCAGGTGCGTGCCCATGCCACGG
GACCCGTCGCTACGGTAGCCGACGCCGAAGCGCTCGGAACCGCCGTCGCGGGCGATCTGCTGGCCCAGGGCGCGGACGGC
GTGCTGGCCGCGCTTTCCACGGACTCCGCCGCCGGACCTGCTTGA

Upstream 100 bases:

>100_bases
GTAGCTTTTCTATATTGACCGGCCGCAAAGCCTTGCCGGATCGTACTTTTACGGCTTATCAGGGGCCTGAGGCTACCAGC
CTGCGTGCTAACATGCGCGG

Downstream 100 bases:

>100_bases
GGAACCCGCAATGCCTCGCCCGACCGTCGTAGTAACACGACCCGCCGGGCAGTCCCGGCAACTGACCGAAGCGTTACAGG
CCGCGGGTCTCGACGTGCTC

Product: porphobilinogen deaminase

Products: NA

Alternate protein names: PBG; Hydroxymethylbilane synthase; HMBS; Pre-uroporphyrinogen synthase [H]

Number of amino acids: Translated: 334; Mature: 334

Protein sequence:

>334_residues
MQAPANPSSSSAAVSSSMPHKLVIASRESRLAMWQAEHVRAALQQYYPSCDVSILGMTTRGDQILDRTLSKVGGKGLFVK
ELEVAMSEGRADLAVHSLKDVPMELPEGFTLTAVMEREDPRDALVSAQFASLEEMPAGTVVGTSSLRREAALRSRFPHLV
IKPLRGNLDTRLGKLDRGEYGAIILAAAGLKRLGLGDRIRALIAPESSLPAAGQGALGIEIRADRPELAEWLAPLNHLPT
LLAVSAERAVSRRLGGSCQVPLAAHARWRDASLQLDAFVALPDGSRQVRAHATGPVATVADAEALGTAVAGDLLAQGADG
VLAALSTDSAAGPA

Sequences:

>Translated_334_residues
MQAPANPSSSSAAVSSSMPHKLVIASRESRLAMWQAEHVRAALQQYYPSCDVSILGMTTRGDQILDRTLSKVGGKGLFVK
ELEVAMSEGRADLAVHSLKDVPMELPEGFTLTAVMEREDPRDALVSAQFASLEEMPAGTVVGTSSLRREAALRSRFPHLV
IKPLRGNLDTRLGKLDRGEYGAIILAAAGLKRLGLGDRIRALIAPESSLPAAGQGALGIEIRADRPELAEWLAPLNHLPT
LLAVSAERAVSRRLGGSCQVPLAAHARWRDASLQLDAFVALPDGSRQVRAHATGPVATVADAEALGTAVAGDLLAQGADG
VLAALSTDSAAGPA
>Mature_334_residues
MQAPANPSSSSAAVSSSMPHKLVIASRESRLAMWQAEHVRAALQQYYPSCDVSILGMTTRGDQILDRTLSKVGGKGLFVK
ELEVAMSEGRADLAVHSLKDVPMELPEGFTLTAVMEREDPRDALVSAQFASLEEMPAGTVVGTSSLRREAALRSRFPHLV
IKPLRGNLDTRLGKLDRGEYGAIILAAAGLKRLGLGDRIRALIAPESSLPAAGQGALGIEIRADRPELAEWLAPLNHLPT
LLAVSAERAVSRRLGGSCQVPLAAHARWRDASLQLDAFVALPDGSRQVRAHATGPVATVADAEALGTAVAGDLLAQGADG
VLAALSTDSAAGPA

Specific function: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps [H]

COG id: COG0181

COG function: function code H; Porphobilinogen deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMBS family [H]

Homologues:

Organism=Homo sapiens, GI20149500, Length=348, Percent_Identity=41.3793103448276, Blast_Score=239, Evalue=3e-63,
Organism=Homo sapiens, GI66933009, Length=329, Percent_Identity=42.8571428571429, Blast_Score=238, Evalue=5e-63,
Organism=Escherichia coli, GI48994974, Length=313, Percent_Identity=54.3130990415335, Blast_Score=317, Evalue=7e-88,
Organism=Saccharomyces cerevisiae, GI6319996, Length=322, Percent_Identity=38.5093167701863, Blast_Score=215, Evalue=8e-57,
Organism=Drosophila melanogaster, GI20130425, Length=282, Percent_Identity=41.4893617021277, Blast_Score=207, Evalue=7e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000860
- InterPro:   IPR022419
- InterPro:   IPR022417
- InterPro:   IPR022418 [H]

Pfam domain/function: PF01379 Porphobil_deam; PF03900 Porphobil_deamC [H]

EC number: =2.5.1.61 [H]

Molecular weight: Translated: 35032; Mature: 35032

Theoretical pI: Translated: 6.89; Mature: 6.89

Prosite motif: PS00533 PORPHOBILINOGEN_DEAM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQAPANPSSSSAAVSSSMPHKLVIASRESRLAMWQAEHVRAALQQYYPSCDVSILGMTTR
CCCCCCCCCCCHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEECCC
GDQILDRTLSKVGGKGLFVKELEVAMSEGRADLAVHSLKDVPMELPEGFTLTAVMEREDP
CHHHHHHHHHHHCCCCEEHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCEEEEEEECCCCC
RDALVSAQFASLEEMPAGTVVGTSSLRREAALRSRFPHLVIKPLRGNLDTRLGKLDRGEY
HHHHHHHHHHHHHHCCCCCEECCHHHHHHHHHHHCCCCEEEEECCCCHHHHHCCCCCCCC
GAIILAAAGLKRLGLGDRIRALIAPESSLPAAGQGALGIEIRADRPELAEWLAPLNHLPT
CEEEEEECCHHHCCCCHHHHEEECCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHCHH
LLAVSAERAVSRRLGGSCQVPLAAHARWRDASLQLDAFVALPDGSRQVRAHATGPVATVA
HHHHHHHHHHHHHCCCCCCCCHHHCCCCCCCCEEEEEEEECCCCCCEEEEECCCCEEEHH
DAEALGTAVAGDLLAQGADGVLAALSTDSAAGPA
HHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCC
>Mature Secondary Structure
MQAPANPSSSSAAVSSSMPHKLVIASRESRLAMWQAEHVRAALQQYYPSCDVSILGMTTR
CCCCCCCCCCCHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEECCC
GDQILDRTLSKVGGKGLFVKELEVAMSEGRADLAVHSLKDVPMELPEGFTLTAVMEREDP
CHHHHHHHHHHHCCCCEEHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCEEEEEEECCCCC
RDALVSAQFASLEEMPAGTVVGTSSLRREAALRSRFPHLVIKPLRGNLDTRLGKLDRGEY
HHHHHHHHHHHHHHCCCCCEECCHHHHHHHHHHHCCCCEEEEECCCCHHHHHCCCCCCCC
GAIILAAAGLKRLGLGDRIRALIAPESSLPAAGQGALGIEIRADRPELAEWLAPLNHLPT
CEEEEEECCHHHCCCCHHHHEEECCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHCHH
LLAVSAERAVSRRLGGSCQVPLAAHARWRDASLQLDAFVALPDGSRQVRAHATGPVATVA
HHHHHHHHHHHHHCCCCCCCCHHHCCCCCCCCEEEEEEEECCCCCCEEEEECCCCEEEHH
DAEALGTAVAGDLLAQGADGVLAALSTDSAAGPA
HHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]