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The map label for this gene is hemDX [H]

Identifier: 94311680

GI number: 94311680

Start: 2983756

End: 2985837

Strand: Reverse

Name: hemDX [H]

Synonym: Rmet_2748

Alternate gene names: 94311680

Gene position: 2985837-2983756 (Counterclockwise)

Preceding gene: 94311681

Following gene: 94311679

Centisome position: 76.01

GC content: 68.16

Gene sequence:

>2082_bases
ATGCCTCGCCCGACCGTCGTAGTAACACGACCCGCCGGGCAGTCCCGGCAACTGACCGAAGCGTTACAGGCCGCGGGTCT
CGACGTGCTCAGTTTTCCGCTGCTGGCGATCGGGCCCGCGGCCGATGACGTGCCGCTGCGCGCCGAGCTTGGCCGGATCG
AGGACTACGCGCTGGTGGTGTTCGTGAGCCCGAACGCGGTGTCCTATGGACTGGACACCCTTGCTCAGGTCCAGAACGCC
CCGGGCGGAGCCCGGTGGCCGGAAAGCGTGCCGGTGGCCGTGGTGGGGCCATCGAGCGTGGTTGCGCTGGCGGAACGGGG
TATCACCCCGCCCGCGTATCGCGTGATCGCGCCTGCTGGCGCGCAGGGTAATGACACGGCCGGCGACGCAGCGCGCTTCG
ATTCAGAGGCGCTCTGGTCCGAACTCGACACCTCGCCGGGCGCGTTTGCCGGCCGCAAGGTCCTGATCATCCGTGGCAGC
GGCGGGCGCGAATGGCTGGCCGATCGTCTGCGCGACGCCGGCGCGTCCGTCGAAGCCGTGGAAGCCTACAGCCGCACGCT
GCCCGAGCCGAGCGGCATGCAATGGCAGGCCGTGCGCGACAGCCTCAAGCCCGATGCGCCGCCGTACGCGTGGCTGCTGA
CCAGTTCGGAAGCCGTGCGCAACCTGGACGGGCTGGCGCGTTTGCATCTGTCGCCTCAGGAACACGAACGTCTGAAGCAG
ATGCAGTGCATCGCACCACATGCGAGAATTGCCGCGCAGGCCCAGTCGCTGGGATTTGCCCACGTGCTGCCCGCCGCGCC
CGGAGATGCCGGGCTGCTGGCCGCATGCACGCAATGGGGCGAAGCCTATGCTGGGCCGGCCACGCCAGCGCCCGCCCCCG
TATCGCCTGCACCCGCTCCGGTGGTCGTGCAGCCGGAACCGGAGCCGACACCGGCGCCAATGGCACCCAAGGAACCCACG
TCAACCAAAGTCGAACGCGTGACGACAGACACCACGTCCCCCTCGCCGAATCCGGGCGGTAACCCCGGTAGTTCCGGCAT
GTCCGGCGCATTTGTGACACCCGCGCGCCGAATGAATCCATGGTGGCTGCTCGTCGCCGTGCTGGTGGTCGCCGTTGCCG
GGGGCTTCTGGTGGTTGCAGATGCGGGTCGAGCATCTGACCCAGGAACTGGCGCGCCGCCAGCAGAGCGCGGACACGCTG
GTGCAGGAAACGCGGGTGCTGTCGCGCGATGCGCAGGAGACGGTCAAGGCGTTGCAGGGCAAGGTGGGCGCACTCGACGG
CCAAATCACGGAGACGCGCGACAAGCAGGCCGCGCTGGAACAGGTCTATCAGGACCTGATGCGCAACCGCGACGACTGGG
AAATCGCCGAAATCCAGCAGTTGCTGACCAACGCCGGCCAGCAGCTTCAGCTCACCGGCAACGTGCAGGTGGCGCTGGCC
GCGCTGCAAAGCGCCGACGCGCGCCTGGCGCGCTCGGACAAGCCGCAATACAACCAGCTTCGCCGCGCTATTGCGCGCGA
TATCGGTCGGATGAAGGCCGTGCCGGATACCGACCTGACCGGGGCGGCGATCAAGCTTGACGAGGCGATCAACCAGATCG
ATTCATTGCCGCTGCTGTCGGGCGAGCGGATGCTCGACCGCACGCCTGGCGAGGGCAACAAGCCGGCACCGGCCGCGCCG
AAGGGCGCCTCGACGCCCGCGGCTGCCAGCGCGACGGGTGGCAATATGGTGTCGCGACTGTGGACGTACGTGCTTGACGA
GCTTGGTCAGGTGATCCGCGTGCGCAAGGTCGATGACACCAACGCGCTACTGCTCTCGGGTGACCAGGGCTGGTTCCTGC
GCGAGAACATCAAGCTGCGCCTGCTCAATGCGCGGCTGGCGCTACTGTCGCGCAACGAACCGGTCTTCCGGAACGACCTC
GCCGCCGCGCAGGGCATGATCGCGCGCTATTGCGATACCCGTTCGCGCCGCGTGCAGGGCGTGCTGACGATGCTCAAGCA
GGCCCAGGCCAGCGCGGTGACGGTATCCCTGCCGACGATGGCGGAGAGCCTCGGCGCGTTGCATGCCCTGAAGAAGGAGT
AG

Upstream 100 bases:

>100_bases
GGAACCGCCGTCGCGGGCGATCTGCTGGCCCAGGGCGCGGACGGCGTGCTGGCCGCGCTTTCCACGGACTCCGCCGCCGG
ACCTGCTTGAGGAACCCGCA

Downstream 100 bases:

>100_bases
CCGTCATGCGACTCCTTTTCTGGGTAGCTGTTTTATTCGGCGGCGCCGTCGGCCTGGCACTGTTTACACAGTTCAACCAG
AGCAATGTGGTGCTGTTCTA

Product: bifunctional uroporphyrinogen-III synthetase/uroporphyrin-III C-methyltransferase

Products: NA

Alternate protein names: Urogen-III methylase; ORF X [H]

Number of amino acids: Translated: 693; Mature: 692

Protein sequence:

>693_residues
MPRPTVVVTRPAGQSRQLTEALQAAGLDVLSFPLLAIGPAADDVPLRAELGRIEDYALVVFVSPNAVSYGLDTLAQVQNA
PGGARWPESVPVAVVGPSSVVALAERGITPPAYRVIAPAGAQGNDTAGDAARFDSEALWSELDTSPGAFAGRKVLIIRGS
GGREWLADRLRDAGASVEAVEAYSRTLPEPSGMQWQAVRDSLKPDAPPYAWLLTSSEAVRNLDGLARLHLSPQEHERLKQ
MQCIAPHARIAAQAQSLGFAHVLPAAPGDAGLLAACTQWGEAYAGPATPAPAPVSPAPAPVVVQPEPEPTPAPMAPKEPT
STKVERVTTDTTSPSPNPGGNPGSSGMSGAFVTPARRMNPWWLLVAVLVVAVAGGFWWLQMRVEHLTQELARRQQSADTL
VQETRVLSRDAQETVKALQGKVGALDGQITETRDKQAALEQVYQDLMRNRDDWEIAEIQQLLTNAGQQLQLTGNVQVALA
ALQSADARLARSDKPQYNQLRRAIARDIGRMKAVPDTDLTGAAIKLDEAINQIDSLPLLSGERMLDRTPGEGNKPAPAAP
KGASTPAAASATGGNMVSRLWTYVLDELGQVIRVRKVDDTNALLLSGDQGWFLRENIKLRLLNARLALLSRNEPVFRNDL
AAAQGMIARYCDTRSRRVQGVLTMLKQAQASAVTVSLPTMAESLGALHALKKE

Sequences:

>Translated_693_residues
MPRPTVVVTRPAGQSRQLTEALQAAGLDVLSFPLLAIGPAADDVPLRAELGRIEDYALVVFVSPNAVSYGLDTLAQVQNA
PGGARWPESVPVAVVGPSSVVALAERGITPPAYRVIAPAGAQGNDTAGDAARFDSEALWSELDTSPGAFAGRKVLIIRGS
GGREWLADRLRDAGASVEAVEAYSRTLPEPSGMQWQAVRDSLKPDAPPYAWLLTSSEAVRNLDGLARLHLSPQEHERLKQ
MQCIAPHARIAAQAQSLGFAHVLPAAPGDAGLLAACTQWGEAYAGPATPAPAPVSPAPAPVVVQPEPEPTPAPMAPKEPT
STKVERVTTDTTSPSPNPGGNPGSSGMSGAFVTPARRMNPWWLLVAVLVVAVAGGFWWLQMRVEHLTQELARRQQSADTL
VQETRVLSRDAQETVKALQGKVGALDGQITETRDKQAALEQVYQDLMRNRDDWEIAEIQQLLTNAGQQLQLTGNVQVALA
ALQSADARLARSDKPQYNQLRRAIARDIGRMKAVPDTDLTGAAIKLDEAINQIDSLPLLSGERMLDRTPGEGNKPAPAAP
KGASTPAAASATGGNMVSRLWTYVLDELGQVIRVRKVDDTNALLLSGDQGWFLRENIKLRLLNARLALLSRNEPVFRNDL
AAAQGMIARYCDTRSRRVQGVLTMLKQAQASAVTVSLPTMAESLGALHALKKE
>Mature_692_residues
PRPTVVVTRPAGQSRQLTEALQAAGLDVLSFPLLAIGPAADDVPLRAELGRIEDYALVVFVSPNAVSYGLDTLAQVQNAP
GGARWPESVPVAVVGPSSVVALAERGITPPAYRVIAPAGAQGNDTAGDAARFDSEALWSELDTSPGAFAGRKVLIIRGSG
GREWLADRLRDAGASVEAVEAYSRTLPEPSGMQWQAVRDSLKPDAPPYAWLLTSSEAVRNLDGLARLHLSPQEHERLKQM
QCIAPHARIAAQAQSLGFAHVLPAAPGDAGLLAACTQWGEAYAGPATPAPAPVSPAPAPVVVQPEPEPTPAPMAPKEPTS
TKVERVTTDTTSPSPNPGGNPGSSGMSGAFVTPARRMNPWWLLVAVLVVAVAGGFWWLQMRVEHLTQELARRQQSADTLV
QETRVLSRDAQETVKALQGKVGALDGQITETRDKQAALEQVYQDLMRNRDDWEIAEIQQLLTNAGQQLQLTGNVQVALAA
LQSADARLARSDKPQYNQLRRAIARDIGRMKAVPDTDLTGAAIKLDEAINQIDSLPLLSGERMLDRTPGEGNKPAPAAPK
GASTPAAASATGGNMVSRLWTYVLDELGQVIRVRKVDDTNALLLSGDQGWFLRENIKLRLLNARLALLSRNEPVFRNDLA
AAQGMIARYCDTRSRRVQGVLTMLKQAQASAVTVSLPTMAESLGALHALKKE

Specific function: Siroheme and cobalamin biosynthesis. [C]

COG id: COG2959

COG function: function code H; Uncharacterized enzyme of heme biosynthesis

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1790235, Length=304, Percent_Identity=28.6184210526316, Blast_Score=91, Evalue=3e-19,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007470 [H]

Pfam domain/function: PF04375 HemX [H]

EC number: =2.1.1.107 [H]

Molecular weight: Translated: 73955; Mature: 73824

Theoretical pI: Translated: 6.55; Mature: 6.55

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPRPTVVVTRPAGQSRQLTEALQAAGLDVLSFPLLAIGPAADDVPLRAELGRIEDYALVV
CCCCCEEEECCCCCCHHHHHHHHHCCCHHHHCCHHEECCCCCCCCCHHHHCCCCCEEEEE
FVSPNAVSYGLDTLAQVQNAPGGARWPESVPVAVVGPSSVVALAERGITPPAYRVIAPAG
EECCCCHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCHHHHHHHHCCCCCCCEEEEECCC
AQGNDTAGDAARFDSEALWSELDTSPGAFAGRKVLIIRGSGGREWLADRLRDAGASVEAV
CCCCCCCCCHHHCCHHHHHHHHCCCCCCCCCCEEEEEECCCCHHHHHHHHHHCCCCHHHH
EAYSRTLPEPSGMQWQAVRDSLKPDAPPYAWLLTSSEAVRNLDGLARLHLSPQEHERLKQ
HHHHHHCCCCCCCCHHHHHHHCCCCCCCEEEEEECHHHHHHHHHHHHHCCCHHHHHHHHH
MQCIAPHARIAAQAQSLGFAHVLPAAPGDAGLLAACTQWGEAYAGPATPAPAPVSPAPAP
HHHHCCHHHHHHHHHHCCCCEECCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
VVVQPEPEPTPAPMAPKEPTSTKVERVTTDTTSPSPNPGGNPGSSGMSGAFVTPARRMNP
EEECCCCCCCCCCCCCCCCCCCHHHEEECCCCCCCCCCCCCCCCCCCCCCEECCHHHCCH
WWLLVAVLVVAVAGGFWWLQMRVEHLTQELARRQQSADTLVQETRVLSRDAQETVKALQG
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
KVGALDGQITETRDKQAALEQVYQDLMRNRDDWEIAEIQQLLTNAGQQLQLTGNVQVALA
CCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCEEEEECCHHHHHH
ALQSADARLARSDKPQYNQLRRAIARDIGRMKAVPDTDLTGAAIKLDEAINQIDSLPLLS
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEHHHHHHHHHCCCCCC
GERMLDRTPGEGNKPAPAAPKGASTPAAASATGGNMVSRLWTYVLDELGQVIRVRKVDDT
CCHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHEEEEECCC
NALLLSGDQGWFLRENIKLRLLNARLALLSRNEPVFRNDLAAAQGMIARYCDTRSRRVQG
CEEEEECCCCCEEECCCEEEEEEHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
VLTMLKQAQASAVTVSLPTMAESLGALHALKKE
HHHHHHHHCCCEEEEECHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
PRPTVVVTRPAGQSRQLTEALQAAGLDVLSFPLLAIGPAADDVPLRAELGRIEDYALVV
CCCCEEEECCCCCCHHHHHHHHHCCCHHHHCCHHEECCCCCCCCCHHHHCCCCCEEEEE
FVSPNAVSYGLDTLAQVQNAPGGARWPESVPVAVVGPSSVVALAERGITPPAYRVIAPAG
EECCCCHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCHHHHHHHHCCCCCCCEEEEECCC
AQGNDTAGDAARFDSEALWSELDTSPGAFAGRKVLIIRGSGGREWLADRLRDAGASVEAV
CCCCCCCCCHHHCCHHHHHHHHCCCCCCCCCCEEEEEECCCCHHHHHHHHHHCCCCHHHH
EAYSRTLPEPSGMQWQAVRDSLKPDAPPYAWLLTSSEAVRNLDGLARLHLSPQEHERLKQ
HHHHHHCCCCCCCCHHHHHHHCCCCCCCEEEEEECHHHHHHHHHHHHHCCCHHHHHHHHH
MQCIAPHARIAAQAQSLGFAHVLPAAPGDAGLLAACTQWGEAYAGPATPAPAPVSPAPAP
HHHHCCHHHHHHHHHHCCCCEECCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
VVVQPEPEPTPAPMAPKEPTSTKVERVTTDTTSPSPNPGGNPGSSGMSGAFVTPARRMNP
EEECCCCCCCCCCCCCCCCCCCHHHEEECCCCCCCCCCCCCCCCCCCCCCEECCHHHCCH
WWLLVAVLVVAVAGGFWWLQMRVEHLTQELARRQQSADTLVQETRVLSRDAQETVKALQG
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
KVGALDGQITETRDKQAALEQVYQDLMRNRDDWEIAEIQQLLTNAGQQLQLTGNVQVALA
CCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCEEEEECCHHHHHH
ALQSADARLARSDKPQYNQLRRAIARDIGRMKAVPDTDLTGAAIKLDEAINQIDSLPLLS
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEHHHHHHHHHCCCCCC
GERMLDRTPGEGNKPAPAAPKGASTPAAASATGGNMVSRLWTYVLDELGQVIRVRKVDDT
CCHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHEEEEECCC
NALLLSGDQGWFLRENIKLRLLNARLALLSRNEPVFRNDLAAAQGMIARYCDTRSRRVQG
CEEEEECCCCCEEECCCEEEEEEHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
VLTMLKQAQASAVTVSLPTMAESLGALHALKKE
HHHHHHHHCCCEEEEECHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3062586; 3054815; 1379743; 9278503; 9298646 [H]