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The map label for this gene is lon [H]

Identifier: 94310821

GI number: 94310821

Start: 2046844

End: 2049255

Strand: Reverse

Name: lon [H]

Synonym: Rmet_1883

Alternate gene names: 94310821

Gene position: 2049255-2046844 (Counterclockwise)

Preceding gene: 94310822

Following gene: 94310820

Centisome position: 52.17

GC content: 61.61

Gene sequence:

>2412_bases
ATGTCCGGAACACAACTCCTCCCGGCTGAGCCGATTCGCCTCCCACTGTTGCCGCTGCGCGACGTGGTGGTGTTTCCGCA
CATGGTGATCCCGCTGTTCGTGGGACGCCCGAAGTCCATCAAGGCGCTTGAGACTGCGATGGAGTCGGGCAAGAGCATCA
TGCTCGTGGCCCAGAAGACTGCGGCCAAAGATGAGCCCACCGCGGATGACCTGTATGAGGTCGGCTGCATCGCCAATATC
CTGCAAATGCTGAAGCTGCCCGACGGCACCGTGAAGGTGCTGGTGGAGGGTACGCAACGTGCAAATATCACCGAGGTGAG
CGAGGACGATTCGCACTTCATGTGCGAAGCCGTGCCTGTGCCGCCCGCACCGGTTGAATCGGCCGAGACCGAGGCCCTGC
GCCGCGCGATCGTGTCCCAGTTCGACCAGTACGTGAAGCTGAACAAGAAGATCCCTCCTGAGATCCTGACGTCGCTGTCC
GGTATCGATGAGGCCGGTCGTTTGGCCGATACGATCGCCGCGCATCTGCCGATCAAGCTCGAGCAGAAGCAGAAGATCCT
TGAGATGGTCAAGGTGACCGAGCGTCTCGAGAGCCTGCTGTCGCAGCTCGAGGGCGAGATCGACATCCTGCAGGTGGAAA
AGCGCATTCGTGGCCGCGTCAAGCGCCAGATGGAAAAGAGCCAGCGCGAGTACTACCTGAACGAGCAGGTCAAGGCGATC
CAGAAGGAACTGGGCGAGGGCGAGGAAGGCGCTGATCTGGAAGAACTGGACAAGCGCATCAAGGCCGCCCGCATGCCCAA
GGAGGCCAAGAAGAAGGCCGACGCCGAGTTCAAGAAGCTCAAGCTGATGTCGCCGATGTCGGCCGAGGCCACCGTCGTGC
GCAACTATATCGACACGCTGGTCAGCCTGCCGTGGCGCAAGAAGAGCAAGGTCAACAACGACCTGGCTAACGCCGAGCGC
GTGCTCGATGAAGACCACTATGGCCTCGAGAAGGTCAAGGAACGGATTCTCGAGTACCTTGCCGTGCAACAGCGCGTGGA
CAAGGTGAAGGCGCCGATCCTGTGCCTGGTTGGCCCTCCGGGCGTCGGCAAGACCTCGCTCGGTCAGTCGGTTGCGCGTG
CCACGAACCGCAAGTTCGTGCGTATGGCGCTGGGTGGTGTGCGTGACGAGGCCGAGATCCGCGGTCACCGTCGTACGTAC
ATTGGATCGATGCCGGGCAAGATCCTGCAGAGCCTGTCGAAGGTTGGCGTGCGCAATCCGCTGTTCCTGCTCGACGAGAT
CGACAAGATGGGCATGGATTTCCGTGGCGATCCTTCGTCGGCGCTGCTCGAGGTGCTGGACCCGGAACAGAACCACACGT
TCCAGGACCACTACATCGAGGTGGACTTTGACCTGTCGGATGTGATGTTCGTGGCGACGTCGAACTCGCTGAACATTCCG
CCGCCGCTGCTGGACCGGATGGAAGTGATCCGCCTGTCAGGCTACACGGAGGACGAAAAGGTCAACATCGCTACGCGCTA
CCTGTTACCGAAGCAGATCCGTAACAACGGCCTGAAGCAAGGCGAGATCGAGGTGACCGAAGCGGCAATCCGCGACATCA
TCCGCTACTACACGCGAGAAGCCGGTGTGCGTTCGCTGGAACGCGAAGTGTCGAAGATCGCTCGCAAGGTTGTGAAGATG
CTGCTCCTGAAGAAGGAGTCCACGGCGGTGAAGGTGGATTCCGAGAACCTGGACAAATTCCTTGGCGTGCGCAAGTACGA
CTTCGGTTTAGCCGGCAAGGAAAACCAGGTGGGTCAGGTGACGGGTCTGGCGTGGACGGAAGTCGGCGGCGACCTGCTGA
CGATTGAAGCCGCGATCATGCCAGGCAAGGGCAACATCACGCGCACCGGTTCGCTCGGCGATGTGATGAAGGAGTCGGTC
GAAGCCGCGCGCTCGGTGGTGCGTTCGCGGGCGCGTCGTCTGGGTATCGCGGATGAGATGTTCGAGAAGCGCGACATCCA
CATCCACGTGCCCGAGGGCGCCACGCCGAAGGATGGTCCGTCGGCCGGTATCGCGATGACGACCGCGCTAGTGTCGGTGC
TGACTGGCATCCCGGTGCGTGCCGATGTGGCGATGACGGGTGAAATCACGCTGCGCGGAGAGGTGCTGCCGATCGGCGGT
CTCAAGGAGAAGCTGCTGGCTGCCCATCGCGGCGGTATCAAGCTGGTGCTGATCCCCGAAGAGAACGTCAAGGATCTGGC
TGACATTCCGGACAACGTGAAGAACGCCATCGAGATCATGCCGGTGCGCTGGATCGACCGGGTGCTGGAGCTGGCGCTCG
AGCGAAAGCCCGAGCCGCTGCCTGAGGAAGATGCCAAGCCCGCCGAGGTGGCGGACAAGGCCGCGTCCCAGGTGGAGCGT
ATCCATCACTGA

Upstream 100 bases:

>100_bases
GTTTGCAGCATGTTTTTCTGCGTACAGATTCGATGATGGGCATCTTGCAATCGAATTCCGCGACCCTATTTACGCCTTAA
ATGACTGACTGGGGAAAATG

Downstream 100 bases:

>100_bases
TCGACGCACACGTCAGTCTGAGATGTAGTTAGGAACGCCGCAGGGTCAAACCTGCGGCGTTTTTGTTTGCGCAATGCCCG
CGGCACCGTGTGCCTTGCGG

Product: DNA-binding ATP-dependent protease La

Products: NA

Alternate protein names: ATP-dependent protease La [H]

Number of amino acids: Translated: 803; Mature: 802

Protein sequence:

>803_residues
MSGTQLLPAEPIRLPLLPLRDVVVFPHMVIPLFVGRPKSIKALETAMESGKSIMLVAQKTAAKDEPTADDLYEVGCIANI
LQMLKLPDGTVKVLVEGTQRANITEVSEDDSHFMCEAVPVPPAPVESAETEALRRAIVSQFDQYVKLNKKIPPEILTSLS
GIDEAGRLADTIAAHLPIKLEQKQKILEMVKVTERLESLLSQLEGEIDILQVEKRIRGRVKRQMEKSQREYYLNEQVKAI
QKELGEGEEGADLEELDKRIKAARMPKEAKKKADAEFKKLKLMSPMSAEATVVRNYIDTLVSLPWRKKSKVNNDLANAER
VLDEDHYGLEKVKERILEYLAVQQRVDKVKAPILCLVGPPGVGKTSLGQSVARATNRKFVRMALGGVRDEAEIRGHRRTY
IGSMPGKILQSLSKVGVRNPLFLLDEIDKMGMDFRGDPSSALLEVLDPEQNHTFQDHYIEVDFDLSDVMFVATSNSLNIP
PPLLDRMEVIRLSGYTEDEKVNIATRYLLPKQIRNNGLKQGEIEVTEAAIRDIIRYYTREAGVRSLEREVSKIARKVVKM
LLLKKESTAVKVDSENLDKFLGVRKYDFGLAGKENQVGQVTGLAWTEVGGDLLTIEAAIMPGKGNITRTGSLGDVMKESV
EAARSVVRSRARRLGIADEMFEKRDIHIHVPEGATPKDGPSAGIAMTTALVSVLTGIPVRADVAMTGEITLRGEVLPIGG
LKEKLLAAHRGGIKLVLIPEENVKDLADIPDNVKNAIEIMPVRWIDRVLELALERKPEPLPEEDAKPAEVADKAASQVER
IHH

Sequences:

>Translated_803_residues
MSGTQLLPAEPIRLPLLPLRDVVVFPHMVIPLFVGRPKSIKALETAMESGKSIMLVAQKTAAKDEPTADDLYEVGCIANI
LQMLKLPDGTVKVLVEGTQRANITEVSEDDSHFMCEAVPVPPAPVESAETEALRRAIVSQFDQYVKLNKKIPPEILTSLS
GIDEAGRLADTIAAHLPIKLEQKQKILEMVKVTERLESLLSQLEGEIDILQVEKRIRGRVKRQMEKSQREYYLNEQVKAI
QKELGEGEEGADLEELDKRIKAARMPKEAKKKADAEFKKLKLMSPMSAEATVVRNYIDTLVSLPWRKKSKVNNDLANAER
VLDEDHYGLEKVKERILEYLAVQQRVDKVKAPILCLVGPPGVGKTSLGQSVARATNRKFVRMALGGVRDEAEIRGHRRTY
IGSMPGKILQSLSKVGVRNPLFLLDEIDKMGMDFRGDPSSALLEVLDPEQNHTFQDHYIEVDFDLSDVMFVATSNSLNIP
PPLLDRMEVIRLSGYTEDEKVNIATRYLLPKQIRNNGLKQGEIEVTEAAIRDIIRYYTREAGVRSLEREVSKIARKVVKM
LLLKKESTAVKVDSENLDKFLGVRKYDFGLAGKENQVGQVTGLAWTEVGGDLLTIEAAIMPGKGNITRTGSLGDVMKESV
EAARSVVRSRARRLGIADEMFEKRDIHIHVPEGATPKDGPSAGIAMTTALVSVLTGIPVRADVAMTGEITLRGEVLPIGG
LKEKLLAAHRGGIKLVLIPEENVKDLADIPDNVKNAIEIMPVRWIDRVLELALERKPEPLPEEDAKPAEVADKAASQVER
IHH
>Mature_802_residues
SGTQLLPAEPIRLPLLPLRDVVVFPHMVIPLFVGRPKSIKALETAMESGKSIMLVAQKTAAKDEPTADDLYEVGCIANIL
QMLKLPDGTVKVLVEGTQRANITEVSEDDSHFMCEAVPVPPAPVESAETEALRRAIVSQFDQYVKLNKKIPPEILTSLSG
IDEAGRLADTIAAHLPIKLEQKQKILEMVKVTERLESLLSQLEGEIDILQVEKRIRGRVKRQMEKSQREYYLNEQVKAIQ
KELGEGEEGADLEELDKRIKAARMPKEAKKKADAEFKKLKLMSPMSAEATVVRNYIDTLVSLPWRKKSKVNNDLANAERV
LDEDHYGLEKVKERILEYLAVQQRVDKVKAPILCLVGPPGVGKTSLGQSVARATNRKFVRMALGGVRDEAEIRGHRRTYI
GSMPGKILQSLSKVGVRNPLFLLDEIDKMGMDFRGDPSSALLEVLDPEQNHTFQDHYIEVDFDLSDVMFVATSNSLNIPP
PLLDRMEVIRLSGYTEDEKVNIATRYLLPKQIRNNGLKQGEIEVTEAAIRDIIRYYTREAGVRSLEREVSKIARKVVKML
LLKKESTAVKVDSENLDKFLGVRKYDFGLAGKENQVGQVTGLAWTEVGGDLLTIEAAIMPGKGNITRTGSLGDVMKESVE
AARSVVRSRARRLGIADEMFEKRDIHIHVPEGATPKDGPSAGIAMTTALVSVLTGIPVRADVAMTGEITLRGEVLPIGGL
KEKLLAAHRGGIKLVLIPEENVKDLADIPDNVKNAIEIMPVRWIDRVLELALERKPEPLPEEDAKPAEVADKAASQVERI
HH

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain [H]

Homologues:

Organism=Homo sapiens, GI31377667, Length=838, Percent_Identity=38.5441527446301, Blast_Score=529, Evalue=1e-150,
Organism=Homo sapiens, GI21396489, Length=827, Percent_Identity=37.1221281741233, Blast_Score=513, Evalue=1e-145,
Organism=Escherichia coli, GI1786643, Length=770, Percent_Identity=70.1298701298701, Blast_Score=1090, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17505831, Length=705, Percent_Identity=40, Blast_Score=491, Evalue=1e-139,
Organism=Caenorhabditis elegans, GI17556486, Length=801, Percent_Identity=32.9588014981273, Blast_Score=423, Evalue=1e-118,
Organism=Saccharomyces cerevisiae, GI6319449, Length=709, Percent_Identity=40.9026798307475, Blast_Score=518, Evalue=1e-147,
Organism=Drosophila melanogaster, GI221513036, Length=620, Percent_Identity=44.0322580645161, Blast_Score=515, Evalue=1e-146,
Organism=Drosophila melanogaster, GI24666867, Length=620, Percent_Identity=44.0322580645161, Blast_Score=514, Evalue=1e-146,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 89106; Mature: 88974

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: PS01046 LON_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGTQLLPAEPIRLPLLPLRDVVVFPHMVIPLFVGRPKSIKALETAMESGKSIMLVAQKT
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCEEEEEEECC
AAKDEPTADDLYEVGCIANILQMLKLPDGTVKVLVEGTQRANITEVSEDDSHFMCEAVPV
CCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCEEEEECCC
PPAPVESAETEALRRAIVSQFDQYVKLNKKIPPEILTSLSGIDEAGRLADTIAAHLPIKL
CCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHHCCCCH
EQKQKILEMVKVTERLESLLSQLEGEIDILQVEKRIRGRVKRQMEKSQREYYLNEQVKAI
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QKELGEGEEGADLEELDKRIKAARMPKEAKKKADAEFKKLKLMSPMSAEATVVRNYIDTL
HHHHCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
VSLPWRKKSKVNNDLANAERVLDEDHYGLEKVKERILEYLAVQQRVDKVKAPILCLVGPP
HCCCCCHHHHCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCC
GVGKTSLGQSVARATNRKFVRMALGGVRDEAEIRGHRRTYIGSMPGKILQSLSKVGVRNP
CCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCHHHHCCCCHHHHHHHHHHCCCCCC
LFLLDEIDKMGMDFRGDPSSALLEVLDPEQNHTFQDHYIEVDFDLSDVMFVATSNSLNIP
HHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCCCCEEEEEECCCCEEEEEECCCCCCC
PPLLDRMEVIRLSGYTEDEKVNIATRYLLPKQIRNNGLKQGEIEVTEAAIRDIIRYYTRE
CHHHHHHHHHHHCCCCCCCCEEHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHH
AGVRSLEREVSKIARKVVKMLLLKKESTAVKVDSENLDKFLGVRKYDFGLAGKENQVGQV
HHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECHHHHHHHHCCHHCCCCCCCCCCCCCCE
TGLAWTEVGGDLLTIEAAIMPGKGNITRTGSLGDVMKESVEAARSVVRSRARRLGIADEM
ECEEHHHCCCCEEEEEEEEECCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
FEKRDIHIHVPEGATPKDGPSAGIAMTTALVSVLTGIPVRADVAMTGEITLRGEVLPIGG
HCCCCCEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEECEEEECEEEEECEEEECCC
LKEKLLAAHRGGIKLVLIPEENVKDLADIPDNVKNAIEIMPVRWIDRVLELALERKPEPL
HHHHHHHHHCCCEEEEEECCCCHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHHCCCCCC
PEEDAKPAEVADKAASQVERIHH
CCCCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SGTQLLPAEPIRLPLLPLRDVVVFPHMVIPLFVGRPKSIKALETAMESGKSIMLVAQKT
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCEEEEEEECC
AAKDEPTADDLYEVGCIANILQMLKLPDGTVKVLVEGTQRANITEVSEDDSHFMCEAVPV
CCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCEEEEECCC
PPAPVESAETEALRRAIVSQFDQYVKLNKKIPPEILTSLSGIDEAGRLADTIAAHLPIKL
CCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHHCCCCH
EQKQKILEMVKVTERLESLLSQLEGEIDILQVEKRIRGRVKRQMEKSQREYYLNEQVKAI
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QKELGEGEEGADLEELDKRIKAARMPKEAKKKADAEFKKLKLMSPMSAEATVVRNYIDTL
HHHHCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
VSLPWRKKSKVNNDLANAERVLDEDHYGLEKVKERILEYLAVQQRVDKVKAPILCLVGPP
HCCCCCHHHHCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCC
GVGKTSLGQSVARATNRKFVRMALGGVRDEAEIRGHRRTYIGSMPGKILQSLSKVGVRNP
CCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCHHHHCCCCHHHHHHHHHHCCCCCC
LFLLDEIDKMGMDFRGDPSSALLEVLDPEQNHTFQDHYIEVDFDLSDVMFVATSNSLNIP
HHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCCCCEEEEEECCCCEEEEEECCCCCCC
PPLLDRMEVIRLSGYTEDEKVNIATRYLLPKQIRNNGLKQGEIEVTEAAIRDIIRYYTRE
CHHHHHHHHHHHCCCCCCCCEEHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHH
AGVRSLEREVSKIARKVVKMLLLKKESTAVKVDSENLDKFLGVRKYDFGLAGKENQVGQV
HHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECHHHHHHHHCCHHCCCCCCCCCCCCCCE
TGLAWTEVGGDLLTIEAAIMPGKGNITRTGSLGDVMKESVEAARSVVRSRARRLGIADEM
ECEEHHHCCCCEEEEEEEEECCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
FEKRDIHIHVPEGATPKDGPSAGIAMTTALVSVLTGIPVRADVAMTGEITLRGEVLPIGG
HCCCCCEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEECEEEECEEEEECEEEECCC
LKEKLLAAHRGGIKLVLIPEENVKDLADIPDNVKNAIEIMPVRWIDRVLELALERKPEPL
HHHHHHHHHCCCEEEEEECCCCHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHHCCCCCC
PEEDAKPAEVADKAASQVERIHH
CCCCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8981986; 12620739 [H]