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The map label for this gene is creC [H]

Identifier: 94310593

GI number: 94310593

Start: 1785985

End: 1787430

Strand: Reverse

Name: creC [H]

Synonym: Rmet_1651

Alternate gene names: 94310593

Gene position: 1787430-1785985 (Counterclockwise)

Preceding gene: 94310594

Following gene: 94310592

Centisome position: 45.5

GC content: 64.18

Gene sequence:

>1446_bases
ATGCATATCGGCCTGCGCATCTTCTTCGGCTTCTTCCTGATCGTCGGGCTGGCAGCGTTCCTGACCTTGCGCGTGTTTGT
CCAGGAAGTAAAACCTGGCGTGCGTCAGGCCATGGAAGATACCCTCGTGGACACCGCCAACGTCCTCGCCGTGCTGGCCA
CCGACGATTTCAAGAGCGGTCATCTCTCCGACGGCAGTTTCGCGAATCATCTGGCGCGGCTGCATGAGCAGCCCGTCGAA
GCCAGCGTGTGGGGGATGCACAAGGGTGCCGTCGGTTACCGCATCTACATCACCGATGATCGTGGCATCGTTCGCTTCGA
TTCGTCCGGCGCGGCGGTCGGGCAAGACTACTCCCGGTGGAACGATGTCTACCTGACCTTGCAAGGCAAGTATGGCGCTC
GCAGCACACCCTCCGACCCCAACGACGACAGCAGCACGATCATGTATGTGGCAGCCCCGATCCGCGACGGCGAACGGATC
ATCGGCGTGCTGACCGTGGCCAAGCCGAATCAGACCGTGGCGCCGTTCATCGCGCGCAGTCAGCGGACTATCCTGATGTA
CGGGCTGTTGCTGATCGGCGGCGCCGCGGTCATTGGACTGGTGTGCACGCTCTGGCTCGTGTACGGGCTACGCAAGCTGC
AGCGCTATACTCGGGCCGTCGCGGCCGGCGAGCGCGCCGAGATGCCCTTGCGCGGCGCCAGCGAACTCGCGGAACTCGGC
CGAGCGGTGGAAACCATGCGCGTGCGTCTGGAAGACAAGCAGTACGTTGAGCACTATATCCACACGCTGACGCACGAAAT
GAAGAGCCCGCTGGCCGCCATCGGCGGCGCGGCGGAACTGCTTCAGGAGGACATGCCGACGGCAGACCGCCAACGCTTTC
TCGGCAATATCCGCAGTCAGGCGCAGCGGCTCGATTTGTTGATCCGCAAGCTTCTGGCACTCGCCGAAGTCGAACAACGC
CAGCGTCTGGAGAAGCGCGAACCCGTGCGGCTGGCGCAGGAGATCGAGCATATTCTTGCGTCACTGGAGCCACGGGCGCG
CCAACGCGGCGTAAGCCTGCATTGGCAGCCACCGGCGCAGGGACAATCCTTCGACGTCTCCGGCGACGTGTTCCTGCTGC
GGCAGGCAATCGTCAACCTGATCGAGAATGCCCTGGATTTCGCGCCGTCGGGGACCGACGTCGACGTGGTCCTGGAACCC
GGCCCCCATCAGGATCAGATCACGCTCAGGATCGAGGACCGAGGGCCCGGCATCCCCGAGTACGCGCTTTCGCGGCTGTT
CGAGCGCTTCTATTCCCTGCCCCGCCCCGGTGGCGGCGAGCGCAGCACCGGGCTTGGCCTATGTCTGGTTCGCGAAGTAG
CCCTGCTGCACCACGGCAGCGCTACCGTTACCAACAGAGAGGGCGGTGGCGCCAGCGCCGTGATGGTCCTGCCCATCTCC
GCATGA

Upstream 100 bases:

>100_bases
AGCCAAGCTCCGCGAGATCGCCCCCGCTGGCGACCCGATCCGGACCCATCGCGGCATGGGCTACTCACTCGAATCACGAT
AAGGAAGATAAGGGCATTCC

Downstream 100 bases:

>100_bases
CGCGCAACACATGACGTAACGCGAAAGACGGAGCGCAGCCTTCACAACGGCTTCACGCCAACCACACGCCCTCCTCACCC
GCGATCGCTAGTCTTGCTGC

Product: sensory histidine kinase CreC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 481; Mature: 481

Protein sequence:

>481_residues
MHIGLRIFFGFFLIVGLAAFLTLRVFVQEVKPGVRQAMEDTLVDTANVLAVLATDDFKSGHLSDGSFANHLARLHEQPVE
ASVWGMHKGAVGYRIYITDDRGIVRFDSSGAAVGQDYSRWNDVYLTLQGKYGARSTPSDPNDDSSTIMYVAAPIRDGERI
IGVLTVAKPNQTVAPFIARSQRTILMYGLLLIGGAAVIGLVCTLWLVYGLRKLQRYTRAVAAGERAEMPLRGASELAELG
RAVETMRVRLEDKQYVEHYIHTLTHEMKSPLAAIGGAAELLQEDMPTADRQRFLGNIRSQAQRLDLLIRKLLALAEVEQR
QRLEKREPVRLAQEIEHILASLEPRARQRGVSLHWQPPAQGQSFDVSGDVFLLRQAIVNLIENALDFAPSGTDVDVVLEP
GPHQDQITLRIEDRGPGIPEYALSRLFERFYSLPRPGGGERSTGLGLCLVREVALLHHGSATVTNREGGGASAVMVLPIS
A

Sequences:

>Translated_481_residues
MHIGLRIFFGFFLIVGLAAFLTLRVFVQEVKPGVRQAMEDTLVDTANVLAVLATDDFKSGHLSDGSFANHLARLHEQPVE
ASVWGMHKGAVGYRIYITDDRGIVRFDSSGAAVGQDYSRWNDVYLTLQGKYGARSTPSDPNDDSSTIMYVAAPIRDGERI
IGVLTVAKPNQTVAPFIARSQRTILMYGLLLIGGAAVIGLVCTLWLVYGLRKLQRYTRAVAAGERAEMPLRGASELAELG
RAVETMRVRLEDKQYVEHYIHTLTHEMKSPLAAIGGAAELLQEDMPTADRQRFLGNIRSQAQRLDLLIRKLLALAEVEQR
QRLEKREPVRLAQEIEHILASLEPRARQRGVSLHWQPPAQGQSFDVSGDVFLLRQAIVNLIENALDFAPSGTDVDVVLEP
GPHQDQITLRIEDRGPGIPEYALSRLFERFYSLPRPGGGERSTGLGLCLVREVALLHHGSATVTNREGGGASAVMVLPIS
A
>Mature_481_residues
MHIGLRIFFGFFLIVGLAAFLTLRVFVQEVKPGVRQAMEDTLVDTANVLAVLATDDFKSGHLSDGSFANHLARLHEQPVE
ASVWGMHKGAVGYRIYITDDRGIVRFDSSGAAVGQDYSRWNDVYLTLQGKYGARSTPSDPNDDSSTIMYVAAPIRDGERI
IGVLTVAKPNQTVAPFIARSQRTILMYGLLLIGGAAVIGLVCTLWLVYGLRKLQRYTRAVAAGERAEMPLRGASELAELG
RAVETMRVRLEDKQYVEHYIHTLTHEMKSPLAAIGGAAELLQEDMPTADRQRFLGNIRSQAQRLDLLIRKLLALAEVEQR
QRLEKREPVRLAQEIEHILASLEPRARQRGVSLHWQPPAQGQSFDVSGDVFLLRQAIVNLIENALDFAPSGTDVDVVLEP
GPHQDQITLRIEDRGPGIPEYALSRLFERFYSLPRPGGGERSTGLGLCLVREVALLHHGSATVTNREGGGASAVMVLPIS
A

Specific function: Member of the two-component regulatory system CreC/CreB involved in catabolic regulation. CreC may function as a membrane- associated protein kinase that phosphorylates CreB in response to environmental signals. CreC can also phosphorylate PhoB [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790861, Length=478, Percent_Identity=46.0251046025105, Blast_Score=403, Evalue=1e-113,
Organism=Escherichia coli, GI1786783, Length=305, Percent_Identity=25.9016393442623, Blast_Score=92, Evalue=1e-19,
Organism=Escherichia coli, GI48994928, Length=228, Percent_Identity=29.8245614035088, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1786600, Length=229, Percent_Identity=29.2576419213974, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1788393, Length=280, Percent_Identity=26.0714285714286, Blast_Score=82, Evalue=8e-17,
Organism=Escherichia coli, GI145693157, Length=250, Percent_Identity=26.8, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI1788279, Length=309, Percent_Identity=26.2135922330097, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1786912, Length=345, Percent_Identity=24.9275362318841, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI1790346, Length=277, Percent_Identity=27.0758122743682, Blast_Score=76, Evalue=5e-15,
Organism=Escherichia coli, GI1789149, Length=220, Percent_Identity=27.7272727272727, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1789403, Length=211, Percent_Identity=30.8056872037915, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1790551, Length=306, Percent_Identity=27.1241830065359, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI1788549, Length=219, Percent_Identity=24.6575342465753, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI87081816, Length=273, Percent_Identity=27.1062271062271, Blast_Score=62, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 52969; Mature: 52969

Theoretical pI: Translated: 7.01; Mature: 7.01

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHIGLRIFFGFFLIVGLAAFLTLRVFVQEVKPGVRQAMEDTLVDTANVLAVLATDDFKSG
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHEEEEEEECCCCCC
HLSDGSFANHLARLHEQPVEASVWGMHKGAVGYRIYITDDRGIVRFDSSGAAVGQDYSRW
CCCCCHHHHHHHHHHCCCCCHHHHCCCCCCCEEEEEEECCCCEEEECCCCCCCCCCHHCC
NDVYLTLQGKYGARSTPSDPNDDSSTIMYVAAPIRDGERIIGVLTVAKPNQTVAPFIARS
CCEEEEEECCCCCCCCCCCCCCCCCEEEEEEECCCCCCEEEEEEEECCCCCCHHHHHHCC
QRTILMYGLLLIGGAAVIGLVCTLWLVYGLRKLQRYTRAVAAGERAEMPLRGASELAELG
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHH
RAVETMRVRLEDKQYVEHYIHTLTHEMKSPLAAIGGAAELLQEDMPTADRQRFLGNIRSQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHCHHHHHHHHCCCCHHHHHHHHHHHHH
AQRLDLLIRKLLALAEVEQRQRLEKREPVRLAQEIEHILASLEPRARQRGVSLHWQPPAQ
HHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCHHHHHCCCCEEECCCCC
GQSFDVSGDVFLLRQAIVNLIENALDFAPSGTDVDVVLEPGPHQDQITLRIEDRGPGIPE
CCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCEEEEEEECCCCCCHH
YALSRLFERFYSLPRPGGGERSTGLGLCLVREVALLHHGSATVTNREGGGASAVMVLPIS
HHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEECCCCCCCEEEEEEEEC
A
C
>Mature Secondary Structure
MHIGLRIFFGFFLIVGLAAFLTLRVFVQEVKPGVRQAMEDTLVDTANVLAVLATDDFKSG
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHEEEEEEECCCCCC
HLSDGSFANHLARLHEQPVEASVWGMHKGAVGYRIYITDDRGIVRFDSSGAAVGQDYSRW
CCCCCHHHHHHHHHHCCCCCHHHHCCCCCCCEEEEEEECCCCEEEECCCCCCCCCCHHCC
NDVYLTLQGKYGARSTPSDPNDDSSTIMYVAAPIRDGERIIGVLTVAKPNQTVAPFIARS
CCEEEEEECCCCCCCCCCCCCCCCCEEEEEEECCCCCCEEEEEEEECCCCCCHHHHHHCC
QRTILMYGLLLIGGAAVIGLVCTLWLVYGLRKLQRYTRAVAAGERAEMPLRGASELAELG
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHH
RAVETMRVRLEDKQYVEHYIHTLTHEMKSPLAAIGGAAELLQEDMPTADRQRFLGNIRSQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHCHHHHHHHHCCCCHHHHHHHHHHHHH
AQRLDLLIRKLLALAEVEQRQRLEKREPVRLAQEIEHILASLEPRARQRGVSLHWQPPAQ
HHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCHHHHHCCCCEEECCCCC
GQSFDVSGDVFLLRQAIVNLIENALDFAPSGTDVDVVLEPGPHQDQITLRIEDRGPGIPE
CCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCEEEEEEECCCCCCHH
YALSRLFERFYSLPRPGGGERSTGLGLCLVREVALLHHGSATVTNREGGGASAVMVLPIS
HHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEECCCCCCCEEEEEEEEC
A
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3531171; 7610040; 9278503; 2835585; 2228961 [H]