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The map label for this gene is uppS [H]

Identifier: 94310381

GI number: 94310381

Start: 1559846

End: 1560616

Strand: Direct

Name: uppS [H]

Synonym: Rmet_1439

Alternate gene names: 94310381

Gene position: 1559846-1560616 (Clockwise)

Preceding gene: 94310380

Following gene: 94310382

Centisome position: 39.71

GC content: 64.33

Gene sequence:

>771_bases
ATGCAGCACATCAGTTCGACGCTAGGCGTTCCCGATACCACCTATGTGCCTCGGCACGTTGCCATCATCATGGATGGCAA
CGGTCGCTGGGCGACGCAGCGTCATCTACCCCGTGTGGCCGGCCACAACCGTGGCCTGGACGCAGTGCGCGAGATCGTGC
AGGCGTGCGCCGCTCGTGGCGTGCAGTACCTGACGCTGTTTGCATTCAGTTCCGAGAATTGGCGCAGGCCCGCCGACGAG
GTGTCATTCCTGATGCGTCTGTTCATGACCGCCTTGCGTCGCGAAGTGGTCAGGATGCACGCCAACAATATTCGCCTGCG
TGTGGTCGGCGATCTCAGCCGGTTCAGCCCGCGCATCCAGCAGGCGATCAAGGATGCCGAGGCGCGCACGGAAGGCAATA
CGGGCCTGACCGTGACGATCGCCGCCAACTATGGCGGCCGCTGGGACCTGCTCCAGGCGATGCGCAAGATGCTGGCGCGT
TCGCCGTTGCTCGATTCGGACGCGATCGACGAGTCCGTTCTGGCGCCGCATCTGGCTATGGCCTACGCGCCCGAGCCGGA
CCTGTTCATCCGCACCGGCGGGGAGCAGCGCATCAGCAACTTCCTGCTCTGGCAGCTTGCCTACACGGAGTTGTACTTCA
CCGAAACGTTCTGGCCGGATTTTGATGCCGCCGAGCTGGACAAGGCCTTTGCCTCGTACCGTCAGCGCGAGCGGCGCTTC
GGACGGACCAGCGCGCAGCTGGTGGCGCCAGGCCTGTCCGGTACAGCCTGA

Upstream 100 bases:

>100_bases
ATCGACAAGCTCGTTGCCGAGAAAGAGAAGGAGATCATGACGGTGTAAGGCCGTCCTGGCGGCCGAGCCGCCAGGGTTGC
CGGATATCGTCCGCGAATCC

Downstream 100 bases:

>100_bases
CGCATCCAACGCCCAACAAACTCACGGGAACCCACAGCGCATATGCTCCTTACCCGCGTCATCACCGCCGTATGCCTGTT
GCTGTTGATCCTGCCGATCC

Product: undecaprenyl pyrophosphate synthase

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS [H]

Number of amino acids: Translated: 256; Mature: 256

Protein sequence:

>256_residues
MQHISSTLGVPDTTYVPRHVAIIMDGNGRWATQRHLPRVAGHNRGLDAVREIVQACAARGVQYLTLFAFSSENWRRPADE
VSFLMRLFMTALRREVVRMHANNIRLRVVGDLSRFSPRIQQAIKDAEARTEGNTGLTVTIAANYGGRWDLLQAMRKMLAR
SPLLDSDAIDESVLAPHLAMAYAPEPDLFIRTGGEQRISNFLLWQLAYTELYFTETFWPDFDAAELDKAFASYRQRERRF
GRTSAQLVAPGLSGTA

Sequences:

>Translated_256_residues
MQHISSTLGVPDTTYVPRHVAIIMDGNGRWATQRHLPRVAGHNRGLDAVREIVQACAARGVQYLTLFAFSSENWRRPADE
VSFLMRLFMTALRREVVRMHANNIRLRVVGDLSRFSPRIQQAIKDAEARTEGNTGLTVTIAANYGGRWDLLQAMRKMLAR
SPLLDSDAIDESVLAPHLAMAYAPEPDLFIRTGGEQRISNFLLWQLAYTELYFTETFWPDFDAAELDKAFASYRQRERRF
GRTSAQLVAPGLSGTA
>Mature_256_residues
MQHISSTLGVPDTTYVPRHVAIIMDGNGRWATQRHLPRVAGHNRGLDAVREIVQACAARGVQYLTLFAFSSENWRRPADE
VSFLMRLFMTALRREVVRMHANNIRLRVVGDLSRFSPRIQQAIKDAEARTEGNTGLTVTIAANYGGRWDLLQAMRKMLAR
SPLLDSDAIDESVLAPHLAMAYAPEPDLFIRTGGEQRISNFLLWQLAYTELYFTETFWPDFDAAELDKAFASYRQRERRF
GRTSAQLVAPGLSGTA

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide [H]

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI45580742, Length=224, Percent_Identity=33.0357142857143, Blast_Score=134, Evalue=6e-32,
Organism=Homo sapiens, GI45580738, Length=224, Percent_Identity=33.0357142857143, Blast_Score=134, Evalue=6e-32,
Organism=Escherichia coli, GI1786371, Length=228, Percent_Identity=55.2631578947368, Blast_Score=259, Evalue=1e-70,
Organism=Caenorhabditis elegans, GI71993029, Length=227, Percent_Identity=35.6828193832599, Blast_Score=145, Evalue=3e-35,
Organism=Saccharomyces cerevisiae, GI6319474, Length=214, Percent_Identity=35.0467289719626, Blast_Score=124, Evalue=1e-29,
Organism=Saccharomyces cerevisiae, GI6323748, Length=213, Percent_Identity=33.3333333333333, Blast_Score=118, Evalue=7e-28,
Organism=Drosophila melanogaster, GI18857969, Length=228, Percent_Identity=34.6491228070175, Blast_Score=143, Evalue=1e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001441
- InterPro:   IPR018520 [H]

Pfam domain/function: PF01255 Prenyltransf [H]

EC number: =2.5.1.31 [H]

Molecular weight: Translated: 28898; Mature: 28898

Theoretical pI: Translated: 9.67; Mature: 9.67

Prosite motif: PS01066 UPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQHISSTLGVPDTTYVPRHVAIIMDGNGRWATQRHLPRVAGHNRGLDAVREIVQACAARG
CCCCHHHCCCCCCCCCCCEEEEEECCCCCCCHHHHCHHHHCCCCCHHHHHHHHHHHHHCC
VQYLTLFAFSSENWRRPADEVSFLMRLFMTALRREVVRMHANNIRLRVVGDLSRFSPRIQ
CEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCHHHCCHHHH
QAIKDAEARTEGNTGLTVTIAANYGGRWDLLQAMRKMLARSPLLDSDAIDESVLAPHLAM
HHHHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCCCCHHCCHHHHHHHHHH
AYAPEPDLFIRTGGEQRISNFLLWQLAYTELYFTETFWPDFDAAELDKAFASYRQRERRF
HCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHH
GRTSAQLVAPGLSGTA
CCCHHHHCCCCCCCCC
>Mature Secondary Structure
MQHISSTLGVPDTTYVPRHVAIIMDGNGRWATQRHLPRVAGHNRGLDAVREIVQACAARG
CCCCHHHCCCCCCCCCCCEEEEEECCCCCCCHHHHCHHHHCCCCCHHHHHHHHHHHHHCC
VQYLTLFAFSSENWRRPADEVSFLMRLFMTALRREVVRMHANNIRLRVVGDLSRFSPRIQ
CEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCHHHCCHHHH
QAIKDAEARTEGNTGLTVTIAANYGGRWDLLQAMRKMLARSPLLDSDAIDESVLAPHLAM
HHHHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCCCCHHCCHHHHHHHHHH
AYAPEPDLFIRTGGEQRISNFLLWQLAYTELYFTETFWPDFDAAELDKAFASYRQRERRF
HCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHH
GRTSAQLVAPGLSGTA
CCCHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]