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The map label for this gene is ppiA [H]

Identifier: 94310028

GI number: 94310028

Start: 1175061

End: 1175669

Strand: Reverse

Name: ppiA [H]

Synonym: Rmet_1083

Alternate gene names: 94310028

Gene position: 1175669-1175061 (Counterclockwise)

Preceding gene: 94310029

Following gene: 94310027

Centisome position: 29.93

GC content: 62.89

Gene sequence:

>609_bases
ATGATCCTTTCCCGCCGCATCGTCCTGACCGGCCTGATGGCCGCCGCCACTGCCCTGTCTCCGCTGGCCGCAATGGCCCA
GGGCGCCAGCCCCGCCACCGCCGCGCCGAAGACCGAGCGCGTGCAGTTCGTGACGAGCGCCGGCAAGTTCACTATCGAGC
TGTACCCCGATGCCGCCCCGAAGACCGTGGCCAACTTCATGGGCTACGTAAAAAGCGGCTTCTATTCCGGCACGATCTTC
CATCGCGTGATCAACGGCTTCATGGTTCAGGGCGGTGGCTTCGACCGCGACATGAAGGAAAAGCCGACGCTGGCGCCGAT
CGCGCTGGAATCGCAGAACGGCCTGAAGAACAAGGCCGGGACCGTCGCCATGGCACGCACGTCGAACCCGAACTCGGCAA
CCGCCCAGTTCTTCGTCAATGTGGTGGATAATCCGAACCTCGACTACCCACAGCCGGACGGCAATGGATATGCCGTCTTT
GGCAAGGTGGTAGAGGGAATGGACACGATCGACAAGATCAAGACCACGCCGACTACGGCGTATGGCGCCATGCGCAACGT
GCCTGCCGCGCCGATCGTGATCGAATCGGCCACCGTGGTCACCAAGTGA

Upstream 100 bases:

>100_bases
CACGCCCGACGCACGCTGAACTCGCACAGTATTCAACGCCTTATCCGGCGACGTCCAAGTGACGTTGCCGACTGCCAGAC
CTGCAACCCGGAGTCCAGAC

Downstream 100 bases:

>100_bases
CCCCAGGCAACCCCGAATACAACCGTCATCGCATCATCGAACAGAGGTAACCCTATGAGCAAGGTACAACTCCAAACCAC
GCAAGGCGCCATCGTCATCG

Product: peptidyl-prolyl cis-trans isomerase A

Products: NA

Alternate protein names: PPIase A; Cyclophilin A; Rotamase A [H]

Number of amino acids: Translated: 202; Mature: 202

Protein sequence:

>202_residues
MILSRRIVLTGLMAAATALSPLAAMAQGASPATAAPKTERVQFVTSAGKFTIELYPDAAPKTVANFMGYVKSGFYSGTIF
HRVINGFMVQGGGFDRDMKEKPTLAPIALESQNGLKNKAGTVAMARTSNPNSATAQFFVNVVDNPNLDYPQPDGNGYAVF
GKVVEGMDTIDKIKTTPTTAYGAMRNVPAAPIVIESATVVTK

Sequences:

>Translated_202_residues
MILSRRIVLTGLMAAATALSPLAAMAQGASPATAAPKTERVQFVTSAGKFTIELYPDAAPKTVANFMGYVKSGFYSGTIF
HRVINGFMVQGGGFDRDMKEKPTLAPIALESQNGLKNKAGTVAMARTSNPNSATAQFFVNVVDNPNLDYPQPDGNGYAVF
GKVVEGMDTIDKIKTTPTTAYGAMRNVPAAPIVIESATVVTK
>Mature_202_residues
MILSRRIVLTGLMAAATALSPLAAMAQGASPATAAPKTERVQFVTSAGKFTIELYPDAAPKTVANFMGYVKSGFYSGTIF
HRVINGFMVQGGGFDRDMKEKPTLAPIALESQNGLKNKAGTVAMARTSNPNSATAQFFVNVVDNPNLDYPQPDGNGYAVF
GKVVEGMDTIDKIKTTPTTAYGAMRNVPAAPIVIESATVVTK

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI19557636, Length=161, Percent_Identity=33.5403726708075, Blast_Score=84, Evalue=7e-17,
Organism=Homo sapiens, GI24308049, Length=166, Percent_Identity=33.7349397590361, Blast_Score=77, Evalue=8e-15,
Organism=Homo sapiens, GI5454154, Length=163, Percent_Identity=31.9018404907975, Blast_Score=74, Evalue=8e-14,
Organism=Homo sapiens, GI22547212, Length=165, Percent_Identity=31.5151515151515, Blast_Score=72, Evalue=3e-13,
Organism=Homo sapiens, GI7657473, Length=165, Percent_Identity=31.5151515151515, Blast_Score=72, Evalue=3e-13,
Organism=Homo sapiens, GI22547215, Length=165, Percent_Identity=31.5151515151515, Blast_Score=72, Evalue=3e-13,
Organism=Homo sapiens, GI7706339, Length=143, Percent_Identity=31.4685314685315, Blast_Score=71, Evalue=7e-13,
Organism=Homo sapiens, GI10863927, Length=133, Percent_Identity=35.3383458646617, Blast_Score=68, Evalue=6e-12,
Organism=Escherichia coli, GI1789763, Length=189, Percent_Identity=53.4391534391534, Blast_Score=179, Evalue=8e-47,
Organism=Escherichia coli, GI1786736, Length=161, Percent_Identity=54.6583850931677, Blast_Score=179, Evalue=1e-46,
Organism=Caenorhabditis elegans, GI71980594, Length=138, Percent_Identity=37.6811594202899, Blast_Score=87, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI71980590, Length=138, Percent_Identity=37.6811594202899, Blast_Score=87, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI17565860, Length=161, Percent_Identity=33.5403726708075, Blast_Score=74, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17539496, Length=142, Percent_Identity=33.8028169014084, Blast_Score=73, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI17532641, Length=175, Percent_Identity=30.8571428571429, Blast_Score=70, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17552780, Length=156, Percent_Identity=33.3333333333333, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17506311, Length=147, Percent_Identity=31.9727891156463, Blast_Score=68, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17559074, Length=149, Percent_Identity=32.2147651006711, Blast_Score=68, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17506307, Length=135, Percent_Identity=36.2962962962963, Blast_Score=67, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17566266, Length=147, Percent_Identity=33.3333333333333, Blast_Score=67, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17552782, Length=162, Percent_Identity=30.8641975308642, Blast_Score=66, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6323562, Length=161, Percent_Identity=35.4037267080745, Blast_Score=79, Evalue=7e-16,
Organism=Saccharomyces cerevisiae, GI6320510, Length=169, Percent_Identity=33.1360946745562, Blast_Score=65, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6320359, Length=134, Percent_Identity=33.5820895522388, Blast_Score=65, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24652460, Length=140, Percent_Identity=33.5714285714286, Blast_Score=80, Evalue=8e-16,
Organism=Drosophila melanogaster, GI19922912, Length=157, Percent_Identity=35.031847133758, Blast_Score=78, Evalue=4e-15,
Organism=Drosophila melanogaster, GI19922376, Length=210, Percent_Identity=29.5238095238095, Blast_Score=77, Evalue=7e-15,
Organism=Drosophila melanogaster, GI17986117, Length=162, Percent_Identity=30.8641975308642, Blast_Score=74, Evalue=6e-14,
Organism=Drosophila melanogaster, GI45549139, Length=153, Percent_Identity=33.9869281045752, Blast_Score=73, Evalue=1e-13,
Organism=Drosophila melanogaster, GI17136360, Length=209, Percent_Identity=29.6650717703349, Blast_Score=70, Evalue=7e-13,
Organism=Drosophila melanogaster, GI24664125, Length=169, Percent_Identity=33.1360946745562, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI21357783, Length=169, Percent_Identity=33.1360946745562, Blast_Score=69, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 21297; Mature: 21297

Theoretical pI: Translated: 9.96; Mature: 9.96

Prosite motif: PS00170 CSA_PPIASE_1 ; PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILSRRIVLTGLMAAATALSPLAAMAQGASPATAAPKTERVQFVTSAGKFTIELYPDAAP
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHEEEEECCCEEEEEECCCCCH
KTVANFMGYVKSGFYSGTIFHRVINGFMVQGGGFDRDMKEKPTLAPIALESQNGLKNKAG
HHHHHHHHHHHCCCCCHHHHHHHHHHEEEECCCCCCCCCCCCCCCEEEECCCCCCCCCCC
TVAMARTSNPNSATAQFFVNVVDNPNLDYPQPDGNGYAVFGKVVEGMDTIDKIKTTPTTA
EEEEEECCCCCCCEEEEEEEECCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHCCCCCHH
YGAMRNVPAAPIVIESATVVTK
HHHHHCCCCCCEEEECEEEECC
>Mature Secondary Structure
MILSRRIVLTGLMAAATALSPLAAMAQGASPATAAPKTERVQFVTSAGKFTIELYPDAAP
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHEEEEECCCEEEEEECCCCCH
KTVANFMGYVKSGFYSGTIFHRVINGFMVQGGGFDRDMKEKPTLAPIALESQNGLKNKAG
HHHHHHHHHHHCCCCCHHHHHHHHHHEEEECCCCCCCCCCCCCCCEEEECCCCCCCCCCC
TVAMARTSNPNSATAQFFVNVVDNPNLDYPQPDGNGYAVFGKVVEGMDTIDKIKTTPTTA
EEEEEECCCCCCCEEEEEEEECCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHCCCCCHH
YGAMRNVPAAPIVIESATVVTK
HHHHHCCCCCCEEEECEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9418240 [H]