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The map label for this gene is iclR [H]

Identifier: 94309785

GI number: 94309785

Start: 919278

End: 920093

Strand: Reverse

Name: iclR [H]

Synonym: Rmet_0840

Alternate gene names: 94309785

Gene position: 920093-919278 (Counterclockwise)

Preceding gene: 94309792

Following gene: 94309778

Centisome position: 23.42

GC content: 65.32

Gene sequence:

>816_bases
ATGGACACCAAGAAAACCCGGAGTACGAGCGAGGGAGAGACAGAAATGCGCGATGAGGCGGTGGGAAGGAAGACCGCGGG
CGCGCAAACATTGCGCCGGGGGCTGGAAATCCTGAGGCTGCTGGCCCGCCATCAGGAAGAAGGCGCGACGCTGGCGGATA
TCGTCACGGAAAGCGGCCTGGAGCGGCCGACGGCATATCGGCTGCTCTGCTCGCTCGAGGAGGAACGCTTCGTCGAGCGC
AACATCCACAGCAAGCGCTACCGGCTCGGCATCGACGCTATGCAGCTTGGCGCCGCCGCCGCGGAGAAGGCGCCAATCGT
CGATCTGGTCGCGCCTCTGATGAAAAAGCTGGCTCGCGTGTCGGGCGACACGGTCTTCCTGGTGGTGCCACAAGGAGACT
TCACGGTCTGCCTGCACCGCGAGGAAGGGCCGTTCCCCGTGCGCGTGTTCACGACGGTGCCGGGCCAACGCCGGCTACTG
GGCATCGGCGCTGGCGGCCTCGCGCTGATGTCGGCAATGTCGGACGACGCGATCCGCGAGGTTCACAAGCGCAAGCACGC
ACTTTATGCCGAAGCCGGAATGCCGATCTCGCGACTACTGGCGGCGGCAGCCAGAAGCCGACGCAAGGGCTATGCGGAGA
TCGTGGATACCATCACCGAAGGCGTCTCCGGCGTGGGATGCGCGTTCCAGTTGCCGTTTGGCGCGTCGGCGGCCATCAGC
TTCGGCGCGATCAGCAGCCGCATGAACGCAAGCCGCCGAGACGAACTCGGCGCGTTGATGGTGCGGGAGCTATCGACGAT
GAACCCGGCTGGATAG

Upstream 100 bases:

>100_bases
TCGATGTGGTTTGACGTCTTGGCTGTGTCGAGTGATTCCAATCGAGTGTAAAAGCAGGTATTTTCACAATACAAACACAA
GCAACTGTTTTGACCACTAT

Downstream 100 bases:

>100_bases
CGCTACGCCGTCCGGCCCATCAACGTCGACGCATCAATATCGCGCAGTGTCGGCCTGCCGAGCAATGCCATCGCGGCTTC
CAGTTCGGTTTGCAGCAGCG

Product: IclR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 271; Mature: 271

Protein sequence:

>271_residues
MDTKKTRSTSEGETEMRDEAVGRKTAGAQTLRRGLEILRLLARHQEEGATLADIVTESGLERPTAYRLLCSLEEERFVER
NIHSKRYRLGIDAMQLGAAAAEKAPIVDLVAPLMKKLARVSGDTVFLVVPQGDFTVCLHREEGPFPVRVFTTVPGQRRLL
GIGAGGLALMSAMSDDAIREVHKRKHALYAEAGMPISRLLAAAARSRRKGYAEIVDTITEGVSGVGCAFQLPFGASAAIS
FGAISSRMNASRRDELGALMVRELSTMNPAG

Sequences:

>Translated_271_residues
MDTKKTRSTSEGETEMRDEAVGRKTAGAQTLRRGLEILRLLARHQEEGATLADIVTESGLERPTAYRLLCSLEEERFVER
NIHSKRYRLGIDAMQLGAAAAEKAPIVDLVAPLMKKLARVSGDTVFLVVPQGDFTVCLHREEGPFPVRVFTTVPGQRRLL
GIGAGGLALMSAMSDDAIREVHKRKHALYAEAGMPISRLLAAAARSRRKGYAEIVDTITEGVSGVGCAFQLPFGASAAIS
FGAISSRMNASRRDELGALMVRELSTMNPAG
>Mature_271_residues
MDTKKTRSTSEGETEMRDEAVGRKTAGAQTLRRGLEILRLLARHQEEGATLADIVTESGLERPTAYRLLCSLEEERFVER
NIHSKRYRLGIDAMQLGAAAAEKAPIVDLVAPLMKKLARVSGDTVFLVVPQGDFTVCLHREEGPFPVRVFTTVPGQRRLL
GIGAGGLALMSAMSDDAIREVHKRKHALYAEAGMPISRLLAAAARSRRKGYAEIVDTITEGVSGVGCAFQLPFGASAAIS
FGAISSRMNASRRDELGALMVRELSTMNPAG

Specific function: Regulation of the glyoxylate bypass operon (aceBAK), which encodes isocitrate lyase, malate synthase as well as isocitrate dehydrogenase kinase/phosphorylase. Glyoxylate disrupts the interaction with the promoter by favoring the inactive dimeric form. Pyr

COG id: COG1414

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 iclR-ED (iclR effector binding) domain [H]

Homologues:

Organism=Escherichia coli, GI87082359, Length=250, Percent_Identity=25.2, Blast_Score=68, Evalue=6e-13,
Organism=Escherichia coli, GI1786715, Length=259, Percent_Identity=27.4131274131274, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014757
- InterPro:   IPR005471
- InterPro:   IPR011991 [H]

Pfam domain/function: PF09339 HTH_IclR; PF01614 IclR [H]

EC number: NA

Molecular weight: Translated: 29322; Mature: 29322

Theoretical pI: Translated: 9.52; Mature: 9.52

Prosite motif: PS51077 HTH_ICLR ; PS51078 ICLR_ED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDTKKTRSTSEGETEMRDEAVGRKTAGAQTLRRGLEILRLLARHQEEGATLADIVTESGL
CCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCC
ERPTAYRLLCSLEEERFVERNIHSKRYRLGIDAMQLGAAAAEKAPIVDLVAPLMKKLARV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHC
SGDTVFLVVPQGDFTVCLHREEGPFPVRVFTTVPGQRRLLGIGAGGLALMSAMSDDAIRE
CCCEEEEEEECCCEEEEEECCCCCCCEEEEEECCCCCEEEEECCHHHHHHHHHCHHHHHH
VHKRKHALYAEAGMPISRLLAAAARSRRKGYAEIVDTITEGVSGVGCAFQLPFGASAAIS
HHHHHHHHHHHCCCCHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCEEEECCCCCHHHHH
FGAISSRMNASRRDELGALMVRELSTMNPAG
HHHHHHHHCCHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MDTKKTRSTSEGETEMRDEAVGRKTAGAQTLRRGLEILRLLARHQEEGATLADIVTESGL
CCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCC
ERPTAYRLLCSLEEERFVERNIHSKRYRLGIDAMQLGAAAAEKAPIVDLVAPLMKKLARV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHC
SGDTVFLVVPQGDFTVCLHREEGPFPVRVFTTVPGQRRLLGIGAGGLALMSAMSDDAIRE
CCCEEEEEEECCCEEEEEECCCCCCCEEEEEECCCCCEEEEECCHHHHHHHHHCHHHHHH
VHKRKHALYAEAGMPISRLLAAAARSRRKGYAEIVDTITEGVSGVGCAFQLPFGASAAIS
HHHHHHHHHHHCCCCHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCEEEECCCCCHHHHH
FGAISSRMNASRRDELGALMVRELSTMNPAG
HHHHHHHHCCHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2185227; 1995431; 8265357; 9278503; 1995429 [H]