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The map label for this gene is cysM [H]

Identifier: 94309676

GI number: 94309676

Start: 808717

End: 809652

Strand: Direct

Name: cysM [H]

Synonym: Rmet_0731

Alternate gene names: 94309676

Gene position: 808717-809652 (Clockwise)

Preceding gene: 94309675

Following gene: 94309678

Centisome position: 20.59

GC content: 61.75

Gene sequence:

>936_bases
ATGGCCTGCGAAAAACCGACCGACTCCGCACCCATGGCATATAAAACGATTGAAGACACCATTGGCAACACGCCGTTGGT
CAGACTCCAACGCATTCCCGGCACCGCGATCGAGGCACGCGGCAATGTGATTCTCGGCAAGCTTGAAGGCAATAACCCGG
CAGGTTCGGTCAAGGACCGTCCGGCGGTGTCGATGATCCGCCATGCCGAGGCCCGTGGCCGCATCAAGCCCGGCGATACG
CTGATCGAAGCAACTTCCGGCAATACCGGCATCGCGCTGGCCATGGCCGCGGCTATCCGCGGCTATCGCATGGTCCTGAT
CATGCCCGAGGATCTGAGTCTCGAGCGTCGCCAGAGCATGGCGGCGTATGGCGCCGAGATCATCCTGACGCCGGTCAAGG
GTGGAATGGAATACGCCCGCGATCTGGCCGATGCCATGGAGCGTGACGGCAAGGGCGTGATCCTCGACCAGTTCGCCAAT
CCGGACAATCCGCTGGCGCACTACGAGACGACTGGCCCGGAGATCTGGAAGGACACCGACGGTCGCGTGACCCACTTCGT
TTCGGCGATGGGCACCACGGGCACGATCACCGGCGTGTCACGCTATCTGAAGGAAAAGAATCCGCTGATCCAGATCATTG
GCGCGCAGCCGGCGGAAGGTTCGCGTATCCCGGGTATCCGCAAATGGCCGGAAGCGTATCTGCCGAAGATCTACGATCCG
AAGTTCATTGATCGCCAGGAGCCCGTAACGCAGGCCGATGCGGAGCATATGGCTCGCCGCATGGCGCGTGAGGAAGGTAT
CTTTGCAGGTATCTCTGCCGCAGGCGCCCTGTGCGTGGCGCTGAGGATTGCCGAAGAAGTCGAGAATGCGACGATCGTGT
TCGTCGTGTGCGATCGCGGCGACCGCTATCTGTCGACGGGCGTGTTCCCGGCCTGA

Upstream 100 bases:

>100_bases
AGGAGCAGGGCCTGACGCATTGATCCACCAAAGGGAATCCCGCCGGCTGGCCGCCTGGAAATGGCCCGGCCGCCGGTGCG
GATAAGTTGGGTGCATTACA

Downstream 100 bases:

>100_bases
TCGCCCGGACTTGCCCTGAAAGAAAGGCCCCGCAGGCTTGCGCCGCGGGGCCTTTTTCTTTGCTCTTGCCGCTTGGCGTT
CAGGCCATGGCGGCCTTCAC

Product: cysteine synthase B

Products: NA

Alternate protein names: CSase B; O-acetylserine (thiol)-lyase B; OAS-TL B; O-acetylserine sulfhydrylase B [H]

Number of amino acids: Translated: 311; Mature: 310

Protein sequence:

>311_residues
MACEKPTDSAPMAYKTIEDTIGNTPLVRLQRIPGTAIEARGNVILGKLEGNNPAGSVKDRPAVSMIRHAEARGRIKPGDT
LIEATSGNTGIALAMAAAIRGYRMVLIMPEDLSLERRQSMAAYGAEIILTPVKGGMEYARDLADAMERDGKGVILDQFAN
PDNPLAHYETTGPEIWKDTDGRVTHFVSAMGTTGTITGVSRYLKEKNPLIQIIGAQPAEGSRIPGIRKWPEAYLPKIYDP
KFIDRQEPVTQADAEHMARRMAREEGIFAGISAAGALCVALRIAEEVENATIVFVVCDRGDRYLSTGVFPA

Sequences:

>Translated_311_residues
MACEKPTDSAPMAYKTIEDTIGNTPLVRLQRIPGTAIEARGNVILGKLEGNNPAGSVKDRPAVSMIRHAEARGRIKPGDT
LIEATSGNTGIALAMAAAIRGYRMVLIMPEDLSLERRQSMAAYGAEIILTPVKGGMEYARDLADAMERDGKGVILDQFAN
PDNPLAHYETTGPEIWKDTDGRVTHFVSAMGTTGTITGVSRYLKEKNPLIQIIGAQPAEGSRIPGIRKWPEAYLPKIYDP
KFIDRQEPVTQADAEHMARRMAREEGIFAGISAAGALCVALRIAEEVENATIVFVVCDRGDRYLSTGVFPA
>Mature_310_residues
ACEKPTDSAPMAYKTIEDTIGNTPLVRLQRIPGTAIEARGNVILGKLEGNNPAGSVKDRPAVSMIRHAEARGRIKPGDTL
IEATSGNTGIALAMAAAIRGYRMVLIMPEDLSLERRQSMAAYGAEIILTPVKGGMEYARDLADAMERDGKGVILDQFANP
DNPLAHYETTGPEIWKDTDGRVTHFVSAMGTTGTITGVSRYLKEKNPLIQIIGAQPAEGSRIPGIRKWPEAYLPKIYDPK
FIDRQEPVTQADAEHMARRMAREEGIFAGISAAGALCVALRIAEEVENATIVFVVCDRGDRYLSTGVFPA

Specific function: Two Cysteine Synthase Enzymes Are Found. Both Catalyze The Same Reaction. Cysteine Synthase B Can Also Use Thiosulfate In Place Of Sulfide To Give Cysteine Thiosulfonate As A Product. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=314, Percent_Identity=37.5796178343949, Blast_Score=190, Evalue=2e-48,
Organism=Homo sapiens, GI295821200, Length=314, Percent_Identity=37.5796178343949, Blast_Score=190, Evalue=2e-48,
Organism=Homo sapiens, GI4557415, Length=314, Percent_Identity=37.5796178343949, Blast_Score=190, Evalue=2e-48,
Organism=Escherichia coli, GI2367138, Length=294, Percent_Identity=61.2244897959184, Blast_Score=367, Evalue=1e-103,
Organism=Escherichia coli, GI1788754, Length=318, Percent_Identity=44.9685534591195, Blast_Score=210, Evalue=8e-56,
Organism=Caenorhabditis elegans, GI17535051, Length=305, Percent_Identity=44.5901639344262, Blast_Score=229, Evalue=9e-61,
Organism=Caenorhabditis elegans, GI17562970, Length=302, Percent_Identity=42.7152317880795, Blast_Score=216, Evalue=1e-56,
Organism=Caenorhabditis elegans, GI32566674, Length=297, Percent_Identity=43.4343434343434, Blast_Score=214, Evalue=6e-56,
Organism=Caenorhabditis elegans, GI115535073, Length=304, Percent_Identity=41.4473684210526, Blast_Score=201, Evalue=6e-52,
Organism=Caenorhabditis elegans, GI17561720, Length=302, Percent_Identity=41.3907284768212, Blast_Score=187, Evalue=6e-48,
Organism=Caenorhabditis elegans, GI25147552, Length=316, Percent_Identity=36.7088607594937, Blast_Score=154, Evalue=5e-38,
Organism=Caenorhabditis elegans, GI17534315, Length=318, Percent_Identity=36.7924528301887, Blast_Score=150, Evalue=7e-37,
Organism=Caenorhabditis elegans, GI32566672, Length=212, Percent_Identity=37.7358490566038, Blast_Score=141, Evalue=6e-34,
Organism=Saccharomyces cerevisiae, GI6321594, Length=322, Percent_Identity=37.2670807453416, Blast_Score=175, Evalue=8e-45,
Organism=Saccharomyces cerevisiae, GI6321449, Length=343, Percent_Identity=32.6530612244898, Blast_Score=136, Evalue=4e-33,
Organism=Drosophila melanogaster, GI24643623, Length=311, Percent_Identity=37.2990353697749, Blast_Score=174, Evalue=7e-44,
Organism=Drosophila melanogaster, GI20129101, Length=311, Percent_Identity=37.2990353697749, Blast_Score=174, Evalue=7e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR005856
- InterPro:   IPR005858
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 33679; Mature: 33548

Theoretical pI: Translated: 6.17; Mature: 6.17

Prosite motif: PS00901 CYS_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MACEKPTDSAPMAYKTIEDTIGNTPLVRLQRIPGTAIEARGNVILGKLEGNNPAGSVKDR
CCCCCCCCCCCEEHHHHHHHCCCCCEEEEECCCCCEEECCCCEEEEEECCCCCCCCCCCC
PAVSMIRHAEARGRIKPGDTLIEATSGNTGIALAMAAAIRGYRMVLIMPEDLSLERRQSM
HHHHHHHHHHHCCCCCCCCEEEEECCCCCCHHHHHHHHHCCEEEEEEECCCCCHHHHHHH
AAYGAEIILTPVKGGMEYARDLADAMERDGKGVILDQFANPDNPLAHYETTGPEIWKDTD
HHCCCEEEEEECCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCEEECCCCCCCCCCC
GRVTHFVSAMGTTGTITGVSRYLKEKNPLIQIIGAQPAEGSRIPGIRKWPEAYLPKIYDP
CHHHHHHHHCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCHHHCCCCCCC
KFIDRQEPVTQADAEHMARRMAREEGIFAGISAAGALCVALRIAEEVENATIVFVVCDRG
CCCCCCCCCHHHHHHHHHHHHHHHCCCEECHHHHHHHHHHHHHHHHHCCCEEEEEEECCC
DRYLSTGVFPA
CCEECCCCCCC
>Mature Secondary Structure 
ACEKPTDSAPMAYKTIEDTIGNTPLVRLQRIPGTAIEARGNVILGKLEGNNPAGSVKDR
CCCCCCCCCCEEHHHHHHHCCCCCEEEEECCCCCEEECCCCEEEEEECCCCCCCCCCCC
PAVSMIRHAEARGRIKPGDTLIEATSGNTGIALAMAAAIRGYRMVLIMPEDLSLERRQSM
HHHHHHHHHHHCCCCCCCCEEEEECCCCCCHHHHHHHHHCCEEEEEEECCCCCHHHHHHH
AAYGAEIILTPVKGGMEYARDLADAMERDGKGVILDQFANPDNPLAHYETTGPEIWKDTD
HHCCCEEEEEECCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCEEECCCCCCCCCCC
GRVTHFVSAMGTTGTITGVSRYLKEKNPLIQIIGAQPAEGSRIPGIRKWPEAYLPKIYDP
CHHHHHHHHCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCHHHCCCCCCC
KFIDRQEPVTQADAEHMARRMAREEGIFAGISAAGALCVALRIAEEVENATIVFVVCDRG
CCCCCCCCCHHHHHHHHHHHHHHHCCCEECHHHHHHHHHHHHHHHHHCCCEEEEEEECCC
DRYLSTGVFPA
CCEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]