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The map label for this gene is iorA [H]

Identifier: 94309539

GI number: 94309539

Start: 641064

End: 641522

Strand: Direct

Name: iorA [H]

Synonym: Rmet_0594

Alternate gene names: 94309539

Gene position: 641064-641522 (Clockwise)

Preceding gene: 94309538

Following gene: 94309540

Centisome position: 16.32

GC content: 66.67

Gene sequence:

>459_bases
ATGACTTCCCTCACCATCAACGGCAAGACCGTGGAGGTGGACGCCGATCCGTCCACGCCGCTGCTGTGGGCCCTGCGCGA
TAACCTCGGCATGACTGGCACCAAGTTCGGCTGCGGCATGGCCTCGTGCGGCGCCTGCACGGTCCATATCAACGGCACGG
CCACGCGTAGCTGCGTGATGCCGATTTCCGGCACCGCCGGCAGCAAGATCACCACGATCGAGGCGATGGGCGACGACAAG
GTCGGCCGCGCAGTGCTGGCCGCCTGGCTCAAGCACGACGTCGCGCAATGCGGCTACTGCCAGAACGGCCAGGTCATGAG
CGCGGTGGGTCTGCTGCGCAGCAAACCACGGCCGACTGACGCCGACATCGACCAGGCCATGGCCGGCAACGTCTGCCGCT
GTGGCACCTATCAACGGATTCGCGCGGCCATCAAGGACGCAGCGCACGCCATCGCCTGA

Upstream 100 bases:

>100_bases
TATGCTCCTCGGGTCTGCCGGCCTGGCCAGCCCCCGTGTCGCCAGGCCCGGCGGTAGATCGAACAACCGACTGGGCAATG
CACCCAAGGAGTTTCCCCCG

Downstream 100 bases:

>100_bases
GGAGCCAACATGCGAATTCGTGGGATTGAAGCACTGGCCGGCGGCAGCGGCGCAGCGGTGAAAACTGGCGATGCCGTGGC
GCCGCTGACGCGCCGTGGCT

Product: Isoquinoline 1-oxidoreductase subunit alpha

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 152; Mature: 151

Protein sequence:

>152_residues
MTSLTINGKTVEVDADPSTPLLWALRDNLGMTGTKFGCGMASCGACTVHINGTATRSCVMPISGTAGSKITTIEAMGDDK
VGRAVLAAWLKHDVAQCGYCQNGQVMSAVGLLRSKPRPTDADIDQAMAGNVCRCGTYQRIRAAIKDAAHAIA

Sequences:

>Translated_152_residues
MTSLTINGKTVEVDADPSTPLLWALRDNLGMTGTKFGCGMASCGACTVHINGTATRSCVMPISGTAGSKITTIEAMGDDK
VGRAVLAAWLKHDVAQCGYCQNGQVMSAVGLLRSKPRPTDADIDQAMAGNVCRCGTYQRIRAAIKDAAHAIA
>Mature_151_residues
TSLTINGKTVEVDADPSTPLLWALRDNLGMTGTKFGCGMASCGACTVHINGTATRSCVMPISGTAGSKITTIEAMGDDKV
GRAVLAAWLKHDVAQCGYCQNGQVMSAVGLLRSKPRPTDADIDQAMAGNVCRCGTYQRIRAAIKDAAHAIA

Specific function: Specific towards N-containing N-heterocyclic substrates, including isoquinoline, isoquinolin-5-ol, phthalazine and quinazoline [H]

COG id: COG2080

COG function: function code C; Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 2Fe-2S ferredoxin-type domain [H]

Homologues:

Organism=Homo sapiens, GI91823271, Length=147, Percent_Identity=40.1360544217687, Blast_Score=83, Evalue=7e-17,
Organism=Homo sapiens, GI71773480, Length=152, Percent_Identity=36.1842105263158, Blast_Score=69, Evalue=1e-12,
Organism=Escherichia coli, GI1786480, Length=164, Percent_Identity=42.0731707317073, Blast_Score=127, Evalue=4e-31,
Organism=Escherichia coli, GI1789232, Length=147, Percent_Identity=39.4557823129252, Blast_Score=93, Evalue=6e-21,
Organism=Caenorhabditis elegans, GI17540638, Length=149, Percent_Identity=42.2818791946309, Blast_Score=114, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI17539860, Length=152, Percent_Identity=33.5526315789474, Blast_Score=96, Evalue=6e-21,
Organism=Caenorhabditis elegans, GI32566215, Length=153, Percent_Identity=33.9869281045752, Blast_Score=92, Evalue=1e-19,
Organism=Drosophila melanogaster, GI17737937, Length=152, Percent_Identity=38.1578947368421, Blast_Score=100, Evalue=5e-22,
Organism=Drosophila melanogaster, GI24647193, Length=162, Percent_Identity=35.1851851851852, Blast_Score=88, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24647201, Length=156, Percent_Identity=33.3333333333333, Blast_Score=77, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24647199, Length=156, Percent_Identity=31.4102564102564, Blast_Score=75, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24647197, Length=160, Percent_Identity=30.625, Blast_Score=73, Evalue=9e-14,
Organism=Drosophila melanogaster, GI24647195, Length=160, Percent_Identity=30.625, Blast_Score=72, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002888
- InterPro:   IPR006058
- InterPro:   IPR012675
- InterPro:   IPR001041 [H]

Pfam domain/function: PF00111 Fer2; PF01799 Fer2_2 [H]

EC number: =1.3.99.16 [H]

Molecular weight: Translated: 15817; Mature: 15686

Theoretical pI: Translated: 8.21; Mature: 8.21

Prosite motif: PS00197 2FE2S_FER_1 ; PS51085 2FE2S_FER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

5.3 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
9.9 %Cys+Met (Translated Protein)
5.3 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
9.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSLTINGKTVEVDADPSTPLLWALRDNLGMTGTKFGCGMASCGACTVHINGTATRSCVM
CCEEECCCEEEEEECCCCCCEEEEEECCCCCCCCCCCCCCCCCCEEEEEECCCCCCEEEE
PISGTAGSKITTIEAMGDDKVGRAVLAAWLKHDVAQCGYCQNGQVMSAVGLLRSKPRPTD
EECCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCC
ADIDQAMAGNVCRCGTYQRIRAAIKDAAHAIA
CCHHHHHCCCEECCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TSLTINGKTVEVDADPSTPLLWALRDNLGMTGTKFGCGMASCGACTVHINGTATRSCVM
CEEECCCEEEEEECCCCCCEEEEEECCCCCCCCCCCCCCCCCCEEEEEECCCCCCEEEE
PISGTAGSKITTIEAMGDDKVGRAVLAAWLKHDVAQCGYCQNGQVMSAVGLLRSKPRPTD
EECCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCC
ADIDQAMAGNVCRCGTYQRIRAAIKDAAHAIA
CCHHHHHCCCEECCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7782304; 8157655 [H]