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The map label for this gene is iorB [H]

Identifier: 94309540

GI number: 94309540

Start: 641532

End: 643784

Strand: Direct

Name: iorB [H]

Synonym: Rmet_0595

Alternate gene names: 94309540

Gene position: 641532-643784 (Clockwise)

Preceding gene: 94309539

Following gene: 94309543

Centisome position: 16.33

GC content: 66.93

Gene sequence:

>2253_bases
ATGCGAATTCGTGGGATTGAAGCACTGGCCGGCGGCAGCGGCGCAGCGGTGAAAACTGGCGATGCCGTGGCGCCGCTGAC
GCGCCGTGGCTTCCTCAAACTGACCGGCATGGCCGGTGGCGGGCTGGCGCTCGGCATCGGTAGCGTCGTGGAATCGGCCC
ATGCGCAGGGTGCGGCCAAGCCGGCTTCCTCGCCGCAGGCCTTTCTGCAGATCGCGCCGGACAACACCGTGACGGTTGCC
GTGAACCGGCTCGAATTCGGCCAGGGCGTGCACACCGCGCTGCCGATGGCGCTGGCCGAGGAGCTCGACGTCGACTGGAA
GAACGTGCGCGCGATCCTGGCGCCGGCAGGCGATCCTTACAAGGACCCGATGTTCGGCATCCAGATGACCGGCGGCTCCA
CGGCGGTCAATCATTCGTTCGAACAGTACCGCGAGCTGGGCGCGCGGGCGCGCGCGATGCTGATCGCCGCGGCGGCCCAG
CAGTGGAAGGTGGACCCGGCAAGCTGCGCGACGTCGCTCGGCGTGGTGACTTCGGGCGCCAACCGCGCCACGTATGGCGA
ATTGGCGCAGGCCGCCATGGCGCAGCCGGTGCCGGCGCAGGTCAAGCTCAAGGACCCGGCGCAGTTCCGCATCGTCGGCA
AGCCGACGCCGCGCCTGGATGCCGCTTCCAAGCTGCATGGCGATGGCGTGTTCGGGCTGGACGTGAAGCTCAAGGATATG
AAGGTGGCCGTGGTGGCCCATCCGCCGCGCTTCGGTGGCAAGGTCAAGTCGTTCAATGCGGACAAGGCGCGCAAGATCAA
GGGCGTGGCCGATGTCTTCCTGGTGCCCGTCGATCGTGGTGGCACCGGCGTGGCGGTGGTGGCCGATGGCTACTGGCCGG
CGAAGACCGCGCGCGAGGCACTGGAAATCGTCTGGGAAGACGCAGGCTCGAAGGTCAGTTCGGCGGCGCTGTTCGATGAG
TACAGCAAGCTGGCCGCGCAGCCGGGCACCGTGGCCAGGGCGCTGGAAGGCGGCAACATCGACACGGCGCTGTCCGGCGC
CGCGAAGGTGATCGAGGCCGAGTACCGCGTGCCGTACCTGGCCCATGCGCCGATGGAACCGTTGAACTGCACGATGCAGG
CCGAGATCGCCGCGAACAAGGCCACGGCCGTCAAGGTGTGGGTGGGCTCGCAGTTCCAGACCATCGACCAGGCCGCGATC
GCCCGCACGCTGGGGCTCACGCCGGACAAGGTCACGCTCAACACGATGATGGCGGGCGGCGGCTTCGGACGCCGTGCCGT
ACCGACTTCCGACTATCTGGTGGAATCGGCCAACGTGATGCGTAGCTGGATCGCCGCTGGCCACACCGAACCGCTCAAGG
TGATGTGGAGCCGTGAGGACGACATCAAGGGTGGCTACTACCGTCCGCTGCACGTGCACCGCGCGCGCGTCGGTGTGGAC
GCGCAAGGCAAGGTGGTGGGTTGGCAGCATACGATCGTCGGCCAGTCGATCATCACCGGCACGCCGTTCGAGCCGATGAT
GGTCAAGAACGGCGTCGATGCGACCATGGTCGAGGGCATCATCGAAAACGACTACGGCCTGCCGCTGCAGCTGAACGTGC
ATCACCCGAAGACCGATGTGCCCGTACTCTGGTGGCGCTCCGTGGGCAACACGCACACGGCGTTCGTCAAGGAAACGCTG
GCCGACGAGATGGCCACTGCCGCCAAGCAGGACCCCGTGGCATGGCGCATGGCGCGGCTCGACGAGAAGGCGCACGCACG
TCATCGCGCGGCGCTCCAGCTTGCCGTGGACAAGTCGGGCTACGGCAAGAAGAAATTGCCCAAGGGACACGCCTGGGGCG
TGGCCGTGCATGAATCGTTCGGCTCGGTGGTGGCGTACGTGGTCGACGTGTCGATCGAGAAGGGCCAGCCGAAGGTGCAC
CGCGTCACGGCGGGTGTGCATGCCAACCGCGTGGTCAACCCGCTGACCGCGGAAGCCCAGGTCCAGGGCGGCTGCGTGTT
CGGCATATCGATGACCAAGCCCGGGTTTGCGATCGAGATCGAGAACGGCGTGGTGAAGAACAGCAACTTCCCCGACTATC
CGCCTCCCCGCATTACCGATGCGCCAGTGGTGGACGTGTTCTTCGTGCCGTCGAACGACAACCCGACCGGGCTCGGCGAG
CCGGGCGTTCCGGCGATCTCGCCGGCGATCGCCAACGCGCTGTTCCGGCTGACGGGCAAGCGTCAGCGTCAGATGCCGTT
TGTGCTGACCTGA

Upstream 100 bases:

>100_bases
CGACCAGGCCATGGCCGGCAACGTCTGCCGCTGTGGCACCTATCAACGGATTCGCGCGGCCATCAAGGACGCAGCGCACG
CCATCGCCTGAGGAGCCAAC

Downstream 100 bases:

>100_bases
GCGTTTGCGCGTTTGCGTGTTTGCGTTAAGGTGGGTTTGCGCCCCCGCTCCTACAAATGGGAGCGGGGGCGCACAACACG
AGCAATCCCACGGCTCCTAG

Product: Isoquinoline 1-oxidoreductase subunit beta

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 750; Mature: 750

Protein sequence:

>750_residues
MRIRGIEALAGGSGAAVKTGDAVAPLTRRGFLKLTGMAGGGLALGIGSVVESAHAQGAAKPASSPQAFLQIAPDNTVTVA
VNRLEFGQGVHTALPMALAEELDVDWKNVRAILAPAGDPYKDPMFGIQMTGGSTAVNHSFEQYRELGARARAMLIAAAAQ
QWKVDPASCATSLGVVTSGANRATYGELAQAAMAQPVPAQVKLKDPAQFRIVGKPTPRLDAASKLHGDGVFGLDVKLKDM
KVAVVAHPPRFGGKVKSFNADKARKIKGVADVFLVPVDRGGTGVAVVADGYWPAKTAREALEIVWEDAGSKVSSAALFDE
YSKLAAQPGTVARALEGGNIDTALSGAAKVIEAEYRVPYLAHAPMEPLNCTMQAEIAANKATAVKVWVGSQFQTIDQAAI
ARTLGLTPDKVTLNTMMAGGGFGRRAVPTSDYLVESANVMRSWIAAGHTEPLKVMWSREDDIKGGYYRPLHVHRARVGVD
AQGKVVGWQHTIVGQSIITGTPFEPMMVKNGVDATMVEGIIENDYGLPLQLNVHHPKTDVPVLWWRSVGNTHTAFVKETL
ADEMATAAKQDPVAWRMARLDEKAHARHRAALQLAVDKSGYGKKKLPKGHAWGVAVHESFGSVVAYVVDVSIEKGQPKVH
RVTAGVHANRVVNPLTAEAQVQGGCVFGISMTKPGFAIEIENGVVKNSNFPDYPPPRITDAPVVDVFFVPSNDNPTGLGE
PGVPAISPAIANALFRLTGKRQRQMPFVLT

Sequences:

>Translated_750_residues
MRIRGIEALAGGSGAAVKTGDAVAPLTRRGFLKLTGMAGGGLALGIGSVVESAHAQGAAKPASSPQAFLQIAPDNTVTVA
VNRLEFGQGVHTALPMALAEELDVDWKNVRAILAPAGDPYKDPMFGIQMTGGSTAVNHSFEQYRELGARARAMLIAAAAQ
QWKVDPASCATSLGVVTSGANRATYGELAQAAMAQPVPAQVKLKDPAQFRIVGKPTPRLDAASKLHGDGVFGLDVKLKDM
KVAVVAHPPRFGGKVKSFNADKARKIKGVADVFLVPVDRGGTGVAVVADGYWPAKTAREALEIVWEDAGSKVSSAALFDE
YSKLAAQPGTVARALEGGNIDTALSGAAKVIEAEYRVPYLAHAPMEPLNCTMQAEIAANKATAVKVWVGSQFQTIDQAAI
ARTLGLTPDKVTLNTMMAGGGFGRRAVPTSDYLVESANVMRSWIAAGHTEPLKVMWSREDDIKGGYYRPLHVHRARVGVD
AQGKVVGWQHTIVGQSIITGTPFEPMMVKNGVDATMVEGIIENDYGLPLQLNVHHPKTDVPVLWWRSVGNTHTAFVKETL
ADEMATAAKQDPVAWRMARLDEKAHARHRAALQLAVDKSGYGKKKLPKGHAWGVAVHESFGSVVAYVVDVSIEKGQPKVH
RVTAGVHANRVVNPLTAEAQVQGGCVFGISMTKPGFAIEIENGVVKNSNFPDYPPPRITDAPVVDVFFVPSNDNPTGLGE
PGVPAISPAIANALFRLTGKRQRQMPFVLT
>Mature_750_residues
MRIRGIEALAGGSGAAVKTGDAVAPLTRRGFLKLTGMAGGGLALGIGSVVESAHAQGAAKPASSPQAFLQIAPDNTVTVA
VNRLEFGQGVHTALPMALAEELDVDWKNVRAILAPAGDPYKDPMFGIQMTGGSTAVNHSFEQYRELGARARAMLIAAAAQ
QWKVDPASCATSLGVVTSGANRATYGELAQAAMAQPVPAQVKLKDPAQFRIVGKPTPRLDAASKLHGDGVFGLDVKLKDM
KVAVVAHPPRFGGKVKSFNADKARKIKGVADVFLVPVDRGGTGVAVVADGYWPAKTAREALEIVWEDAGSKVSSAALFDE
YSKLAAQPGTVARALEGGNIDTALSGAAKVIEAEYRVPYLAHAPMEPLNCTMQAEIAANKATAVKVWVGSQFQTIDQAAI
ARTLGLTPDKVTLNTMMAGGGFGRRAVPTSDYLVESANVMRSWIAAGHTEPLKVMWSREDDIKGGYYRPLHVHRARVGVD
AQGKVVGWQHTIVGQSIITGTPFEPMMVKNGVDATMVEGIIENDYGLPLQLNVHHPKTDVPVLWWRSVGNTHTAFVKETL
ADEMATAAKQDPVAWRMARLDEKAHARHRAALQLAVDKSGYGKKKLPKGHAWGVAVHESFGSVVAYVVDVSIEKGQPKVH
RVTAGVHANRVVNPLTAEAQVQGGCVFGISMTKPGFAIEIENGVVKNSNFPDYPPPRITDAPVVDVFFVPSNDNPTGLGE
PGVPAISPAIANALFRLTGKRQRQMPFVLT

Specific function: Specific towards N-containing N-heterocyclic substrates, including isoquinoline, isoquinolin-5-ol, phthalazine and quinazoline [H]

COG id: COG1529

COG function: function code C; Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000674
- InterPro:   IPR008274
- InterPro:   IPR012368
- InterPro:   IPR006311 [H]

Pfam domain/function: PF02738 Ald_Xan_dh_C2 [H]

EC number: =1.3.99.16 [H]

Molecular weight: Translated: 79537; Mature: 79537

Theoretical pI: Translated: 9.70; Mature: 9.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIRGIEALAGGSGAAVKTGDAVAPLTRRGFLKLTGMAGGGLALGIGSVVESAHAQGAAK
CCCCCEEEECCCCCCEEECCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCC
PASSPQAFLQIAPDNTVTVAVNRLEFGQGVHTALPMALAEELDVDWKNVRAILAPAGDPY
CCCCCCEEEEECCCCEEEEEEEEEECCCCHHHHHHHHHHHHCCCCHHHEEEEEECCCCCC
KDPMFGIQMTGGSTAVNHSFEQYRELGARARAMLIAAAAQQWKVDPASCATSLGVVTSGA
CCCCEEEEECCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHEEECCC
NRATYGELAQAAMAQPVPAQVKLKDPAQFRIVGKPTPRLDAASKLHGDGVFGLDVKLKDM
CCCHHHHHHHHHHCCCCCCEEEECCCCEEEEECCCCCCCCHHHHHCCCCEEEEEEEEECE
KVAVVAHPPRFGGKVKSFNADKARKIKGVADVFLVPVDRGGTGVAVVADGYWPAKTAREA
EEEEEECCCCCCCEEECCCCCHHHHHCCCEEEEEEEECCCCCEEEEEECCCCCHHHHHHH
LEIVWEDAGSKVSSAALFDEYSKLAAQPGTVARALEGGNIDTALSGAAKVIEAEYRVPYL
HHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCHHHHHHHHHHHHHCCCCEE
AHAPMEPLNCTMQAEIAANKATAVKVWVGSQFQTIDQAAIARTLGLTPDKVTLNTMMAGG
ECCCCCCCCCEEEEEEECCCCEEEEEEECCCHHHHHHHHHHHHHCCCCCCEEEEEEEECC
GFGRRAVPTSDYLVESANVMRSWIAAGHTEPLKVMWSREDDIKGGYYRPLHVHRARVGVD
CCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCEECCEEEEEEEECCC
AQGKVVGWQHTIVGQSIITGTPFEPMMVKNGVDATMVEGIIENDYGLPLQLNVHHPKTDV
CCCCEEEEEEEECCCCEECCCCCCCCEECCCCCHHHHHHHHCCCCCCEEEEEECCCCCCC
PVLWWRSVGNTHTAFVKETLADEMATAAKQDPVAWRMARLDEKAHARHRAALQLAVDKSG
CEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCHHHHHHHHEEEEEEECCCC
YGKKKLPKGHAWGVAVHESFGSVVAYVVDVSIEKGQPKVHRVTAGVHANRVVNPLTAEAQ
CCCCCCCCCCCEEEEEHHHHHCEEEEEEEEEECCCCCCEEEEECCCCCCCCCCCCCCCEE
VQGGCVFGISMTKPGFAIEIENGVVKNSNFPDYPPPRITDAPVVDVFFVPSNDNPTGLGE
ECCCEEEEEEECCCCEEEEECCCEEECCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCCC
PGVPAISPAIANALFRLTGKRQRQMPFVLT
CCCCCCCHHHHHHHHHHCCCHHHCCCCEEC
>Mature Secondary Structure
MRIRGIEALAGGSGAAVKTGDAVAPLTRRGFLKLTGMAGGGLALGIGSVVESAHAQGAAK
CCCCCEEEECCCCCCEEECCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCC
PASSPQAFLQIAPDNTVTVAVNRLEFGQGVHTALPMALAEELDVDWKNVRAILAPAGDPY
CCCCCCEEEEECCCCEEEEEEEEEECCCCHHHHHHHHHHHHCCCCHHHEEEEEECCCCCC
KDPMFGIQMTGGSTAVNHSFEQYRELGARARAMLIAAAAQQWKVDPASCATSLGVVTSGA
CCCCEEEEECCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHEEECCC
NRATYGELAQAAMAQPVPAQVKLKDPAQFRIVGKPTPRLDAASKLHGDGVFGLDVKLKDM
CCCHHHHHHHHHHCCCCCCEEEECCCCEEEEECCCCCCCCHHHHHCCCCEEEEEEEEECE
KVAVVAHPPRFGGKVKSFNADKARKIKGVADVFLVPVDRGGTGVAVVADGYWPAKTAREA
EEEEEECCCCCCCEEECCCCCHHHHHCCCEEEEEEEECCCCCEEEEEECCCCCHHHHHHH
LEIVWEDAGSKVSSAALFDEYSKLAAQPGTVARALEGGNIDTALSGAAKVIEAEYRVPYL
HHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCHHHHHHHHHHHHHCCCCEE
AHAPMEPLNCTMQAEIAANKATAVKVWVGSQFQTIDQAAIARTLGLTPDKVTLNTMMAGG
ECCCCCCCCCEEEEEEECCCCEEEEEEECCCHHHHHHHHHHHHHCCCCCCEEEEEEEECC
GFGRRAVPTSDYLVESANVMRSWIAAGHTEPLKVMWSREDDIKGGYYRPLHVHRARVGVD
CCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCEECCEEEEEEEECCC
AQGKVVGWQHTIVGQSIITGTPFEPMMVKNGVDATMVEGIIENDYGLPLQLNVHHPKTDV
CCCCEEEEEEEECCCCEECCCCCCCCEECCCCCHHHHHHHHCCCCCCEEEEEECCCCCCC
PVLWWRSVGNTHTAFVKETLADEMATAAKQDPVAWRMARLDEKAHARHRAALQLAVDKSG
CEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCHHHHHHHHEEEEEEECCCC
YGKKKLPKGHAWGVAVHESFGSVVAYVVDVSIEKGQPKVHRVTAGVHANRVVNPLTAEAQ
CCCCCCCCCCCEEEEEHHHHHCEEEEEEEEEECCCCCCEEEEECCCCCCCCCCCCCCCEE
VQGGCVFGISMTKPGFAIEIENGVVKNSNFPDYPPPRITDAPVVDVFFVPSNDNPTGLGE
ECCCEEEEEEECCCCEEEEECCCEEECCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCCC
PGVPAISPAIANALFRLTGKRQRQMPFVLT
CCCCCCCHHHHHHHHHHCCCHHHCCCCEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7782304; 8157655 [H]