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The map label for this gene is csgA [H]

Identifier: 94309052

GI number: 94309052

Start: 114493

End: 115173

Strand: Direct

Name: csgA [H]

Synonym: Rmet_0107

Alternate gene names: 94309052

Gene position: 114493-115173 (Clockwise)

Preceding gene: 94309051

Following gene: 94309053

Centisome position: 2.91

GC content: 68.43

Gene sequence:

>681_bases
ATGCCCACCGCTCTCGTCCTCGGCGCCTCGCGCGGCCTGGGTCTCGAATTTGTCCGGCAGTACCGCGCCGATGGCTGGCG
CGTCATCGCCGCCGCGCGTAGCGACGAGGGCGTTGCCGCGCTCACGGCGCTCGGCGCGGAAGCGCACAAGCTCGACCTCA
CCGACGCGGCCGCCGTGGCGGGGCTCGCCTGGAAGCTCGATGGCGAGACGCTGGACGTGGCGATCTACAACGCCGGCGTG
ATCGGCCCGCGTTCGGAAACGGCGGAACCGGTGACCCGCGAGGAATTCGACGCGGTGATGCACACCAACGTGCTCGGTCC
GATGATGGCGCTGCCGGTGCTGCTGCCGTTCGTCGAATCCGGCAATCATGGCCGCGGTGGCGTGCTGGCGGTGCTGTCGT
CGCGCATGGGCAGCATCGGCGCGATGGACAGCAACCGTAGCTGGCTCTATCGCGTGAGCAAGGCATCGGTGAACGCCGCG
CTGAAGTCCGTTTCGCTCGATGCGCGCCATGCGATCTGCGTGGCACTGCATCCGGGCTGGGTGCAGACCGACATGGGTGG
CCCGAAAGCCGACCTCACGCCGCAGCAGAGCGTGGCGGGTATGCGCCGCGTGCTGGCCGGCGTAGCGCGTCACGATAACG
GCAGCTTCCACAACTACGACGGTACGTCGATTCCCTGGTAA

Upstream 100 bases:

>100_bases
CTCTGCATCGGCGGCGGCGAAGCCACTGCGGTCGGCATCGAACTCTACTGAAGTTACGGACGTTACTGACGCGCTCGCAA
TCATCCACAGGAGGCTGAAC

Downstream 100 bases:

>100_bases
GAGACCCGGTACAACATGCTGCTGACCCCTGAACAGGAAATGATCCGTGACGCCGTGCGGCAGTTCGCGCAGGACGTCAT
CGCGCCGCAGGCCGCCCGAT

Product: short chain dehydrogenase

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: C signal [H]

Number of amino acids: Translated: 226; Mature: 225

Protein sequence:

>226_residues
MPTALVLGASRGLGLEFVRQYRADGWRVIAAARSDEGVAALTALGAEAHKLDLTDAAAVAGLAWKLDGETLDVAIYNAGV
IGPRSETAEPVTREEFDAVMHTNVLGPMMALPVLLPFVESGNHGRGGVLAVLSSRMGSIGAMDSNRSWLYRVSKASVNAA
LKSVSLDARHAICVALHPGWVQTDMGGPKADLTPQQSVAGMRRVLAGVARHDNGSFHNYDGTSIPW

Sequences:

>Translated_226_residues
MPTALVLGASRGLGLEFVRQYRADGWRVIAAARSDEGVAALTALGAEAHKLDLTDAAAVAGLAWKLDGETLDVAIYNAGV
IGPRSETAEPVTREEFDAVMHTNVLGPMMALPVLLPFVESGNHGRGGVLAVLSSRMGSIGAMDSNRSWLYRVSKASVNAA
LKSVSLDARHAICVALHPGWVQTDMGGPKADLTPQQSVAGMRRVLAGVARHDNGSFHNYDGTSIPW
>Mature_225_residues
PTALVLGASRGLGLEFVRQYRADGWRVIAAARSDEGVAALTALGAEAHKLDLTDAAAVAGLAWKLDGETLDVAIYNAGVI
GPRSETAEPVTREEFDAVMHTNVLGPMMALPVLLPFVESGNHGRGGVLAVLSSRMGSIGAMDSNRSWLYRVSKASVNAAL
KSVSLDARHAICVALHPGWVQTDMGGPKADLTPQQSVAGMRRVLAGVARHDNGSFHNYDGTSIPW

Specific function: Cell-cell signaling protein required for fruiting body morphogenesis. Necessary for cellular aggregation, for spore differentiation, and for gene expression that is initiated after 6 hour of starvation [H]

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: To yeast YKL071W [H]

Homologues:

Organism=Caenorhabditis elegans, GI17558996, Length=248, Percent_Identity=28.6290322580645, Blast_Score=89, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17559962, Length=245, Percent_Identity=29.3877551020408, Blast_Score=77, Evalue=8e-15,
Organism=Caenorhabditis elegans, GI17558990, Length=247, Percent_Identity=26.7206477732794, Blast_Score=74, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI193207563, Length=243, Percent_Identity=28.8065843621399, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17558994, Length=250, Percent_Identity=27.6, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17532177, Length=234, Percent_Identity=26.4957264957265, Blast_Score=70, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17559964, Length=243, Percent_Identity=27.1604938271605, Blast_Score=70, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17558992, Length=238, Percent_Identity=31.0924369747899, Blast_Score=69, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17541382, Length=247, Percent_Identity=25.5060728744939, Blast_Score=64, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6322779, Length=252, Percent_Identity=28.1746031746032, Blast_Score=77, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24640547, Length=250, Percent_Identity=32, Blast_Score=109, Evalue=1e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 23809; Mature: 23678

Theoretical pI: Translated: 6.89; Mature: 6.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTALVLGASRGLGLEFVRQYRADGWRVIAAARSDEGVAALTALGAEAHKLDLTDAAAVA
CCCEEEEECCCCCCHHHHHHHCCCCEEEEEEECCCCCEEEHHHHCCCCEEECCHHHHHHH
GLAWKLDGETLDVAIYNAGVIGPRSETAEPVTREEFDAVMHTNVLGPMMALPVLLPFVES
HEEEEECCCEEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GNHGRGGVLAVLSSRMGSIGAMDSNRSWLYRVSKASVNAALKSVSLDARHAICVALHPGW
CCCCCCHHHHHHHHHCCCCCCCCCCCCEEEEEHHHHHHHHHHHCCCCCCEEEEEEECCCE
VQTDMGGPKADLTPQQSVAGMRRVLAGVARHDNGSFHNYDGTSIPW
EEECCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEECCCCCCCCC
>Mature Secondary Structure 
PTALVLGASRGLGLEFVRQYRADGWRVIAAARSDEGVAALTALGAEAHKLDLTDAAAVA
CCEEEEECCCCCCHHHHHHHCCCCEEEEEEECCCCCEEEHHHHCCCCEEECCHHHHHHH
GLAWKLDGETLDVAIYNAGVIGPRSETAEPVTREEFDAVMHTNVLGPMMALPVLLPFVES
HEEEEECCCEEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GNHGRGGVLAVLSSRMGSIGAMDSNRSWLYRVSKASVNAALKSVSLDARHAICVALHPGW
CCCCCCHHHHHHHHHCCCCCCCCCCCCEEEEEHHHHHHHHHHHCCCCCCEEEEEEECCCE
VQTDMGGPKADLTPQQSVAGMRRVLAGVARHDNGSFHNYDGTSIPW
EEECCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2152896; 2107980; 2118510; 1372277 [H]