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The map label for this gene is atoB [H]

Identifier: 94309051

GI number: 94309051

Start: 113259

End: 114443

Strand: Direct

Name: atoB [H]

Synonym: Rmet_0106

Alternate gene names: 94309051

Gene position: 113259-114443 (Clockwise)

Preceding gene: 94309050

Following gene: 94309052

Centisome position: 2.88

GC content: 66.41

Gene sequence:

>1185_bases
ATGCAGAAGGACCCAGTCGTTATCGTTTCCGCGGTGCGTACCCCGATGGGTGCGTTCCAGAGTGAACTGAGCAGTCTGAT
GGCGCCGCAGCTTGGCGCCGCCGCGATCCGCGCGGCGGTTGAGCGCGCGGGCATCAAGCCTGAGCAGGTGCAGGAGGTGG
TGTTCGGCTGTGTGCTGCCAGCCGGACAGGGTCAGGCGCCCGCCCGACAGGCCGCGCTTGGCGCGGGCCTGCCGCTCGAC
GTGGCGTGTACCACCGTCAACAAGATGTGCGGCTCCGGCATGCGTGCGGCGATGAGCGTCTACGACGGCCTGCTGGCCGG
ATCGTTCGATATCGCCGTGGCCGGCGGCATGGAAAGCATGACCAACGCGCCATACCTGGTGCCGAAGGCGCGTGGTGGCT
ATCGCATCGGCCACGGCATGATCTACGACCACATGATGCTGGACGGCCTGGAGGACGCGTACGACAAGGGCCGGGCCATG
GGCACTTTCGGCGAGGACTGCGCCGCCAAGTACCACTTCACGCGCGAACAGCAGGATGCGTTCGCGATGGAGTCGGTGCG
CCGCGCCCAGCGTGCCACCGAGCAGGGCGACTTCCGCTGGGAGATCGTGCCGGTGACGGTGTCGGGCAAGGGTGGCGATA
CCGTCATCGACACCGATGAGGGGCCGCGCCGCATCAAGGTCGACAAGATCCCGTCGCTGAAGCCGGCGTTTGCCAAGGAC
GGCACGATTACCGCTGCGTCGTCGTCGTCGATCAATGACGGCGCCTCGGCGCTGGTGATGATGCGCGAATCCACCGCGAA
ATCGCTCGGGTTGCAGCCAATCGCCAGAATGCTCGGCCATACCTCCCACGCACAGGCGCCGGGCTGGTTCACCACCGCGC
CGGTGGAGGCCATCGCCAAGCTGTATCGCAAGCTCGACTGGAACACTGGCAGCGTCGATCTGTTCGAAATCAACGAGGCC
TTTGCCGTGGTGCCGATGGCCGCGATGCACGATCTCGACATTCCGCGCGACAAGGTCAACATCCATGGCGGCGCATGCGC
GCTGGGCCATCCGATCGGCGCGTCCGGCGCACGTATCATGACCACGCTGATCGGCGCATTGCGCAAGACCGGCGGCAAGC
GCGGCGTGGCCAGCCTCTGCATCGGCGGCGGCGAAGCCACTGCGGTCGGCATCGAACTCTACTGA

Upstream 100 bases:

>100_bases
CGCAGATTGCAGCCGCGCTGCGCCAGTACGGCGATCCGCCACAAGCATCGATTCGCTGATTTCAACCCACGAAGCTCCAC
CCCTGCTTCAGGAGACAGAC

Downstream 100 bases:

>100_bases
AGTTACGGACGTTACTGACGCGCTCGCAATCATCCACAGGAGGCTGAACATGCCCACCGCTCTCGTCCTCGGCGCCTCGC
GCGGCCTGGGTCTCGAATTT

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetoacetyl-CoA thiolase [H]

Number of amino acids: Translated: 394; Mature: 394

Protein sequence:

>394_residues
MQKDPVVIVSAVRTPMGAFQSELSSLMAPQLGAAAIRAAVERAGIKPEQVQEVVFGCVLPAGQGQAPARQAALGAGLPLD
VACTTVNKMCGSGMRAAMSVYDGLLAGSFDIAVAGGMESMTNAPYLVPKARGGYRIGHGMIYDHMMLDGLEDAYDKGRAM
GTFGEDCAAKYHFTREQQDAFAMESVRRAQRATEQGDFRWEIVPVTVSGKGGDTVIDTDEGPRRIKVDKIPSLKPAFAKD
GTITAASSSSINDGASALVMMRESTAKSLGLQPIARMLGHTSHAQAPGWFTTAPVEAIAKLYRKLDWNTGSVDLFEINEA
FAVVPMAAMHDLDIPRDKVNIHGGACALGHPIGASGARIMTTLIGALRKTGGKRGVASLCIGGGEATAVGIELY

Sequences:

>Translated_394_residues
MQKDPVVIVSAVRTPMGAFQSELSSLMAPQLGAAAIRAAVERAGIKPEQVQEVVFGCVLPAGQGQAPARQAALGAGLPLD
VACTTVNKMCGSGMRAAMSVYDGLLAGSFDIAVAGGMESMTNAPYLVPKARGGYRIGHGMIYDHMMLDGLEDAYDKGRAM
GTFGEDCAAKYHFTREQQDAFAMESVRRAQRATEQGDFRWEIVPVTVSGKGGDTVIDTDEGPRRIKVDKIPSLKPAFAKD
GTITAASSSSINDGASALVMMRESTAKSLGLQPIARMLGHTSHAQAPGWFTTAPVEAIAKLYRKLDWNTGSVDLFEINEA
FAVVPMAAMHDLDIPRDKVNIHGGACALGHPIGASGARIMTTLIGALRKTGGKRGVASLCIGGGEATAVGIELY
>Mature_394_residues
MQKDPVVIVSAVRTPMGAFQSELSSLMAPQLGAAAIRAAVERAGIKPEQVQEVVFGCVLPAGQGQAPARQAALGAGLPLD
VACTTVNKMCGSGMRAAMSVYDGLLAGSFDIAVAGGMESMTNAPYLVPKARGGYRIGHGMIYDHMMLDGLEDAYDKGRAM
GTFGEDCAAKYHFTREQQDAFAMESVRRAQRATEQGDFRWEIVPVTVSGKGGDTVIDTDEGPRRIKVDKIPSLKPAFAKD
GTITAASSSSINDGASALVMMRESTAKSLGLQPIARMLGHTSHAQAPGWFTTAPVEAIAKLYRKLDWNTGSVDLFEINEA
FAVVPMAAMHDLDIPRDKVNIHGGACALGHPIGASGARIMTTLIGALRKTGGKRGVASLCIGGGEATAVGIELY

Specific function: SHORT-CHAIN FATTY ACIDS METABOLISM. [C]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI4557237, Length=389, Percent_Identity=46.5295629820051, Blast_Score=328, Evalue=4e-90,
Organism=Homo sapiens, GI148539872, Length=392, Percent_Identity=43.8775510204082, Blast_Score=310, Evalue=2e-84,
Organism=Homo sapiens, GI167614485, Length=389, Percent_Identity=34.7043701799486, Blast_Score=235, Evalue=5e-62,
Organism=Homo sapiens, GI4501853, Length=370, Percent_Identity=36.7567567567568, Blast_Score=210, Evalue=2e-54,
Organism=Homo sapiens, GI4504327, Length=436, Percent_Identity=31.4220183486239, Blast_Score=170, Evalue=2e-42,
Organism=Homo sapiens, GI194353979, Length=365, Percent_Identity=29.041095890411, Blast_Score=129, Evalue=7e-30,
Organism=Escherichia coli, GI1788554, Length=388, Percent_Identity=46.9072164948454, Blast_Score=308, Evalue=3e-85,
Organism=Escherichia coli, GI87082165, Length=388, Percent_Identity=40.979381443299, Blast_Score=303, Evalue=2e-83,
Organism=Escherichia coli, GI1787663, Length=395, Percent_Identity=33.9240506329114, Blast_Score=202, Evalue=2e-53,
Organism=Escherichia coli, GI48994986, Length=401, Percent_Identity=34.1645885286783, Blast_Score=186, Evalue=3e-48,
Organism=Escherichia coli, GI1788683, Length=418, Percent_Identity=28.4688995215311, Blast_Score=147, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI25147385, Length=385, Percent_Identity=43.8961038961039, Blast_Score=314, Evalue=4e-86,
Organism=Caenorhabditis elegans, GI17535921, Length=394, Percent_Identity=42.3857868020305, Blast_Score=296, Evalue=9e-81,
Organism=Caenorhabditis elegans, GI133906874, Length=388, Percent_Identity=38.1443298969072, Blast_Score=271, Evalue=3e-73,
Organism=Caenorhabditis elegans, GI17535917, Length=392, Percent_Identity=35.4591836734694, Blast_Score=205, Evalue=3e-53,
Organism=Caenorhabditis elegans, GI17551802, Length=425, Percent_Identity=33.6470588235294, Blast_Score=189, Evalue=2e-48,
Organism=Saccharomyces cerevisiae, GI6325229, Length=396, Percent_Identity=46.2121212121212, Blast_Score=330, Evalue=3e-91,
Organism=Saccharomyces cerevisiae, GI6322031, Length=395, Percent_Identity=32.9113924050633, Blast_Score=189, Evalue=6e-49,
Organism=Drosophila melanogaster, GI24655093, Length=391, Percent_Identity=44.7570332480818, Blast_Score=327, Evalue=1e-89,
Organism=Drosophila melanogaster, GI24640423, Length=389, Percent_Identity=46.2724935732648, Blast_Score=323, Evalue=1e-88,
Organism=Drosophila melanogaster, GI17648125, Length=390, Percent_Identity=33.8461538461538, Blast_Score=221, Evalue=1e-57,
Organism=Drosophila melanogaster, GI17137578, Length=424, Percent_Identity=31.3679245283019, Blast_Score=172, Evalue=5e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.9 [H]

Molecular weight: Translated: 41356; Mature: 41356

Theoretical pI: Translated: 7.21; Mature: 7.21

Prosite motif: PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
6.3 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
6.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQKDPVVIVSAVRTPMGAFQSELSSLMAPQLGAAAIRAAVERAGIKPEQVQEVVFGCVLP
CCCCCEEEEEEHHCCHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHCC
AGQGQAPARQAALGAGLPLDVACTTVNKMCGSGMRAAMSVYDGLLAGSFDIAVAGGMESM
CCCCCCCHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCEEEEEECCHHHH
TNAPYLVPKARGGYRIGHGMIYDHMMLDGLEDAYDKGRAMGTFGEDCAAKYHFTREQQDA
CCCCEEEECCCCCEEECCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCHHHHH
FAMESVRRAQRATEQGDFRWEIVPVTVSGKGGDTVIDTDEGPRRIKVDKIPSLKPAFAKD
HHHHHHHHHHHHHCCCCEEEEEEEEEEECCCCCEEEECCCCCCEEEECCCCCCCCCCCCC
GTITAASSSSINDGASALVMMRESTAKSLGLQPIARMLGHTSHAQAPGWFTTAPVEAIAK
CEEEECCCCCCCCCCCEEEEEHHHHHHHCCHHHHHHHHCCCCCCCCCCCCCCCHHHHHHH
LYRKLDWNTGSVDLFEINEAFAVVPMAAMHDLDIPRDKVNIHGGACALGHPIGASGARIM
HHHHHCCCCCCEEEEECCCHHHHHHHHHHHCCCCCCCCEEECCCEEECCCCCCCCCHHHH
TTLIGALRKTGGKRGVASLCIGGGEATAVGIELY
HHHHHHHHHCCCCCCCHHEEECCCCEEEEEEEEC
>Mature Secondary Structure
MQKDPVVIVSAVRTPMGAFQSELSSLMAPQLGAAAIRAAVERAGIKPEQVQEVVFGCVLP
CCCCCEEEEEEHHCCHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHCC
AGQGQAPARQAALGAGLPLDVACTTVNKMCGSGMRAAMSVYDGLLAGSFDIAVAGGMESM
CCCCCCCHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCEEEEEECCHHHH
TNAPYLVPKARGGYRIGHGMIYDHMMLDGLEDAYDKGRAMGTFGEDCAAKYHFTREQQDA
CCCCEEEECCCCCEEECCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCHHHHH
FAMESVRRAQRATEQGDFRWEIVPVTVSGKGGDTVIDTDEGPRRIKVDKIPSLKPAFAKD
HHHHHHHHHHHHHCCCCEEEEEEEEEEECCCCCEEEECCCCCCEEEECCCCCCCCCCCCC
GTITAASSSSINDGASALVMMRESTAKSLGLQPIARMLGHTSHAQAPGWFTTAPVEAIAK
CEEEECCCCCCCCCCCEEEEEHHHHHHHCCHHHHHHHHCCCCCCCCCCCCCCCHHHHHHH
LYRKLDWNTGSVDLFEINEAFAVVPMAAMHDLDIPRDKVNIHGGACALGHPIGASGARIM
HHHHHCCCCCCEEEEECCCHHHHHHHHHHHCCCCCCCCEEECCCEEECCCCCCCCCHHHH
TTLIGALRKTGGKRGVASLCIGGGEATAVGIELY
HHHHHHHHHCCCCCCCHHEEECCCCEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7867955; 11075929; 11466286; 1685080 [H]