Click here to switch to the map view.

The map label for this gene is can [H]

Identifier: 94309050

GI number: 94309050

Start: 112546

End: 113217

Strand: Direct

Name: can [H]

Synonym: Rmet_0105

Alternate gene names: 94309050

Gene position: 112546-113217 (Clockwise)

Preceding gene: 94309049

Following gene: 94309051

Centisome position: 2.87

GC content: 65.03

Gene sequence:

>672_bases
ATGAGTGACGCCATCGCCCAGCTGTTCCGCAACAACCGCGAATGGGTAGACCGCGTCAACGCGGAAGACCCGACTTTCTT
CACGCGCCTGGCCAACCAGCAGGCCCCCGAGTACCTGTGGATTGGTTGTTCCGATTCGCGCGTGCCGGCCAACCAGATTC
TTGGCCTGGCGCCGGGCGAGGTCTTCGTCCATCGCAATATCGCCAACGTGATTTCGCACAGCGATCTGAACGCGCTGTCG
GTGCTGCAATTCGCTGTCGATGTGCTCAAGGTTCGCCACGTGACCGTGGTGGGCCACTACGGCTGCGGCGGCGTGAAGGT
GGCGCTCAAGCGCGAGCGCGTCGGCCTGGCCGACAACTGGCTGCGCCACGTGCAGGATGTGGCCGACAAGCACGCGGGCT
ATCTGGGCACCGTGCTGCGCGAGGACGACGCGCATACCCGCCTGTGCGAGCTGAACGTGATCGAGCAGGTCAACAACGTC
TGCCAGACCACCGTGCTCCAGGATGCCTGGGCGCGCGGTCAGGCCGTCACGGTGCATGGCTGGGTCTACGGCGTGTCCGA
CGGCCTGCTGCGCGATCTCGGCATGGCCGCCAGCAACAATGACGAACTGCACGCGCAGATTGCAGCCGCGCTGCGCCAGT
ACGGCGATCCGCCACAAGCATCGATTCGCTGA

Upstream 100 bases:

>100_bases
ATGTCCATGACTTTTTTGCGTACCACAGCCAAGAACGCTTCATCCACCGCTACGGGTCCGGCGCAACCGGCCCCGCAACT
GAAGAACCAAGGAGGGCAGC

Downstream 100 bases:

>100_bases
TTTCAACCCACGAAGCTCCACCCCTGCTTCAGGAGACAGACATGCAGAAGGACCCAGTCGTTATCGTTTCCGCGGTGCGT
ACCCCGATGGGTGCGTTCCA

Product: carbonic anhydrase

Products: NA

Alternate protein names: Carbonate dehydratase 2 [H]

Number of amino acids: Translated: 223; Mature: 222

Protein sequence:

>223_residues
MSDAIAQLFRNNREWVDRVNAEDPTFFTRLANQQAPEYLWIGCSDSRVPANQILGLAPGEVFVHRNIANVISHSDLNALS
VLQFAVDVLKVRHVTVVGHYGCGGVKVALKRERVGLADNWLRHVQDVADKHAGYLGTVLREDDAHTRLCELNVIEQVNNV
CQTTVLQDAWARGQAVTVHGWVYGVSDGLLRDLGMAASNNDELHAQIAAALRQYGDPPQASIR

Sequences:

>Translated_223_residues
MSDAIAQLFRNNREWVDRVNAEDPTFFTRLANQQAPEYLWIGCSDSRVPANQILGLAPGEVFVHRNIANVISHSDLNALS
VLQFAVDVLKVRHVTVVGHYGCGGVKVALKRERVGLADNWLRHVQDVADKHAGYLGTVLREDDAHTRLCELNVIEQVNNV
CQTTVLQDAWARGQAVTVHGWVYGVSDGLLRDLGMAASNNDELHAQIAAALRQYGDPPQASIR
>Mature_222_residues
SDAIAQLFRNNREWVDRVNAEDPTFFTRLANQQAPEYLWIGCSDSRVPANQILGLAPGEVFVHRNIANVISHSDLNALSV
LQFAVDVLKVRHVTVVGHYGCGGVKVALKRERVGLADNWLRHVQDVADKHAGYLGTVLREDDAHTRLCELNVIEQVNNVC
QTTVLQDAWARGQAVTVHGWVYGVSDGLLRDLGMAASNNDELHAQIAAALRQYGDPPQASIR

Specific function: Unknown

COG id: COG0288

COG function: function code P; Carbonic anhydrase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-class carbonic anhydrase family [H]

Homologues:

Organism=Escherichia coli, GI1786318, Length=199, Percent_Identity=54.7738693467337, Blast_Score=239, Evalue=1e-64,
Organism=Escherichia coli, GI1786534, Length=201, Percent_Identity=26.865671641791, Blast_Score=74, Evalue=9e-15,
Organism=Saccharomyces cerevisiae, GI6324292, Length=191, Percent_Identity=33.5078534031414, Blast_Score=106, Evalue=3e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001765
- InterPro:   IPR015892 [H]

Pfam domain/function: PF00484 Pro_CA [H]

EC number: =4.2.1.1 [H]

Molecular weight: Translated: 24625; Mature: 24494

Theoretical pI: Translated: 6.41; Mature: 6.41

Prosite motif: PS00704 PROK_CO2_ANHYDRASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDAIAQLFRNNREWVDRVNAEDPTFFTRLANQQAPEYLWIGCSDSRVPANQILGLAPGE
CCHHHHHHHHCCHHHHHHCCCCCCHHHHHHHCCCCCCEEEEECCCCCCCHHHHEECCCCC
VFVHRNIANVISHSDLNALSVLQFAVDVLKVRHVTVVGHYGCGGVKVALKRERVGLADNW
EEEEHHHHHHHHCCCCHHHHHHHHHHHHHHHHHEEEEEECCCCCEEEEEECCCCCHHHHH
LRHVQDVADKHAGYLGTVLREDDAHTRLCELNVIEQVNNVCQTTVLQDAWARGQAVTVHG
HHHHHHHHHHHCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEE
WVYGVSDGLLRDLGMAASNNDELHAQIAAALRQYGDPPQASIR
EEEECCHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
SDAIAQLFRNNREWVDRVNAEDPTFFTRLANQQAPEYLWIGCSDSRVPANQILGLAPGE
CHHHHHHHHCCHHHHHHCCCCCCHHHHHHHCCCCCCEEEEECCCCCCCHHHHEECCCCC
VFVHRNIANVISHSDLNALSVLQFAVDVLKVRHVTVVGHYGCGGVKVALKRERVGLADNW
EEEEHHHHHHHHCCCCHHHHHHHHHHHHHHHHHEEEEEECCCCCEEEEEECCCCCHHHHH
LRHVQDVADKHAGYLGTVLREDDAHTRLCELNVIEQVNNVCQTTVLQDAWARGQAVTVHG
HHHHHHHHHHHCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEE
WVYGVSDGLLRDLGMAASNNDELHAQIAAALRQYGDPPQASIR
EEEECCHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8202364; 9278503; 10493123 [H]