Click here to switch to the map view.

The map label for this gene is glmU [H]

Identifier: 93007220

GI number: 93007220

Start: 2944617

End: 2945993

Strand: Direct

Name: glmU [H]

Synonym: Pcryo_2396

Alternate gene names: 93007220

Gene position: 2944617-2945993 (Clockwise)

Preceding gene: 93007219

Following gene: 93007221

Centisome position: 96.23

GC content: 44.08

Gene sequence:

>1377_bases
ATGACATCTTCTCTTTCGGTAATTATCCTCGCTGCTGGTAAAGGCACGCGTATGCAGTCGGCTAAGCCAAAAGTGCTACA
GACATTGGCTGGCAAGTCATTGCTAGGTCACGTGTTAGACACTTGCCATCAATTGACGGTTGATGACACCATCATTGTCC
ATGGTTTTGGTGGCGAGCAAGTACAAGATCACATTGACCAGCAATATGCGCATTTGCCCATTACTTGGGTTGCCCAAACT
GAGCAGTTGGGCACGGGACATGCGGTCAAAGTGACTCTATCTGAGCTACCAAAAGATGGACAAAGCCTCATTCTTTACGG
CGACGTGCCATTGGTTAGCTGTCAAACGTTAGCGACACTACAGGATGCCAATACTGACGGCATGTCTATGTTGACGCTAA
CCGTAGATAATCCATTTGGTCTTGGTCGTATTAAACGTGATAAAGATGGCAATATTGAAGCCATTATTGAGCAAAAAGAC
GCCAATAGCGATGAGCAGCAGATACAAGAAATTAATAGCGGTATTTACTGCGTCGATAATGCTTTATTGCATAAATTTTT
GCCCAAGCTATCAAATGACAATGCGCAGCAAGAATACTATCTGACCGATATTGTCAAAATGGCGGTTGCTGATGGCATCA
CTATTGCAGCGATTGAGCCTGAGCATACCTTTGAGATTGAAGGCGTGAATAACCGTCAACAACTTGCTAGCTTAGAGCGT
ACATGGCAAGGTAAACTTGTCGCCGACTTACAAGAAGCTGGCGTACAGTTCGCTGACCCTACTCGTGTCGATATTCGTGG
CACCTTGAGCGCAGGTCAGGACGTGTTTGTCGATGTGGGTGTGGTATTTGAGGGTGATTGTGTCTTAGGTGATAATGTTT
ATATTGAAGCGGGCTGTGTCATTAAAAACGCCCAGATAGGCAACGCTTGTCATATAAAGCCTTATTGCGTGATTGATAGC
GCTGAAGTTGGCGCAGGTGTAGATATTGGTCCTTTTGCGCATTTACGTCCTGAGACCATACTCTCTGACAACAGCAAAGT
CGGTAATTTTGTCGAAATTAAAAAATCAACAATTGGTGATGGTAGCAAGGTTAATCATCTAAGCTATATTGGTGATGCCA
CTATTGGTACTGGTGTCAATGTTGGCGCTGGTGTGATTACTTGCAATTATGATGGTGTGAATAAATCACAAACCATCATT
GACGATAATGCCTTTATTGGCTCTAACTCAAGTCTAGTGGCGCCAGTGAAAATTGGTGATACCGCTACTGTGGCAGCTGG
TTCAGTGATTACTAAAAACGTTGATGCTCATGCACTAGCCTTTGGTCGTGCTCGTCAAACACAGAAAAATGACTTTAAGC
GTCCGACTAAAAAATAA

Upstream 100 bases:

>100_bases
CGATAGCTGAATTACAAAGAGGTCACGACATAGCGTTTTAGTTAAATGCCAATTTACGCTATAATCCCAAATTATATTTT
GTTACATTTGTAGGGCTATT

Downstream 100 bases:

>100_bases
TGGCAGCGTTGACAGTTAGTTAAATAAAAATGGCTCTTAGCAATCTCAAGCAGTACGACAATGATTTGTGGTGCTGCTTA
TTTATATTTATAGATTAACC

Product: UDP-N-acetylglucosamine pyrophosphorylase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine pyrophosphorylase; N-acetylglucosamine-1-phosphate uridyltransferase; Glucosamine-1-phosphate N-acetyltransferase [H]

Number of amino acids: Translated: 458; Mature: 457

Protein sequence:

>458_residues
MTSSLSVIILAAGKGTRMQSAKPKVLQTLAGKSLLGHVLDTCHQLTVDDTIIVHGFGGEQVQDHIDQQYAHLPITWVAQT
EQLGTGHAVKVTLSELPKDGQSLILYGDVPLVSCQTLATLQDANTDGMSMLTLTVDNPFGLGRIKRDKDGNIEAIIEQKD
ANSDEQQIQEINSGIYCVDNALLHKFLPKLSNDNAQQEYYLTDIVKMAVADGITIAAIEPEHTFEIEGVNNRQQLASLER
TWQGKLVADLQEAGVQFADPTRVDIRGTLSAGQDVFVDVGVVFEGDCVLGDNVYIEAGCVIKNAQIGNACHIKPYCVIDS
AEVGAGVDIGPFAHLRPETILSDNSKVGNFVEIKKSTIGDGSKVNHLSYIGDATIGTGVNVGAGVITCNYDGVNKSQTII
DDNAFIGSNSSLVAPVKIGDTATVAAGSVITKNVDAHALAFGRARQTQKNDFKRPTKK

Sequences:

>Translated_458_residues
MTSSLSVIILAAGKGTRMQSAKPKVLQTLAGKSLLGHVLDTCHQLTVDDTIIVHGFGGEQVQDHIDQQYAHLPITWVAQT
EQLGTGHAVKVTLSELPKDGQSLILYGDVPLVSCQTLATLQDANTDGMSMLTLTVDNPFGLGRIKRDKDGNIEAIIEQKD
ANSDEQQIQEINSGIYCVDNALLHKFLPKLSNDNAQQEYYLTDIVKMAVADGITIAAIEPEHTFEIEGVNNRQQLASLER
TWQGKLVADLQEAGVQFADPTRVDIRGTLSAGQDVFVDVGVVFEGDCVLGDNVYIEAGCVIKNAQIGNACHIKPYCVIDS
AEVGAGVDIGPFAHLRPETILSDNSKVGNFVEIKKSTIGDGSKVNHLSYIGDATIGTGVNVGAGVITCNYDGVNKSQTII
DDNAFIGSNSSLVAPVKIGDTATVAAGSVITKNVDAHALAFGRARQTQKNDFKRPTKK
>Mature_457_residues
TSSLSVIILAAGKGTRMQSAKPKVLQTLAGKSLLGHVLDTCHQLTVDDTIIVHGFGGEQVQDHIDQQYAHLPITWVAQTE
QLGTGHAVKVTLSELPKDGQSLILYGDVPLVSCQTLATLQDANTDGMSMLTLTVDNPFGLGRIKRDKDGNIEAIIEQKDA
NSDEQQIQEINSGIYCVDNALLHKFLPKLSNDNAQQEYYLTDIVKMAVADGITIAAIEPEHTFEIEGVNNRQQLASLERT
WQGKLVADLQEAGVQFADPTRVDIRGTLSAGQDVFVDVGVVFEGDCVLGDNVYIEAGCVIKNAQIGNACHIKPYCVIDSA
EVGAGVDIGPFAHLRPETILSDNSKVGNFVEIKKSTIGDGSKVNHLSYIGDATIGTGVNVGAGVITCNYDGVNKSQTIID
DNAFIGSNSSLVAPVKIGDTATVAAGSVITKNVDAHALAFGRARQTQKNDFKRPTKK

Specific function: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-GlcNAc. Responsible for the acetylation of Glc-N-1-P to give GlcNAc-1-P and for the uridyl transfer from UTP to GlcNAc-1-P which produces UDP-GlcNAc [H]

COG id: COG1207

COG function: function code M; N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transferase hexapeptide repeat family [H]

Homologues:

Organism=Escherichia coli, GI1790168, Length=459, Percent_Identity=49.6732026143791, Blast_Score=455, Evalue=1e-129,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005882
- InterPro:   IPR018357
- InterPro:   IPR005835
- InterPro:   IPR011004 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.23; =2.3.1.157 [H]

Molecular weight: Translated: 48936; Mature: 48805

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSSLSVIILAAGKGTRMQSAKPKVLQTLAGKSLLGHVLDTCHQLTVDDTIIVHGFGGEQ
CCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHEEECCCEEEEECCCCHH
VQDHIDQQYAHLPITWVAQTEQLGTGHAVKVTLSELPKDGQSLILYGDVPLVSCQTLATL
HHHHHHHHHHCCCEEEEEECHHCCCCCEEEEEHHHCCCCCCEEEEECCCCEECHHHHHHH
QDANTDGMSMLTLTVDNPFGLGRIKRDKDGNIEAIIEQKDANSDEQQIQEINSGIYCVDN
HCCCCCCEEEEEEEECCCCCCCEEECCCCCCEEEEEEECCCCCHHHHHHHHCCCEEEEHH
ALLHKFLPKLSNDNAQQEYYLTDIVKMAVADGITIAAIEPEHTFEIEGVNNRQQLASLER
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCEEEEEECCCCEEEEECCCCHHHHHHHHH
TWQGKLVADLQEAGVQFADPTRVDIRGTLSAGQDVFVDVGVVFEGDCVLGDNVYIEAGCV
HHCCCCEEEHHHCCCEECCCCEEEEEEECCCCCEEEEEEEEEEECCEEECCCEEEEECEE
IKNAQIGNACHIKPYCVIDSAEVGAGVDIGPFAHLRPETILSDNSKVGNFVEIKKSTIGD
EECCCCCCEEECCEEEEEECCCCCCCCCCCCCCCCCCCCEECCCCCCCCEEEEECCCCCC
GSKVNHLSYIGDATIGTGVNVGAGVITCNYDGVNKSQTIIDDNAFIGSNSSLVAPVKIGD
CCCCCEEEEECCCCCCCCCCCCCEEEEEECCCCCCCCEEEECCCEECCCCCEEEEEEECC
TATVAAGSVITKNVDAHALAFGRARQTQKNDFKRPTKK
CCEEECCCEEECCCCHHHEEHHHHHCCCHHHCCCCCCC
>Mature Secondary Structure 
TSSLSVIILAAGKGTRMQSAKPKVLQTLAGKSLLGHVLDTCHQLTVDDTIIVHGFGGEQ
CCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHEEECCCEEEEECCCCHH
VQDHIDQQYAHLPITWVAQTEQLGTGHAVKVTLSELPKDGQSLILYGDVPLVSCQTLATL
HHHHHHHHHHCCCEEEEEECHHCCCCCEEEEEHHHCCCCCCEEEEECCCCEECHHHHHHH
QDANTDGMSMLTLTVDNPFGLGRIKRDKDGNIEAIIEQKDANSDEQQIQEINSGIYCVDN
HCCCCCCEEEEEEEECCCCCCCEEECCCCCCEEEEEEECCCCCHHHHHHHHCCCEEEEHH
ALLHKFLPKLSNDNAQQEYYLTDIVKMAVADGITIAAIEPEHTFEIEGVNNRQQLASLER
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCEEEEEECCCCEEEEECCCCHHHHHHHHH
TWQGKLVADLQEAGVQFADPTRVDIRGTLSAGQDVFVDVGVVFEGDCVLGDNVYIEAGCV
HHCCCCEEEHHHCCCEECCCCEEEEEEECCCCCEEEEEEEEEEECCEEECCCEEEEECEE
IKNAQIGNACHIKPYCVIDSAEVGAGVDIGPFAHLRPETILSDNSKVGNFVEIKKSTIGD
EECCCCCCEEECCEEEEEECCCCCCCCCCCCCCCCCCCCEECCCCCCCCEEEEECCCCCC
GSKVNHLSYIGDATIGTGVNVGAGVITCNYDGVNKSQTIIDDNAFIGSNSSLVAPVKIGD
CCCCCEEEEECCCCCCCCCCCCCEEEEEECCCCCCCCEEEECCCEECCCCCEEEEEEECC
TATVAAGSVITKNVDAHALAFGRARQTQKNDFKRPTKK
CCEEECCCEEECCCCHHHEEHHHHHCCCHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA