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The map label for this gene is tyrB [H]

Identifier: 93006381

GI number: 93006381

Start: 1910649

End: 1911845

Strand: Direct

Name: tyrB [H]

Synonym: Pcryo_1557

Alternate gene names: 93006381

Gene position: 1910649-1911845 (Clockwise)

Preceding gene: 93006380

Following gene: 93006382

Centisome position: 62.44

GC content: 45.2

Gene sequence:

>1197_bases
ATGTTTGAACGTATCGATTACTATGCCGGCGACCCAATCTTAGGATTGATGGACAAATTTGCAGCCGATAACAACCCAGA
TAAAGTCAATTTGGGTGTCGGTGTCTATTATGACGAAGATGGCAAAATGCCAGTACTTGAGTGTGTAAAAACAGCTGAAC
AACGTATTGCAGACCCAATCTCTCCTCGCCCGTATTTACCAATGGCAGGTTTACCAGGACATCGCAAAGGCTGTCAAGAA
TTGCTGTTTGGTAAAGACGCTCAGATTTTACAAGATGGCTTAGTGGCTACTATCGCGACCATCGGTGGCTCTGGTGCACT
AAAAGTCGGCGCAGAATTCATCCACGAATGGTTCCCGCAGTCTAAGTGTTACGTGAGCGACCCTACATGGGGCAATCACA
TTGCTATTTTTGAAGGGTCTGACGTCGAAGTCGGTAAATACCCGTACTACGATACTGCTACTGGTGGCATCAAATTTGAT
GAGATGATCGCGTTTTTTGAGACATTGAATAAAGATGATGTTCTGCTGCTTCATCCTTGTTGTCATAACCCAACGGGCGT
TGATTTGACTCGTGAGCAATGGGATCAAGTCCTAAACGTCATTCAAGCGCGCGAGCTGATTCCGTTTATGGACATCGCTT
ATCAAGGCTTTGGCGAAGATATGGACAGCGATGCTTACGCCATTCGTAAAGCCGTCGATATGGGTCTGCCATTGTTTGTG
AGTAACTCATTCTCTAAAAACTTATCGCTATATGGCGAGCGTGTCGGTGGTCTATCAGTTGTTTGCCCAACGGTAGATGA
AACTGATCGCGTCTTTGGTCAGCTGAACTCTACGGTACGTCGTATCTACTCAAGCCCGCCATCACATGGTGGTCGTGTGG
TTGATATCGTTATGAACGACGAAGCCTTGCATGAGCAATGGGTTGGCGAAGTATATGCGATGCGTGACCGTATCAAATCT
ATGCGTACCAAACTCAAATCAGTATTAGAAGAAAAAATCCCAGGTCGTAGCTTTGATTACTTGACCGCCCAGAACGGTAT
GTTTAGCTTTACAGGTCTGACGCCTGAACAAGTTGCACAACTACAAAGCAAGTATGGTATCTATATGGTATCGAACTCAC
GTATGTGTGTTGCCGGCTTAAACAGTACCAATATCGACTATGTTGCCAATGCGATGGTTGACGTTTTAAAAGATTAA

Upstream 100 bases:

>100_bases
GGATAATGGAATCTAACATTGAGTTAATGCCCAAACTGGTTTATGCTTTTTAGCGCCTCAACTTATACCTTTGTACTTAT
ATCCCTTGTAAGGAAAACAC

Downstream 100 bases:

>100_bases
TTCCCTCATCGCTTTTATTAACATATAAACAAAGGCTAAGTATCGTTACTTAGCCTTTTTTCATGCGTTGGATTTCGTAG
TGGGGATATTTTTAGCAAAA

Product: aromatic amino acid aminotransferase

Products: NA

Alternate protein names: ARAT; AROAT [H]

Number of amino acids: Translated: 398; Mature: 398

Protein sequence:

>398_residues
MFERIDYYAGDPILGLMDKFAADNNPDKVNLGVGVYYDEDGKMPVLECVKTAEQRIADPISPRPYLPMAGLPGHRKGCQE
LLFGKDAQILQDGLVATIATIGGSGALKVGAEFIHEWFPQSKCYVSDPTWGNHIAIFEGSDVEVGKYPYYDTATGGIKFD
EMIAFFETLNKDDVLLLHPCCHNPTGVDLTREQWDQVLNVIQARELIPFMDIAYQGFGEDMDSDAYAIRKAVDMGLPLFV
SNSFSKNLSLYGERVGGLSVVCPTVDETDRVFGQLNSTVRRIYSSPPSHGGRVVDIVMNDEALHEQWVGEVYAMRDRIKS
MRTKLKSVLEEKIPGRSFDYLTAQNGMFSFTGLTPEQVAQLQSKYGIYMVSNSRMCVAGLNSTNIDYVANAMVDVLKD

Sequences:

>Translated_398_residues
MFERIDYYAGDPILGLMDKFAADNNPDKVNLGVGVYYDEDGKMPVLECVKTAEQRIADPISPRPYLPMAGLPGHRKGCQE
LLFGKDAQILQDGLVATIATIGGSGALKVGAEFIHEWFPQSKCYVSDPTWGNHIAIFEGSDVEVGKYPYYDTATGGIKFD
EMIAFFETLNKDDVLLLHPCCHNPTGVDLTREQWDQVLNVIQARELIPFMDIAYQGFGEDMDSDAYAIRKAVDMGLPLFV
SNSFSKNLSLYGERVGGLSVVCPTVDETDRVFGQLNSTVRRIYSSPPSHGGRVVDIVMNDEALHEQWVGEVYAMRDRIKS
MRTKLKSVLEEKIPGRSFDYLTAQNGMFSFTGLTPEQVAQLQSKYGIYMVSNSRMCVAGLNSTNIDYVANAMVDVLKD
>Mature_398_residues
MFERIDYYAGDPILGLMDKFAADNNPDKVNLGVGVYYDEDGKMPVLECVKTAEQRIADPISPRPYLPMAGLPGHRKGCQE
LLFGKDAQILQDGLVATIATIGGSGALKVGAEFIHEWFPQSKCYVSDPTWGNHIAIFEGSDVEVGKYPYYDTATGGIKFD
EMIAFFETLNKDDVLLLHPCCHNPTGVDLTREQWDQVLNVIQARELIPFMDIAYQGFGEDMDSDAYAIRKAVDMGLPLFV
SNSFSKNLSLYGERVGGLSVVCPTVDETDRVFGQLNSTVRRIYSSPPSHGGRVVDIVMNDEALHEQWVGEVYAMRDRIKS
MRTKLKSVLEEKIPGRSFDYLTAQNGMFSFTGLTPEQVAQLQSKYGIYMVSNSRMCVAGLNSTNIDYVANAMVDVLKD

Specific function: Biosynthesis of Phe, Tyr, Asp and Leu. [C]

COG id: COG1448

COG function: function code E; Aspartate/tyrosine/aromatic aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI73486658, Length=389, Percent_Identity=42.4164524421594, Blast_Score=334, Evalue=7e-92,
Organism=Homo sapiens, GI4504067, Length=393, Percent_Identity=39.6946564885496, Blast_Score=295, Evalue=6e-80,
Organism=Homo sapiens, GI117414139, Length=380, Percent_Identity=27.3684210526316, Blast_Score=155, Evalue=5e-38,
Organism=Escherichia coli, GI1790488, Length=397, Percent_Identity=55.4156171284635, Blast_Score=472, Evalue=1e-134,
Organism=Escherichia coli, GI1787159, Length=396, Percent_Identity=41.9191919191919, Blast_Score=342, Evalue=2e-95,
Organism=Caenorhabditis elegans, GI25147133, Length=390, Percent_Identity=41.7948717948718, Blast_Score=337, Evalue=7e-93,
Organism=Caenorhabditis elegans, GI71981858, Length=397, Percent_Identity=39.0428211586902, Blast_Score=337, Evalue=9e-93,
Organism=Caenorhabditis elegans, GI17569539, Length=379, Percent_Identity=37.9947229551451, Blast_Score=271, Evalue=3e-73,
Organism=Caenorhabditis elegans, GI17569537, Length=404, Percent_Identity=32.4257425742574, Blast_Score=207, Evalue=7e-54,
Organism=Caenorhabditis elegans, GI17550384, Length=269, Percent_Identity=33.8289962825279, Blast_Score=172, Evalue=4e-43,
Organism=Caenorhabditis elegans, GI25147136, Length=204, Percent_Identity=39.2156862745098, Blast_Score=165, Evalue=4e-41,
Organism=Saccharomyces cerevisiae, GI6323055, Length=407, Percent_Identity=36.1179361179361, Blast_Score=286, Evalue=3e-78,
Organism=Saccharomyces cerevisiae, GI6322743, Length=434, Percent_Identity=31.1059907834101, Blast_Score=224, Evalue=2e-59,
Organism=Drosophila melanogaster, GI24580972, Length=398, Percent_Identity=38.6934673366834, Blast_Score=311, Evalue=5e-85,
Organism=Drosophila melanogaster, GI24580970, Length=398, Percent_Identity=38.6934673366834, Blast_Score=311, Evalue=6e-85,
Organism=Drosophila melanogaster, GI19920542, Length=389, Percent_Identity=39.3316195372751, Blast_Score=310, Evalue=7e-85,
Organism=Drosophila melanogaster, GI19922362, Length=383, Percent_Identity=38.1201044386423, Blast_Score=274, Evalue=6e-74,
Organism=Drosophila melanogaster, GI24654046, Length=383, Percent_Identity=38.1201044386423, Blast_Score=274, Evalue=7e-74,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR000796
- InterPro:   IPR004838
- InterPro:   IPR015424
- InterPro:   IPR015421 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.57 [H]

Molecular weight: Translated: 44204; Mature: 44204

Theoretical pI: Translated: 4.58; Mature: 4.58

Prosite motif: PS00105 AA_TRANSFER_CLASS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFERIDYYAGDPILGLMDKFAADNNPDKVNLGVGVYYDEDGKMPVLECVKTAEQRIADPI
CCCCCCCCCCCCHHHHHHHHHCCCCCCEEEEEEEEEECCCCCCHHHHHHHHHHHHHCCCC
SPRPYLPMAGLPGHRKGCQELLFGKDAQILQDGLVATIATIGGSGALKVGAEFIHEWFPQ
CCCCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCC
SKCYVSDPTWGNHIAIFEGSDVEVGKYPYYDTATGGIKFDEMIAFFETLNKDDVLLLHPC
CCEEECCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEECC
CHNPTGVDLTREQWDQVLNVIQARELIPFMDIAYQGFGEDMDSDAYAIRKAVDMGLPLFV
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCEEE
SNSFSKNLSLYGERVGGLSVVCPTVDETDRVFGQLNSTVRRIYSSPPSHGGRVVDIVMND
CCCCCCCHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECC
EALHEQWVGEVYAMRDRIKSMRTKLKSVLEEKIPGRSFDYLTAQNGMFSFTGLTPEQVAQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCEEEECCCCHHHHHH
LQSKYGIYMVSNSRMCVAGLNSTNIDYVANAMVDVLKD
HHHHCCEEEEECCEEEEEECCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MFERIDYYAGDPILGLMDKFAADNNPDKVNLGVGVYYDEDGKMPVLECVKTAEQRIADPI
CCCCCCCCCCCCHHHHHHHHHCCCCCCEEEEEEEEEECCCCCCHHHHHHHHHHHHHCCCC
SPRPYLPMAGLPGHRKGCQELLFGKDAQILQDGLVATIATIGGSGALKVGAEFIHEWFPQ
CCCCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCC
SKCYVSDPTWGNHIAIFEGSDVEVGKYPYYDTATGGIKFDEMIAFFETLNKDDVLLLHPC
CCEEECCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEECC
CHNPTGVDLTREQWDQVLNVIQARELIPFMDIAYQGFGEDMDSDAYAIRKAVDMGLPLFV
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCEEE
SNSFSKNLSLYGERVGGLSVVCPTVDETDRVFGQLNSTVRRIYSSPPSHGGRVVDIVMND
CCCCCCCHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECC
EALHEQWVGEVYAMRDRIKSMRTKLKSVLEEKIPGRSFDYLTAQNGMFSFTGLTPEQVAQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCEEEECCCCHHHHHH
LQSKYGIYMVSNSRMCVAGLNSTNIDYVANAMVDVLKD
HHHHCCEEEEECCEEEEEECCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3521591; 3907634; 8265357; 9278503; 3308851; 10417420 [H]