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The map label for this gene is 93006382

Identifier: 93006382

GI number: 93006382

Start: 1912222

End: 1913511

Strand: Direct

Name: 93006382

Synonym: Pcryo_1558

Alternate gene names: NA

Gene position: 1912222-1913511 (Clockwise)

Preceding gene: 93006381

Following gene: 93006383

Centisome position: 62.49

GC content: 44.96

Gene sequence:

>1290_bases
ATGTCAACGATTGACAAAAACCTCTCATCTTTCCTCGATATCGCAACCGATTCTGACTTCTCTATTCATAACCTACCTTA
TGGCATTTTTAGCGATACTGCCGACGGCAAACGCCGCGCTGGTGTGGCTATTGGCAAGCACGTATTGGACTTATCGGTAC
TTGAAGCTGAAGGGCTATTAAGTCTAGACGGTGGTCCATATTTTGATCAAAATACCTTAAACGCCTTTATTGATTCTGGT
CGAGACAACTGGACCAAAGCACGTCAAACCATACAGACGTTACTTTCTAGCGACTGCGATACCTTACGTGATAACGAAGA
TTTGCAGCAAATAGCCCTATTTCAACAATCAGACGTCACTATGCATCTGCCGGTTCAAGTGCCCGGCTTTACCGATTTCT
ATTCGTCTAAAGAGCACGCAACCAATGTCGGTACTATGTTCCGTGACCCAAGTAATGCCTTACTGCCTAACTGGACTGAG
ATGCCAGTAGGTTATAACGGACGCGCCAGCACCGTCATCGTCAGTGGTACAGATGTGATACGTCCATCAGGTCAGCTAAA
ACCCAATGCCGATGACCGCCCTATTTTCTCACCCTGTAAGCGTCTGGACTTTGAGCTTGAAACGGCGTTTGTCGTTGGCA
AAGGTAATAATATTGGTCAACCAATTGCCGTAGATAATGCTATTGATCATATTTTTGGTATGGTTTTGCTAAACGATTGG
TCAGCTCGTGACATTCAAAAATGGGAATATGTGCCGTTAGGTCCATTTAACGCCAAAACTTTTGCCTCTGAAGTGTCTCC
TTGGATTGTGACGATGGAAGCCTTAGCACCGTTCAAGATGCCATGCCCAACGCAAGAACCAAAGCCGCTTGCTTATCTAA
ACGAAAAAAACAGCAATAATAGTTACGATATCCATTTATCAGTAGAACTATTGCCTGAAAATGCTGAAGAAGCAACGGTG
GTTTGCGAAACCAATTTTAAATATATGTACTGGTCAATGGCGCAGCAGTTGACTCACCATACTATCACTGGCTGTAAAGT
AGAAGTGGGCGATATGATGGGTTCAGGGACTATCTCAGGACCGATGCCTGATTCTTATGGCTCGATGTTAGAGATTGCGT
GGAATGCAACCAAACCTGTCACCCTCCAAGGCGGTGAGACACGCAGCTTTATCGAAGATGGTGACACGGTCATCATGAAA
GGCTATAGCGAAAAAGACGGTATTCGTGTTGGCTTTGGTGAAGTACGCGGCAAAGTATTGCCTGCCCTTACCTTCGATTT
TGACAAATAG

Upstream 100 bases:

>100_bases
GCACATAAAAAAACTTGCAATCGATTACACTATAAATTACATTATACGTAAGTAGTTAATTATAACGTAATTTAATATTC
GCTTTAGCAAGGAGCCGATC

Downstream 100 bases:

>100_bases
TACTTATTTGTTGACCTGTATATAGTAAACGTTTATGTATAAAAAGGCGTGCAAACGATAGCGTTACGCTGTTAGGGGTT
AATGACTTATATTCATAGTT

Product: fumarylacetoacetase

Products: acetoacetate; fumarate

Alternate protein names: Fumarylacetoacetate Hydrolase; Hydroxylase; Fumarylacetoacetate Hydrolase Family Protein; Fumarylacetoacetate Hydrolase Domain-Containing; Fumarylacetoacetase Hydrolase; 2-Hydroxyhepta-2 4-Diene-1 7-Dioate Isomerase; LOW QUALITY PROTEIN Fumarylacetoacetase

Number of amino acids: Translated: 429; Mature: 428

Protein sequence:

>429_residues
MSTIDKNLSSFLDIATDSDFSIHNLPYGIFSDTADGKRRAGVAIGKHVLDLSVLEAEGLLSLDGGPYFDQNTLNAFIDSG
RDNWTKARQTIQTLLSSDCDTLRDNEDLQQIALFQQSDVTMHLPVQVPGFTDFYSSKEHATNVGTMFRDPSNALLPNWTE
MPVGYNGRASTVIVSGTDVIRPSGQLKPNADDRPIFSPCKRLDFELETAFVVGKGNNIGQPIAVDNAIDHIFGMVLLNDW
SARDIQKWEYVPLGPFNAKTFASEVSPWIVTMEALAPFKMPCPTQEPKPLAYLNEKNSNNSYDIHLSVELLPENAEEATV
VCETNFKYMYWSMAQQLTHHTITGCKVEVGDMMGSGTISGPMPDSYGSMLEIAWNATKPVTLQGGETRSFIEDGDTVIMK
GYSEKDGIRVGFGEVRGKVLPALTFDFDK

Sequences:

>Translated_429_residues
MSTIDKNLSSFLDIATDSDFSIHNLPYGIFSDTADGKRRAGVAIGKHVLDLSVLEAEGLLSLDGGPYFDQNTLNAFIDSG
RDNWTKARQTIQTLLSSDCDTLRDNEDLQQIALFQQSDVTMHLPVQVPGFTDFYSSKEHATNVGTMFRDPSNALLPNWTE
MPVGYNGRASTVIVSGTDVIRPSGQLKPNADDRPIFSPCKRLDFELETAFVVGKGNNIGQPIAVDNAIDHIFGMVLLNDW
SARDIQKWEYVPLGPFNAKTFASEVSPWIVTMEALAPFKMPCPTQEPKPLAYLNEKNSNNSYDIHLSVELLPENAEEATV
VCETNFKYMYWSMAQQLTHHTITGCKVEVGDMMGSGTISGPMPDSYGSMLEIAWNATKPVTLQGGETRSFIEDGDTVIMK
GYSEKDGIRVGFGEVRGKVLPALTFDFDK
>Mature_428_residues
STIDKNLSSFLDIATDSDFSIHNLPYGIFSDTADGKRRAGVAIGKHVLDLSVLEAEGLLSLDGGPYFDQNTLNAFIDSGR
DNWTKARQTIQTLLSSDCDTLRDNEDLQQIALFQQSDVTMHLPVQVPGFTDFYSSKEHATNVGTMFRDPSNALLPNWTEM
PVGYNGRASTVIVSGTDVIRPSGQLKPNADDRPIFSPCKRLDFELETAFVVGKGNNIGQPIAVDNAIDHIFGMVLLNDWS
ARDIQKWEYVPLGPFNAKTFASEVSPWIVTMEALAPFKMPCPTQEPKPLAYLNEKNSNNSYDIHLSVELLPENAEEATVV
CETNFKYMYWSMAQQLTHHTITGCKVEVGDMMGSGTISGPMPDSYGSMLEIAWNATKPVTLQGGETRSFIEDGDTVIMKG
YSEKDGIRVGFGEVRGKVLPALTFDFDK

Specific function: Unknown

COG id: COG0179

COG function: function code Q; 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4557587, Length=421, Percent_Identity=54.3942992874109, Blast_Score=491, Evalue=1e-139,
Organism=Caenorhabditis elegans, GI17568863, Length=423, Percent_Identity=52.7186761229314, Blast_Score=453, Evalue=1e-128,
Organism=Drosophila melanogaster, GI24657182, Length=415, Percent_Identity=49.6385542168675, Blast_Score=424, Evalue=1e-119,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 3.7.1.2

Molecular weight: Translated: 47338; Mature: 47207

Theoretical pI: Translated: 4.44; Mature: 4.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTIDKNLSSFLDIATDSDFSIHNLPYGIFSDTADGKRRAGVAIGKHVLDLSVLEAEGLL
CCCHHHHHHHHHHHCCCCCCEECCCCCCCCCCCCCCCHHCCHHHHHHHHEEEEEECCCEE
SLDGGPYFDQNTLNAFIDSGRDNWTKARQTIQTLLSSDCDTLRDNEDLQQIALFQQSDVT
EECCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHCCCHHHCCCHHHHHHHHHHCCCCE
MHLPVQVPGFTDFYSSKEHATNVGTMFRDPSNALLPNWTEMPVGYNGRASTVIVSGTDVI
EEEEEECCCCHHHHCCCHHCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCEEEEECCCEE
RPSGQLKPNADDRPIFSPCKRLDFELETAFVVGKGNNIGQPIAVDNAIDHIFGMVLLNDW
CCCCCCCCCCCCCCCHHHHHHCCEEEEEEEEEECCCCCCCCEEHHHHHHHHHHHHHCCCC
SARDIQKWEYVPLGPFNAKTFASEVSPWIVTMEALAPFKMPCPTQEPKPLAYLNEKNSNN
CCCCCCCCEEEECCCCCHHHHHHHCCCEEEEEEHHCCCCCCCCCCCCCCEEEEECCCCCC
SYDIHLSVELLPENAEEATVVCETNFKYMYWSMAQQLTHHTITGCKVEVGDMMGSGTISG
CEEEEEEEEECCCCCCCEEEEEECCCCEEHHHHHHHHHHHHCCCCEEEECCCCCCCCCCC
PMPDSYGSMLEIAWNATKPVTLQGGETRSFIEDGDTVIMKGYSEKDGIRVGFGEVRGKVL
CCCCCCCCEEEEEECCCCCEEECCCCCHHHHHCCCEEEEECCCCCCCEEEEHHHHCCEEE
PALTFDFDK
EEEEECCCC
>Mature Secondary Structure 
STIDKNLSSFLDIATDSDFSIHNLPYGIFSDTADGKRRAGVAIGKHVLDLSVLEAEGLL
CCHHHHHHHHHHHCCCCCCEECCCCCCCCCCCCCCCHHCCHHHHHHHHEEEEEECCCEE
SLDGGPYFDQNTLNAFIDSGRDNWTKARQTIQTLLSSDCDTLRDNEDLQQIALFQQSDVT
EECCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHCCCHHHCCCHHHHHHHHHHCCCCE
MHLPVQVPGFTDFYSSKEHATNVGTMFRDPSNALLPNWTEMPVGYNGRASTVIVSGTDVI
EEEEEECCCCHHHHCCCHHCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCEEEEECCCEE
RPSGQLKPNADDRPIFSPCKRLDFELETAFVVGKGNNIGQPIAVDNAIDHIFGMVLLNDW
CCCCCCCCCCCCCCCHHHHHHCCEEEEEEEEEECCCCCCCCEEHHHHHHHHHHHHHCCCC
SARDIQKWEYVPLGPFNAKTFASEVSPWIVTMEALAPFKMPCPTQEPKPLAYLNEKNSNN
CCCCCCCCEEEECCCCCHHHHHHHCCCEEEEEEHHCCCCCCCCCCCCCCEEEEECCCCCC
SYDIHLSVELLPENAEEATVVCETNFKYMYWSMAQQLTHHTITGCKVEVGDMMGSGTISG
CEEEEEEEEECCCCCCCEEEEEECCCCEEHHHHHHHHHHHHCCCCEEEECCCCCCCCCCC
PMPDSYGSMLEIAWNATKPVTLQGGETRSFIEDGDTVIMKGYSEKDGIRVGFGEVRGKVL
CCCCCCCCEEEEEECCCCCEEECCCCCHHHHHCCCEEEEECCCCCCCEEEEHHHHCCEEE
PALTFDFDK
EEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 4-fumarylacetoacetate; H2O

Specific reaction: 4-fumarylacetoacetate + H2O = acetoacetate + fumarate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA