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The map label for this gene is paaH [H]

Identifier: 93006063

GI number: 93006063

Start: 1504218

End: 1505819

Strand: Direct

Name: paaH [H]

Synonym: Pcryo_1235

Alternate gene names: 93006063

Gene position: 1504218-1505819 (Clockwise)

Preceding gene: 93006062

Following gene: 93006064

Centisome position: 49.16

GC content: 43.51

Gene sequence:

>1602_bases
ATGACTGTTAAATCATTGGCCATTATTGGCACCGGTATTATGGGTATGGGTATTGCCCAAATCGCCGCCCAAGTAGGCAT
TCAAGTGCTGTTATTTGATGCCAAAGCAGGCGCTGCTGAGCAAGGACGCCAATCGCTTCAAGCTATGTTAGAGAAGCTAG
CCGCCAAAGGTAAATTCACCGATGAGCAGCTGCAATCTACTTTGAAAAATCTGATCGTGATTGAAGATATAGCCAAAATT
GCCGAGGCTGATGTCGTTATTGAAGCAATTATTGAAAATTTAGAAATAAAACAACAGCTTTTTAAACAGTTAGAAAGCAT
TGTTCCTGCCGAGACGATTTTGGCAACCAATACCTCCTCGCTAGCGGTGACCGCGATTGCTTCTAATTGCGAGCACCCAG
AGCGTGTGGCAGGATTTCACTTTTTTAATCCAGTACCCTTAATGAAAATCGTTGAAGTTATTCCGGGTATCTCTACCAAA
TCTTCAGTGGTTGAGACGCTGACGTCTTTAGCCAAACGCATGGGACATTTAGGGGTGGTGGCAAAAGATACCCCAGGATT
TATCGTCAATCATGGCGGTAGAGCTTACGGTACAGAAGCGTTGAAAATATTAGGCGAGGGAGTTGCAAGTTTCGAGGACA
TCGACCATATTTTACGTGACGGCGCTGGCTTTCGCATGGGGCCATTCGAGCTGCTTGATCTTACGGGTATCGATGTCTCT
CATCCAGTTATGGAGTCGATTTATAATCAATATTACTTTGAGCCTCGCTATCGTCCGCATCCCTTGACCCGTCAAATGCT
AACGGGTAACAAGCTTGGGCGTAAAGTTGGTGAAGGCTTTTATCACTACACAGAAAATAAAAAACAAGACGGTCAAAAAG
TGTCAGCAGATACGTCTGAACAATCATTGTTTGAATCATTAGTTCTTAAAACAGGGTCTGATACCTCAAATATCTCAGTT
TGGATTGGCGCAGATTTAGCAGAAGATAGACAACAGCTGATTGATCATCTAAACGCTAATGGTATTACTATCGACGATAA
TGATAAGCCAAACCCTGATAGTTTAGTATTACTGGCAATCTATGGCGAGGATACAACCAATGCGGCTATCCGCTATCAAG
TCAATCCTAACCAAGCAGTCGCTATTGATATGCTGACTGACTTATCTAAGCATCGCACCTTGATGCCAAGTATTGTCACC
CAAGATAACTTTATTGCACAAGCTTATGCTTTATTTGGTAAAAATAATAAGTTCGGTAAAAGCTCGGATGAAGGTTCAAA
TGCTGCTGTTGATGCCACGTTAATTACTGAAAGCACTGGGTTTGTGGCGCAGCGAGTCGTGGCTATGGTGATTAATTTAG
GCTGTGATATTGCGATGCAAGGCATTGCGTCTCCTGAAGATATCGATAATGCCGTCAAGCTTGGATTAGGGTATCCATAT
GGCCCTATTTCATGGGGAGACGAGCTTGGGGCTCAGAGAATCTTACTTATCTTAGAGCGTATTTATGGGTTAACAGGTGA
TCCGCGTTATCGCCCAAGCCCGTGGTTACAACGCCGCGCCACGCTAGGTATTTCACTATTTACTCAGCAAACTAATCATT
AA

Upstream 100 bases:

>100_bases
ATAGACTTTTCAAAGCATAGAAAGAAACAGCACATATACTTTGAAAACGAGACTCTTCAATAAGAGCATATAAATTAACA
AGACCATATAAAGGATTATT

Downstream 100 bases:

>100_bases
TATTAATACCAACAACCTAGCAATCTTGCTAAACCATATATTTTAATAAGACAAACTCTCAAAACACAACAAGGAAAAGT
TATGTTAGATGCCTATATTT

Product: 3-hydroxy-acyl-CoA dehydrogenase

Products: NA

Alternate protein names: Beta-hydroxybutyryl-CoA dehydrogenase; BHBD [H]

Number of amino acids: Translated: 533; Mature: 532

Protein sequence:

>533_residues
MTVKSLAIIGTGIMGMGIAQIAAQVGIQVLLFDAKAGAAEQGRQSLQAMLEKLAAKGKFTDEQLQSTLKNLIVIEDIAKI
AEADVVIEAIIENLEIKQQLFKQLESIVPAETILATNTSSLAVTAIASNCEHPERVAGFHFFNPVPLMKIVEVIPGISTK
SSVVETLTSLAKRMGHLGVVAKDTPGFIVNHGGRAYGTEALKILGEGVASFEDIDHILRDGAGFRMGPFELLDLTGIDVS
HPVMESIYNQYYFEPRYRPHPLTRQMLTGNKLGRKVGEGFYHYTENKKQDGQKVSADTSEQSLFESLVLKTGSDTSNISV
WIGADLAEDRQQLIDHLNANGITIDDNDKPNPDSLVLLAIYGEDTTNAAIRYQVNPNQAVAIDMLTDLSKHRTLMPSIVT
QDNFIAQAYALFGKNNKFGKSSDEGSNAAVDATLITESTGFVAQRVVAMVINLGCDIAMQGIASPEDIDNAVKLGLGYPY
GPISWGDELGAQRILLILERIYGLTGDPRYRPSPWLQRRATLGISLFTQQTNH

Sequences:

>Translated_533_residues
MTVKSLAIIGTGIMGMGIAQIAAQVGIQVLLFDAKAGAAEQGRQSLQAMLEKLAAKGKFTDEQLQSTLKNLIVIEDIAKI
AEADVVIEAIIENLEIKQQLFKQLESIVPAETILATNTSSLAVTAIASNCEHPERVAGFHFFNPVPLMKIVEVIPGISTK
SSVVETLTSLAKRMGHLGVVAKDTPGFIVNHGGRAYGTEALKILGEGVASFEDIDHILRDGAGFRMGPFELLDLTGIDVS
HPVMESIYNQYYFEPRYRPHPLTRQMLTGNKLGRKVGEGFYHYTENKKQDGQKVSADTSEQSLFESLVLKTGSDTSNISV
WIGADLAEDRQQLIDHLNANGITIDDNDKPNPDSLVLLAIYGEDTTNAAIRYQVNPNQAVAIDMLTDLSKHRTLMPSIVT
QDNFIAQAYALFGKNNKFGKSSDEGSNAAVDATLITESTGFVAQRVVAMVINLGCDIAMQGIASPEDIDNAVKLGLGYPY
GPISWGDELGAQRILLILERIYGLTGDPRYRPSPWLQRRATLGISLFTQQTNH
>Mature_532_residues
TVKSLAIIGTGIMGMGIAQIAAQVGIQVLLFDAKAGAAEQGRQSLQAMLEKLAAKGKFTDEQLQSTLKNLIVIEDIAKIA
EADVVIEAIIENLEIKQQLFKQLESIVPAETILATNTSSLAVTAIASNCEHPERVAGFHFFNPVPLMKIVEVIPGISTKS
SVVETLTSLAKRMGHLGVVAKDTPGFIVNHGGRAYGTEALKILGEGVASFEDIDHILRDGAGFRMGPFELLDLTGIDVSH
PVMESIYNQYYFEPRYRPHPLTRQMLTGNKLGRKVGEGFYHYTENKKQDGQKVSADTSEQSLFESLVLKTGSDTSNISVW
IGADLAEDRQQLIDHLNANGITIDDNDKPNPDSLVLLAIYGEDTTNAAIRYQVNPNQAVAIDMLTDLSKHRTLMPSIVTQ
DNFIAQAYALFGKNNKFGKSSDEGSNAAVDATLITESTGFVAQRVVAMVINLGCDIAMQGIASPEDIDNAVKLGLGYPYG
PISWGDELGAQRILLILERIYGLTGDPRYRPSPWLQRRATLGISLFTQQTNH

Specific function: Butyrate/butanol-producing pathway. Phenylacetic acid aerobic catabolism. [C]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI296179429, Length=287, Percent_Identity=41.4634146341463, Blast_Score=222, Evalue=8e-58,
Organism=Homo sapiens, GI296179427, Length=304, Percent_Identity=39.8026315789474, Blast_Score=213, Evalue=5e-55,
Organism=Homo sapiens, GI20127408, Length=318, Percent_Identity=34.2767295597484, Blast_Score=164, Evalue=2e-40,
Organism=Homo sapiens, GI261878539, Length=293, Percent_Identity=31.0580204778157, Blast_Score=143, Evalue=3e-34,
Organism=Homo sapiens, GI68989263, Length=293, Percent_Identity=31.0580204778157, Blast_Score=143, Evalue=3e-34,
Organism=Homo sapiens, GI115430219, Length=240, Percent_Identity=27.9166666666667, Blast_Score=100, Evalue=2e-21,
Organism=Escherichia coli, GI1787661, Length=524, Percent_Identity=38.5496183206107, Blast_Score=332, Evalue=5e-92,
Organism=Escherichia coli, GI1788682, Length=226, Percent_Identity=38.0530973451327, Blast_Score=149, Evalue=5e-37,
Organism=Escherichia coli, GI1790281, Length=287, Percent_Identity=31.0104529616725, Blast_Score=142, Evalue=6e-35,
Organism=Caenorhabditis elegans, GI17549919, Length=289, Percent_Identity=39.4463667820069, Blast_Score=212, Evalue=4e-55,
Organism=Caenorhabditis elegans, GI17553560, Length=288, Percent_Identity=36.8055555555556, Blast_Score=196, Evalue=3e-50,
Organism=Caenorhabditis elegans, GI17563036, Length=288, Percent_Identity=37.5, Blast_Score=182, Evalue=4e-46,
Organism=Caenorhabditis elegans, GI71985923, Length=284, Percent_Identity=31.3380281690141, Blast_Score=154, Evalue=8e-38,
Organism=Caenorhabditis elegans, GI17508951, Length=290, Percent_Identity=33.1034482758621, Blast_Score=154, Evalue=9e-38,
Organism=Caenorhabditis elegans, GI25144276, Length=290, Percent_Identity=33.1034482758621, Blast_Score=154, Evalue=9e-38,
Organism=Caenorhabditis elegans, GI17508953, Length=290, Percent_Identity=33.1034482758621, Blast_Score=154, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI71985930, Length=293, Percent_Identity=30.3754266211604, Blast_Score=152, Evalue=5e-37,
Organism=Caenorhabditis elegans, GI17558304, Length=313, Percent_Identity=31.3099041533546, Blast_Score=144, Evalue=8e-35,
Organism=Drosophila melanogaster, GI24583077, Length=293, Percent_Identity=30.7167235494881, Blast_Score=146, Evalue=3e-35,
Organism=Drosophila melanogaster, GI24583079, Length=293, Percent_Identity=30.7167235494881, Blast_Score=146, Evalue=3e-35,
Organism=Drosophila melanogaster, GI19921000, Length=293, Percent_Identity=30.7167235494881, Blast_Score=146, Evalue=3e-35,
Organism=Drosophila melanogaster, GI45549573, Length=262, Percent_Identity=28.2442748091603, Blast_Score=96, Evalue=4e-20,
Organism=Drosophila melanogaster, GI20129993, Length=230, Percent_Identity=25.6521739130435, Blast_Score=87, Evalue=4e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006180
- InterPro:   IPR006176
- InterPro:   IPR011967
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N [H]

EC number: =1.1.1.157 [H]

Molecular weight: Translated: 57957; Mature: 57826

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVKSLAIIGTGIMGMGIAQIAAQVGIQVLLFDAKAGAAEQGRQSLQAMLEKLAAKGKFT
CCCCHHHHHHCCHHHHHHHHHHHHCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCC
DEQLQSTLKNLIVIEDIAKIAEADVVIEAIIENLEIKQQLFKQLESIVPAETILATNTSS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHEECCCCC
LAVTAIASNCEHPERVAGFHFFNPVPLMKIVEVIPGISTKSSVVETLTSLAKRMGHLGVV
EEEEEHHHCCCCHHHHCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCEE
AKDTPGFIVNHGGRAYGTEALKILGEGVASFEDIDHILRDGAGFRMGPFELLDLTGIDVS
EECCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHEEEECCCCCC
HPVMESIYNQYYFEPRYRPHPLTRQMLTGNKLGRKVGEGFYHYTENKKQDGQKVSADTSE
HHHHHHHHHHHCCCCCCCCCCHHHHHHCCHHHHHHHHCCHHCCCCCCCCCCCCCCCCCHH
QSLFESLVLKTGSDTSNISVWIGADLAEDRQQLIDHLNANGITIDDNDKPNPDSLVLLAI
HHHHHHHHHHCCCCCCCEEEEEECCHHHHHHHHHHHCCCCCEEECCCCCCCCCCEEEEEE
YGEDTTNAAIRYQVNPNQAVAIDMLTDLSKHRTLMPSIVTQDNFIAQAYALFGKNNKFGK
ECCCCCCCEEEEEECCCCEEEHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCC
SSDEGSNAAVDATLITESTGFVAQRVVAMVINLGCDIAMQGIASPEDIDNAVKLGLGYPY
CCCCCCCCEEEEEEEECCCCHHHHHHHHHHHHCCCHHHHHCCCCHHHHHHHHHHCCCCCC
GPISWGDELGAQRILLILERIYGLTGDPRYRPSPWLQRRATLGISLFTQQTNH
CCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCEEEEECCCCC
>Mature Secondary Structure 
TVKSLAIIGTGIMGMGIAQIAAQVGIQVLLFDAKAGAAEQGRQSLQAMLEKLAAKGKFT
CCCHHHHHHCCHHHHHHHHHHHHCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCC
DEQLQSTLKNLIVIEDIAKIAEADVVIEAIIENLEIKQQLFKQLESIVPAETILATNTSS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHEECCCCC
LAVTAIASNCEHPERVAGFHFFNPVPLMKIVEVIPGISTKSSVVETLTSLAKRMGHLGVV
EEEEEHHHCCCCHHHHCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCEE
AKDTPGFIVNHGGRAYGTEALKILGEGVASFEDIDHILRDGAGFRMGPFELLDLTGIDVS
EECCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHEEEECCCCCC
HPVMESIYNQYYFEPRYRPHPLTRQMLTGNKLGRKVGEGFYHYTENKKQDGQKVSADTSE
HHHHHHHHHHHCCCCCCCCCCHHHHHHCCHHHHHHHHCCHHCCCCCCCCCCCCCCCCCHH
QSLFESLVLKTGSDTSNISVWIGADLAEDRQQLIDHLNANGITIDDNDKPNPDSLVLLAI
HHHHHHHHHHCCCCCCCEEEEEECCHHHHHHHHHHHCCCCCEEECCCCCCCCCCEEEEEE
YGEDTTNAAIRYQVNPNQAVAIDMLTDLSKHRTLMPSIVTQDNFIAQAYALFGKNNKFGK
ECCCCCCCEEEEEECCCCEEEHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCC
SSDEGSNAAVDATLITESTGFVAQRVVAMVINLGCDIAMQGIASPEDIDNAVKLGLGYPY
CCCCCCCCEEEEEEEECCCCHHHHHHHHHHHHCCCHHHHHCCCCHHHHHHHHHHCCCCCC
GPISWGDELGAQRILLILERIYGLTGDPRYRPSPWLQRRATLGISLFTQQTNH
CCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9748275; 9097039; 9278503; 10766858 [H]