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The map label for this gene is catF [H]

Identifier: 93006064

GI number: 93006064

Start: 1505901

End: 1507103

Strand: Direct

Name: catF [H]

Synonym: Pcryo_1236

Alternate gene names: 93006064

Gene position: 1505901-1507103 (Clockwise)

Preceding gene: 93006063

Following gene: 93006065

Centisome position: 49.21

GC content: 46.3

Gene sequence:

>1203_bases
ATGTTAGATGCCTATATTTATGACGGATTAAGAAGCCCTTTTGGTCGCCATGGAGGCGCATTAGCCACCGTTCGTCCTGA
TGACATGATTGCGACAGTAATGAAAGCTTTGGTTGAAAAGCATCAATTACCTAATGATATCTTTAATGAAGTGCTGATCG
GTAATACCAATCAAGCTGGTGAGGACTCACGCAATATCGCCCGCAATGCTGCGTTATTGGCAGGATTAGATGTCAAAACA
CCCGGTCAAACCGTCAATCGCTTATGCGCTTCAGGACTATCGACCATTATCGATGCCGCTCGTAGTATTACTTGTCATGA
AGGGGATATATTTTTAGCAGGGGGCGTTGAGTCCATGACCCGCGCACCTTTTGTCTTTGCTAAGACTGAGCAGCCTTTTA
GTCGTGAATTTAAAGTATTTGATACGACTATTGGCAGCCGGTTCCCCAATCCTATCATCGAAAAACAGTTTGGCAGCGAT
AGCATGCCGCAAACGGGTGATAATGTCGCCCTCAAATACGGTATCACTCGCGAAGAAGCGGATAAATTTGCAGCGGCCTC
GCAAGCCAAATACCAAGCGGCAAAACAAGCTGGGTTCTTCAACGATGAAATAACACCAATTATGGTATCGCAAGGTAAAA
AGTTACCCGAAAAAGCAATAGTAGAAGATGAGCATCCTCGTGCCAGCTCTACTGTTGAGGCACTACAAAAGCTAAAACCT
TTAAATAATGAAGGTATCGTCACAGCAGGCAATGCGTCAGGTATCAATGATGGTGCAGCTGCGTTGATTATTGGGTCAAA
GCGAGCAGAGGAAACGTTAGGCTTTAAGCCTATCGCTAAGATTCTTTCGTCCGGTGCTATGGGTGTTGAGCCTAATATTA
TGGGCGTAGGCCCTGTTGAGGCGATTAAACTGGCATTGAAACGTGCAAATTTGACCCTTGATGATATGTCCATTATTGAG
ATTAATGAAGCGTTTGCCTCGCAAGTACTCGGCTGCTTGAAAGGTTTAGATATTGACTTTGATGACAAACGCGTCAACCC
TAACGGCGGAGCAATTGCCGTCGGTCATCCGCTGGGTGCATCAGGCGCAAGACTTGCGTTAAGTACGGCGCGTGAGCTAC
AGCGTACGGGCGAAAAATACGCGGTGGTCAGTTTATGCATTGGCATTGGGCAAGGGCTTGCCATGGTGATTGAACGAGTC
TAA

Upstream 100 bases:

>100_bases
TCAGCAAACTAATCATTAATATTAATACCAACAACCTAGCAATCTTGCTAAACCATATATTTTAATAAGACAAACTCTCA
AAACACAACAAGGAAAAGTT

Downstream 100 bases:

>100_bases
CCCTTTCAATACTTTTGCCATATATTTTTTATTATCAAGGATGACCATAATGACTACGATACTTAACCAACATGAGGATT
ACCAGCAAGCTCAAGAAGCC

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: 3-oxoadipyl-CoA thiolase [H]

Number of amino acids: Translated: 400; Mature: 400

Protein sequence:

>400_residues
MLDAYIYDGLRSPFGRHGGALATVRPDDMIATVMKALVEKHQLPNDIFNEVLIGNTNQAGEDSRNIARNAALLAGLDVKT
PGQTVNRLCASGLSTIIDAARSITCHEGDIFLAGGVESMTRAPFVFAKTEQPFSREFKVFDTTIGSRFPNPIIEKQFGSD
SMPQTGDNVALKYGITREEADKFAAASQAKYQAAKQAGFFNDEITPIMVSQGKKLPEKAIVEDEHPRASSTVEALQKLKP
LNNEGIVTAGNASGINDGAAALIIGSKRAEETLGFKPIAKILSSGAMGVEPNIMGVGPVEAIKLALKRANLTLDDMSIIE
INEAFASQVLGCLKGLDIDFDDKRVNPNGGAIAVGHPLGASGARLALSTARELQRTGEKYAVVSLCIGIGQGLAMVIERV

Sequences:

>Translated_400_residues
MLDAYIYDGLRSPFGRHGGALATVRPDDMIATVMKALVEKHQLPNDIFNEVLIGNTNQAGEDSRNIARNAALLAGLDVKT
PGQTVNRLCASGLSTIIDAARSITCHEGDIFLAGGVESMTRAPFVFAKTEQPFSREFKVFDTTIGSRFPNPIIEKQFGSD
SMPQTGDNVALKYGITREEADKFAAASQAKYQAAKQAGFFNDEITPIMVSQGKKLPEKAIVEDEHPRASSTVEALQKLKP
LNNEGIVTAGNASGINDGAAALIIGSKRAEETLGFKPIAKILSSGAMGVEPNIMGVGPVEAIKLALKRANLTLDDMSIIE
INEAFASQVLGCLKGLDIDFDDKRVNPNGGAIAVGHPLGASGARLALSTARELQRTGEKYAVVSLCIGIGQGLAMVIERV
>Mature_400_residues
MLDAYIYDGLRSPFGRHGGALATVRPDDMIATVMKALVEKHQLPNDIFNEVLIGNTNQAGEDSRNIARNAALLAGLDVKT
PGQTVNRLCASGLSTIIDAARSITCHEGDIFLAGGVESMTRAPFVFAKTEQPFSREFKVFDTTIGSRFPNPIIEKQFGSD
SMPQTGDNVALKYGITREEADKFAAASQAKYQAAKQAGFFNDEITPIMVSQGKKLPEKAIVEDEHPRASSTVEALQKLKP
LNNEGIVTAGNASGINDGAAALIIGSKRAEETLGFKPIAKILSSGAMGVEPNIMGVGPVEAIKLALKRANLTLDDMSIIE
INEAFASQVLGCLKGLDIDFDDKRVNPNGGAIAVGHPLGASGARLALSTARELQRTGEKYAVVSLCIGIGQGLAMVIERV

Specific function: Catalyzes thiolytic cleavage of beta-ketoadipyl-CoA to succinyl-CoA and acetyl-CoA [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI167614485, Length=400, Percent_Identity=40.75, Blast_Score=298, Evalue=5e-81,
Organism=Homo sapiens, GI148539872, Length=398, Percent_Identity=38.1909547738693, Blast_Score=257, Evalue=1e-68,
Organism=Homo sapiens, GI4501853, Length=406, Percent_Identity=38.423645320197, Blast_Score=236, Evalue=4e-62,
Organism=Homo sapiens, GI4557237, Length=400, Percent_Identity=34.25, Blast_Score=213, Evalue=2e-55,
Organism=Homo sapiens, GI4504327, Length=423, Percent_Identity=28.3687943262411, Blast_Score=182, Evalue=3e-46,
Organism=Homo sapiens, GI194353979, Length=398, Percent_Identity=29.1457286432161, Blast_Score=134, Evalue=2e-31,
Organism=Escherichia coli, GI1787663, Length=402, Percent_Identity=50.4975124378109, Blast_Score=408, Evalue=1e-115,
Organism=Escherichia coli, GI1788554, Length=403, Percent_Identity=41.9354838709677, Blast_Score=266, Evalue=2e-72,
Organism=Escherichia coli, GI48994986, Length=406, Percent_Identity=39.9014778325123, Blast_Score=260, Evalue=1e-70,
Organism=Escherichia coli, GI87082165, Length=401, Percent_Identity=38.6533665835411, Blast_Score=259, Evalue=3e-70,
Organism=Escherichia coli, GI1788683, Length=423, Percent_Identity=29.5508274231678, Blast_Score=168, Evalue=7e-43,
Organism=Caenorhabditis elegans, GI133906874, Length=402, Percent_Identity=38.0597014925373, Blast_Score=266, Evalue=2e-71,
Organism=Caenorhabditis elegans, GI25147385, Length=398, Percent_Identity=32.4120603015075, Blast_Score=191, Evalue=5e-49,
Organism=Caenorhabditis elegans, GI17551802, Length=428, Percent_Identity=31.0747663551402, Blast_Score=179, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI17535921, Length=402, Percent_Identity=31.8407960199005, Blast_Score=178, Evalue=5e-45,
Organism=Caenorhabditis elegans, GI17535917, Length=405, Percent_Identity=29.6296296296296, Blast_Score=135, Evalue=3e-32,
Organism=Saccharomyces cerevisiae, GI6322031, Length=407, Percent_Identity=35.8722358722359, Blast_Score=207, Evalue=2e-54,
Organism=Saccharomyces cerevisiae, GI6325229, Length=412, Percent_Identity=33.495145631068, Blast_Score=194, Evalue=2e-50,
Organism=Drosophila melanogaster, GI17648125, Length=404, Percent_Identity=38.8613861386139, Blast_Score=262, Evalue=3e-70,
Organism=Drosophila melanogaster, GI24655093, Length=401, Percent_Identity=36.9077306733167, Blast_Score=262, Evalue=3e-70,
Organism=Drosophila melanogaster, GI24640423, Length=399, Percent_Identity=33.3333333333333, Blast_Score=196, Evalue=3e-50,
Organism=Drosophila melanogaster, GI17137578, Length=425, Percent_Identity=32.4705882352941, Blast_Score=194, Evalue=8e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012793
- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.174 [H]

Molecular weight: Translated: 42452; Mature: 42452

Theoretical pI: Translated: 5.78; Mature: 5.78

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDAYIYDGLRSPFGRHGGALATVRPDDMIATVMKALVEKHQLPNDIFNEVLIGNTNQAG
CCCHHHHHHHHCCCCCCCCEEEEECCHHHHHHHHHHHHHHHCCCHHHHHHHEECCCCCCC
EDSRNIARNAALLAGLDVKTPGQTVNRLCASGLSTIIDAARSITCHEGDIFLAGGVESMT
CHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCEECCCCEEEECCHHHHH
RAPFVFAKTEQPFSREFKVFDTTIGSRFPNPIIEKQFGSDSMPQTGDNVALKYGITREEA
CCCEEEEECCCCCHHHHHHHHHHHHCCCCCHHHHHCCCCCCCCCCCCCEEEEECCCHHHH
DKFAAASQAKYQAAKQAGFFNDEITPIMVSQGKKLPEKAIVEDEHPRASSTVEALQKLKP
HHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCHHHCCCCCCCCHHHHHHHHHHHCC
LNNEGIVTAGNASGINDGAAALIIGSKRAEETLGFKPIAKILSSGAMGVEPNIMGVGPVE
CCCCCEEEECCCCCCCCCCEEEEEECCHHHHHCCHHHHHHHHCCCCCCCCCCEECCCHHH
AIKLALKRANLTLDDMSIIEINEAFASQVLGCLKGLDIDFDDKRVNPNGGAIAVGHPLGA
HHHHHHHHCCCEECCCEEEEHHHHHHHHHHHHHHCCCCCCCCCEECCCCCEEEECCCCCC
SGARLALSTARELQRTGEKYAVVSLCIGIGQGLAMVIERV
CCCHHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHCC
>Mature Secondary Structure
MLDAYIYDGLRSPFGRHGGALATVRPDDMIATVMKALVEKHQLPNDIFNEVLIGNTNQAG
CCCHHHHHHHHCCCCCCCCEEEEECCHHHHHHHHHHHHHHHCCCHHHHHHHEECCCCCCC
EDSRNIARNAALLAGLDVKTPGQTVNRLCASGLSTIIDAARSITCHEGDIFLAGGVESMT
CHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCEECCCCEEEECCHHHHH
RAPFVFAKTEQPFSREFKVFDTTIGSRFPNPIIEKQFGSDSMPQTGDNVALKYGITREEA
CCCEEEEECCCCCHHHHHHHHHHHHCCCCCHHHHHCCCCCCCCCCCCCEEEEECCCHHHH
DKFAAASQAKYQAAKQAGFFNDEITPIMVSQGKKLPEKAIVEDEHPRASSTVEALQKLKP
HHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCHHHCCCCCCCCHHHHHHHHHHHCC
LNNEGIVTAGNASGINDGAAALIIGSKRAEETLGFKPIAKILSSGAMGVEPNIMGVGPVE
CCCCCEEEECCCCCCCCCCEEEEEECCHHHHHCCHHHHHHHHCCCCCCCCCCEECCCHHH
AIKLALKRANLTLDDMSIIEINEAFASQVLGCLKGLDIDFDDKRVNPNGGAIAVGHPLGA
HHHHHHHHCCCEECCCEEEEHHHHHHHHHHHHHHCCCCCCCCCEECCCCCEEEECCCCCC
SGARLALSTARELQRTGEKYAVVSLCIGIGQGLAMVIERV
CCCHHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8125318 [H]