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The map label for this gene is 93006047

Identifier: 93006047

GI number: 93006047

Start: 1477775

End: 1478773

Strand: Reverse

Name: 93006047

Synonym: Pcryo_1219

Alternate gene names: NA

Gene position: 1478773-1477775 (Counterclockwise)

Preceding gene: 93006049

Following gene: 93006046

Centisome position: 48.33

GC content: 45.25

Gene sequence:

>999_bases
ATGGCTTCTTCTCTATTTAATTTCAAAATTATTGACTCACATACGGGCGGTGAGCCTACTCGTATGGTCTATGACGGCTT
TCCTGACCTCGTCGGCGATACTATTCAAGACAAACTACAATCCTTCAAACAAAACTTCGATCACCTACGTCAAAGTATCA
TTTTAGAGCCCCGCGGCAATGATGTCCTTGTTGGCGCGCTACTTCTTCCCGCAAGCCATCCTAAAGCCACAGCGGGCGTT
ATATTTTTTAATAACGCTGGTTATCTGGGCATGTGCGGTCATGGCACGATTGGCGTCATCGTCTCTTTAGCTTATCAACA
AAAAATATCAGCAGGCGTACATTGGCTTGAGACTCCCGTAGGTCTGGTTAAAGCAACCCTACATGATGATGGCAGTTGCA
GTGTACAAAACGTCCCTTCTTATCGTTATAAAAAACAAGTCGAAGTTCACGTTCCTGAGTTAGGGCTTATTCGCGGTGAT
ATCGCTTGGGGTGGCAACTGGTTCTTTTTAGTTAGTGAGCATGGACAAGACATTCAAGCCAGCAATGTTAAACAGCTTAC
TCAAGTAACCATGCAAATTAAGCAAGCACTGGTCGCCGCCAACATCACTGGCGAAAACAGTAGCGAGATTGACCATATTG
AGTTATTTGCCGATAGCGATGATACACAAGTAGATAGTAAAAACTTTGTTTTGTGCCCAGGTTCAGCCTACGATCGCTCC
CCTTGTGGTACCGGCACAAGTGCCAAACTTGCTTGCCTAGCGGCTGACAATAAACTGGCTCCTGAACAATTATGGCAGCA
ACAAGGCGTCGTCGGCAGCGTATTTACTGGCAGTTATCAGTATGCATCTGAGCTTAATACTACGCTCAAAAATCCAGCTG
GTGCAGCTTATCCTGAACAGACCATCATCCCAACGATTTGTGGTCATGCTTATGTTTGTGCTGAAACCACGCTCATTATG
CAAGAAGACGATCCCTTTAAATGGGGAATCCCATCTTAA

Upstream 100 bases:

>100_bases
TTCATTCTATATACAGACCGCGTTAACAGGATGGTTTTGACAAGGTCTAGCAAACAACAATGGAATGTTACTTTTTCACG
GATGAATTAGGATGTCGGTC

Downstream 100 bases:

>100_bases
TAAAATCGCAGCATTATTTATGCAATGACAGGTTTATTGATAAACGCATGAACACTCTTAAAACTACTTCATCGACCGAA
CGTAATCGAGAAAAACCATG

Product: proline racemase

Products: NA

Alternate protein names: Hydroxyproline-2-epimerase; PaHyPRE [H]

Number of amino acids: Translated: 332; Mature: 331

Protein sequence:

>332_residues
MASSLFNFKIIDSHTGGEPTRMVYDGFPDLVGDTIQDKLQSFKQNFDHLRQSIILEPRGNDVLVGALLLPASHPKATAGV
IFFNNAGYLGMCGHGTIGVIVSLAYQQKISAGVHWLETPVGLVKATLHDDGSCSVQNVPSYRYKKQVEVHVPELGLIRGD
IAWGGNWFFLVSEHGQDIQASNVKQLTQVTMQIKQALVAANITGENSSEIDHIELFADSDDTQVDSKNFVLCPGSAYDRS
PCGTGTSAKLACLAADNKLAPEQLWQQQGVVGSVFTGSYQYASELNTTLKNPAGAAYPEQTIIPTICGHAYVCAETTLIM
QEDDPFKWGIPS

Sequences:

>Translated_332_residues
MASSLFNFKIIDSHTGGEPTRMVYDGFPDLVGDTIQDKLQSFKQNFDHLRQSIILEPRGNDVLVGALLLPASHPKATAGV
IFFNNAGYLGMCGHGTIGVIVSLAYQQKISAGVHWLETPVGLVKATLHDDGSCSVQNVPSYRYKKQVEVHVPELGLIRGD
IAWGGNWFFLVSEHGQDIQASNVKQLTQVTMQIKQALVAANITGENSSEIDHIELFADSDDTQVDSKNFVLCPGSAYDRS
PCGTGTSAKLACLAADNKLAPEQLWQQQGVVGSVFTGSYQYASELNTTLKNPAGAAYPEQTIIPTICGHAYVCAETTLIM
QEDDPFKWGIPS
>Mature_331_residues
ASSLFNFKIIDSHTGGEPTRMVYDGFPDLVGDTIQDKLQSFKQNFDHLRQSIILEPRGNDVLVGALLLPASHPKATAGVI
FFNNAGYLGMCGHGTIGVIVSLAYQQKISAGVHWLETPVGLVKATLHDDGSCSVQNVPSYRYKKQVEVHVPELGLIRGDI
AWGGNWFFLVSEHGQDIQASNVKQLTQVTMQIKQALVAANITGENSSEIDHIELFADSDDTQVDSKNFVLCPGSAYDRSP
CGTGTSAKLACLAADNKLAPEQLWQQQGVVGSVFTGSYQYASELNTTLKNPAGAAYPEQTIIPTICGHAYVCAETTLIMQ
EDDPFKWGIPS

Specific function: Allows intracellular utilization of 4-hydroxyproline, one of the major constituents of host collagen, by converting 4- hydroxy-L-proline to 4-hydroxy-D-proline, which can be further metabolized by intracellular 4-hydroxy-D-proline oxidases. Strong B-cell

COG id: COG3938

COG function: function code E; Proline racemase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the proline racemase family. 4- hydroxyproline epimerase subfamily [H]

Homologues:

Organism=Homo sapiens, GI21389361, Length=343, Percent_Identity=27.4052478134111, Blast_Score=139, Evalue=4e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008794 [H]

Pfam domain/function: PF05544 Pro_racemase [H]

EC number: =5.1.1.8 [H]

Molecular weight: Translated: 35949; Mature: 35818

Theoretical pI: Translated: 4.97; Mature: 4.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASSLFNFKIIDSHTGGEPTRMVYDGFPDLVGDTIQDKLQSFKQNFDHLRQSIILEPRGN
CCCCEEEEEEEECCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCC
DVLVGALLLPASHPKATAGVIFFNNAGYLGMCGHGTIGVIVSLAYQQKISAGVHWLETPV
CEEEEEEEECCCCCCCEEEEEEEECCCEEEECCCCHHHHHHHHHHHHHHHHCCHHHHCCH
GLVKATLHDDGSCSVQNVPSYRYKKQVEVHVPELGLIRGDIAWGGNWFFLVSEHGQDIQA
HHEEEEECCCCCCEECCCCCCCCCEEEEEECCCEEEEEEEEEECCCEEEEECCCCCCCCH
SNVKQLTQVTMQIKQALVAANITGENSSEIDHIELFADSDDTQVDSKNFVLCPGSAYDRS
HHHHHHHHHHHHHHHHHHHEECCCCCCCCCEEEEEEECCCCCEECCCCEEECCCCCCCCC
PCGTGTSAKLACLAADNKLAPEQLWQQQGVVGSVFTGSYQYASELNTTLKNPAGAAYPEQ
CCCCCCCCEEEEEECCCCCCHHHHHHHCCCEEEEEECCCHHHHHHHHHHCCCCCCCCCCC
TIIPTICGHAYVCAETTLIMQEDDPFKWGIPS
CCHHHHCCCEEEEEEEEEEEECCCCCCCCCCC
>Mature Secondary Structure 
ASSLFNFKIIDSHTGGEPTRMVYDGFPDLVGDTIQDKLQSFKQNFDHLRQSIILEPRGN
CCCEEEEEEEECCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCC
DVLVGALLLPASHPKATAGVIFFNNAGYLGMCGHGTIGVIVSLAYQQKISAGVHWLETPV
CEEEEEEEECCCCCCCEEEEEEEECCCEEEECCCCHHHHHHHHHHHHHHHHCCHHHHCCH
GLVKATLHDDGSCSVQNVPSYRYKKQVEVHVPELGLIRGDIAWGGNWFFLVSEHGQDIQA
HHEEEEECCCCCCEECCCCCCCCCEEEEEECCCEEEEEEEEEECCCEEEEECCCCCCCCH
SNVKQLTQVTMQIKQALVAANITGENSSEIDHIELFADSDDTQVDSKNFVLCPGSAYDRS
HHHHHHHHHHHHHHHHHHHEECCCCCCCCCEEEEEEECCCCCEECCCCEEECCCCCCCCC
PCGTGTSAKLACLAADNKLAPEQLWQQQGVVGSVFTGSYQYASELNTTLKNPAGAAYPEQ
CCCCCCCCEEEEEECCCCCCHHHHHHHCCCEEEEEECCCHHHHHHHHHHCCCCCCCCCCC
TIIPTICGHAYVCAETTLIMQEDDPFKWGIPS
CCHHHHCCCEEEEEEEEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]