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The map label for this gene is gabT [H]

Identifier: 93005721

GI number: 93005721

Start: 1056196

End: 1057467

Strand: Direct

Name: gabT [H]

Synonym: Pcryo_0893

Alternate gene names: 93005721

Gene position: 1056196-1057467 (Clockwise)

Preceding gene: 93005720

Following gene: 93005722

Centisome position: 34.52

GC content: 47.48

Gene sequence:

>1272_bases
ATGGATTCGTTGTATAACGTTACCGATGCATTCACCATGGTGCATCCAGTAACCCTTAGCAAAGGTAAAAATGCGCACGT
TTGGGATACGAATGGCAAGCACTATATTGATTTCGTCGGTGGTATCGGCGTATTAAATTTTGGTCATTGTCATCCGCATA
TCGTGGACGCTATCATCGATCAATCACAAAACCTCATCCACTACGCTTATAATGCGGCAGGTCACCTGCCTTACCAAAAG
CTCATGCCGAGACTTTGCGATTTAGTTCCCATTGCAGGCAAACTTGCAGGCATGTTAACCAATTGCGGCGCCGAAGCGAC
CGAAAACGCGATCAAAATTGCCCGTATGAAGACTGGTCGTGTCGGTGTGATTGCTTTTGATGGCGGCTTTCATGGCCGTA
CCCTCGCAGCTGTTAATCTCAATGGTAAAGTGGCCCCGTATAAACGTGGTCTTGGCCCTCTTGCCGGCAGTGTCTATCAT
ATCCCATTCCCAAGCCCTGATAATAATATCAGTGACCAGCAAGCGATTGACACTTTGCTGCGCCTGTTCGAGGTCGAAAC
GGATATTGGTAATATCGGCGCTATCATCGCAGAACCTGTACAAGGCGAGGGCGGTTTTCAATTAATGTCGTCAAAATTTG
CTCAATACTTACGTAAGTTTTGTGATGATCATGGCATCTTGCTCATTATGGACGAGATTCAGTCAGGCTTTGGGCGTACA
GGTACACCTTTTGCTTTCAGCCATCTAGGTATCGAGCCTGATATGGTATTGCTGGGTAAAAGTATTGCCGGCGGTTTACC
ATTGGGGGCAGTCATTGGTAAAGGCACTGTCATGAACGACTTACCAAAGGGCAGCTTGGGCGGTACTTATTCTGGCAACC
CAGTAGCATGTGCTGCTGCCAATGCCACGCTCGATATCATGGCAGAAAATGCCGTATGGGACTTCGCAAAACACTATCAG
CAGACCATTGAAAAGACGATAGCGCAGTGGCAGCAAGAGGGTATAACGCCTTGGTTATATAGTTTAACCGGTATCGGTGC
TATGCGTGGCATTGAACTGCGTCATCCGTCTCACGGTACGCACCCAAGCGTGATGGCCTATATTTTAGCGGAAGCTCGTA
AGCAAGGACTGCTGTTGATGCCTAGTGGTAAATACCGCCATATTATTCGCTTATTACCGCCATTAACGATTGAGCCTGAA
ACCCTACAAGAAGGTCTTGATATCTTGAAAGGCATTCTAGCATCCATCCCAAACGAGCTGCCGATTCAATGA

Upstream 100 bases:

>100_bases
CGATGACAAAAAGGAATGCCCGCCCAACTATTATTCGTTTGCCCAAATCCTATCGTTTTGTTGAAATGAGCGTCTAACTC
AAGGAAGATGAGAGACGTTC

Downstream 100 bases:

>100_bases
GTAATATTGCTTGTAGCTTCTATTTTTCTATATCAAGTAGCCATCATTTTTAACTATTATTCATTTGTCATCACAAGCAG
TTTAAGGAGAATAACCGTGA

Product: class III aminotransferase

Products: NA

Alternate protein names: (S)-3-amino-2-methylpropionate transaminase; GABA aminotransferase; GABA-AT; Gamma-amino-N-butyrate transaminase; GABA transaminase; Glutamate:succinic semialdehyde transaminase; L-AIBAT [H]

Number of amino acids: Translated: 423; Mature: 423

Protein sequence:

>423_residues
MDSLYNVTDAFTMVHPVTLSKGKNAHVWDTNGKHYIDFVGGIGVLNFGHCHPHIVDAIIDQSQNLIHYAYNAAGHLPYQK
LMPRLCDLVPIAGKLAGMLTNCGAEATENAIKIARMKTGRVGVIAFDGGFHGRTLAAVNLNGKVAPYKRGLGPLAGSVYH
IPFPSPDNNISDQQAIDTLLRLFEVETDIGNIGAIIAEPVQGEGGFQLMSSKFAQYLRKFCDDHGILLIMDEIQSGFGRT
GTPFAFSHLGIEPDMVLLGKSIAGGLPLGAVIGKGTVMNDLPKGSLGGTYSGNPVACAAANATLDIMAENAVWDFAKHYQ
QTIEKTIAQWQQEGITPWLYSLTGIGAMRGIELRHPSHGTHPSVMAYILAEARKQGLLLMPSGKYRHIIRLLPPLTIEPE
TLQEGLDILKGILASIPNELPIQ

Sequences:

>Translated_423_residues
MDSLYNVTDAFTMVHPVTLSKGKNAHVWDTNGKHYIDFVGGIGVLNFGHCHPHIVDAIIDQSQNLIHYAYNAAGHLPYQK
LMPRLCDLVPIAGKLAGMLTNCGAEATENAIKIARMKTGRVGVIAFDGGFHGRTLAAVNLNGKVAPYKRGLGPLAGSVYH
IPFPSPDNNISDQQAIDTLLRLFEVETDIGNIGAIIAEPVQGEGGFQLMSSKFAQYLRKFCDDHGILLIMDEIQSGFGRT
GTPFAFSHLGIEPDMVLLGKSIAGGLPLGAVIGKGTVMNDLPKGSLGGTYSGNPVACAAANATLDIMAENAVWDFAKHYQ
QTIEKTIAQWQQEGITPWLYSLTGIGAMRGIELRHPSHGTHPSVMAYILAEARKQGLLLMPSGKYRHIIRLLPPLTIEPE
TLQEGLDILKGILASIPNELPIQ
>Mature_423_residues
MDSLYNVTDAFTMVHPVTLSKGKNAHVWDTNGKHYIDFVGGIGVLNFGHCHPHIVDAIIDQSQNLIHYAYNAAGHLPYQK
LMPRLCDLVPIAGKLAGMLTNCGAEATENAIKIARMKTGRVGVIAFDGGFHGRTLAAVNLNGKVAPYKRGLGPLAGSVYH
IPFPSPDNNISDQQAIDTLLRLFEVETDIGNIGAIIAEPVQGEGGFQLMSSKFAQYLRKFCDDHGILLIMDEIQSGFGRT
GTPFAFSHLGIEPDMVLLGKSIAGGLPLGAVIGKGTVMNDLPKGSLGGTYSGNPVACAAANATLDIMAENAVWDFAKHYQ
QTIEKTIAQWQQEGITPWLYSLTGIGAMRGIELRHPSHGTHPSVMAYILAEARKQGLLLMPSGKYRHIIRLLPPLTIEPE
TLQEGLDILKGILASIPNELPIQ

Specific function: 4-aminobutyrate (GABA) degradation. [C]

COG id: COG0160

COG function: function code E; 4-aminobutyrate aminotransferase and related aminotransferases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=414, Percent_Identity=29.2270531400966, Blast_Score=176, Evalue=3e-44,
Organism=Homo sapiens, GI37574042, Length=438, Percent_Identity=25.5707762557078, Blast_Score=138, Evalue=1e-32,
Organism=Homo sapiens, GI284507298, Length=324, Percent_Identity=29.320987654321, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI13994255, Length=430, Percent_Identity=26.2790697674419, Blast_Score=132, Evalue=6e-31,
Organism=Homo sapiens, GI24119277, Length=437, Percent_Identity=26.0869565217391, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI226442709, Length=402, Percent_Identity=26.1194029850746, Blast_Score=122, Evalue=7e-28,
Organism=Homo sapiens, GI226442705, Length=438, Percent_Identity=24.8858447488584, Blast_Score=121, Evalue=1e-27,
Organism=Homo sapiens, GI188536080, Length=458, Percent_Identity=22.4890829694323, Blast_Score=77, Evalue=4e-14,
Organism=Homo sapiens, GI38679950, Length=458, Percent_Identity=22.4890829694323, Blast_Score=77, Evalue=4e-14,
Organism=Homo sapiens, GI38679946, Length=458, Percent_Identity=22.4890829694323, Blast_Score=77, Evalue=4e-14,
Organism=Escherichia coli, GI1789016, Length=398, Percent_Identity=41.9597989949749, Blast_Score=322, Evalue=2e-89,
Organism=Escherichia coli, GI1787560, Length=395, Percent_Identity=43.0379746835443, Blast_Score=322, Evalue=3e-89,
Organism=Escherichia coli, GI1789759, Length=402, Percent_Identity=32.3383084577114, Blast_Score=211, Evalue=9e-56,
Organism=Escherichia coli, GI1788044, Length=400, Percent_Identity=32, Blast_Score=191, Evalue=6e-50,
Organism=Escherichia coli, GI145693181, Length=403, Percent_Identity=31.0173697270471, Blast_Score=167, Evalue=1e-42,
Organism=Escherichia coli, GI1786349, Length=387, Percent_Identity=30.2325581395349, Blast_Score=139, Evalue=4e-34,
Organism=Escherichia coli, GI1786991, Length=415, Percent_Identity=30.1204819277108, Blast_Score=124, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI25144271, Length=407, Percent_Identity=28.2555282555283, Blast_Score=171, Evalue=8e-43,
Organism=Caenorhabditis elegans, GI32564660, Length=421, Percent_Identity=28.978622327791, Blast_Score=149, Evalue=3e-36,
Organism=Caenorhabditis elegans, GI71992977, Length=445, Percent_Identity=25.3932584269663, Blast_Score=135, Evalue=5e-32,
Organism=Caenorhabditis elegans, GI25144274, Length=295, Percent_Identity=27.1186440677966, Blast_Score=117, Evalue=8e-27,
Organism=Caenorhabditis elegans, GI17541228, Length=370, Percent_Identity=24.5945945945946, Blast_Score=90, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI71981843, Length=170, Percent_Identity=28.2352941176471, Blast_Score=77, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6324432, Length=431, Percent_Identity=30.3944315545244, Blast_Score=195, Evalue=1e-50,
Organism=Saccharomyces cerevisiae, GI6323470, Length=409, Percent_Identity=32.7628361858191, Blast_Score=190, Evalue=4e-49,
Organism=Saccharomyces cerevisiae, GI6324386, Length=456, Percent_Identity=23.6842105263158, Blast_Score=96, Evalue=1e-20,
Organism=Drosophila melanogaster, GI21357415, Length=412, Percent_Identity=27.9126213592233, Blast_Score=169, Evalue=4e-42,
Organism=Drosophila melanogaster, GI28574759, Length=445, Percent_Identity=27.1910112359551, Blast_Score=141, Evalue=9e-34,
Organism=Drosophila melanogaster, GI161085790, Length=436, Percent_Identity=27.2935779816514, Blast_Score=140, Evalue=1e-33,
Organism=Drosophila melanogaster, GI21356575, Length=436, Percent_Identity=25.6880733944954, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI281366494, Length=288, Percent_Identity=25, Blast_Score=83, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24667139, Length=288, Percent_Identity=25, Blast_Score=83, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24667143, Length=288, Percent_Identity=25, Blast_Score=83, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004632
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.19; =2.6.1.22 [H]

Molecular weight: Translated: 45599; Mature: 45599

Theoretical pI: Translated: 6.87; Mature: 6.87

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDSLYNVTDAFTMVHPVTLSKGKNAHVWDTNGKHYIDFVGGIGVLNFGHCHPHIVDAIID
CCCHHHHHHHHHHHEEEEECCCCCCEEECCCCCEEEEEECCCCEECCCCCCHHHHHHHHH
QSQNLIHYAYNAAGHLPYQKLMPRLCDLVPIAGKLAGMLTNCGAEATENAIKIARMKTGR
CCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHEEEEEEECCC
VGVIAFDGGFHGRTLAAVNLNGKVAPYKRGLGPLAGSVYHIPFPSPDNNISDQQAIDTLL
EEEEEECCCCCCCEEEEEECCCCCCCHHHCCCCCCCCEEECCCCCCCCCCCHHHHHHHHH
RLFEVETDIGNIGAIIAEPVQGEGGFQLMSSKFAQYLRKFCDDHGILLIMDEIQSGFGRT
HHHHHHCCCCCCCHHEECCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHCCCCC
GTPFAFSHLGIEPDMVLLGKSIAGGLPLGAVIGKGTVMNDLPKGSLGGTYSGNPVACAAA
CCCCCHHHCCCCCCCEEECHHHCCCCCHHHHHCCCCHHCCCCCCCCCCCCCCCCEEEEEC
NATLDIMAENAVWDFAKHYQQTIEKTIAQWQQEGITPWLYSLTGIGAMRGIELRHPSHGT
CCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCHHHCCEEEECCCCCC
HPSVMAYILAEARKQGLLLMPSGKYRHIIRLLPPLTIEPETLQEGLDILKGILASIPNEL
CHHHHHHHHHHHHHCCEEEECCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCC
PIQ
CCC
>Mature Secondary Structure
MDSLYNVTDAFTMVHPVTLSKGKNAHVWDTNGKHYIDFVGGIGVLNFGHCHPHIVDAIID
CCCHHHHHHHHHHHEEEEECCCCCCEEECCCCCEEEEEECCCCEECCCCCCHHHHHHHHH
QSQNLIHYAYNAAGHLPYQKLMPRLCDLVPIAGKLAGMLTNCGAEATENAIKIARMKTGR
CCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHEEEEEEECCC
VGVIAFDGGFHGRTLAAVNLNGKVAPYKRGLGPLAGSVYHIPFPSPDNNISDQQAIDTLL
EEEEEECCCCCCCEEEEEECCCCCCCHHHCCCCCCCCEEECCCCCCCCCCCHHHHHHHHH
RLFEVETDIGNIGAIIAEPVQGEGGFQLMSSKFAQYLRKFCDDHGILLIMDEIQSGFGRT
HHHHHHCCCCCCCHHEECCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHCCCCC
GTPFAFSHLGIEPDMVLLGKSIAGGLPLGAVIGKGTVMNDLPKGSLGGTYSGNPVACAAA
CCCCCHHHCCCCCCCEEECHHHCCCCCHHHHHCCCCHHCCCCCCCCCCCCCCCCEEEEEC
NATLDIMAENAVWDFAKHYQQTIEKTIAQWQQEGITPWLYSLTGIGAMRGIELRHPSHGT
CCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCHHHCCEEEECCCCCC
HPSVMAYILAEARKQGLLLMPSGKYRHIIRLLPPLTIEPETLQEGLDILKGILASIPNEL
CHHHHHHHHHHHHHCCEEEECCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCC
PIQ
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2254272; 9205837; 9278503; 2178550 [H]