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The map label for this gene is fabG2 [H]

Identifier: 93005669

GI number: 93005669

Start: 993004

End: 993795

Strand: Direct

Name: fabG2 [H]

Synonym: Pcryo_0839

Alternate gene names: 93005669

Gene position: 993004-993795 (Clockwise)

Preceding gene: 93005668

Following gene: 93005670

Centisome position: 32.45

GC content: 49.24

Gene sequence:

>792_bases
ATGCAAATTGAACAACACAGCTTTTTGGTCACGGGCGGTGCGTCAGGTCTGGGTGAGTCGGTAGTGCGTGCTATCGTGGC
TCAAGGCGGCAAGGTTGTCATCGCTGATCTTAATGAGTCGATGGGGCAAGCACTGGTTGATGAATTGGGTGACCATGCTC
GTTTTGTACGCTGTGATGTGACCAGTGGCGATGAGGTACAAGCGGCTGTGGATATGGCTGAAAAAGAATTTGGCGGCTTA
CAAGGTTCTATCAACTGTGCAGGTATTGCCGTTGTGCAAAAGCTGCTGGACCGTGATAATAACCCAGCAAATCTCGATGC
TTTTAGTCGCGGCGTCAATATTAATCTTGTTGGTTCCTTTAATGTCGCGCGTTTGGTCGCAGCGAGTATTGCGAAGCGTG
TAGCCAATGCCAATAACGCAGACAGCTCCGTAGAGAAGAACGCTGATAATGGCGTCATTATTAATACGGCTTCTATCGCG
GCTTTTGATGGGCAAGTAGGGCAAGCAAGCTATTCATCGTCTAAAGCTGGCGTCGTTGGTCTGACCTTGCCGCTAGCGCG
TGAGCTGGCGCGTCATGGTATTCGCGTTATGACCATCGCACCTGGTGTTTTTGCCACACCGATGATGGATACTATCCCTG
AAAAAGCGCGCGAACAGCTAGAGGCCGGTGTTCCTTATCCAAAGCGTTTAGGCAATCCAAATGAGTTTGCTAAATTGGTC
ACGCACATTATTGATAATGCCTACCTAAATGGTGAAGTGATTCGCCTAGATGGCGCAATTCGTATGGTGTAA

Upstream 100 bases:

>100_bases
ATCTGCGGCTTAATAAAGCAATACATTCATATCGTCAGGTTAAGATAAAAATCGATAACTGATAAAAATAACAGTGAAAA
TATCAATTAAAGGAAAAATT

Downstream 100 bases:

>100_bases
GGTGATTTTAGATTTTGATTGCAGCAAATTTACCCTTAATTCATAAAGCTTGCACAAACTTGGCATAGTATTTTGCTATC
TTATAAAAGATGGTTTTATC

Product: short-chain dehydrogenase/reductase SDR

Products: 3-oxoacyl-CoA; NADH; H+

Alternate protein names: NA

Number of amino acids: Translated: 263; Mature: 263

Protein sequence:

>263_residues
MQIEQHSFLVTGGASGLGESVVRAIVAQGGKVVIADLNESMGQALVDELGDHARFVRCDVTSGDEVQAAVDMAEKEFGGL
QGSINCAGIAVVQKLLDRDNNPANLDAFSRGVNINLVGSFNVARLVAASIAKRVANANNADSSVEKNADNGVIINTASIA
AFDGQVGQASYSSSKAGVVGLTLPLARELARHGIRVMTIAPGVFATPMMDTIPEKAREQLEAGVPYPKRLGNPNEFAKLV
THIIDNAYLNGEVIRLDGAIRMV

Sequences:

>Translated_263_residues
MQIEQHSFLVTGGASGLGESVVRAIVAQGGKVVIADLNESMGQALVDELGDHARFVRCDVTSGDEVQAAVDMAEKEFGGL
QGSINCAGIAVVQKLLDRDNNPANLDAFSRGVNINLVGSFNVARLVAASIAKRVANANNADSSVEKNADNGVIINTASIA
AFDGQVGQASYSSSKAGVVGLTLPLARELARHGIRVMTIAPGVFATPMMDTIPEKAREQLEAGVPYPKRLGNPNEFAKLV
THIIDNAYLNGEVIRLDGAIRMV
>Mature_263_residues
MQIEQHSFLVTGGASGLGESVVRAIVAQGGKVVIADLNESMGQALVDELGDHARFVRCDVTSGDEVQAAVDMAEKEFGGL
QGSINCAGIAVVQKLLDRDNNPANLDAFSRGVNINLVGSFNVARLVAASIAKRVANANNADSSVEKNADNGVIINTASIA
AFDGQVGQASYSSSKAGVVGLTLPLARELARHGIRVMTIAPGVFATPMMDTIPEKAREQLEAGVPYPKRLGNPNEFAKLV
THIIDNAYLNGEVIRLDGAIRMV

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI4758504, Length=255, Percent_Identity=50.5882352941176, Blast_Score=245, Evalue=3e-65,
Organism=Homo sapiens, GI83715985, Length=255, Percent_Identity=47.0588235294118, Blast_Score=219, Evalue=1e-57,
Organism=Homo sapiens, GI15277342, Length=268, Percent_Identity=30.9701492537313, Blast_Score=114, Evalue=8e-26,
Organism=Homo sapiens, GI40254992, Length=258, Percent_Identity=29.4573643410853, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI59889578, Length=227, Percent_Identity=29.0748898678414, Blast_Score=82, Evalue=4e-16,
Organism=Homo sapiens, GI31542939, Length=263, Percent_Identity=26.9961977186312, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI10190704, Length=262, Percent_Identity=28.2442748091603, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI109715829, Length=257, Percent_Identity=29.5719844357977, Blast_Score=65, Evalue=6e-11,
Organism=Homo sapiens, GI40548397, Length=212, Percent_Identity=28.3018867924528, Blast_Score=65, Evalue=7e-11,
Organism=Homo sapiens, GI214010158, Length=212, Percent_Identity=28.3018867924528, Blast_Score=65, Evalue=7e-11,
Organism=Homo sapiens, GI214010156, Length=212, Percent_Identity=28.3018867924528, Blast_Score=65, Evalue=7e-11,
Organism=Homo sapiens, GI22758144, Length=212, Percent_Identity=28.3018867924528, Blast_Score=65, Evalue=7e-11,
Organism=Escherichia coli, GI1787335, Length=268, Percent_Identity=28.7313432835821, Blast_Score=105, Evalue=3e-24,
Organism=Escherichia coli, GI87082100, Length=270, Percent_Identity=26.2962962962963, Blast_Score=91, Evalue=9e-20,
Organism=Escherichia coli, GI1787905, Length=269, Percent_Identity=27.8810408921933, Blast_Score=78, Evalue=5e-16,
Organism=Escherichia coli, GI1789208, Length=266, Percent_Identity=28.9473684210526, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI1790717, Length=258, Percent_Identity=27.1317829457364, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI87082160, Length=257, Percent_Identity=24.9027237354086, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI2367175, Length=264, Percent_Identity=27.2727272727273, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1788459, Length=260, Percent_Identity=23.8461538461538, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1789378, Length=260, Percent_Identity=25.7692307692308, Blast_Score=61, Evalue=7e-11,
Organism=Escherichia coli, GI1787820, Length=195, Percent_Identity=26.1538461538462, Blast_Score=61, Evalue=9e-11,
Organism=Caenorhabditis elegans, GI17538182, Length=255, Percent_Identity=44.7058823529412, Blast_Score=214, Evalue=2e-56,
Organism=Caenorhabditis elegans, GI25147288, Length=259, Percent_Identity=30.5019305019305, Blast_Score=112, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17555706, Length=258, Percent_Identity=29.8449612403101, Blast_Score=102, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17561402, Length=270, Percent_Identity=26.2962962962963, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17567345, Length=213, Percent_Identity=24.4131455399061, Blast_Score=67, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI17563726, Length=281, Percent_Identity=24.1992882562278, Blast_Score=64, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6322861, Length=225, Percent_Identity=29.7777777777778, Blast_Score=80, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6320089, Length=218, Percent_Identity=26.605504587156, Blast_Score=72, Evalue=1e-13,
Organism=Drosophila melanogaster, GI17737361, Length=256, Percent_Identity=51.5625, Blast_Score=251, Evalue=4e-67,
Organism=Drosophila melanogaster, GI24639444, Length=260, Percent_Identity=32.6923076923077, Blast_Score=118, Evalue=4e-27,
Organism=Drosophila melanogaster, GI221331218, Length=221, Percent_Identity=26.2443438914027, Blast_Score=65, Evalue=5e-11,
Organism=Drosophila melanogaster, GI24665243, Length=221, Percent_Identity=26.2443438914027, Blast_Score=65, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.35

Molecular weight: Translated: 27580; Mature: 27580

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQIEQHSFLVTGGASGLGESVVRAIVAQGGKVVIADLNESMGQALVDELGDHARFVRCDV
CCCCCCEEEEECCCCCHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHCCCCEEEEEEC
TSGDEVQAAVDMAEKEFGGLQGSINCAGIAVVQKLLDRDNNPANLDAFSRGVNINLVGSF
CCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHCCCCEEEEECC
NVARLVAASIAKRVANANNADSSVEKNADNGVIINTASIAAFDGQVGQASYSSSKAGVVG
HHHHHHHHHHHHHHHCCCCCCCHHHCCCCCCEEEEECEEEEECCCCCCCCCCCCCCCEEE
LTLPLARELARHGIRVMTIAPGVFATPMMDTIPEKAREQLEAGVPYPKRLGNPNEFAKLV
EHHHHHHHHHHCCEEEEEECCCCHHCCHHHHHHHHHHHHHHCCCCCHHHCCCHHHHHHHH
THIIDNAYLNGEVIRLDGAIRMV
HHHHHCCCCCCEEEEECCEEECC
>Mature Secondary Structure
MQIEQHSFLVTGGASGLGESVVRAIVAQGGKVVIADLNESMGQALVDELGDHARFVRCDV
CCCCCCEEEEECCCCCHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHCCCCEEEEEEC
TSGDEVQAAVDMAEKEFGGLQGSINCAGIAVVQKLLDRDNNPANLDAFSRGVNINLVGSF
CCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHCCCCEEEEECC
NVARLVAASIAKRVANANNADSSVEKNADNGVIINTASIAAFDGQVGQASYSSSKAGVVG
HHHHHHHHHHHHHHHCCCCCCCHHHCCCCCCEEEEECEEEEECCCCCCCCCCCCCCCEEE
LTLPLARELARHGIRVMTIAPGVFATPMMDTIPEKAREQLEAGVPYPKRLGNPNEFAKLV
EHHHHHHHHHHCCEEEEEECCCCHHCCHHHHHHHHHHHHHHCCCCCHHHCCCHHHHHHHH
THIIDNAYLNGEVIRLDGAIRMV
HHHHHCCCCCCEEEEECCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (S)-3-hydroxyacyl-CoA; NAD+

Specific reaction: (S)-3-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]