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The map label for this gene is acsA [H]

Identifier: 93005668

GI number: 93005668

Start: 991195

End: 992916

Strand: Direct

Name: acsA [H]

Synonym: Pcryo_0838

Alternate gene names: 93005668

Gene position: 991195-992916 (Clockwise)

Preceding gene: 93005667

Following gene: 93005669

Centisome position: 32.39

GC content: 45.47

Gene sequence:

>1722_bases
ATGAATACCTCTCCTTCAAGTACTACCTCTTTAAACACCCCTTCAAATCATGCTGTAAATACCTCACAGGCGCTAACGAG
TTATAGTGACTATTATAATAATTTTGATATGAACGCATTACTGACAGAGATATTTGGTGAAAATGTAGATGATCGTTTAA
ACGCCTATATGGCGTGCTGTGGACGTCATGTACGTGACGGTCGCGGTGATAATATTGCGCTAGTTCATGAAGATACGGCT
GGCAATGTCACGCGTATGAGCTTTGCTGAGCTTGATAAAGCAAGTGCACAGGTTGCCAGTTTACTACTTTCTTATGGCGT
GCAAGCGGGTGACCAAGTGGCAACTATGCTACCGCGTACCCCTGAGTTACTCACCATTGTATTAGCCACTTGGCGGATTG
GCGCAGTCTATCAACCGCTGTTTACCGCCTTTGGTTATGATTCGATTAAGTATCGAATGGACAAAGCTAATACTAAAGTT
GTTTTTACCAATCAAGACAATCGTGGCAAGTTTGACGACTTGGCGAAGCAAACCAAAATGGTGTTGGTTGGTAGCAAGGT
AGATGCGCAAAGCTGGGGTGATGATAACTATGCTGACAAGATATCAAAGCAGCCACAAACTATAGAATCAGTGTTACTAA
ATACCGATGCACCATTTTTACAGATGTTTACCTCGGGTACGGTTGGTAAGTCAAAAGGCGTTAGTGTGCCACTAAGCGCA
CTTTCGGCTTTTTATCTGTACATGCGTTATGCAATTGACCTGCGCGCGGATGACAACTACTGGAATATGGCAGATCCAGG
CTGGGCGTATGGGTTATATTATGCGATTACTGGGCCATTATTATTAGGTATTACTACCTATTTTAATGAAGCGGGCTTCG
ATGCTGCCAATACCCGCGACTTTATGGTACGCCATAAAATTAGCAATTTGGCGTCTTCACCGACTGCATTTCGTATGATG
AAATCGAGTGGCGTATTTGAAGCTGCTCACAATGACGCAGCGGCTAAATTATCACTGCGCTGTGCCAATTCAGCAGGCGA
GACCTTAAATACCGAAGTGGTCAATTGGGTTGAGACCTACTTAAACTGCAAGGTTTGTGATCAGTACGGACAGACCGAGA
CAGGAATGACCTGCTGTGAGCACCATGCATTGGCACATGACTGTCCAGTAGGCTCGATGGGCATGGCGCTACCGGGGCAC
ACATTGGTGGTGTTAGATGATGATATGAATATATTACCTGATGGCGAGCAAGGACAGCTTGCCGTAGTGGTCAGTCAATC
GTCCGCGTTTTATTTCCGCGGCTATAGCTGGAATGAAAAAGATGCCTTCGCTGATGACTATTATTTAACAGGTGACGTGG
TTGAGCGTCATAGTGATGGCAGCTATTGGTTTTCAGGGCGTGATGACGACATTATCATTACAGCAGGTTACCGCGTTGGA
CCAACCGATGTTGAAAACACAGTGCTTGAGCATGAGGCAGTCGCAGAGTCAGCGGCAGTTGGGGTGCCAGACGAAGTGCG
TGGTCATACCATTAAGTCTTATGTGGTGCTAAAAGATGGTATCAAAGGCACAGACGAGATTGCTAAAGAGATTCAAGACT
TGGTACGCAGGCGTCTATCAACTCATGCTTATCCACGTGAGGTTGAGTTTGTGAAAGAGTTACCAAAAACCCCAAGTGGT
AAAATTCAGCGCTTTTTGCTGCGCAGTTTATCTGCGGCTTAA

Upstream 100 bases:

>100_bases
TGTTTAAATGGTTGATCAAATATAGCTGTTTTACGATTTATTCTATTATTTCTAACTCTCTGATTTTGTCAGTGATTCTC
GATTGCTAAAGGATTAGCTT

Downstream 100 bases:

>100_bases
TAAAGCAATACATTCATATCGTCAGGTTAAGATAAAAATCGATAACTGATAAAAATAACAGTGAAAATATCAATTAAAGG
AAAAATTATGCAAATTGAAC

Product: AMP-dependent synthetase and ligase

Products: NA

Alternate protein names: Acetate--CoA ligase; Acetyl-CoA synthase; Acyl-activating enzyme [H]

Number of amino acids: Translated: 573; Mature: 573

Protein sequence:

>573_residues
MNTSPSSTTSLNTPSNHAVNTSQALTSYSDYYNNFDMNALLTEIFGENVDDRLNAYMACCGRHVRDGRGDNIALVHEDTA
GNVTRMSFAELDKASAQVASLLLSYGVQAGDQVATMLPRTPELLTIVLATWRIGAVYQPLFTAFGYDSIKYRMDKANTKV
VFTNQDNRGKFDDLAKQTKMVLVGSKVDAQSWGDDNYADKISKQPQTIESVLLNTDAPFLQMFTSGTVGKSKGVSVPLSA
LSAFYLYMRYAIDLRADDNYWNMADPGWAYGLYYAITGPLLLGITTYFNEAGFDAANTRDFMVRHKISNLASSPTAFRMM
KSSGVFEAAHNDAAAKLSLRCANSAGETLNTEVVNWVETYLNCKVCDQYGQTETGMTCCEHHALAHDCPVGSMGMALPGH
TLVVLDDDMNILPDGEQGQLAVVVSQSSAFYFRGYSWNEKDAFADDYYLTGDVVERHSDGSYWFSGRDDDIIITAGYRVG
PTDVENTVLEHEAVAESAAVGVPDEVRGHTIKSYVVLKDGIKGTDEIAKEIQDLVRRRLSTHAYPREVEFVKELPKTPSG
KIQRFLLRSLSAA

Sequences:

>Translated_573_residues
MNTSPSSTTSLNTPSNHAVNTSQALTSYSDYYNNFDMNALLTEIFGENVDDRLNAYMACCGRHVRDGRGDNIALVHEDTA
GNVTRMSFAELDKASAQVASLLLSYGVQAGDQVATMLPRTPELLTIVLATWRIGAVYQPLFTAFGYDSIKYRMDKANTKV
VFTNQDNRGKFDDLAKQTKMVLVGSKVDAQSWGDDNYADKISKQPQTIESVLLNTDAPFLQMFTSGTVGKSKGVSVPLSA
LSAFYLYMRYAIDLRADDNYWNMADPGWAYGLYYAITGPLLLGITTYFNEAGFDAANTRDFMVRHKISNLASSPTAFRMM
KSSGVFEAAHNDAAAKLSLRCANSAGETLNTEVVNWVETYLNCKVCDQYGQTETGMTCCEHHALAHDCPVGSMGMALPGH
TLVVLDDDMNILPDGEQGQLAVVVSQSSAFYFRGYSWNEKDAFADDYYLTGDVVERHSDGSYWFSGRDDDIIITAGYRVG
PTDVENTVLEHEAVAESAAVGVPDEVRGHTIKSYVVLKDGIKGTDEIAKEIQDLVRRRLSTHAYPREVEFVKELPKTPSG
KIQRFLLRSLSAA
>Mature_573_residues
MNTSPSSTTSLNTPSNHAVNTSQALTSYSDYYNNFDMNALLTEIFGENVDDRLNAYMACCGRHVRDGRGDNIALVHEDTA
GNVTRMSFAELDKASAQVASLLLSYGVQAGDQVATMLPRTPELLTIVLATWRIGAVYQPLFTAFGYDSIKYRMDKANTKV
VFTNQDNRGKFDDLAKQTKMVLVGSKVDAQSWGDDNYADKISKQPQTIESVLLNTDAPFLQMFTSGTVGKSKGVSVPLSA
LSAFYLYMRYAIDLRADDNYWNMADPGWAYGLYYAITGPLLLGITTYFNEAGFDAANTRDFMVRHKISNLASSPTAFRMM
KSSGVFEAAHNDAAAKLSLRCANSAGETLNTEVVNWVETYLNCKVCDQYGQTETGMTCCEHHALAHDCPVGSMGMALPGH
TLVVLDDDMNILPDGEQGQLAVVVSQSSAFYFRGYSWNEKDAFADDYYLTGDVVERHSDGSYWFSGRDDDIIITAGYRVG
PTDVENTVLEHEAVAESAAVGVPDEVRGHTIKSYVVLKDGIKGTDEIAKEIQDLVRRRLSTHAYPREVEFVKELPKTPSG
KIQRFLLRSLSAA

Specific function: Has a role in growth and sporulation on acetate [H]

COG id: COG0365

COG function: function code I; Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI122937307, Length=511, Percent_Identity=32.6810176125245, Blast_Score=263, Evalue=5e-70,
Organism=Homo sapiens, GI38505220, Length=519, Percent_Identity=32.3699421965318, Blast_Score=242, Evalue=8e-64,
Organism=Homo sapiens, GI42544132, Length=562, Percent_Identity=29.3594306049822, Blast_Score=231, Evalue=1e-60,
Organism=Homo sapiens, GI58082049, Length=509, Percent_Identity=30.8447937131631, Blast_Score=221, Evalue=2e-57,
Organism=Homo sapiens, GI28416953, Length=576, Percent_Identity=28.6458333333333, Blast_Score=219, Evalue=5e-57,
Organism=Homo sapiens, GI157311624, Length=509, Percent_Identity=30.6483300589391, Blast_Score=216, Evalue=3e-56,
Organism=Homo sapiens, GI157311622, Length=509, Percent_Identity=30.6483300589391, Blast_Score=216, Evalue=3e-56,
Organism=Homo sapiens, GI115511026, Length=514, Percent_Identity=29.9610894941634, Blast_Score=210, Evalue=3e-54,
Organism=Homo sapiens, GI13375727, Length=556, Percent_Identity=27.8776978417266, Blast_Score=207, Evalue=2e-53,
Organism=Homo sapiens, GI8923896, Length=577, Percent_Identity=26.6897746967071, Blast_Score=191, Evalue=1e-48,
Organism=Homo sapiens, GI253970489, Length=590, Percent_Identity=26.271186440678, Blast_Score=189, Evalue=8e-48,
Organism=Homo sapiens, GI195947378, Length=431, Percent_Identity=25.754060324826, Blast_Score=122, Evalue=7e-28,
Organism=Homo sapiens, GI187761345, Length=538, Percent_Identity=24.3494423791822, Blast_Score=107, Evalue=3e-23,
Organism=Homo sapiens, GI187761343, Length=538, Percent_Identity=24.3494423791822, Blast_Score=107, Evalue=3e-23,
Organism=Homo sapiens, GI156151445, Length=542, Percent_Identity=24.7232472324723, Blast_Score=105, Evalue=2e-22,
Organism=Homo sapiens, GI42544134, Length=392, Percent_Identity=24.234693877551, Blast_Score=97, Evalue=6e-20,
Organism=Escherichia coli, GI1790505, Length=557, Percent_Identity=29.6229802513465, Blast_Score=243, Evalue=2e-65,
Organism=Escherichia coli, GI1786529, Length=526, Percent_Identity=28.7072243346008, Blast_Score=149, Evalue=5e-37,
Organism=Escherichia coli, GI145693145, Length=518, Percent_Identity=25.2895752895753, Blast_Score=141, Evalue=1e-34,
Organism=Escherichia coli, GI221142682, Length=529, Percent_Identity=22.117202268431, Blast_Score=110, Evalue=4e-25,
Organism=Escherichia coli, GI1788107, Length=536, Percent_Identity=25.1865671641791, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI1786810, Length=531, Percent_Identity=22.5988700564972, Blast_Score=90, Evalue=3e-19,
Organism=Escherichia coli, GI1786801, Length=439, Percent_Identity=22.7790432801822, Blast_Score=79, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI71983001, Length=593, Percent_Identity=26.9814502529511, Blast_Score=188, Evalue=6e-48,
Organism=Caenorhabditis elegans, GI71982997, Length=593, Percent_Identity=26.9814502529511, Blast_Score=188, Evalue=8e-48,
Organism=Caenorhabditis elegans, GI17557194, Length=525, Percent_Identity=24, Blast_Score=132, Evalue=3e-31,
Organism=Caenorhabditis elegans, GI71996755, Length=518, Percent_Identity=25.2895752895753, Blast_Score=124, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI17538037, Length=520, Percent_Identity=22.3076923076923, Blast_Score=117, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI17558820, Length=488, Percent_Identity=21.7213114754098, Blast_Score=108, Evalue=6e-24,
Organism=Caenorhabditis elegans, GI71994703, Length=536, Percent_Identity=22.0149253731343, Blast_Score=107, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI71994694, Length=536, Percent_Identity=22.0149253731343, Blast_Score=107, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI71994690, Length=536, Percent_Identity=22.0149253731343, Blast_Score=107, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17560308, Length=540, Percent_Identity=23.7037037037037, Blast_Score=105, Evalue=5e-23,
Organism=Caenorhabditis elegans, GI17560140, Length=509, Percent_Identity=23.7721021611002, Blast_Score=103, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17559526, Length=534, Percent_Identity=23.2209737827715, Blast_Score=98, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI32563687, Length=492, Percent_Identity=22.1544715447154, Blast_Score=94, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17531443, Length=515, Percent_Identity=22.5242718446602, Blast_Score=91, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI71985884, Length=366, Percent_Identity=25.6830601092896, Blast_Score=75, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6323182, Length=570, Percent_Identity=31.2280701754386, Blast_Score=242, Evalue=2e-64,
Organism=Saccharomyces cerevisiae, GI6319264, Length=570, Percent_Identity=30.1754385964912, Blast_Score=221, Evalue=2e-58,
Organism=Saccharomyces cerevisiae, GI6319699, Length=232, Percent_Identity=29.3103448275862, Blast_Score=109, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24667955, Length=560, Percent_Identity=27.6785714285714, Blast_Score=195, Evalue=9e-50,
Organism=Drosophila melanogaster, GI62472339, Length=535, Percent_Identity=27.1028037383178, Blast_Score=185, Evalue=6e-47,
Organism=Drosophila melanogaster, GI21355225, Length=559, Percent_Identity=26.4758497316637, Blast_Score=172, Evalue=4e-43,
Organism=Drosophila melanogaster, GI24667959, Length=503, Percent_Identity=27.4353876739563, Blast_Score=169, Evalue=4e-42,
Organism=Drosophila melanogaster, GI19922652, Length=510, Percent_Identity=24.7058823529412, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24581924, Length=528, Percent_Identity=23.2954545454545, Blast_Score=98, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24656500, Length=510, Percent_Identity=23.3333333333333, Blast_Score=90, Evalue=4e-18,
Organism=Drosophila melanogaster, GI18859661, Length=517, Percent_Identity=24.9516441005803, Blast_Score=83, Evalue=5e-16,
Organism=Drosophila melanogaster, GI21355181, Length=553, Percent_Identity=22.4231464737794, Blast_Score=82, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24648253, Length=510, Percent_Identity=22.9411764705882, Blast_Score=79, Evalue=6e-15,
Organism=Drosophila melanogaster, GI24648255, Length=510, Percent_Identity=23.1372549019608, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI21356947, Length=509, Percent_Identity=21.6110019646365, Blast_Score=70, Evalue=4e-12,
Organism=Drosophila melanogaster, GI21356441, Length=515, Percent_Identity=22.1359223300971, Blast_Score=70, Evalue=5e-12,
Organism=Drosophila melanogaster, GI21358303, Length=478, Percent_Identity=19.8744769874477, Blast_Score=69, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.1 [H]

Molecular weight: Translated: 63098; Mature: 63098

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTSPSSTTSLNTPSNHAVNTSQALTSYSDYYNNFDMNALLTEIFGENVDDRLNAYMACC
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHHH
GRHVRDGRGDNIALVHEDTAGNVTRMSFAELDKASAQVASLLLSYGVQAGDQVATMLPRT
HHHHCCCCCCEEEEEEECCCCCEEEHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCC
PELLTIVLATWRIGAVYQPLFTAFGYDSIKYRMDKANTKVVFTNQDNRGKFDDLAKQTKM
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHEEEEECCCEEEEEECCCCCCCHHHHHHHCEE
VLVGSKVDAQSWGDDNYADKISKQPQTIESVLLNTDAPFLQMFTSGTVGKSKGVSVPLSA
EEEECCCCCCCCCCCCHHHHHCCCHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCCCCHHH
LSAFYLYMRYAIDLRADDNYWNMADPGWAYGLYYAITGPLLLGITTYFNEAGFDAANTRD
HHHHHHHHHHHEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHH
FMVRHKISNLASSPTAFRMMKSSGVFEAAHNDAAAKLSLRCANSAGETLNTEVVNWVETY
HHHHHHHHHHHCCCHHHHHHHCCCCEEECCCCCCEEEEEEECCCCCCCHHHHHHHHHHHH
LNCKVCDQYGQTETGMTCCEHHALAHDCPVGSMGMALPGHTLVVLDDDMNILPDGEQGQL
HCHHHHHHCCCCCCCHHHHHHCCHHHCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCE
AVVVSQSSAFYFRGYSWNEKDAFADDYYLTGDVVERHSDGSYWFSGRDDDIIITAGYRVG
EEEEECCCEEEEECCCCCCCCCCCCCEEEECHHHHHCCCCCEEECCCCCCEEEECCCCCC
PTDVENTVLEHEAVAESAAVGVPDEVRGHTIKSYVVLKDGIKGTDEIAKEIQDLVRRRLS
CCCHHHHHHHHHHHHHHHCCCCCHHHCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHH
THAYPREVEFVKELPKTPSGKIQRFLLRSLSAA
HCCCCHHHHHHHHCCCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MNTSPSSTTSLNTPSNHAVNTSQALTSYSDYYNNFDMNALLTEIFGENVDDRLNAYMACC
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHHH
GRHVRDGRGDNIALVHEDTAGNVTRMSFAELDKASAQVASLLLSYGVQAGDQVATMLPRT
HHHHCCCCCCEEEEEEECCCCCEEEHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCC
PELLTIVLATWRIGAVYQPLFTAFGYDSIKYRMDKANTKVVFTNQDNRGKFDDLAKQTKM
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHEEEEECCCEEEEEECCCCCCCHHHHHHHCEE
VLVGSKVDAQSWGDDNYADKISKQPQTIESVLLNTDAPFLQMFTSGTVGKSKGVSVPLSA
EEEECCCCCCCCCCCCHHHHHCCCHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCCCCHHH
LSAFYLYMRYAIDLRADDNYWNMADPGWAYGLYYAITGPLLLGITTYFNEAGFDAANTRD
HHHHHHHHHHHEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHH
FMVRHKISNLASSPTAFRMMKSSGVFEAAHNDAAAKLSLRCANSAGETLNTEVVNWVETY
HHHHHHHHHHHCCCHHHHHHHCCCCEEECCCCCCEEEEEEECCCCCCCHHHHHHHHHHHH
LNCKVCDQYGQTETGMTCCEHHALAHDCPVGSMGMALPGHTLVVLDDDMNILPDGEQGQL
HCHHHHHHCCCCCCCHHHHHHCCHHHCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCE
AVVVSQSSAFYFRGYSWNEKDAFADDYYLTGDVVERHSDGSYWFSGRDDDIIITAGYRVG
EEEEECCCEEEEECCCCCCCCCCCCCEEEECHHHHHCCCCCEEECCCCCCEEEECCCCCC
PTDVENTVLEHEAVAESAAVGVPDEVRGHTIKSYVVLKDGIKGTDEIAKEIQDLVRRRLS
CCCHHHHHHHHHHHHHHHCCCCCHHHCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHH
THAYPREVEFVKELPKTPSGKIQRFLLRSLSAA
HCCCCHHHHHHHHCCCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7934817; 9387221; 9384377 [H]