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The map label for this gene is moeA [H]

Identifier: 93005543

GI number: 93005543

Start: 841343

End: 842632

Strand: Reverse

Name: moeA [H]

Synonym: Pcryo_0713

Alternate gene names: 93005543

Gene position: 842632-841343 (Counterclockwise)

Preceding gene: 93005544

Following gene: 93005542

Centisome position: 27.54

GC content: 43.88

Gene sequence:

>1290_bases
ATGATTACGGTTGAAGGGCTTGTAGCTGAGATACAGCAGCGCGTAGAGAATTATAATAATAACGACTATCCGCTTGATAA
AAGAGCCGTCAGTAACTACGATTTATTAGACAGCTGTCATCACATACTGGCTGAAGATATCGTCTCGCCTTTTTCGGTAC
CAAGACAGAACCTATCTGCGATGGATGGTTATGCGATTGCTAAAAGGACTAAGCTTGCAACAAATACTACCATCACCATC
ATCGGAGAATCGCAAGCTGGTAGCCCTTATAATGGTGATATCCAGTCAAGTCAAGGAGTACGCATCTTTACTGGTGCAGT
CGTACCTGATGAATGTGATACCGTTATCATGCAAGAAAACACCAATTTTGCCGCGATAAAAGGCAGCATTGATAAATCAA
AGCCATACTCAATCATCCTTAGCCAAACGGCTCAGTCTGATGACCATATTCGCAAACAAGGCGAAGAAATTGCAGCGGGA
GAAGCCGTTTTACTCAAAGGTAAGCGCCTAAATCCTGCTGATATCAGTTTATTGGCGAATTTGGGTTTTGATAAAGTCAA
CGTTTATCAACCCTTGACGGTTGGTGTGCTCGCGACAGGCGACGAGCTGGTTGCGATTGGTAATGCGCTTAAAAGCTTGG
CGCAGATTTATAACTCTAATACCCCCACTCTTAAAAGTCTGCTCTCTGATTTACCTATAAATATTCGTGATTATGGGATT
ATCCCTGATGATTTAGACAAAACGACGGCTGCTGTCACTCAAGCCATGCAAGAGTGTGACGTACTGATCTCTACCGCTGG
TGTATCCGTTGGTGATTATGATTTTTTGACCACCGTCATTGAGCAATTGGGCAAGATTAACCACTACAAAGTCGCAATGA
AACCTGGTAAGCCGTTTGTCTTTGGTGAGCTGACGCAAAACCTTGCCAAGCCTGTCTTATATTTTGGTTTGCCTGGTAAT
CCACTATCGACGGTCGTTGGTACGCTACAGTTTGTAATTCCTGCTTTGTGGCAAATGGCAGGCGCGTCTCATTCAGAGCG
ACCCATGCAATTAACAGTCATGGCAACACTTAAAAACGATGTTAAAAAATCAGCGGGTCGTAAGGACTTCCAAAGAGGCG
TTTTAACCCAAGATGAAGCAGGCATTTTTTACGTTGAAAGCTTTACCAAACAACAATCACACCGTATCAAACAGCTGAGC
CATGCCAACTGCTTTATTGTAATGGCACAAGATTCTGGCAATGTAGCCGCTGGCGAAAGCGTACAAGTGCAACCTTTCCC
TTGGATATAG

Upstream 100 bases:

>100_bases
GACTCCGCTTATAAAATCCCTGTCAGCCATGTCATTCTTATGGTATAAAGTATGTCTGATGCTATATATAGCTCAACATT
AATAAGATGAGTACAAGGTT

Downstream 100 bases:

>100_bases
TGAATGTCGCTTAAAAATGATACAGTGAATAAACCTCTATGCTATAGACCGTGTGAAACTTAACATTTATTATCTAACTG
CTACTCTGGTGTTAGTCACT

Product: molybdopterin binding domain-containing protein

Products: NA

Alternate protein names: MPT Mo-transferase [H]

Number of amino acids: Translated: 429; Mature: 429

Protein sequence:

>429_residues
MITVEGLVAEIQQRVENYNNNDYPLDKRAVSNYDLLDSCHHILAEDIVSPFSVPRQNLSAMDGYAIAKRTKLATNTTITI
IGESQAGSPYNGDIQSSQGVRIFTGAVVPDECDTVIMQENTNFAAIKGSIDKSKPYSIILSQTAQSDDHIRKQGEEIAAG
EAVLLKGKRLNPADISLLANLGFDKVNVYQPLTVGVLATGDELVAIGNALKSLAQIYNSNTPTLKSLLSDLPINIRDYGI
IPDDLDKTTAAVTQAMQECDVLISTAGVSVGDYDFLTTVIEQLGKINHYKVAMKPGKPFVFGELTQNLAKPVLYFGLPGN
PLSTVVGTLQFVIPALWQMAGASHSERPMQLTVMATLKNDVKKSAGRKDFQRGVLTQDEAGIFYVESFTKQQSHRIKQLS
HANCFIVMAQDSGNVAAGESVQVQPFPWI

Sequences:

>Translated_429_residues
MITVEGLVAEIQQRVENYNNNDYPLDKRAVSNYDLLDSCHHILAEDIVSPFSVPRQNLSAMDGYAIAKRTKLATNTTITI
IGESQAGSPYNGDIQSSQGVRIFTGAVVPDECDTVIMQENTNFAAIKGSIDKSKPYSIILSQTAQSDDHIRKQGEEIAAG
EAVLLKGKRLNPADISLLANLGFDKVNVYQPLTVGVLATGDELVAIGNALKSLAQIYNSNTPTLKSLLSDLPINIRDYGI
IPDDLDKTTAAVTQAMQECDVLISTAGVSVGDYDFLTTVIEQLGKINHYKVAMKPGKPFVFGELTQNLAKPVLYFGLPGN
PLSTVVGTLQFVIPALWQMAGASHSERPMQLTVMATLKNDVKKSAGRKDFQRGVLTQDEAGIFYVESFTKQQSHRIKQLS
HANCFIVMAQDSGNVAAGESVQVQPFPWI
>Mature_429_residues
MITVEGLVAEIQQRVENYNNNDYPLDKRAVSNYDLLDSCHHILAEDIVSPFSVPRQNLSAMDGYAIAKRTKLATNTTITI
IGESQAGSPYNGDIQSSQGVRIFTGAVVPDECDTVIMQENTNFAAIKGSIDKSKPYSIILSQTAQSDDHIRKQGEEIAAG
EAVLLKGKRLNPADISLLANLGFDKVNVYQPLTVGVLATGDELVAIGNALKSLAQIYNSNTPTLKSLLSDLPINIRDYGI
IPDDLDKTTAAVTQAMQECDVLISTAGVSVGDYDFLTTVIEQLGKINHYKVAMKPGKPFVFGELTQNLAKPVLYFGLPGN
PLSTVVGTLQFVIPALWQMAGASHSERPMQLTVMATLKNDVKKSAGRKDFQRGVLTQDEAGIFYVESFTKQQSHRIKQLS
HANCFIVMAQDSGNVAAGESVQVQPFPWI

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI10880983, Length=375, Percent_Identity=31.7333333333333, Blast_Score=160, Evalue=2e-39,
Organism=Homo sapiens, GI66932975, Length=375, Percent_Identity=31.7333333333333, Blast_Score=160, Evalue=3e-39,
Organism=Escherichia coli, GI1787049, Length=392, Percent_Identity=38.7755102040816, Blast_Score=253, Evalue=2e-68,
Organism=Caenorhabditis elegans, GI25147659, Length=356, Percent_Identity=28.6516853932584, Blast_Score=141, Evalue=6e-34,
Organism=Caenorhabditis elegans, GI17562606, Length=308, Percent_Identity=29.5454545454545, Blast_Score=96, Evalue=4e-20,
Organism=Drosophila melanogaster, GI17136978, Length=384, Percent_Identity=27.8645833333333, Blast_Score=115, Evalue=4e-26,
Organism=Drosophila melanogaster, GI24638841, Length=384, Percent_Identity=27.8645833333333, Blast_Score=115, Evalue=4e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 46609; Mature: 46609

Theoretical pI: Translated: 5.25; Mature: 5.25

Prosite motif: PS01079 MOCF_BIOSYNTHESIS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITVEGLVAEIQQRVENYNNNDYPLDKRAVSNYDLLDSCHHILAEDIVSPFSVPRQNLSA
CEEHHHHHHHHHHHHHCCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHCHHHCCHHHHHH
MDGYAIAKRTKLATNTTITIIGESQAGSPYNGDIQSSQGVRIFTGAVVPDECDTVIMQEN
CCCHHHHHHCEEECCCEEEEEECCCCCCCCCCCCCCCCCEEEEECCCCCCCCCEEEEECC
TNFAAIKGSIDKSKPYSIILSQTAQSDDHIRKQGEEIAAGEAVLLKGKRLNPADISLLAN
CCEEEEECCCCCCCCEEEEEECCCCCHHHHHHCCCHHHCCCEEEEECCCCCHHHHHHHHH
LGFDKVNVYQPLTVGVLATGDELVAIGNALKSLAQIYNSNTPTLKSLLSDLPINIRDYGI
CCCCCEEEECCEEEEEEECCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCEECCC
IPDDLDKTTAAVTQAMQECDVLISTAGVSVGDYDFLTTVIEQLGKINHYKVAMKPGKPFV
CCCCCHHHHHHHHHHHHHHHHEEEECCCCCCCHHHHHHHHHHHCCCCCEEEEECCCCCEE
FGELTQNLAKPVLYFGLPGNPLSTVVGTLQFVIPALWQMAGASHSERPMQLTVMATLKND
EHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEHHHHHH
VKKSAGRKDFQRGVLTQDEAGIFYVESFTKQQSHRIKQLSHANCFIVMAQDSGNVAAGES
HHHHCCHHHHHHCCCCCCCCCEEEEHHHHHHHHHHHHHHCCCCEEEEEEECCCCEECCCC
VQVQPFPWI
EEECCCCCC
>Mature Secondary Structure
MITVEGLVAEIQQRVENYNNNDYPLDKRAVSNYDLLDSCHHILAEDIVSPFSVPRQNLSA
CEEHHHHHHHHHHHHHCCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHCHHHCCHHHHHH
MDGYAIAKRTKLATNTTITIIGESQAGSPYNGDIQSSQGVRIFTGAVVPDECDTVIMQEN
CCCHHHHHHCEEECCCEEEEEECCCCCCCCCCCCCCCCCEEEEECCCCCCCCCEEEEECC
TNFAAIKGSIDKSKPYSIILSQTAQSDDHIRKQGEEIAAGEAVLLKGKRLNPADISLLAN
CCEEEEECCCCCCCCEEEEEECCCCCHHHHHHCCCHHHCCCEEEEECCCCCHHHHHHHHH
LGFDKVNVYQPLTVGVLATGDELVAIGNALKSLAQIYNSNTPTLKSLLSDLPINIRDYGI
CCCCCEEEECCEEEEEEECCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCEECCC
IPDDLDKTTAAVTQAMQECDVLISTAGVSVGDYDFLTTVIEQLGKINHYKVAMKPGKPFV
CCCCCHHHHHHHHHHHHHHHHEEEECCCCCCCHHHHHHHHHHHCCCCCEEEEECCCCCEE
FGELTQNLAKPVLYFGLPGNPLSTVVGTLQFVIPALWQMAGASHSERPMQLTVMATLKND
EHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEHHHHHH
VKKSAGRKDFQRGVLTQDEAGIFYVESFTKQQSHRIKQLSHANCFIVMAQDSGNVAAGES
HHHHCCHHHHHHCCCCCCCCCEEEEHHHHHHHHHHHHHHCCCCEEEEEEECCCCEECCCC
VQVQPFPWI
EEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]