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The map label for this gene is iscS [H]

Identifier: 92114965

GI number: 92114965

Start: 3179317

End: 3180465

Strand: Direct

Name: iscS [H]

Synonym: Csal_2848

Alternate gene names: 92114965

Gene position: 3179317-3180465 (Clockwise)

Preceding gene: 92114964

Following gene: 92114966

Centisome position: 86.01

GC content: 68.49

Gene sequence:

>1149_bases
ATGACCTCACCCGTGTACCTCGATTATGCCGCCACCACGCCCGTCGACCCGCGGGTCGCCGAGCTGATGGCACGTCACCT
GACACTCGATGGCGTCTACGCCAACCCCGCCTCGCGCAGCCACATGCCCGGCTGGCTGGCCGAACAGGCGGTGGAAAGCG
CCCGGCGTCAGGTCGCCGACCTGATCGCGGCCGACCCGCGTGAAATCGTCTGGACCAGCGGCGCCACCGAAGCGGACAAC
CTCGCGCTGATCGGCTTCATGCGGGCCAACTGCGCACGCGGCCGGCACCTGGTGACCTCGCGCATCGAGCACAAGGCGGT
CGTCGACACCGCCACGGCCCTCGAGGCCGAGGGCTTCGAGGTGACCTGGCTGACGCCCGGCGCGGATGGCCGCGTGACGC
CCACGCAGCTCAACGATGCCATGCGCGAGGATACCGTGCTGGTCTCGCTGATGGCCGTCAACAACGAGCTGGGCAGCATT
CACGACCTGGCCGCGCTCGCCGAGGTGACCCATGCCGGTGGCGCGGTCCTGCATGTCGATGCCGCCCAGGCCACCGGCAA
GATCGCGCTCGACGTCGGCGCCCTGGGCATCGACCTGATGTCGATGTCGGCGCACAAGACCTACGGCCCCAAGGGCGTGG
GCGCGCTTTACGTCCGGCGCAGCCCCGACATCCGCCTCGAGGCCTTGATCCACGGCGGCGGCCACGAGCGCGGCATGCGT
TCGGGCACCCTGCCCACGCACCAGATCGCCGGCATGGGGGAAGCCTTCTCCCTGGCGGCCGACGAGCTCGAGCGCGATCG
CGACAGGAGCCTGGCGCTGCGGCAACGCTTTCTCGACGGGCTCGACGACTGCGCGGGCATCCATTGCAACACGGCACTCG
ACGTCTCGGTGCCCAACATCGTCAACCTGGCATTCGAAGGCGTCGATGGCGAATCATTGCTGATGGCGCTGCGCGCGCTG
GCCGTCTCGACCGGCTCGGCGTGCAACTCGGCGAGTGTCGAGCCATCCTATGTATTGAAAGCCATCGGGGTGGATCGCAT
CCTCGCGCTGTCGTCCATACGCTTCAGCTTCGGACGCTTCACCACCGAGGCCGACATCGACACCGCGACCGCCGAACTTC
GTCACGCACTCGGCGCCCTGCGCCAATGA

Upstream 100 bases:

>100_bases
CGCGTGGCAACGGACACGATCAGTACCGATACCATCAGCATCGCCCCGCAGTGACCCTGCGTGGCGACAGGCGCCAGCGC
CATCAGCGATACGAGCCGTC

Downstream 100 bases:

>100_bases
ATCGATGTCGCCGCGCCCACCGCGTGGCGACGCTCGCAAGGAGGTCATCATGGCTAACATTCGCATCAGCCCCGCCGCCG
CCGACCAGATCCAGCACGTG

Product: class V aminotransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 382; Mature: 381

Protein sequence:

>382_residues
MTSPVYLDYAATTPVDPRVAELMARHLTLDGVYANPASRSHMPGWLAEQAVESARRQVADLIAADPREIVWTSGATEADN
LALIGFMRANCARGRHLVTSRIEHKAVVDTATALEAEGFEVTWLTPGADGRVTPTQLNDAMREDTVLVSLMAVNNELGSI
HDLAALAEVTHAGGAVLHVDAAQATGKIALDVGALGIDLMSMSAHKTYGPKGVGALYVRRSPDIRLEALIHGGGHERGMR
SGTLPTHQIAGMGEAFSLAADELERDRDRSLALRQRFLDGLDDCAGIHCNTALDVSVPNIVNLAFEGVDGESLLMALRAL
AVSTGSACNSASVEPSYVLKAIGVDRILALSSIRFSFGRFTTEADIDTATAELRHALGALRQ

Sequences:

>Translated_382_residues
MTSPVYLDYAATTPVDPRVAELMARHLTLDGVYANPASRSHMPGWLAEQAVESARRQVADLIAADPREIVWTSGATEADN
LALIGFMRANCARGRHLVTSRIEHKAVVDTATALEAEGFEVTWLTPGADGRVTPTQLNDAMREDTVLVSLMAVNNELGSI
HDLAALAEVTHAGGAVLHVDAAQATGKIALDVGALGIDLMSMSAHKTYGPKGVGALYVRRSPDIRLEALIHGGGHERGMR
SGTLPTHQIAGMGEAFSLAADELERDRDRSLALRQRFLDGLDDCAGIHCNTALDVSVPNIVNLAFEGVDGESLLMALRAL
AVSTGSACNSASVEPSYVLKAIGVDRILALSSIRFSFGRFTTEADIDTATAELRHALGALRQ
>Mature_381_residues
TSPVYLDYAATTPVDPRVAELMARHLTLDGVYANPASRSHMPGWLAEQAVESARRQVADLIAADPREIVWTSGATEADNL
ALIGFMRANCARGRHLVTSRIEHKAVVDTATALEAEGFEVTWLTPGADGRVTPTQLNDAMREDTVLVSLMAVNNELGSIH
DLAALAEVTHAGGAVLHVDAAQATGKIALDVGALGIDLMSMSAHKTYGPKGVGALYVRRSPDIRLEALIHGGGHERGMRS
GTLPTHQIAGMGEAFSLAADELERDRDRSLALRQRFLDGLDDCAGIHCNTALDVSVPNIVNLAFEGVDGESLLMALRALA
VSTGSACNSASVEPSYVLKAIGVDRILALSSIRFSFGRFTTEADIDTATAELRHALGALRQ

Specific function: Catalyzes the removal of elemental sulfur from cysteine to produce alanine [H]

COG id: COG1104

COG function: function code E; Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=380, Percent_Identity=49.4736842105263, Blast_Score=370, Evalue=1e-102,
Organism=Homo sapiens, GI156713448, Length=414, Percent_Identity=31.8840579710145, Blast_Score=172, Evalue=3e-43,
Organism=Escherichia coli, GI48994898, Length=381, Percent_Identity=57.2178477690289, Blast_Score=462, Evalue=1e-131,
Organism=Escherichia coli, GI1789175, Length=399, Percent_Identity=27.5689223057644, Blast_Score=89, Evalue=5e-19,
Organism=Escherichia coli, GI1787970, Length=177, Percent_Identity=32.7683615819209, Blast_Score=85, Evalue=9e-18,
Organism=Caenorhabditis elegans, GI25143064, Length=366, Percent_Identity=49.1803278688525, Blast_Score=349, Evalue=2e-96,
Organism=Caenorhabditis elegans, GI17533177, Length=330, Percent_Identity=31.5151515151515, Blast_Score=137, Evalue=7e-33,
Organism=Saccharomyces cerevisiae, GI6319831, Length=381, Percent_Identity=48.5564304461942, Blast_Score=362, Evalue=1e-101,
Organism=Drosophila melanogaster, GI20129463, Length=374, Percent_Identity=49.7326203208556, Blast_Score=352, Evalue=2e-97,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR010240
- InterPro:   IPR016454
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7 [H]

Molecular weight: Translated: 40565; Mature: 40434

Theoretical pI: Translated: 5.24; Mature: 5.24

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSPVYLDYAATTPVDPRVAELMARHLTLDGVYANPASRSHMPGWLAEQAVESARRQVAD
CCCCEEEEECCCCCCCHHHHHHHHHHHEECCEECCCCCCCCCCHHHHHHHHHHHHHHHHH
LIAADPREIVWTSGATEADNLALIGFMRANCARGRHLVTSRIEHKAVVDTATALEAEGFE
HHHCCCCCEEEECCCCCCCCEEEEEEHHHHHCCCCHHHHHHHHHHHHHHHHHHEECCCEE
VTWLTPGADGRVTPTQLNDAMREDTVLVSLMAVNNELGSIHDLAALAEVTHAGGAVLHVD
EEEECCCCCCCCCHHHHHHHHHHHHHEEEEEECCCCCCHHHHHHHHHHHHHCCCEEEEEE
AAQATGKIALDVGALGIDLMSMSAHKTYGPKGVGALYVRRSPDIRLEALIHGGGHERGMR
CCCCCCEEEEEECHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCEEEEEEECCCCCCCCC
SGTLPTHQIAGMGEAFSLAADELERDRDRSLALRQRFLDGLDDCAGIHCNTALDVSVPNI
CCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHCCCEECCEEECCCCCE
VNLAFEGVDGESLLMALRALAVSTGSACNSASVEPSYVLKAIGVDRILALSSIRFSFGRF
EEHEECCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCHHHHHHHHHHHHHHHCC
TTEADIDTATAELRHALGALRQ
CCCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TSPVYLDYAATTPVDPRVAELMARHLTLDGVYANPASRSHMPGWLAEQAVESARRQVAD
CCCEEEEECCCCCCCHHHHHHHHHHHEECCEECCCCCCCCCCHHHHHHHHHHHHHHHHH
LIAADPREIVWTSGATEADNLALIGFMRANCARGRHLVTSRIEHKAVVDTATALEAEGFE
HHHCCCCCEEEECCCCCCCCEEEEEEHHHHHCCCCHHHHHHHHHHHHHHHHHHEECCCEE
VTWLTPGADGRVTPTQLNDAMREDTVLVSLMAVNNELGSIHDLAALAEVTHAGGAVLHVD
EEEECCCCCCCCCHHHHHHHHHHHHHEEEEEECCCCCCHHHHHHHHHHHHHCCCEEEEEE
AAQATGKIALDVGALGIDLMSMSAHKTYGPKGVGALYVRRSPDIRLEALIHGGGHERGMR
CCCCCCEEEEEECHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCEEEEEEECCCCCCCCC
SGTLPTHQIAGMGEAFSLAADELERDRDRSLALRQRFLDGLDDCAGIHCNTALDVSVPNI
CCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHCCCEECCEEECCCCCE
VNLAFEGVDGESLLMALRALAVSTGSACNSASVEPSYVLKAIGVDRILALSSIRFSFGRF
EEHEECCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCHHHHHHHHHHHHHHHCC
TTEADIDTATAELRHALGALRQ
CCCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA