Click here to switch to the map view.

The map label for this gene is uvrC

Identifier: 92114255

GI number: 92114255

Start: 2400940

End: 2402754

Strand: Direct

Name: uvrC

Synonym: Csal_2133

Alternate gene names: 92114255

Gene position: 2400940-2402754 (Clockwise)

Preceding gene: 92114254

Following gene: 92114256

Centisome position: 64.95

GC content: 63.53

Gene sequence:

>1815_bases
ATGAGCTTCGATGCCAAGCACTTCCTCAAGACGGTTTCCGAGTCACCCGGCGTGTATCGCATGCTGGATGCCGAAGGCAA
CGTGCTGTACGTCGGCAAGGCCAAACGGCTGAAGGCCCGCCTCGCCAGCTACTTCCGTGGTGCGCTGAATGCCAAGACCC
AGGCCCTGGTCAGCCGGATCGAGGACATCCAGGTCACCATCACGCGGACCGAGACAGAGGCCCTGCTGCTCGAGCAGACG
CTCATCAAGGAACAGCGTCCGCCGTACAACATCCTCCTGCGTGACGATAAATCGTACCCGTTCATCTTCGTCTCGGATCG
GCACCCCTACCCCGCCCTCGAATTCAAGCGCGCGCGGCAGAAACGTGGCGACGGCCGTTACCTGGGGCCGTTTCCGAGTA
CCACCGCGGTGCGTGAAAGCCTGTCGTTGATGCAGAAGATCTTTCGCATCCGCAACTGCGAGGACAGTGTCTTCGCGCAC
CGCACCCGGCCCTGCCTGCAATATCAAATTCAGCGCTGCAGCGCTCCCTGTGTCGACTACATCGGTCGCGAGGAATACCA
GCGCGATATCGACCACGCCATCATGTGCCTGGAAGGGCGTAGCGAGCAGGTCACCGCGCAACTGACCCGCGACATGGAAA
CCGCCAGTCAGGCGCTGGATTTCGAGGAAGCCGCGCGCCTGCGCGACCAGATCCAGCAACTTCGCCGCCTGCAGGAACGC
CAAATCGTCGATACTGGGGACGGCGATGCCGACATCTTCGCTCTGGCCGAGCGCCCCGGCGGCCTCTGCATCAGCGCACT
GGCCGTGCGTGGCGGCCGCATGCTCGGCGCTCGCCACCATATGCCGCAGAACGGCCTGGACCTCACGGCGGAGGCGCTTC
TCGGCGAGTTCATCAGCCATTACTATCTGGGACATGAGCGCGAGATTCCCGCGGAAGTCATCACGGCTCTGCCCCTGGCG
GACAGCGACGTCATTCAAGCCGCCCTCTCCGAGCGTGCCGGCAAGCGGATTCGCCTGGCCCATCAGGTTCGCGGCCACCG
AGCCCAATGGCTACGCCTGGCGGAAACCAATGCCGAGCAACACCTCACCACGCAACTGGCCAATCGTTCGCAGCTGGCCA
AGCGTTTCGCCTCCCTGCGTGACGCCATGCAGCTGCAGGAGACACCGACACGCCTGGAATGCTTCGACATCAGCCATAGC
CATGGCGAAGCGACGGTCGCCTCCTGCGTGGTGTTCGACCAGGACGGGCCGGTCAAATCCGATTACCGACGTTTCAACAT
CGAGGGCGTGGCAGCGGGGGACGACTACGCGGCCATGCGGCAAGCCCTGACTCGACGCTACAAACGCTTGACTCAGGACG
ACAGCAAGCTTCCCGGCATCCTGATCGTCGATGGCGGCAAGGGACAGCTCAACATGGCACGCGAGGTGCTCGAGGACGTC
GGCATCACCGGAACGCATCTGCTCGGCGTGGCCAAGGGCACGACACGCAAGCCCGGACTCGAGACGCTGTTTCTGGAAAC
CGTCGACAACAGTCTGGCACTGGACAGCGCATCGCCGGGGCTGCACCTCATTCAGCATATTCGCGACGAAGCCCACCGTT
TCGCGATCACCGGTCATCGTCAGCAACGCGACAAGCAACGCCGTACTTCGACCCTGCAGGACATTCCCGGGATCGGGCCC
AAGCGTCGCCGGGAGTTGCTGCGCTTCTTCGGTGGGCTCCAGGGCGTGCGCCAGGCCAGTCGCGACGAGCTGGCGCGTGT
GCCCGGCATCAGCGCCCAAATGGCCACGACCATCCATCAAGCCTTGCATGGATGA

Upstream 100 bases:

>100_bases
CGTCGTGATACCAGGCATATCGGCATCGCAGGGCGCGCCGGGCCCCGTCCTCCTTTGATACACTGGCGGGCATGATCCAT
GCAACGATTCCCCCGCGCCC

Downstream 100 bases:

>100_bases
GCCATGAGCGGAAAGATAGAATAATGCGGTTACCTCATTCACCAGCCAGGACTTACGTCGCTCGATGAACATTCCCAACC
TATTGACGCTTGCTCGAATC

Product: excinuclease ABC subunit C

Products: NA

Alternate protein names: Protein uvrC; Excinuclease ABC subunit C

Number of amino acids: Translated: 604; Mature: 603

Protein sequence:

>604_residues
MSFDAKHFLKTVSESPGVYRMLDAEGNVLYVGKAKRLKARLASYFRGALNAKTQALVSRIEDIQVTITRTETEALLLEQT
LIKEQRPPYNILLRDDKSYPFIFVSDRHPYPALEFKRARQKRGDGRYLGPFPSTTAVRESLSLMQKIFRIRNCEDSVFAH
RTRPCLQYQIQRCSAPCVDYIGREEYQRDIDHAIMCLEGRSEQVTAQLTRDMETASQALDFEEAARLRDQIQQLRRLQER
QIVDTGDGDADIFALAERPGGLCISALAVRGGRMLGARHHMPQNGLDLTAEALLGEFISHYYLGHEREIPAEVITALPLA
DSDVIQAALSERAGKRIRLAHQVRGHRAQWLRLAETNAEQHLTTQLANRSQLAKRFASLRDAMQLQETPTRLECFDISHS
HGEATVASCVVFDQDGPVKSDYRRFNIEGVAAGDDYAAMRQALTRRYKRLTQDDSKLPGILIVDGGKGQLNMAREVLEDV
GITGTHLLGVAKGTTRKPGLETLFLETVDNSLALDSASPGLHLIQHIRDEAHRFAITGHRQQRDKQRRTSTLQDIPGIGP
KRRRELLRFFGGLQGVRQASRDELARVPGISAQMATTIHQALHG

Sequences:

>Translated_604_residues
MSFDAKHFLKTVSESPGVYRMLDAEGNVLYVGKAKRLKARLASYFRGALNAKTQALVSRIEDIQVTITRTETEALLLEQT
LIKEQRPPYNILLRDDKSYPFIFVSDRHPYPALEFKRARQKRGDGRYLGPFPSTTAVRESLSLMQKIFRIRNCEDSVFAH
RTRPCLQYQIQRCSAPCVDYIGREEYQRDIDHAIMCLEGRSEQVTAQLTRDMETASQALDFEEAARLRDQIQQLRRLQER
QIVDTGDGDADIFALAERPGGLCISALAVRGGRMLGARHHMPQNGLDLTAEALLGEFISHYYLGHEREIPAEVITALPLA
DSDVIQAALSERAGKRIRLAHQVRGHRAQWLRLAETNAEQHLTTQLANRSQLAKRFASLRDAMQLQETPTRLECFDISHS
HGEATVASCVVFDQDGPVKSDYRRFNIEGVAAGDDYAAMRQALTRRYKRLTQDDSKLPGILIVDGGKGQLNMAREVLEDV
GITGTHLLGVAKGTTRKPGLETLFLETVDNSLALDSASPGLHLIQHIRDEAHRFAITGHRQQRDKQRRTSTLQDIPGIGP
KRRRELLRFFGGLQGVRQASRDELARVPGISAQMATTIHQALHG
>Mature_603_residues
SFDAKHFLKTVSESPGVYRMLDAEGNVLYVGKAKRLKARLASYFRGALNAKTQALVSRIEDIQVTITRTETEALLLEQTL
IKEQRPPYNILLRDDKSYPFIFVSDRHPYPALEFKRARQKRGDGRYLGPFPSTTAVRESLSLMQKIFRIRNCEDSVFAHR
TRPCLQYQIQRCSAPCVDYIGREEYQRDIDHAIMCLEGRSEQVTAQLTRDMETASQALDFEEAARLRDQIQQLRRLQERQ
IVDTGDGDADIFALAERPGGLCISALAVRGGRMLGARHHMPQNGLDLTAEALLGEFISHYYLGHEREIPAEVITALPLAD
SDVIQAALSERAGKRIRLAHQVRGHRAQWLRLAETNAEQHLTTQLANRSQLAKRFASLRDAMQLQETPTRLECFDISHSH
GEATVASCVVFDQDGPVKSDYRRFNIEGVAAGDDYAAMRQALTRRYKRLTQDDSKLPGILIVDGGKGQLNMAREVLEDVG
ITGTHLLGVAKGTTRKPGLETLFLETVDNSLALDSASPGLHLIQHIRDEAHRFAITGHRQQRDKQRRTSTLQDIPGIGPK
RRRELLRFFGGLQGVRQASRDELARVPGISAQMATTIHQALHG

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain

Homologues:

Organism=Escherichia coli, GI87081999, Length=609, Percent_Identity=50.9031198686371, Blast_Score=602, Evalue=1e-173,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UVRC_CHRSD (Q1QVM4)

Other databases:

- EMBL:   CP000285
- RefSeq:   YP_574183.1
- ProteinModelPortal:   Q1QVM4
- STRING:   Q1QVM4
- GeneID:   4026470
- GenomeReviews:   CP000285_GR
- KEGG:   csa:Csal_2133
- NMPDR:   fig|290398.4.peg.2379
- eggNOG:   COG0322
- HOGENOM:   HBG566029
- OMA:   DVLYVGK
- ProtClustDB:   PRK00558
- BioCyc:   CSAL290398:CSAL_2133-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00203
- InterPro:   IPR000445
- InterPro:   IPR003583
- InterPro:   IPR010994
- InterPro:   IPR001943
- InterPro:   IPR009055
- InterPro:   IPR004791
- InterPro:   IPR001162
- InterPro:   IPR000305
- SMART:   SM00465
- SMART:   SM00278
- TIGRFAMs:   TIGR00194

Pfam domain/function: PF01541 GIY-YIG; PF00633 HHH; PF02151 UVR; PF08459 UvrC_HhH_N; SSF47781 RuvA_2_like; SSF46600 UvrB_C; SSF82771 UvrC_N

EC number: NA

Molecular weight: Translated: 67912; Mature: 67781

Theoretical pI: Translated: 9.11; Mature: 9.11

Prosite motif: PS50151 UVR; PS50164 UVRC_1; PS50165 UVRC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFDAKHFLKTVSESPGVYRMLDAEGNVLYVGKAKRLKARLASYFRGALNAKTQALVSRI
CCCCHHHHHHHHHCCCCEEEEEECCCCEEEECCHHHHHHHHHHHHHHHHCHHHHHHHHHH
EDIQVTITRTETEALLLEQTLIKEQRPPYNILLRDDKSYPFIFVSDRHPYPALEFKRARQ
CCEEEEEEECHHHHHHHHHHHHHHCCCCCEEEEECCCCCCEEEEECCCCCCHHHHHHHHH
KRGDGRYLGPFPSTTAVRESLSLMQKIFRIRNCEDSVFAHRTRPCLQYQIQRCSAPCVDY
HCCCCCEECCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCHHHHHHHHHCCCHHHHH
IGREEYQRDIDHAIMCLEGRSEQVTAQLTRDMETASQALDFEEAARLRDQIQQLRRLQER
HCHHHHHHHHHHHEEEECCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
QIVDTGDGDADIFALAERPGGLCISALAVRGGRMLGARHHMPQNGLDLTAEALLGEFISH
CCCCCCCCCCEEEEEECCCCCHHHHHHHHCCCCCCCHHCCCCCCCCHHHHHHHHHHHHHH
YYLGHEREIPAEVITALPLADSDVIQAALSERAGKRIRLAHQVRGHRAQWLRLAETNAEQ
HHCCCCCCCCHHHHHHCCCCCHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHCCHHH
HLTTQLANRSQLAKRFASLRDAMQLQETPTRLECFDISHSHGEATVASCVVFDQDGPVKS
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCEEEEEEEECCCCCCCC
DYRRFNIEGVAAGDDYAAMRQALTRRYKRLTQDDSKLPGILIVDGGKGQLNMAREVLEDV
CHHEECEEEEECCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCHHHHHHHHHHC
GITGTHLLGVAKGTTRKPGLETLFLETVDNSLALDSASPGLHLIQHIRDEAHRFAITGHR
CCCCHHHEEECCCCCCCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHEEECCCH
QQRDKQRRTSTLQDIPGIGPKRRRELLRFFGGLQGVRQASRDELARVPGISAQMATTIHQ
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
ALHG
HHCC
>Mature Secondary Structure 
SFDAKHFLKTVSESPGVYRMLDAEGNVLYVGKAKRLKARLASYFRGALNAKTQALVSRI
CCCHHHHHHHHHCCCCEEEEEECCCCEEEECCHHHHHHHHHHHHHHHHCHHHHHHHHHH
EDIQVTITRTETEALLLEQTLIKEQRPPYNILLRDDKSYPFIFVSDRHPYPALEFKRARQ
CCEEEEEEECHHHHHHHHHHHHHHCCCCCEEEEECCCCCCEEEEECCCCCCHHHHHHHHH
KRGDGRYLGPFPSTTAVRESLSLMQKIFRIRNCEDSVFAHRTRPCLQYQIQRCSAPCVDY
HCCCCCEECCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCHHHHHHHHHCCCHHHHH
IGREEYQRDIDHAIMCLEGRSEQVTAQLTRDMETASQALDFEEAARLRDQIQQLRRLQER
HCHHHHHHHHHHHEEEECCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
QIVDTGDGDADIFALAERPGGLCISALAVRGGRMLGARHHMPQNGLDLTAEALLGEFISH
CCCCCCCCCCEEEEEECCCCCHHHHHHHHCCCCCCCHHCCCCCCCCHHHHHHHHHHHHHH
YYLGHEREIPAEVITALPLADSDVIQAALSERAGKRIRLAHQVRGHRAQWLRLAETNAEQ
HHCCCCCCCCHHHHHHCCCCCHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHCCHHH
HLTTQLANRSQLAKRFASLRDAMQLQETPTRLECFDISHSHGEATVASCVVFDQDGPVKS
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCEEEEEEEECCCCCCCC
DYRRFNIEGVAAGDDYAAMRQALTRRYKRLTQDDSKLPGILIVDGGKGQLNMAREVLEDV
CHHEECEEEEECCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCHHHHHHHHHHC
GITGTHLLGVAKGTTRKPGLETLFLETVDNSLALDSASPGLHLIQHIRDEAHRFAITGHR
CCCCHHHEEECCCCCCCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHEEECCCH
QQRDKQRRTSTLQDIPGIGPKRRRELLRFFGGLQGVRQASRDELARVPGISAQMATTIHQ
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
ALHG
HHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA