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The map label for this gene is ppiB [H]

Identifier: 92114175

GI number: 92114175

Start: 2317706

End: 2318200

Strand: Direct

Name: ppiB [H]

Synonym: Csal_2053

Alternate gene names: 92114175

Gene position: 2317706-2318200 (Clockwise)

Preceding gene: 92114172

Following gene: 92114176

Centisome position: 62.7

GC content: 61.82

Gene sequence:

>495_bases
ATGATCGTTCTGCAAACCAATTACGGCAGCATTCGCCTGCGCCTCGACCATGACAACGCCCCGAAGACCGCTGCCAATTT
CGAGCAGTACGTGCGCGACGGTCATTACGACGACACCCTGTTCCATCGTGTCATCGACGGCTTCATGGTGCAGGGCGGCG
GCTTCGACACCCAGTTCGAGCAGAAGCCCACGCGCGCGCCGATCGACAACGAGGCCGACAACGGCCTGAAGAACGTCAAG
GGCAGCGTCGCCATGGCGCGCACCCAGGACCCGCACTCCGCGAGCGCACAGTTCTTCATCAACGTCGCCGACAACGACTT
CCTCAACCACCGCGACAAGTCCATGCAAGGCTGGGGTTACTGTGTCTTCGGCGAAGTCGTCGAGGGCATGGACGTCGTCG
AGAAGATCAAGAACGTCCCCACCACGCGCCGCGGCATGCATGCCGACGTACCCGCCGAAGACGTCATTCTCCAGCGCGCC
TACGTCGAAGACTGA

Upstream 100 bases:

>100_bases
GCCTCGACACGGTTTCGCCCGCGGGTGCAAAGCCGCTATTATAGCGCGACGCCAGCGCGCGACGCCAAGTCACGCTCAGT
TCTCTTGCCAGGATACGCCC

Downstream 100 bases:

>100_bases
TCGTTACGCGTCGCCGTGCCCGCGGGCACGGCATCGCCCTTCCGCTTCCTTCTCGCCACGTTCACGAGGACGCCAGCACG
ATGACCACCCTGCTGATTTC

Product: cyclophilin type peptidyl-prolyl cis-trans isomerase

Products: NA

Alternate protein names: PPIase B; Rotamase B [H]

Number of amino acids: Translated: 164; Mature: 164

Protein sequence:

>164_residues
MIVLQTNYGSIRLRLDHDNAPKTAANFEQYVRDGHYDDTLFHRVIDGFMVQGGGFDTQFEQKPTRAPIDNEADNGLKNVK
GSVAMARTQDPHSASAQFFINVADNDFLNHRDKSMQGWGYCVFGEVVEGMDVVEKIKNVPTTRRGMHADVPAEDVILQRA
YVED

Sequences:

>Translated_164_residues
MIVLQTNYGSIRLRLDHDNAPKTAANFEQYVRDGHYDDTLFHRVIDGFMVQGGGFDTQFEQKPTRAPIDNEADNGLKNVK
GSVAMARTQDPHSASAQFFINVADNDFLNHRDKSMQGWGYCVFGEVVEGMDVVEKIKNVPTTRRGMHADVPAEDVILQRA
YVED
>Mature_164_residues
MIVLQTNYGSIRLRLDHDNAPKTAANFEQYVRDGHYDDTLFHRVIDGFMVQGGGFDTQFEQKPTRAPIDNEADNGLKNVK
GSVAMARTQDPHSASAQFFINVADNDFLNHRDKSMQGWGYCVFGEVVEGMDVVEKIKNVPTTRRGMHADVPAEDVILQRA
YVED

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI7706339, Length=171, Percent_Identity=29.2397660818713, Blast_Score=76, Evalue=1e-14,
Organism=Homo sapiens, GI5454154, Length=144, Percent_Identity=34.0277777777778, Blast_Score=73, Evalue=1e-13,
Organism=Homo sapiens, GI19557636, Length=167, Percent_Identity=28.1437125748503, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI24308049, Length=163, Percent_Identity=30.6748466257669, Blast_Score=69, Evalue=1e-12,
Organism=Homo sapiens, GI64276486, Length=134, Percent_Identity=33.5820895522388, Blast_Score=66, Evalue=1e-11,
Organism=Homo sapiens, GI22547212, Length=157, Percent_Identity=30.5732484076433, Blast_Score=65, Evalue=2e-11,
Organism=Homo sapiens, GI7657473, Length=157, Percent_Identity=30.5732484076433, Blast_Score=65, Evalue=2e-11,
Organism=Homo sapiens, GI22547215, Length=157, Percent_Identity=30.5732484076433, Blast_Score=65, Evalue=3e-11,
Organism=Escherichia coli, GI1786736, Length=164, Percent_Identity=60.9756097560976, Blast_Score=221, Evalue=2e-59,
Organism=Escherichia coli, GI1789763, Length=161, Percent_Identity=52.7950310559006, Blast_Score=175, Evalue=1e-45,
Organism=Caenorhabditis elegans, GI17539496, Length=167, Percent_Identity=28.7425149700599, Blast_Score=74, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17506311, Length=146, Percent_Identity=34.9315068493151, Blast_Score=73, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17532641, Length=170, Percent_Identity=28.2352941176471, Blast_Score=70, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI71980590, Length=143, Percent_Identity=32.8671328671329, Blast_Score=69, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI71980594, Length=143, Percent_Identity=32.8671328671329, Blast_Score=69, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17532643, Length=157, Percent_Identity=33.7579617834395, Blast_Score=66, Evalue=7e-12,
Organism=Drosophila melanogaster, GI17986117, Length=164, Percent_Identity=28.0487804878049, Blast_Score=72, Evalue=1e-13,
Organism=Drosophila melanogaster, GI19922376, Length=164, Percent_Identity=28.6585365853659, Blast_Score=71, Evalue=3e-13,
Organism=Drosophila melanogaster, GI19922912, Length=156, Percent_Identity=31.4102564102564, Blast_Score=69, Evalue=2e-12,

Paralogues:

None

Copy number: 780 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 18464; Mature: 18464

Theoretical pI: Translated: 5.00; Mature: 5.00

Prosite motif: PS00170 CSA_PPIASE_1 ; PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIVLQTNYGSIRLRLDHDNAPKTAANFEQYVRDGHYDDTLFHRVIDGFMVQGGGFDTQFE
CEEEECCCCEEEEEECCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHEECCCCCCCCCC
QKPTRAPIDNEADNGLKNVKGSVAMARTQDPHSASAQFFINVADNDFLNHRDKSMQGWGY
CCCCCCCCCCCCCCCHHHCCCCEEEEECCCCCCCCEEEEEEECCCCHHCCCCCCCCCCCE
CVFGEVVEGMDVVEKIKNVPTTRRGMHADVPAEDVILQRAYVED
EEHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCC
>Mature Secondary Structure
MIVLQTNYGSIRLRLDHDNAPKTAANFEQYVRDGHYDDTLFHRVIDGFMVQGGGFDTQFE
CEEEECCCCEEEEEECCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHEECCCCCCCCCC
QKPTRAPIDNEADNGLKNVKGSVAMARTQDPHSASAQFFINVADNDFLNHRDKSMQGWGY
CCCCCCCCCCCCCCCHHHCCCCEEEEECCCCCCCCEEEEEEECCCCHHCCCCCCCCCCCE
CVFGEVVEGMDVVEKIKNVPTTRRGMHADVPAEDVILQRAYVED
EEHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]