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The map label for this gene is cfiB [H]

Identifier: 92113679

GI number: 92113679

Start: 1767796

End: 1769211

Strand: Direct

Name: cfiB [H]

Synonym: Csal_1555

Alternate gene names: 92113679

Gene position: 1767796-1769211 (Clockwise)

Preceding gene: 92113675

Following gene: 92113680

Centisome position: 47.82

GC content: 64.05

Gene sequence:

>1416_bases
GTGTTCAAGAAACTTCTCATCGCCAATCGTGGCGAAATCGCTGTACGCATTGTACGCGCCTGCGCCGAAATGGGCATCCG
GTCGGTGGCGATCTACACCGAGCCCGACCGCTTCGCGCTGCACGTCAAGCGCGCCGACGAGGCGCATTTCGTGGGCGAGG
ACCCCTTGGCGGGATACCTCGATCCGCGGCGCATCGTCGACCTGGCCCGCGAGACGGGCTGTGACGCGATTCACCCCGGC
TACGGCTTCCTCTCGGAGAATGCCGATTTCGCACGCATCTGCGAAGACGCCGGCCTGGCCTTCGTGGGGCCGGACGCCAG
CGTGATCGCGCGGATGGGCGACAAGACGGCGGCGCGCGCCGCGATGCGCGACGCCGGCGTGCCGGTGACGCCGGGCTCGG
ACGGCAATCTCGAGACCTGTGCCGAGGCCTTGGCACTGGCCGACACCATCGGCTATCCGGTCATGCTCAAGGCCACCTCC
GGTGGCGGGGGGCGCGGCATTCGCCGTTGCGACACCCCGGCCCAGCTCGAGCAGGCCTGGGAGCGCGTGATTTCCGAAGC
GACCAAGGCATTCGGCAGTGCCGACGTGTTCATGGAGAAATGCGTCGTCGAGCCGCATCACATCGAGGTGCAGATCCTTG
CCGACAGCGTCGGTAACGTCATCCACCTCTTCGAGCGCGACTGCTCGATCCAGCGCCGCAATCAGAAGCTCATCGAGATC
GCGCCCAGCCCTCAGCTGACGCCCGAACAACGGGCCTACGTCGGCGAGATGGCGGTTCGCGCGGCCAGCGCGGTGGGCTA
CGAAAACGCCGGTACCGTGGAGTTCCTCGTCAAGGGCAACGAGGTCTACTTCATGGAAATGAATACCCGAGTGCAAGTCG
AGCACACCATTTCCGAGGCGATCACCGGCGTGGATATCGTGCGCGAGCAGCTGCGCATCGCCGCCGGCCTGAAGCTGGCC
TACCGCCAGGAGGACATCCGTCATCACGGTTATGCGATCCAGTTCCGCATCAATGCCGAGGATCCCAAGAACGATTTCCT
GCCGTCGTTCGGACGCATCACGCGTTATTACGCTCCCGGAGGGCCGGGGGTGCGCACCGATACCGCGATCTACACCGGCT
ATACGATCCCGCCGTATTTCGACTCCATGTGCTTGAAGCTGATCGTGTGGGGCATGAGCTGGGAAGAAACCCTCGATCGC
GGCATCCGGGCCCTCAACGACATGCGTCTGCAAGGCGTCAAGACGACCGCGCCCTATTACCAGGAGATTCTGCGCCACCC
CGATTTTCGCAGCGGGCATTTTGATACCGGTTTCGTGCCGGGACATCCCGAATTGCTCAATTACTCGGTCAAGCGCAATC
CCGAGGAAGTCGCCCTGGCCATTGCCGCCGCCATCGCCGCCCACGCCGGTCTTTAA

Upstream 100 bases:

>100_bases
TGCCTTGTCTTGCCTTCGCTCGTCGACTTTTCGTACAAACCCTAAACGGACGCCACGCTAATCGTCGATTAGCAGGGCGC
CTGAAACCGGAGGGCAGACG

Downstream 100 bases:

>100_bases
GGAGATACCTCATGAATGCCGTGTCATCTTCCCAGGTCAAAATCACCGATGTCGTGCTGCGCGACGGCCACCAGTCCTTG
ATCGCCACGCGCCTGCGCAC

Product: pyruvate carboxylase subunit A

Products: NA

Alternate protein names: 2-oxoglutarate carboxylase beta subunit [H]

Number of amino acids: Translated: 471; Mature: 471

Protein sequence:

>471_residues
MFKKLLIANRGEIAVRIVRACAEMGIRSVAIYTEPDRFALHVKRADEAHFVGEDPLAGYLDPRRIVDLARETGCDAIHPG
YGFLSENADFARICEDAGLAFVGPDASVIARMGDKTAARAAMRDAGVPVTPGSDGNLETCAEALALADTIGYPVMLKATS
GGGGRGIRRCDTPAQLEQAWERVISEATKAFGSADVFMEKCVVEPHHIEVQILADSVGNVIHLFERDCSIQRRNQKLIEI
APSPQLTPEQRAYVGEMAVRAASAVGYENAGTVEFLVKGNEVYFMEMNTRVQVEHTISEAITGVDIVREQLRIAAGLKLA
YRQEDIRHHGYAIQFRINAEDPKNDFLPSFGRITRYYAPGGPGVRTDTAIYTGYTIPPYFDSMCLKLIVWGMSWEETLDR
GIRALNDMRLQGVKTTAPYYQEILRHPDFRSGHFDTGFVPGHPELLNYSVKRNPEEVALAIAAAIAAHAGL

Sequences:

>Translated_471_residues
MFKKLLIANRGEIAVRIVRACAEMGIRSVAIYTEPDRFALHVKRADEAHFVGEDPLAGYLDPRRIVDLARETGCDAIHPG
YGFLSENADFARICEDAGLAFVGPDASVIARMGDKTAARAAMRDAGVPVTPGSDGNLETCAEALALADTIGYPVMLKATS
GGGGRGIRRCDTPAQLEQAWERVISEATKAFGSADVFMEKCVVEPHHIEVQILADSVGNVIHLFERDCSIQRRNQKLIEI
APSPQLTPEQRAYVGEMAVRAASAVGYENAGTVEFLVKGNEVYFMEMNTRVQVEHTISEAITGVDIVREQLRIAAGLKLA
YRQEDIRHHGYAIQFRINAEDPKNDFLPSFGRITRYYAPGGPGVRTDTAIYTGYTIPPYFDSMCLKLIVWGMSWEETLDR
GIRALNDMRLQGVKTTAPYYQEILRHPDFRSGHFDTGFVPGHPELLNYSVKRNPEEVALAIAAAIAAHAGL
>Mature_471_residues
MFKKLLIANRGEIAVRIVRACAEMGIRSVAIYTEPDRFALHVKRADEAHFVGEDPLAGYLDPRRIVDLARETGCDAIHPG
YGFLSENADFARICEDAGLAFVGPDASVIARMGDKTAARAAMRDAGVPVTPGSDGNLETCAEALALADTIGYPVMLKATS
GGGGRGIRRCDTPAQLEQAWERVISEATKAFGSADVFMEKCVVEPHHIEVQILADSVGNVIHLFERDCSIQRRNQKLIEI
APSPQLTPEQRAYVGEMAVRAASAVGYENAGTVEFLVKGNEVYFMEMNTRVQVEHTISEAITGVDIVREQLRIAAGLKLA
YRQEDIRHHGYAIQFRINAEDPKNDFLPSFGRITRYYAPGGPGVRTDTAIYTGYTIPPYFDSMCLKLIVWGMSWEETLDR
GIRALNDMRLQGVKTTAPYYQEILRHPDFRSGHFDTGFVPGHPELLNYSVKRNPEEVALAIAAAIAAHAGL

Specific function: This Protein Is A Component Of The Acetyl Coenzyme A Carboxylase Complex; First, Biotin Carboxylase Catalyzes The Carboxylation Of The Carrier Protein And Then The Transcarboxylase Transfers The Carboxyl Group To Form Malonyl-CoA. [C]

COG id: COG0439

COG function: function code I; Biotin carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotin carboxylation domain [H]

Homologues:

Organism=Homo sapiens, GI106049528, Length=458, Percent_Identity=46.943231441048, Blast_Score=412, Evalue=1e-115,
Organism=Homo sapiens, GI106049295, Length=458, Percent_Identity=46.943231441048, Blast_Score=412, Evalue=1e-115,
Organism=Homo sapiens, GI106049292, Length=458, Percent_Identity=46.943231441048, Blast_Score=412, Evalue=1e-115,
Organism=Homo sapiens, GI116805327, Length=456, Percent_Identity=42.7631578947368, Blast_Score=377, Evalue=1e-104,
Organism=Homo sapiens, GI189095269, Length=470, Percent_Identity=43.1914893617021, Blast_Score=361, Evalue=1e-100,
Organism=Homo sapiens, GI65506442, Length=470, Percent_Identity=43.1914893617021, Blast_Score=361, Evalue=1e-99,
Organism=Homo sapiens, GI295821183, Length=470, Percent_Identity=43.1914893617021, Blast_Score=360, Evalue=1e-99,
Organism=Homo sapiens, GI38679977, Length=507, Percent_Identity=30.9664694280079, Blast_Score=222, Evalue=7e-58,
Organism=Homo sapiens, GI38679967, Length=507, Percent_Identity=30.9664694280079, Blast_Score=222, Evalue=7e-58,
Organism=Homo sapiens, GI38679960, Length=507, Percent_Identity=30.9664694280079, Blast_Score=222, Evalue=7e-58,
Organism=Homo sapiens, GI38679974, Length=507, Percent_Identity=30.9664694280079, Blast_Score=221, Evalue=8e-58,
Organism=Homo sapiens, GI38679971, Length=507, Percent_Identity=30.9664694280079, Blast_Score=221, Evalue=8e-58,
Organism=Homo sapiens, GI134142062, Length=508, Percent_Identity=30.511811023622, Blast_Score=209, Evalue=5e-54,
Organism=Escherichia coli, GI1789654, Length=434, Percent_Identity=50.9216589861751, Blast_Score=416, Evalue=1e-117,
Organism=Escherichia coli, GI1786216, Length=330, Percent_Identity=23.3333333333333, Blast_Score=65, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17562816, Length=462, Percent_Identity=48.9177489177489, Blast_Score=407, Evalue=1e-114,
Organism=Caenorhabditis elegans, GI71987519, Length=471, Percent_Identity=44.3736730360934, Blast_Score=371, Evalue=1e-103,
Organism=Caenorhabditis elegans, GI17567343, Length=472, Percent_Identity=44.2796610169491, Blast_Score=368, Evalue=1e-102,
Organism=Caenorhabditis elegans, GI71997163, Length=419, Percent_Identity=32.6968973747017, Blast_Score=202, Evalue=3e-52,
Organism=Caenorhabditis elegans, GI71997168, Length=419, Percent_Identity=32.6968973747017, Blast_Score=202, Evalue=4e-52,
Organism=Caenorhabditis elegans, GI133931226, Length=485, Percent_Identity=30.1030927835052, Blast_Score=188, Evalue=5e-48,
Organism=Saccharomyces cerevisiae, GI6319695, Length=475, Percent_Identity=44.8421052631579, Blast_Score=386, Evalue=1e-108,
Organism=Saccharomyces cerevisiae, GI6321376, Length=475, Percent_Identity=45.0526315789474, Blast_Score=369, Evalue=1e-103,
Organism=Saccharomyces cerevisiae, GI6319685, Length=442, Percent_Identity=39.8190045248869, Blast_Score=326, Evalue=5e-90,
Organism=Saccharomyces cerevisiae, GI6323863, Length=433, Percent_Identity=31.8706697459584, Blast_Score=204, Evalue=2e-53,
Organism=Saccharomyces cerevisiae, GI6324343, Length=542, Percent_Identity=28.4132841328413, Blast_Score=188, Evalue=1e-48,
Organism=Drosophila melanogaster, GI24652212, Length=459, Percent_Identity=47.0588235294118, Blast_Score=422, Evalue=1e-118,
Organism=Drosophila melanogaster, GI24652210, Length=459, Percent_Identity=47.0588235294118, Blast_Score=422, Evalue=1e-118,
Organism=Drosophila melanogaster, GI24652214, Length=459, Percent_Identity=47.0588235294118, Blast_Score=422, Evalue=1e-118,
Organism=Drosophila melanogaster, GI19921944, Length=459, Percent_Identity=47.0588235294118, Blast_Score=422, Evalue=1e-118,
Organism=Drosophila melanogaster, GI24652216, Length=459, Percent_Identity=47.0588235294118, Blast_Score=422, Evalue=1e-118,
Organism=Drosophila melanogaster, GI281363050, Length=459, Percent_Identity=47.0588235294118, Blast_Score=422, Evalue=1e-118,
Organism=Drosophila melanogaster, GI24652224, Length=459, Percent_Identity=47.0588235294118, Blast_Score=422, Evalue=1e-118,
Organism=Drosophila melanogaster, GI24652222, Length=459, Percent_Identity=47.0588235294118, Blast_Score=422, Evalue=1e-118,
Organism=Drosophila melanogaster, GI24652220, Length=459, Percent_Identity=47.0588235294118, Blast_Score=422, Evalue=1e-118,
Organism=Drosophila melanogaster, GI24652218, Length=459, Percent_Identity=47.0588235294118, Blast_Score=422, Evalue=1e-118,
Organism=Drosophila melanogaster, GI24651757, Length=469, Percent_Identity=41.7910447761194, Blast_Score=384, Evalue=1e-107,
Organism=Drosophila melanogaster, GI24651759, Length=431, Percent_Identity=41.5313225058005, Blast_Score=342, Evalue=3e-94,
Organism=Drosophila melanogaster, GI161076409, Length=499, Percent_Identity=31.8637274549098, Blast_Score=213, Evalue=3e-55,
Organism=Drosophila melanogaster, GI161076407, Length=499, Percent_Identity=31.8637274549098, Blast_Score=213, Evalue=3e-55,
Organism=Drosophila melanogaster, GI24586460, Length=499, Percent_Identity=31.8637274549098, Blast_Score=213, Evalue=3e-55,
Organism=Drosophila melanogaster, GI24586458, Length=499, Percent_Identity=31.8637274549098, Blast_Score=213, Evalue=3e-55,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004549
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.4.1.7 [H]

Molecular weight: Translated: 51799; Mature: 51799

Theoretical pI: Translated: 5.93; Mature: 5.93

Prosite motif: PS50975 ATP_GRASP ; PS00866 CPSASE_1 ; PS00867 CPSASE_2 ; PS50979 BC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFKKLLIANRGEIAVRIVRACAEMGIRSVAIYTEPDRFALHVKRADEAHFVGEDPLAGYL
CCCCEEECCCCHHHHHHHHHHHHCCCEEEEEEECCCCEEEEEEECCCCCCCCCCCCCCCC
DPRRIVDLARETGCDAIHPGYGFLSENADFARICEDAGLAFVGPDASVIARMGDKTAARA
CHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHCCEEEECCCHHHHHHCCCHHHHHH
AMRDAGVPVTPGSDGNLETCAEALALADTIGYPVMLKATSGGGGRGIRRCDTPAQLEQAW
HHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCHHHHHHHH
ERVISEATKAFGSADVFMEKCVVEPHHIEVQILADSVGNVIHLFERDCSIQRRNQKLIEI
HHHHHHHHHHCCCHHHHHHHHCCCCCCEEEEEEECCHHHHHHHHHHCCCHHHCCCEEEEE
APSPQLTPEQRAYVGEMAVRAASAVGYENAGTVEFLVKGNEVYFMEMNTRVQVEHTISEA
CCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCEEEEEEECCEEEEHHHHHHH
ITGVDIVREQLRIAAGLKLAYRQEDIRHHGYAIQFRINAEDPKNDFLPSFGRITRYYAPG
HHHHHHHHHHHHHHHCCHHHHHHHHHHHCCEEEEEEECCCCCCCCCCCCHHHEEEEECCC
GPGVRTDTAIYTGYTIPPYFDSMCLKLIVWGMSWEETLDRGIRALNDMRLQGVKTTAPYY
CCCCCCCCEEEECCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHH
QEILRHPDFRSGHFDTGFVPGHPELLNYSVKRNPEEVALAIAAAIAAHAGL
HHHHCCCCCCCCCCCCCCCCCCHHHHCCHHCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MFKKLLIANRGEIAVRIVRACAEMGIRSVAIYTEPDRFALHVKRADEAHFVGEDPLAGYL
CCCCEEECCCCHHHHHHHHHHHHCCCEEEEEEECCCCEEEEEEECCCCCCCCCCCCCCCC
DPRRIVDLARETGCDAIHPGYGFLSENADFARICEDAGLAFVGPDASVIARMGDKTAARA
CHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHCCEEEECCCHHHHHHCCCHHHHHH
AMRDAGVPVTPGSDGNLETCAEALALADTIGYPVMLKATSGGGGRGIRRCDTPAQLEQAW
HHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCHHHHHHHH
ERVISEATKAFGSADVFMEKCVVEPHHIEVQILADSVGNVIHLFERDCSIQRRNQKLIEI
HHHHHHHHHHCCCHHHHHHHHCCCCCCEEEEEEECCHHHHHHHHHHCCCHHHCCCEEEEE
APSPQLTPEQRAYVGEMAVRAASAVGYENAGTVEFLVKGNEVYFMEMNTRVQVEHTISEA
CCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCEEEEEEECCEEEEHHHHHHH
ITGVDIVREQLRIAAGLKLAYRQEDIRHHGYAIQFRINAEDPKNDFLPSFGRITRYYAPG
HHHHHHHHHHHHHHHCCHHHHHHHHHHHCCEEEEEEECCCCCCCCCCCCHHHEEEEECCC
GPGVRTDTAIYTGYTIPPYFDSMCLKLIVWGMSWEETLDRGIRALNDMRLQGVKTTAPYY
CCCCCCCCEEEECCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHH
QEILRHPDFRSGHFDTGFVPGHPELLNYSVKRNPEEVALAIAAAIAAHAGL
HHHHCCCCCCCCCCCCCCCCCCHHHHCCHHCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA