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The map label for this gene is lipB

Identifier: 92113675

GI number: 92113675

Start: 1763393

End: 1764055

Strand: Direct

Name: lipB

Synonym: Csal_1551

Alternate gene names: 92113675

Gene position: 1763393-1764055 (Clockwise)

Preceding gene: 92113674

Following gene: 92113679

Centisome position: 47.7

GC content: 68.48

Gene sequence:

>663_bases
ATGGCCGCCGAGCGCGGGCTTCCCCCGATCGAATTGCATCGCCTTGGGCGGCGCCCCTATGTGCCGGTATGGCAGGCCAT
GCGCGAGTTCACCGACACGCGCGATGCCGACAGCCCCGATCAGTTCTGGTTGGTCGAACACGACCCGGTGTTCACCCAGG
GGCAGGCGGGCAAGGCCGAGCACCTGCTCATGCCCGGGGACATCCCCGTGGTGGCTACCGATCGAGGCGGGCAGGTGACC
TATCATGGGCCGGGGCAGGTGGTGTTGTATCCGCTGATCGATGTGCGTCGTGGCAAGCTGGGAGTGCGCGAGCTGGTCAG
CGCGCTCGAGCAGGCGGTCATCGACTTGCTGGCCGCGCATGGCGTCACGGCCCGGGCGCGCCCCGATGCGCCCGGGGTCT
ACGTGGGCGAGACCAAGATCGCCTCGCTGGGGCTGCGCATTCGTCGCGGCGCCAGCTTTCATGGCGTGGCGCTCAACGTC
GACGGCGACCTGGCCCCCTTCCAGTGTATCAACCCCTGCGGCCATGCCGGCATGGCGATGACACGTCTCGTCGATCTCGT
CGACGATTGTCCGGGCTGCGAGGCCGTGGCTCTCGAACTGGCCGAATGCCTGGCCCGGCAACTCGGCCGTCGACTGACGC
CGATGGATACCGTGCCCGCCTGA

Upstream 100 bases:

>100_bases
TTCAATCCGTGCGCGTGGTCATCCGGGCCACGGGGCATGAGCAGCTCAATGCATTGTTCCATTCGCTCAAGGCGACTGGG
CGCGTGCACATGGTGATGTG

Downstream 100 bases:

>100_bases
CCGCGCCGTGCGCAGCCTTCAACGACACGGCCCGCAGTGGACTGGTTCCACTGCGGGCCGTTCGCGTTGCCGATGCTGTC
GGAGGTGGCGTGCGTCAGCC

Product: lipoate-protein ligase B

Products: NA

Alternate protein names: Lipoate-protein ligase B; Lipoyl/octanoyl transferase; Octanoyl-[acyl-carrier-protein]-protein N-octanoyltransferase

Number of amino acids: Translated: 220; Mature: 219

Protein sequence:

>220_residues
MAAERGLPPIELHRLGRRPYVPVWQAMREFTDTRDADSPDQFWLVEHDPVFTQGQAGKAEHLLMPGDIPVVATDRGGQVT
YHGPGQVVLYPLIDVRRGKLGVRELVSALEQAVIDLLAAHGVTARARPDAPGVYVGETKIASLGLRIRRGASFHGVALNV
DGDLAPFQCINPCGHAGMAMTRLVDLVDDCPGCEAVALELAECLARQLGRRLTPMDTVPA

Sequences:

>Translated_220_residues
MAAERGLPPIELHRLGRRPYVPVWQAMREFTDTRDADSPDQFWLVEHDPVFTQGQAGKAEHLLMPGDIPVVATDRGGQVT
YHGPGQVVLYPLIDVRRGKLGVRELVSALEQAVIDLLAAHGVTARARPDAPGVYVGETKIASLGLRIRRGASFHGVALNV
DGDLAPFQCINPCGHAGMAMTRLVDLVDDCPGCEAVALELAECLARQLGRRLTPMDTVPA
>Mature_219_residues
AAERGLPPIELHRLGRRPYVPVWQAMREFTDTRDADSPDQFWLVEHDPVFTQGQAGKAEHLLMPGDIPVVATDRGGQVTY
HGPGQVVLYPLIDVRRGKLGVRELVSALEQAVIDLLAAHGVTARARPDAPGVYVGETKIASLGLRIRRGASFHGVALNVD
GDLAPFQCINPCGHAGMAMTRLVDLVDDCPGCEAVALELAECLARQLGRRLTPMDTVPA

Specific function: Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate

COG id: COG0321

COG function: function code H; Lipoate-protein ligase B

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lipB family

Homologues:

Organism=Homo sapiens, GI221554520, Length=192, Percent_Identity=34.8958333333333, Blast_Score=76, Evalue=3e-14,
Organism=Escherichia coli, GI87081767, Length=174, Percent_Identity=67.816091954023, Blast_Score=250, Evalue=7e-68,
Organism=Saccharomyces cerevisiae, GI6323268, Length=153, Percent_Identity=33.3333333333333, Blast_Score=84, Evalue=2e-17,
Organism=Drosophila melanogaster, GI21355483, Length=223, Percent_Identity=29.5964125560538, Blast_Score=96, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LIPB_CHRSD (Q1QXA4)

Other databases:

- EMBL:   CP000285
- RefSeq:   YP_573603.1
- ProteinModelPortal:   Q1QXA4
- SMR:   Q1QXA4
- STRING:   Q1QXA4
- GeneID:   4028116
- GenomeReviews:   CP000285_GR
- KEGG:   csa:Csal_1551
- NMPDR:   fig|290398.4.peg.2711
- eggNOG:   COG0321
- HOGENOM:   HBG716160
- OMA:   RDELISC
- BioCyc:   CSAL290398:CSAL_1551-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00013
- InterPro:   IPR004143
- InterPro:   IPR000544
- InterPro:   IPR020605
- PIRSF:   PIRSF016262
- TIGRFAMs:   TIGR00214

Pfam domain/function: PF03099 BPL_LipA_LipB

EC number: =2.3.1.181

Molecular weight: Translated: 23769; Mature: 23637

Theoretical pI: Translated: 6.15; Mature: 6.15

Prosite motif: PS01313 LIPB

Important sites: ACT_SITE 173-173

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAERGLPPIELHRLGRRPYVPVWQAMREFTDTRDADSPDQFWLVEHDPVFTQGQAGKAE
CCCCCCCCHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCCCCC
HLLMPGDIPVVATDRGGQVTYHGPGQVVLYPLIDVRRGKLGVRELVSALEQAVIDLLAAH
EEECCCCCCEEEECCCCEEEEECCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHC
GVTARARPDAPGVYVGETKIASLGLRIRRGASFHGVALNVDGDLAPFQCINPCGHAGMAM
CCCCCCCCCCCCEEECCHHHHHHCEEEECCCCCCEEEEECCCCCCCHHHCCCCCHHHHHH
TRLVDLVDDCPGCEAVALELAECLARQLGRRLTPMDTVPA
HHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
AAERGLPPIELHRLGRRPYVPVWQAMREFTDTRDADSPDQFWLVEHDPVFTQGQAGKAE
CCCCCCCHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCCCCC
HLLMPGDIPVVATDRGGQVTYHGPGQVVLYPLIDVRRGKLGVRELVSALEQAVIDLLAAH
EEECCCCCCEEEECCCCEEEEECCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHC
GVTARARPDAPGVYVGETKIASLGLRIRRGASFHGVALNVDGDLAPFQCINPCGHAGMAM
CCCCCCCCCCCCEEECCHHHHHHCEEEECCCCCCEEEEECCCCCCCHHHCCCCCHHHHHH
TRLVDLVDDCPGCEAVALELAECLARQLGRRLTPMDTVPA
HHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA