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The map label for this gene is mrdA [H]

Identifier: 92113669

GI number: 92113669

Start: 1756765

End: 1758666

Strand: Direct

Name: mrdA [H]

Synonym: Csal_1545

Alternate gene names: 92113669

Gene position: 1756765-1758666 (Clockwise)

Preceding gene: 92113668

Following gene: 92113670

Centisome position: 47.52

GC content: 64.62

Gene sequence:

>1902_bases
ATGCGTAAACGTCGCGACGCAATCAAGGATACCGAACGCGAGGTCCGGGTCTTCCGTGGCCGCTCGTTCCTGGCCGCCGT
GCTCGTGCTGTTGATGGCCGGCGGACTCGGTGCCCGCCTGTTCTACCTTCAGGTCGTCGAACACGAGGTGTTCACCACCC
GCTCGGAGAACAACCGCGTCCGGGTCGAGCCGCTGCCCCCGACCCGGGGCTTGATCTACGACCGTCAGGGCAAGCTGGTG
GCGGAGAATCGGCCGACCTATAACCTCACCATCGTGCGCGAGCGAGTCGACGATCTCGACGCCACCCTCGAGCGACTGGT
CGATGTCCTGGGGCTGGACGAAGATCAGGTCGCGGCGTTCCGCAAACGCTCGCGCCAGCGTCAGCGGCCGTATCAACCGG
CCTTGCTGATGAGCGATCTCAGCGAGCGCCAGATTGCCCACCTGGCCGTCAATCGCTACCGGCTTCCGGGTGTCGAGGTC
GAGGCGCAATGGCTGCGCTATTATCCCGACCCCAAGATCATGTCGCACGTGCTGGGCTACGTGGGGCGAATCAACGAGCA
GGAGCTCGCATCGCTGGACGGTGGCAACTACGCGGGTACGCACTATATCGGCAAGACCGGGATCGAGAAGCAGTACGAAG
CCGCCCTGCACGGGCAGGCCGGCTTGCGCAAGGTGGAGACCAACGCGCGCGGGCGCGTGCTTCGCGAGCTTGAGCGTACA
CCGCCGCAACCGGGCAAGGACCTGACGCTGACCATCGATACGCGCCTGCAGCAGCTGGCGTACGATCTGCTGGACGGCCG
GCGCGGGTCCATCGTCGCCATTCAGCCCCAGACGGGCGATATCCTGGCGATGGTGTCGGCGCCGGGGTTCGACTCGAACA
AGTTCGTGACCGGCATTTCCTACAAGGACTATCAAGCCCTGCAGCAGGACCTCGACCTGCCGTTGTTCAACCGGGCCGTA
CGCGGCCACTATCCACCGGGCTCCACGATCAAGCCGTTCGAAGCGCTGGCGGCATTGCAGCACGGCGTGGTGACACCGGA
CGAGGTCATCTACGATCCCGGCTACTACAAGCTGCCCAACGACTCCCGCCATTACCGCAACTGGCTGCGCTGGGGGCATG
GCCGAGTCGATCTGGAGCGTGCCCTGGCCGTGTCCAACAATACGTACTTCTACACCATGGCGCATCGCCTGGGGATCGAC
GCGTTATCCAGCTTCATGCACAAGTTCGGCTTCGGCGAAGTCAACTCGCTGGACGTGCAGGGCGCCTCGGCGGGTACCGT
GCCGTCGCGTGAATGGAAACGCGCGAAGTACGATCAGCCCTGGTACCCCGGGGAAACGCTCTCGGCCGGTATCGGCCAGG
GGTATTGGATGGTCACGCCCCTGCAGCTCGCCACCGCCGAGGCGACCCTGGCCAATCGCGGGCACTGGGTGCGTCCGCAT
CTTGCCAAGCGTGTCGGCGAGACCACGGTCGAGCCGCCTTTCGAGAACACCAGGCAGGACGTGGAGCTCGACAAGGATGC
CTGGTGGGACGACGTGTTCAGCGGCATGCAGAAAGTGGTCAGCGGTCGTGAAGGGACCGCGCGCCACATCGGCAAGGGGC
TGAAGTATGAAATGGCCGGCAAGTCGGGGACGGCGCAGGTGTTTTCGCTGGGGCAAAACCAGAAATACGATGCCGATGAA
CTCAGGGAGCGCCTGCGGGACCATGCCCTGTTCACGGCGTTCGCCCCGGTGGACGATCCCCAGATCGCCATTGCCGTGAT
CGTCGAGAACGCGGGGGGCGGCAGTTCGCACGCCGCCGGACTGGCCCGTGCGCTGGCGGACGAGTGGCTTTTGCCCGATG
ACGAGAACACCCACCAGGCCGAGAAACTGATCGAGGAGGACGTCGAAGTTGAAGGGACTTGA

Upstream 100 bases:

>100_bases
TTGGACCTTGCTGGCCGGGCACCCTTATCACCGATGAGCATCCAGGCCATGACGTGCCGGGGTGAATGCCTTCCACCTTC
CCGCTTGTTATCGGGGACCC

Downstream 100 bases:

>100_bases
GTGGCGTCGATTCAGTCCGGCATCGTCCGATGGCATGGGGCGCAAGCGTTCGTTGTGGTCGCGCCTGCATCTCGACCCCT
GGCTGCTGCTGCTGCTGCTG

Product: peptidoglycan glycosyltransferase

Products: NA

Alternate protein names: PBP-2 [H]

Number of amino acids: Translated: 633; Mature: 633

Protein sequence:

>633_residues
MRKRRDAIKDTEREVRVFRGRSFLAAVLVLLMAGGLGARLFYLQVVEHEVFTTRSENNRVRVEPLPPTRGLIYDRQGKLV
AENRPTYNLTIVRERVDDLDATLERLVDVLGLDEDQVAAFRKRSRQRQRPYQPALLMSDLSERQIAHLAVNRYRLPGVEV
EAQWLRYYPDPKIMSHVLGYVGRINEQELASLDGGNYAGTHYIGKTGIEKQYEAALHGQAGLRKVETNARGRVLRELERT
PPQPGKDLTLTIDTRLQQLAYDLLDGRRGSIVAIQPQTGDILAMVSAPGFDSNKFVTGISYKDYQALQQDLDLPLFNRAV
RGHYPPGSTIKPFEALAALQHGVVTPDEVIYDPGYYKLPNDSRHYRNWLRWGHGRVDLERALAVSNNTYFYTMAHRLGID
ALSSFMHKFGFGEVNSLDVQGASAGTVPSREWKRAKYDQPWYPGETLSAGIGQGYWMVTPLQLATAEATLANRGHWVRPH
LAKRVGETTVEPPFENTRQDVELDKDAWWDDVFSGMQKVVSGREGTARHIGKGLKYEMAGKSGTAQVFSLGQNQKYDADE
LRERLRDHALFTAFAPVDDPQIAIAVIVENAGGGSSHAAGLARALADEWLLPDDENTHQAEKLIEEDVEVEGT

Sequences:

>Translated_633_residues
MRKRRDAIKDTEREVRVFRGRSFLAAVLVLLMAGGLGARLFYLQVVEHEVFTTRSENNRVRVEPLPPTRGLIYDRQGKLV
AENRPTYNLTIVRERVDDLDATLERLVDVLGLDEDQVAAFRKRSRQRQRPYQPALLMSDLSERQIAHLAVNRYRLPGVEV
EAQWLRYYPDPKIMSHVLGYVGRINEQELASLDGGNYAGTHYIGKTGIEKQYEAALHGQAGLRKVETNARGRVLRELERT
PPQPGKDLTLTIDTRLQQLAYDLLDGRRGSIVAIQPQTGDILAMVSAPGFDSNKFVTGISYKDYQALQQDLDLPLFNRAV
RGHYPPGSTIKPFEALAALQHGVVTPDEVIYDPGYYKLPNDSRHYRNWLRWGHGRVDLERALAVSNNTYFYTMAHRLGID
ALSSFMHKFGFGEVNSLDVQGASAGTVPSREWKRAKYDQPWYPGETLSAGIGQGYWMVTPLQLATAEATLANRGHWVRPH
LAKRVGETTVEPPFENTRQDVELDKDAWWDDVFSGMQKVVSGREGTARHIGKGLKYEMAGKSGTAQVFSLGQNQKYDADE
LRERLRDHALFTAFAPVDDPQIAIAVIVENAGGGSSHAAGLARALADEWLLPDDENTHQAEKLIEEDVEVEGT
>Mature_633_residues
MRKRRDAIKDTEREVRVFRGRSFLAAVLVLLMAGGLGARLFYLQVVEHEVFTTRSENNRVRVEPLPPTRGLIYDRQGKLV
AENRPTYNLTIVRERVDDLDATLERLVDVLGLDEDQVAAFRKRSRQRQRPYQPALLMSDLSERQIAHLAVNRYRLPGVEV
EAQWLRYYPDPKIMSHVLGYVGRINEQELASLDGGNYAGTHYIGKTGIEKQYEAALHGQAGLRKVETNARGRVLRELERT
PPQPGKDLTLTIDTRLQQLAYDLLDGRRGSIVAIQPQTGDILAMVSAPGFDSNKFVTGISYKDYQALQQDLDLPLFNRAV
RGHYPPGSTIKPFEALAALQHGVVTPDEVIYDPGYYKLPNDSRHYRNWLRWGHGRVDLERALAVSNNTYFYTMAHRLGID
ALSSFMHKFGFGEVNSLDVQGASAGTVPSREWKRAKYDQPWYPGETLSAGIGQGYWMVTPLQLATAEATLANRGHWVRPH
LAKRVGETTVEPPFENTRQDVELDKDAWWDDVFSGMQKVVSGREGTARHIGKGLKYEMAGKSGTAQVFSLGQNQKYDADE
LRERLRDHALFTAFAPVDDPQIAIAVIVENAGGGSSHAAGLARALADEWLLPDDENTHQAEKLIEEDVEVEGT

Specific function: Cell wall formation; PBP-2 is responsible for the determination of the rod shape of the cell. Its synthesize cross- linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell inner membrane [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786854, Length=625, Percent_Identity=43.04, Blast_Score=535, Evalue=1e-153,
Organism=Escherichia coli, GI1786272, Length=599, Percent_Identity=25.7095158597663, Blast_Score=157, Evalue=1e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460
- InterPro:   IPR017790 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 71140; Mature: 71140

Theoretical pI: Translated: 6.78; Mature: 6.78

Prosite motif: PS00626 RCC1_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKRRDAIKDTEREVRVFRGRSFLAAVLVLLMAGGLGARLFYLQVVEHEVFTTRSENNRV
CCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHEECCCCCEE
RVEPLPPTRGLIYDRQGKLVAENRPTYNLTIVRERVDDLDATLERLVDVLGLDEDQVAAF
EEEECCCCCCEEECCCCCEEECCCCCEEEEEHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
RKRSRQRQRPYQPALLMSDLSERQIAHLAVNRYRLPGVEVEAQWLRYYPDPKIMSHVLGY
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEHHHHHCCCCHHHHHHHHHH
VGRINEQELASLDGGNYAGTHYIGKTGIEKQYEAALHGQAGLRKVETNARGRVLRELERT
HHCCCHHHHHHCCCCCCCCCEECCCCCCCHHHHHHHCCHHCCHHHHCCHHHHHHHHHHCC
PPQPGKDLTLTIDTRLQQLAYDLLDGRRGSIVAIQPQTGDILAMVSAPGFDSNKFVTGIS
CCCCCCCEEEEHHHHHHHHHHHHHCCCCCCEEEEECCCCCEEEEEECCCCCCCCEEECCC
YKDYQALQQDLDLPLFNRAVRGHYPPGSTIKPFEALAALQHGVVTPDEVIYDPGYYKLPN
HHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCHHEEECCCCEECCC
DSRHYRNWLRWGHGRVDLERALAVSNNTYFYTMAHRLGIDALSSFMHKFGFGEVNSLDVQ
CCHHHHHHHHHCCCCEEHHHHHEECCCEEEEEHHHHHCHHHHHHHHHHCCCCCCCCEEEC
GASAGTVPSREWKRAKYDQPWYPGETLSAGIGQGYWMVTPLQLATAEATLANRGHWVRPH
CCCCCCCCCHHHHHCCCCCCCCCCCHHHHCCCCCEEEEECHHHHHHHHHHHCCCCCCCHH
LAKRVGETTVEPPFENTRQDVELDKDAWWDDVFSGMQKVVSGREGTARHIGKGLKYEMAG
HHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHCCCCEEEECC
KSGTAQVFSLGQNQKYDADELRERLRDHALFTAFAPVDDPQIAIAVIVENAGGGSSHAAG
CCCCHHHHCCCCCCCCCHHHHHHHHHHHHEEEEECCCCCCCEEEEEEEECCCCCCHHHHH
LARALADEWLLPDDENTHQAEKLIEEDVEVEGT
HHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MRKRRDAIKDTEREVRVFRGRSFLAAVLVLLMAGGLGARLFYLQVVEHEVFTTRSENNRV
CCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHEECCCCCEE
RVEPLPPTRGLIYDRQGKLVAENRPTYNLTIVRERVDDLDATLERLVDVLGLDEDQVAAF
EEEECCCCCCEEECCCCCEEECCCCCEEEEEHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
RKRSRQRQRPYQPALLMSDLSERQIAHLAVNRYRLPGVEVEAQWLRYYPDPKIMSHVLGY
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEHHHHHCCCCHHHHHHHHHH
VGRINEQELASLDGGNYAGTHYIGKTGIEKQYEAALHGQAGLRKVETNARGRVLRELERT
HHCCCHHHHHHCCCCCCCCCEECCCCCCCHHHHHHHCCHHCCHHHHCCHHHHHHHHHHCC
PPQPGKDLTLTIDTRLQQLAYDLLDGRRGSIVAIQPQTGDILAMVSAPGFDSNKFVTGIS
CCCCCCCEEEEHHHHHHHHHHHHHCCCCCCEEEEECCCCCEEEEEECCCCCCCCEEECCC
YKDYQALQQDLDLPLFNRAVRGHYPPGSTIKPFEALAALQHGVVTPDEVIYDPGYYKLPN
HHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCHHEEECCCCEECCC
DSRHYRNWLRWGHGRVDLERALAVSNNTYFYTMAHRLGIDALSSFMHKFGFGEVNSLDVQ
CCHHHHHHHHHCCCCEEHHHHHEECCCEEEEEHHHHHCHHHHHHHHHHCCCCCCCCEEEC
GASAGTVPSREWKRAKYDQPWYPGETLSAGIGQGYWMVTPLQLATAEATLANRGHWVRPH
CCCCCCCCCHHHHHCCCCCCCCCCCHHHHCCCCCEEEEECHHHHHHHHHHHCCCCCCCHH
LAKRVGETTVEPPFENTRQDVELDKDAWWDDVFSGMQKVVSGREGTARHIGKGLKYEMAG
HHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHCCCCEEEECC
KSGTAQVFSLGQNQKYDADELRERLRDHALFTAFAPVDDPQIAIAVIVENAGGGSSHAAG
CCCCHHHHCCCCCCCCCHHHHHHHHHHHHEEEEECCCCCCCEEEEEEEECCCCCCHHHHH
LARALADEWLLPDDENTHQAEKLIEEDVEVEGT
HHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]