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The map label for this gene is adhA [H]

Identifier: 92113551

GI number: 92113551

Start: 1614373

End: 1615371

Strand: Direct

Name: adhA [H]

Synonym: Csal_1426

Alternate gene names: 92113551

Gene position: 1614373-1615371 (Clockwise)

Preceding gene: 92113543

Following gene: 92113554

Centisome position: 43.67

GC content: 57.56

Gene sequence:

>999_bases
ATGAAGGCCATGGTACTCGAGAGAAGAGGTGGGCCACTTCAAGAGCGGGAGCGACCTGTTCCTGTACCTGGCCCTGGGCA
GGTGTTGCTCAAGGTTGAAGCCTGTGGAGTATGCCGCACCGACCTGCATTTGTTGGATGGTGAGCTGCCGGACATTCTCT
ATCCTATCGTCCCTGGACATGAAATCATTGGCCGCGTTGCGGGTTGTGGCCCCGGCGTCACGCTCTCTCATGGGGTACGC
CTGGGCGTTCCGTGGCTGGGGTACAGCTGTGGTGAGTGCTGGTATTGTCTGCACGAGCAAGAAAACCTATGTGACCGGGC
CCGCTTTACCGGTTATCAAATTGATGGTGGCTTTGCGGACTATACCCTGGCGGATCACCGCTTCTGCCTTCCTGTCAATC
CTGATTGCGATGCAGCTGAAGCGGCACCGTTAATGTGTGCTGGCCTGATCGGCTACCGTGCTTTAAACATGTGCGGCAGT
GGCCTGCAACGCCTGGGCATCTATGGCTTTGGCGCTGCAGCTCATATCGTGGCTCAAGTTGTTTTATGGCAGGGCGTCGA
ATTGTATGCCTTTACTCGACCGGGAGACGAGGAAGGGCAAGAATTTGCGCGTCACATGGGGGCAATCTGGGCAGGGGATT
CCCACCAACTGCCCGATCTGCCATTGGATGCAGCGATCATATTTGCACCCGTAGGTGAGCTTGTACCCGCTGCGCTGCGC
GCCGTGCGTAAAGGCGGGGTGGTCGTTTGTGGTGGCATTCATATGAGTGACATTCCCACCTTTCCCTACGCGCTGCTCTG
GGGCGAGCGTCAGTTGCGCTCGGTCGCCAACCTGACCCGTAAGGACGGTGAAAACTTCCTTGGCCTGATCTCAAAAGTCG
CAATCGACACCCATATAGAGCGGTATCCGCTTCATGCCGCCAACCAGGCACTCAGAGACCTCAAGGAGGGCAGGTTGCAG
GGGGCTGCCGTGCTGGAAATGGCGGGAACTGCTGATTGA

Upstream 100 bases:

>100_bases
CATCAAGGTTCTGGTTCTTGTCGGGGGAGTGGAGCAATCTCGACCAGGTGGGCACACGGTCGAGACTGTTCAGTGATATC
AAGGCTCAGGAATGAACCAC

Downstream 100 bases:

>100_bases
ACAATTAGATAGTAACGACACTGTATTTCTTGATGATTTGCCATGGCGGTCAAGCTGAATGACGCAGCCTGCCGTGTGCC
TGGCTGGCTCCATCTGCCAC

Product: alcohol dehydrogenase GroES-like protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 332; Mature: 332

Protein sequence:

>332_residues
MKAMVLERRGGPLQERERPVPVPGPGQVLLKVEACGVCRTDLHLLDGELPDILYPIVPGHEIIGRVAGCGPGVTLSHGVR
LGVPWLGYSCGECWYCLHEQENLCDRARFTGYQIDGGFADYTLADHRFCLPVNPDCDAAEAAPLMCAGLIGYRALNMCGS
GLQRLGIYGFGAAAHIVAQVVLWQGVELYAFTRPGDEEGQEFARHMGAIWAGDSHQLPDLPLDAAIIFAPVGELVPAALR
AVRKGGVVVCGGIHMSDIPTFPYALLWGERQLRSVANLTRKDGENFLGLISKVAIDTHIERYPLHAANQALRDLKEGRLQ
GAAVLEMAGTAD

Sequences:

>Translated_332_residues
MKAMVLERRGGPLQERERPVPVPGPGQVLLKVEACGVCRTDLHLLDGELPDILYPIVPGHEIIGRVAGCGPGVTLSHGVR
LGVPWLGYSCGECWYCLHEQENLCDRARFTGYQIDGGFADYTLADHRFCLPVNPDCDAAEAAPLMCAGLIGYRALNMCGS
GLQRLGIYGFGAAAHIVAQVVLWQGVELYAFTRPGDEEGQEFARHMGAIWAGDSHQLPDLPLDAAIIFAPVGELVPAALR
AVRKGGVVVCGGIHMSDIPTFPYALLWGERQLRSVANLTRKDGENFLGLISKVAIDTHIERYPLHAANQALRDLKEGRLQ
GAAVLEMAGTAD
>Mature_332_residues
MKAMVLERRGGPLQERERPVPVPGPGQVLLKVEACGVCRTDLHLLDGELPDILYPIVPGHEIIGRVAGCGPGVTLSHGVR
LGVPWLGYSCGECWYCLHEQENLCDRARFTGYQIDGGFADYTLADHRFCLPVNPDCDAAEAAPLMCAGLIGYRALNMCGS
GLQRLGIYGFGAAAHIVAQVVLWQGVELYAFTRPGDEEGQEFARHMGAIWAGDSHQLPDLPLDAAIIFAPVGELVPAALR
AVRKGGVVVCGGIHMSDIPTFPYALLWGERQLRSVANLTRKDGENFLGLISKVAIDTHIERYPLHAANQALRDLKEGRLQ
GAAVLEMAGTAD

Specific function: Preferred Specificity Is Towards 1-Propanol. [C]

COG id: COG1064

COG function: function code R; Zn-dependent alcohol dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI71565154, Length=109, Percent_Identity=37.6146788990826, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI4501939, Length=114, Percent_Identity=35.0877192982456, Blast_Score=65, Evalue=1e-10,
Organism=Escherichia coli, GI87081918, Length=323, Percent_Identity=31.2693498452012, Blast_Score=111, Evalue=6e-26,
Organism=Escherichia coli, GI87082401, Length=335, Percent_Identity=26.5671641791045, Blast_Score=108, Evalue=7e-25,
Organism=Escherichia coli, GI1786518, Length=209, Percent_Identity=32.5358851674641, Blast_Score=86, Evalue=5e-18,
Organism=Escherichia coli, GI1787863, Length=225, Percent_Identity=30.6666666666667, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI226510992, Length=108, Percent_Identity=35.1851851851852, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI1786825, Length=112, Percent_Identity=32.1428571428571, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1786552, Length=201, Percent_Identity=29.8507462686567, Blast_Score=62, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17562584, Length=341, Percent_Identity=25.5131964809384, Blast_Score=115, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI17562582, Length=342, Percent_Identity=25.4385964912281, Blast_Score=114, Evalue=5e-26,
Organism=Caenorhabditis elegans, GI71988145, Length=333, Percent_Identity=24.3243243243243, Blast_Score=98, Evalue=7e-21,
Organism=Caenorhabditis elegans, GI25146526, Length=199, Percent_Identity=33.1658291457286, Blast_Score=74, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI71997431, Length=201, Percent_Identity=32.8358208955224, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17565904, Length=177, Percent_Identity=33.3333333333333, Blast_Score=65, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6323961, Length=157, Percent_Identity=38.8535031847134, Blast_Score=108, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6323729, Length=157, Percent_Identity=36.3057324840764, Blast_Score=103, Evalue=5e-23,
Organism=Saccharomyces cerevisiae, GI6324486, Length=157, Percent_Identity=36.9426751592357, Blast_Score=101, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6319621, Length=157, Percent_Identity=35.6687898089172, Blast_Score=101, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6323980, Length=340, Percent_Identity=27.6470588235294, Blast_Score=92, Evalue=8e-20,
Organism=Saccharomyces cerevisiae, GI6319949, Length=325, Percent_Identity=26.4615384615385, Blast_Score=79, Evalue=1e-15,
Organism=Drosophila melanogaster, GI17737895, Length=113, Percent_Identity=37.1681415929204, Blast_Score=66, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR014187
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 35811; Mature: 35811

Theoretical pI: Translated: 5.75; Mature: 5.75

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
3.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAMVLERRGGPLQERERPVPVPGPGQVLLKVEACGVCRTDLHLLDGELPDILYPIVPGH
CCCEEEECCCCCHHHCCCCCCCCCCCCEEEEEECCCCCHHHHHHHCCCCCHHEECCCCCH
EIIGRVAGCGPGVTLSHGVRLGVPWLGYSCGECWYCLHEQENLCDRARFTGYQIDGGFAD
HHHHHHHCCCCCCCCCCCCEECCCCCCCCCCCCEEEECCHHHHHHHHHCCCEEECCCEEC
YTLADHRFCLPVNPDCDAAEAAPLMCAGLIGYRALNMCGSGLQRLGIYGFGAAAHIVAQV
EEECCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
VLWQGVELYAFTRPGDEEGQEFARHMGAIWAGDSHQLPDLPLDAAIIFAPVGELVPAALR
HHHCCCEEEEEECCCCHHHHHHHHHHCCEECCCCCCCCCCCCCHHEEECCHHHHHHHHHH
AVRKGGVVVCGGIHMSDIPTFPYALLWGERQLRSVANLTRKDGENFLGLISKVAIDTHIE
HHHCCCEEEECCCCCCCCCCCCHHHHHCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
RYPLHAANQALRDLKEGRLQGAAVLEMAGTAD
HCCCHHHHHHHHHHHHHHCCCCEEEEECCCCC
>Mature Secondary Structure
MKAMVLERRGGPLQERERPVPVPGPGQVLLKVEACGVCRTDLHLLDGELPDILYPIVPGH
CCCEEEECCCCCHHHCCCCCCCCCCCCEEEEEECCCCCHHHHHHHCCCCCHHEECCCCCH
EIIGRVAGCGPGVTLSHGVRLGVPWLGYSCGECWYCLHEQENLCDRARFTGYQIDGGFAD
HHHHHHHCCCCCCCCCCCCEECCCCCCCCCCCCEEEECCHHHHHHHHHCCCEEECCCEEC
YTLADHRFCLPVNPDCDAAEAAPLMCAGLIGYRALNMCGSGLQRLGIYGFGAAAHIVAQV
EEECCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
VLWQGVELYAFTRPGDEEGQEFARHMGAIWAGDSHQLPDLPLDAAIIFAPVGELVPAALR
HHHCCCEEEEEECCCCHHHHHHHHHHCCEECCCCCCCCCCCCCHHEEECCHHHHHHHHHH
AVRKGGVVVCGGIHMSDIPTFPYALLWGERQLRSVANLTRKDGENFLGLISKVAIDTHIE
HHHCCCEEEECCCCCCCCCCCCHHHHHCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
RYPLHAANQALRDLKEGRLQGAAVLEMAGTAD
HCCCHHHHHHHHHHHHHHCCCCEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]