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The map label for this gene is frmA [H]

Identifier: 92113113

GI number: 92113113

Start: 1105011

End: 1106120

Strand: Direct

Name: frmA [H]

Synonym: Csal_0985

Alternate gene names: 92113113

Gene position: 1105011-1106120 (Clockwise)

Preceding gene: 92113111

Following gene: 92113114

Centisome position: 29.89

GC content: 63.51

Gene sequence:

>1110_bases
ATGAAATCACGCGCCGCCATTGCTTGGGAAGCCGGCAAGCCGCTGGAACTCGCCGAGATCGACGTCGAAGGGCCCAAGGC
CGGCGAAGTCATGGTTCAGATCAAGGCGACCAGCGTCTGCCATACCGACGCTTACACGTTGTCCGGCGCCGATCCCGAGG
GCAACTTCCCGGCGGTGCTGGGCCATGAAGGGGCCGGGATCGTGCAGGAAGTCGGCGAGGGCGTCACCAGCCTCAAGCCC
GGCGATCACGTCATTCCGCTTTATACCGCCGAGTGCGGCAAGTGCAAATTCTGTCTCTCCGGCAAGACCAACCTGTGCAG
CTCGGTCCGCGCCACCCAGGGCAAGGGCGTGATGCCCGACGGGACCTCGCGCTTCTCCAAGGATGGACAATCGCTGCATC
ACTACATGGGCTGCTCGACGTTCAGCGAGTACACCGTGCTGCCCGAGGTCTCGCTGGCCAAGGTCTCCCCGGAAGCGCCG
CTGGACAAGATCTGCCTGCTGGGCTGCGGGGTGACCACCGGTATCGGCGCGGTCATGAACACCGCCAAGGTCGAGCCGGG
GGCCACCGTCGCCGTGTTCGGTCTCGGCGCCATCGGCCTGGCCGTCATCCAGGGCGCGGTCATGGCCAAGGCGAGCCGCA
TCATCGCCATCGACGTCAATCCGGACAAGTTCGACATGGCGCGTCAATTCGGTGCCACCGACTTCGTCAATCCGAAGGAT
TACGCGGATCCCATTCAGCAGGTCATCGTCGACTTGACCGACGGCGGTGTCGATTATTCCTTCGAATGCATCGGCAATGT
CAATGTCATGCGTTCGGCGCTGGAGTGCTGCCACAAGGGGTGGGGCGAGTCGATCATCATCGGCGTGGCCGGCGCCGGCG
AAGAAATTTCCACGCGTCCGTTCCAGCTGGTCACCGGGCGCGTCTGGAAGGGGTCCGCCTTCGGTGGCGTCAAGGGCCGC
AGCGAACTGCCGGGCTATGTCGACGACTACATGAACGGCAAGCTCAAGATCGACGAGTTCGTCACCCAGGACATGCCGTT
CGAGCAGATCAACGAGGCGTTCGAGCTGCTGCACGCCGGCAAGAGCATCCGCACCGTGCTGCACTATTGA

Upstream 100 bases:

>100_bases
GGCGCGCCGACTGCCTAGACTGGAGGGGTTAACCCCGCGCGCCTGGATTGCCTTTGCTGGTGCCTCGCGCGCCGCCACGA
TCGACGAAGGAGAATGCCTG

Downstream 100 bases:

>100_bases
TCCATCGCGCCCGGTACCGCGCGAAGAGCATCTGATTTATCGCGCCCGATGCCGCGCGACAGGCGCTTGACACGCGCCTG
TGGTGATTCATCGCGTCCGG

Product: alcohol dehydrogenase GroES-like protein

Products: NA

Alternate protein names: Alcohol dehydrogenase class-3; Alcohol dehydrogenase class-III; Glutathione-dependent formaldehyde dehydrogenase; FALDH; FDH; GSH-FDH [H]

Number of amino acids: Translated: 369; Mature: 369

Protein sequence:

>369_residues
MKSRAAIAWEAGKPLELAEIDVEGPKAGEVMVQIKATSVCHTDAYTLSGADPEGNFPAVLGHEGAGIVQEVGEGVTSLKP
GDHVIPLYTAECGKCKFCLSGKTNLCSSVRATQGKGVMPDGTSRFSKDGQSLHHYMGCSTFSEYTVLPEVSLAKVSPEAP
LDKICLLGCGVTTGIGAVMNTAKVEPGATVAVFGLGAIGLAVIQGAVMAKASRIIAIDVNPDKFDMARQFGATDFVNPKD
YADPIQQVIVDLTDGGVDYSFECIGNVNVMRSALECCHKGWGESIIIGVAGAGEEISTRPFQLVTGRVWKGSAFGGVKGR
SELPGYVDDYMNGKLKIDEFVTQDMPFEQINEAFELLHAGKSIRTVLHY

Sequences:

>Translated_369_residues
MKSRAAIAWEAGKPLELAEIDVEGPKAGEVMVQIKATSVCHTDAYTLSGADPEGNFPAVLGHEGAGIVQEVGEGVTSLKP
GDHVIPLYTAECGKCKFCLSGKTNLCSSVRATQGKGVMPDGTSRFSKDGQSLHHYMGCSTFSEYTVLPEVSLAKVSPEAP
LDKICLLGCGVTTGIGAVMNTAKVEPGATVAVFGLGAIGLAVIQGAVMAKASRIIAIDVNPDKFDMARQFGATDFVNPKD
YADPIQQVIVDLTDGGVDYSFECIGNVNVMRSALECCHKGWGESIIIGVAGAGEEISTRPFQLVTGRVWKGSAFGGVKGR
SELPGYVDDYMNGKLKIDEFVTQDMPFEQINEAFELLHAGKSIRTVLHY
>Mature_369_residues
MKSRAAIAWEAGKPLELAEIDVEGPKAGEVMVQIKATSVCHTDAYTLSGADPEGNFPAVLGHEGAGIVQEVGEGVTSLKP
GDHVIPLYTAECGKCKFCLSGKTNLCSSVRATQGKGVMPDGTSRFSKDGQSLHHYMGCSTFSEYTVLPEVSLAKVSPEAP
LDKICLLGCGVTTGIGAVMNTAKVEPGATVAVFGLGAIGLAVIQGAVMAKASRIIAIDVNPDKFDMARQFGATDFVNPKD
YADPIQQVIVDLTDGGVDYSFECIGNVNVMRSALECCHKGWGESIIIGVAGAGEEISTRPFQLVTGRVWKGSAFGGVKGR
SELPGYVDDYMNGKLKIDEFVTQDMPFEQINEAFELLHAGKSIRTVLHY

Specific function: Has High Formaldehyde Dehydrogenase Activity In The Presence Of Glutathione And Catalyzes The Oxidation Of Normal Alcohols In A Reaction That Is Not Gsh-Dependent. In Addition, Hemithiolacetals Other Than Those Formed From Gsh, Including Omega-Thiol Fatty

COG id: COG1062

COG function: function code C; Zn-dependent alcohol dehydrogenases, class III

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily [H]

Homologues:

Organism=Homo sapiens, GI71565154, Length=367, Percent_Identity=66.2125340599455, Blast_Score=517, Evalue=1e-147,
Organism=Homo sapiens, GI34577061, Length=369, Percent_Identity=48.780487804878, Blast_Score=399, Evalue=1e-111,
Organism=Homo sapiens, GI4501933, Length=369, Percent_Identity=48.2384823848238, Blast_Score=392, Evalue=1e-109,
Organism=Homo sapiens, GI4501929, Length=369, Percent_Identity=48.2384823848238, Blast_Score=389, Evalue=1e-108,
Organism=Homo sapiens, GI71565152, Length=373, Percent_Identity=49.3297587131367, Blast_Score=386, Evalue=1e-107,
Organism=Homo sapiens, GI262073058, Length=369, Percent_Identity=46.070460704607, Blast_Score=362, Evalue=1e-100,
Organism=Homo sapiens, GI71743840, Length=369, Percent_Identity=46.070460704607, Blast_Score=362, Evalue=1e-100,
Organism=Homo sapiens, GI156523966, Length=367, Percent_Identity=45.2316076294278, Blast_Score=357, Evalue=1e-98,
Organism=Homo sapiens, GI4501939, Length=361, Percent_Identity=45.1523545706371, Blast_Score=350, Evalue=1e-96,
Organism=Homo sapiens, GI156627571, Length=363, Percent_Identity=25.068870523416, Blast_Score=76, Evalue=4e-14,
Organism=Escherichia coli, GI1786552, Length=369, Percent_Identity=72.0867208672087, Blast_Score=541, Evalue=1e-155,
Organism=Escherichia coli, GI87082125, Length=380, Percent_Identity=24.7368421052632, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1788073, Length=367, Percent_Identity=27.2479564032698, Blast_Score=101, Evalue=7e-23,
Organism=Escherichia coli, GI1787863, Length=355, Percent_Identity=24.7887323943662, Blast_Score=101, Evalue=1e-22,
Organism=Escherichia coli, GI1786825, Length=363, Percent_Identity=27.5482093663912, Blast_Score=96, Evalue=5e-21,
Organism=Escherichia coli, GI87081918, Length=225, Percent_Identity=32.4444444444444, Blast_Score=92, Evalue=4e-20,
Organism=Escherichia coli, GI1790045, Length=357, Percent_Identity=24.6498599439776, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1788075, Length=372, Percent_Identity=24.1935483870968, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1788407, Length=227, Percent_Identity=28.1938325991189, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI1790718, Length=330, Percent_Identity=24.5454545454545, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI226510992, Length=356, Percent_Identity=23.0337078651685, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1786518, Length=369, Percent_Identity=27.9132791327913, Blast_Score=69, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI25146526, Length=373, Percent_Identity=60.0536193029491, Blast_Score=468, Evalue=1e-132,
Organism=Caenorhabditis elegans, GI71997431, Length=375, Percent_Identity=60, Blast_Score=464, Evalue=1e-131,
Organism=Caenorhabditis elegans, GI17565904, Length=340, Percent_Identity=60.2941176470588, Blast_Score=432, Evalue=1e-121,
Organism=Caenorhabditis elegans, GI17562584, Length=294, Percent_Identity=28.5714285714286, Blast_Score=92, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI17562582, Length=257, Percent_Identity=28.0155642023346, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI71988145, Length=220, Percent_Identity=29.0909090909091, Blast_Score=76, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6320033, Length=371, Percent_Identity=64.9595687331536, Blast_Score=509, Evalue=1e-145,
Organism=Saccharomyces cerevisiae, GI6319621, Length=277, Percent_Identity=30.3249097472924, Blast_Score=100, Evalue=3e-22,
Organism=Saccharomyces cerevisiae, GI6323099, Length=385, Percent_Identity=28.5714285714286, Blast_Score=93, Evalue=7e-20,
Organism=Saccharomyces cerevisiae, GI6323961, Length=314, Percent_Identity=27.7070063694268, Blast_Score=88, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6324486, Length=361, Percent_Identity=26.3157894736842, Blast_Score=86, Evalue=7e-18,
Organism=Saccharomyces cerevisiae, GI6323729, Length=252, Percent_Identity=28.1746031746032, Blast_Score=82, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6322619, Length=364, Percent_Identity=27.4725274725275, Blast_Score=77, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6319955, Length=364, Percent_Identity=27.4725274725275, Blast_Score=76, Evalue=9e-15,
Organism=Saccharomyces cerevisiae, GI6319257, Length=276, Percent_Identity=25.3623188405797, Blast_Score=66, Evalue=1e-11,
Organism=Drosophila melanogaster, GI17737895, Length=368, Percent_Identity=64.945652173913, Blast_Score=512, Evalue=1e-145,
Organism=Drosophila melanogaster, GI17137530, Length=355, Percent_Identity=25.9154929577465, Blast_Score=82, Evalue=5e-16,
Organism=Drosophila melanogaster, GI17737897, Length=252, Percent_Identity=26.5873015873016, Blast_Score=72, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014183
- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.284; =1.1.1.1 [H]

Molecular weight: Translated: 39059; Mature: 39059

Theoretical pI: Translated: 4.99; Mature: 4.99

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
3.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSRAAIAWEAGKPLELAEIDVEGPKAGEVMVQIKATSVCHTDAYTLSGADPEGNFPAVL
CCCCCEEEECCCCCCEEEEEECCCCCCCCEEEEEEECEEEECCCEEECCCCCCCCCCEEE
GHEGAGIVQEVGEGVTSLKPGDHVIPLYTAECGKCKFCLSGKTNLCSSVRATQGKGVMPD
CCCCCCHHHHHCCCHHCCCCCCEEEEEEECCCCCEEEEECCCCHHHHHHHHCCCCCCCCC
GTSRFSKDGQSLHHYMGCSTFSEYTVLPEVSLAKVSPEAPLDKICLLGCGVTTGIGAVMN
CCHHHHHCHHHHHHHHCCCCCCCEEECCCCHHCCCCCCCCHHHHHEECCCHHHHHHHHHH
TAKVEPGATVAVFGLGAIGLAVIQGAVMAKASRIIAIDVNPDKFDMARQFGATDFVNPKD
HCCCCCCCEEEEEHHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHCCCCCCCCCHH
YADPIQQVIVDLTDGGVDYSFECIGNVNVMRSALECCHKGWGESIIIGVAGAGEEISTRP
HHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCC
FQLVTGRVWKGSAFGGVKGRSELPGYVDDYMNGKLKIDEFVTQDMPFEQINEAFELLHAG
EEEEECEEECCCCCCCCCCCCCCCCHHHHHCCCCEEEHHHHHCCCCHHHHHHHHHHHHCC
KSIRTVLHY
HHHHHHHCC
>Mature Secondary Structure
MKSRAAIAWEAGKPLELAEIDVEGPKAGEVMVQIKATSVCHTDAYTLSGADPEGNFPAVL
CCCCCEEEECCCCCCEEEEEECCCCCCCCEEEEEEECEEEECCCEEECCCCCCCCCCEEE
GHEGAGIVQEVGEGVTSLKPGDHVIPLYTAECGKCKFCLSGKTNLCSSVRATQGKGVMPD
CCCCCCHHHHHCCCHHCCCCCCEEEEEEECCCCCEEEEECCCCHHHHHHHHCCCCCCCCC
GTSRFSKDGQSLHHYMGCSTFSEYTVLPEVSLAKVSPEAPLDKICLLGCGVTTGIGAVMN
CCHHHHHCHHHHHHHHCCCCCCCEEECCCCHHCCCCCCCCHHHHHEECCCHHHHHHHHHH
TAKVEPGATVAVFGLGAIGLAVIQGAVMAKASRIIAIDVNPDKFDMARQFGATDFVNPKD
HCCCCCCCEEEEEHHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHCCCCCCCCCHH
YADPIQQVIVDLTDGGVDYSFECIGNVNVMRSALECCHKGWGESIIIGVAGAGEEISTRP
HHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCC
FQLVTGRVWKGSAFGGVKGRSELPGYVDDYMNGKLKIDEFVTQDMPFEQINEAFELLHAG
EEEEECEEECCCCCCCCCCCCCCCCHHHHHCCCCEEEHHHHHCCCCHHHHHHHHHHHHCC
KSIRTVLHY
HHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]