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The map label for this gene is aadR [H]

Identifier: 92113111

GI number: 92113111

Start: 1103239

End: 1103976

Strand: Direct

Name: aadR [H]

Synonym: Csal_0983

Alternate gene names: 92113111

Gene position: 1103239-1103976 (Clockwise)

Preceding gene: 92113110

Following gene: 92113113

Centisome position: 29.84

GC content: 62.06

Gene sequence:

>738_bases
ATGAGCGAAAACGATAGCTGCATCATCCGCCATTTTCGGCACTACGCCAATCTATCCGACAGCGATGAGGCCTTGCTGGA
TTCGCTGGAGCGTGAGCCACGTGAGGTCGCCCGTGGCGAGTCACTCTGGCAGACCGACGATCCGGCGGGTCGGTTCTGCA
CGCTTTCCAAGGGCTGGGCATACTCCTTCCGGGATATGGAGGACGGCTCGCGTCAGATTCTGGAGATCTACCTGCCGGGC
GACGTCATCGGTCTGCGCGAGTTCGCCTTTCATGAACGTCTGGCGGGCGTGACGATGATCGACGACGGTGTCGTCTGTGA
CTTCCCGCATCGGCGCTTGATAGAGGTGTTTCGCGAATCCTTCACGCTGTCGATGATCTTCTTCGCCGTGTCCTCGCATC
AACAGGCCCTGCTGACCGAGCGCCTGGTCAATCTGGCACGGCGCAGCGCGCGTCAAAAGATCGCGCACTTGATCTACGAA
ATGTACATGCGCCTGCAGCGCATCATGCCGCATTCCTCGCGGCGCTTTCGCCTGCCGCTGTCGCAGCAGCAGCTCGGCGA
TGCGCTGGGACTGACCTCGGTACACATCAGCCGCACCCTGAGCGGCTTTCGCGAAGAGGGCATCCTGCTGCGTGACCGCC
AGTGGGTGGAGCTGCTCGACCCCGACGCACTGGCGCGTGAGGGCGAGTTCGCCGGAAGGTACCTGCGCGATGGTCTGGGA
CCGTTATCGGGGGAATGA

Upstream 100 bases:

>100_bases
GCGCCTTGTATGGTTTTATTTCGTCGGAACATGTCGGGCACCGGCGTTCTTCTGGATGCCCGACGCACCATCTAGGGATC
GAGAAGATAAAAGGTCGCTC

Downstream 100 bases:

>100_bases
ACCTTCCCCTTGAAGCGTCGCCGGCAGGTGATCGACCAGAAAGTCGACGAACTGACGCACCTTGGGCGACAGGTGACGAT
GCCGTGGATAGATGGCCCAC

Product: Crp/FNR family transcriptional regulator

Products: NA

Alternate protein names: Anaerobic aromatic degradation regulator [H]

Number of amino acids: Translated: 245; Mature: 244

Protein sequence:

>245_residues
MSENDSCIIRHFRHYANLSDSDEALLDSLEREPREVARGESLWQTDDPAGRFCTLSKGWAYSFRDMEDGSRQILEIYLPG
DVIGLREFAFHERLAGVTMIDDGVVCDFPHRRLIEVFRESFTLSMIFFAVSSHQQALLTERLVNLARRSARQKIAHLIYE
MYMRLQRIMPHSSRRFRLPLSQQQLGDALGLTSVHISRTLSGFREEGILLRDRQWVELLDPDALAREGEFAGRYLRDGLG
PLSGE

Sequences:

>Translated_245_residues
MSENDSCIIRHFRHYANLSDSDEALLDSLEREPREVARGESLWQTDDPAGRFCTLSKGWAYSFRDMEDGSRQILEIYLPG
DVIGLREFAFHERLAGVTMIDDGVVCDFPHRRLIEVFRESFTLSMIFFAVSSHQQALLTERLVNLARRSARQKIAHLIYE
MYMRLQRIMPHSSRRFRLPLSQQQLGDALGLTSVHISRTLSGFREEGILLRDRQWVELLDPDALAREGEFAGRYLRDGLG
PLSGE
>Mature_244_residues
SENDSCIIRHFRHYANLSDSDEALLDSLEREPREVARGESLWQTDDPAGRFCTLSKGWAYSFRDMEDGSRQILEIYLPGD
VIGLREFAFHERLAGVTMIDDGVVCDFPHRRLIEVFRESFTLSMIFFAVSSHQQALLTERLVNLARRSARQKIAHLIYEM
YMRLQRIMPHSSRRFRLPLSQQQLGDALGLTSVHISRTLSGFREEGILLRDRQWVELLDPDALAREGEFAGRYLRDGLGP
LSGE

Specific function: Transcriptional activator of anaerobic gene expression. For aromatic acid degradation. Also required for the anaerobic degradation of benzoate [H]

COG id: COG0664

COG function: function code T; cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH crp-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787595, Length=201, Percent_Identity=23.8805970149254, Blast_Score=75, Evalue=6e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018490
- InterPro:   IPR000595
- InterPro:   IPR001808
- InterPro:   IPR012318
- InterPro:   IPR014710
- InterPro:   IPR018335
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00027 cNMP_binding; PF00325 Crp [H]

EC number: NA

Molecular weight: Translated: 28247; Mature: 28115

Theoretical pI: Translated: 6.10; Mature: 6.10

Prosite motif: PS51063 HTH_CRP_2 ; PS00136 SUBTILASE_ASP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSENDSCIIRHFRHYANLSDSDEALLDSLEREPREVARGESLWQTDDPAGRFCTLSKGWA
CCCCHHHHHHHHHHHCCCCCCHHHHHHHHHCCHHHHHCCCCCCCCCCCCCCEEECCCCCC
YSFRDMEDGSRQILEIYLPGDVIGLREFAFHERLAGVTMIDDGVVCDFPHRRLIEVFRES
CCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHCCCEEECCCCEECCCHHHHHHHHHHH
FTLSMIFFAVSSHQQALLTERLVNLARRSARQKIAHLIYEMYMRLQRIMPHSSRRFRLPL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCC
SQQQLGDALGLTSVHISRTLSGFREEGILLRDRQWVELLDPDALAREGEFAGRYLRDGLG
CHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCHHHHHCCCHHHHHCCHHHHHHHHHCCC
PLSGE
CCCCC
>Mature Secondary Structure 
SENDSCIIRHFRHYANLSDSDEALLDSLEREPREVARGESLWQTDDPAGRFCTLSKGWA
CCCHHHHHHHHHHHCCCCCCHHHHHHHHHCCHHHHHCCCCCCCCCCCCCCEEECCCCCC
YSFRDMEDGSRQILEIYLPGDVIGLREFAFHERLAGVTMIDDGVVCDFPHRRLIEVFRES
CCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHCCCEEECCCCEECCCHHHHHHHHHHH
FTLSMIFFAVSSHQQALLTERLVNLARRSARQKIAHLIYEMYMRLQRIMPHSSRRFRLPL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCC
SQQQLGDALGLTSVHISRTLSGFREEGILLRDRQWVELLDPDALAREGEFAGRYLRDGLG
CHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCHHHHHCCCHHHHHCCHHHHHHHHHCCC
PLSGE
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1522059; 10094687 [H]